Modulatory effects of levodopa on cognitive control in young, but not in older subjects: A pharmacological fMRI study

Onur OA, Piefke M, Lie C-H, Thiel C, Fink GR (2011)
Journal of Cognitive Neuroscience 23(10): 2797-2810.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Onur, Oezguer A.; Piefke, MartinaUniBi; Lie, Chun-Hyoun; Thiel, Christiane; Fink, Gereon R.
Journal of Cognitive Neuroscience
Page URI


Onur OA, Piefke M, Lie C-H, Thiel C, Fink GR. Modulatory effects of levodopa on cognitive control in young, but not in older subjects: A pharmacological fMRI study. Journal of Cognitive Neuroscience. 2011;23(10):2797-2810.
Onur, O. A., Piefke, M., Lie, C. - H., Thiel, C., & Fink, G. R. (2011). Modulatory effects of levodopa on cognitive control in young, but not in older subjects: A pharmacological fMRI study. Journal of Cognitive Neuroscience, 23(10), 2797-2810.
Onur, O. A., Piefke, M., Lie, C. - H., Thiel, C., and Fink, G. R. (2011). Modulatory effects of levodopa on cognitive control in young, but not in older subjects: A pharmacological fMRI study. Journal of Cognitive Neuroscience 23, 2797-2810.
Onur, O.A., et al., 2011. Modulatory effects of levodopa on cognitive control in young, but not in older subjects: A pharmacological fMRI study. Journal of Cognitive Neuroscience, 23(10), p 2797-2810.
O.A. Onur, et al., “Modulatory effects of levodopa on cognitive control in young, but not in older subjects: A pharmacological fMRI study”, Journal of Cognitive Neuroscience, vol. 23, 2011, pp. 2797-2810.
Onur, O.A., Piefke, M., Lie, C.-H., Thiel, C., Fink, G.R.: Modulatory effects of levodopa on cognitive control in young, but not in older subjects: A pharmacological fMRI study. Journal of Cognitive Neuroscience. 23, 2797-2810 (2011).
Onur, Oezguer A., Piefke, Martina, Lie, Chun-Hyoun, Thiel, Christiane, and Fink, Gereon R. “Modulatory effects of levodopa on cognitive control in young, but not in older subjects: A pharmacological fMRI study”. Journal of Cognitive Neuroscience 23.10 (2011): 2797-2810.

12 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Levodopa improves response inhibition and enhances striatal activation in early-stage Parkinson's disease.
Manza P, Schwartz G, Masson M, Kann S, Volkow ND, Li CR, Leung HC., Neurobiol Aging 66(), 2018
PMID: 29501966
Effects of levodopa on stimulus-response learning versus response selection in healthy young adults.
Vo A, Seergobin KN, MacDonald PA., Behav Brain Res 317(), 2017
PMID: 27743941
Neurotransmitter changes during interference task in anterior cingulate cortex: evidence from fMRI-guided functional MRS at 3 T.
Kühn S, Schubert F, Mekle R, Wenger E, Ittermann B, Lindenberger U, Gallinat J., Brain Struct Funct 221(5), 2016
PMID: 25976598
Levodopa impairs probabilistic reversal learning in healthy young adults.
Vo A, Seergobin KN, Morrow SA, MacDonald PA., Psychopharmacology (Berl) 233(14), 2016
PMID: 27241710
Correspondence of executive function related functional and anatomical alterations in aging brain.
Di X, Rypma B, Biswal BB., Prog Neuropsychopharmacol Biol Psychiatry 48(), 2014
PMID: 24036319
Neuromodulation in Tourette syndrome: dopamine and beyond.
Buse J, Schoenefeld K, Münchau A, Roessner V., Neurosci Biobehav Rev 37(6), 2013
PMID: 23085211
Learning real-life cognitive abilities in a novel 360°-virtual reality supermarket: a neuropsychological study of healthy participants and patients with epilepsy.
Grewe P, Kohsik A, Flentge D, Dyck E, Botsch M, Winter Y, Markowitsch HJ, Bien CG, Piefke M., J Neuroeng Rehabil 10(), 2013
PMID: 23618596
Acute khat use reduces response conflict in habitual users.
Colzato LS, Sellaro R, Ruiz MJ, Sikora K, Hommel B., Front Hum Neurosci 7(), 2013
PMID: 23801952
Assaying the effect of levodopa on the evaluation of risk in healthy humans.
Symmonds M, Wright ND, Fagan E, Dolan RJ., PLoS One 8(7), 2013
PMID: 23844168
Cognitive dysfunction precedes the onset of motor symptoms in the MitoPark mouse model of Parkinson's disease.
Li X, Redus L, Chen C, Martinez PA, Strong R, Li S, O'Connor JC., PLoS One 8(8), 2013
PMID: 23977020
Effects of L-dopa during auditory instrumental learning in humans.
Weis T, Puschmann S, Brechmann A, Thiel CM., PLoS One 7(12), 2012
PMID: 23285070

71 References

Daten bereitgestellt von Europe PubMed Central.

Brain regions associated with episodic retrieval in normal aging and Alzheimer's disease.
Backman L, Andersson JL, Nyberg L, Winblad B, Nordberg A, Almkvist O., Neurology 52(9), 1999
PMID: 10371535
Age-related cognitive deficits mediated by changes in the striatal dopamine system.
Backman L, Ginovart N, Dixon RA, Wahlin TB, Wahlin A, Halldin C, Farde L., Am J Psychiatry 157(4), 2000
PMID: 10739428
Anterior cingulate cortex and response conflict: effects of response modality and processing domain.
Barch DM, Braver TS, Akbudak E, Conturo T, Ollinger J, Snyder A., Cereb. Cortex 11(9), 2001
PMID: 11532889
Conflict monitoring versus selection-for-action in anterior cingulate cortex.
Botvinick M, Nystrom LE, Fissell K, Carter CS, Cohen JD., Nature 402(6758), 1999
PMID: 10647008
A theory of cognitive control, aging cognition, and neuromodulation.
Braver TS, Barch DM., Neurosci Biobehav Rev 26(7), 2002
PMID: 12470692
Learned predictions of error likelihood in the anterior cingulate cortex.
Brown JW, Braver TS., Science 307(5712), 2005
PMID: 15718473
Cognitive and emotional influences in anterior cingulate cortex.
Bush G, Luu P, Posner MI., Trends Cogn. Sci. (Regul. Ed.) 4(6), 2000
PMID: 10827444
The counting Stroop: an interference task specialized for functional neuroimaging--validation study with functional MRI.
Bush G, Whalen PJ, Rosen BR, Jenike MA, McInerney SC, Rauch SL., Hum Brain Mapp 6(4), 1998
PMID: 9704265
Working memory capacity predicts dopamine synthesis capacity in the human striatum.
Cools R, Gibbs SE, Miyakawa A, Jagust W, D'Esposito M., J. Neurosci. 28(5), 2008
PMID: 18234898
Control of goal-directed and stimulus-driven attention in the brain.
Corbetta M, Shulman GL., Nat. Rev. Neurosci. 3(3), 2002
PMID: 11994752
Neuroanatomical correlates of episodic encoding and retrieval in young and elderly subjects.
Daselaar SM, Veltman DJ, Rombouts SA, Raaijmakers JG, Jonker C., Brain 126(Pt 1), 2003
PMID: 12477696
The effect of aging on the D1 dopamine receptors in human frontal cortex.
de Keyser J, De Backer JP, Vauquelin G, Ebinger G., Brain Res. 528(2), 1990
PMID: 2148706
Age-related changes in midbrain dopaminergic regulation of the human reward system.
Dreher JC, Meyer-Lindenberg A, Kohn P, Berman KF., Proc. Natl. Acad. Sci. U.S.A. 105(39), 2008
PMID: 18794529
Improved assessment of significant activation in functional magnetic resonance imaging (fMRI): use of a cluster-size threshold.
Forman SD, Cohen JD, Fitzgerald M, Eddy WF, Mintun MA, Noll DC., Magn Reson Med 33(5), 1995
PMID: 7596267
Function and structure of the right inferior frontal cortex predict individual differences in response inhibition: a model-based approach.
Forstmann BU, Jahfari S, Scholte HS, Wolfensteller U, van den Wildenberg WP, Ridderinkhof KR., J. Neurosci. 28(39), 2008
PMID: 18815263


Conjunction revisited.
Friston KJ, Penny WD, Glaser DE., Neuroimage 25(3), 2005
PMID: 15808967
Cocaine decreases cortical cerebral blood flow but does not obscure regional activation in functional magnetic resonance imaging in human subjects.
Gollub RL, Breiter HC, Kantor H, Kennedy D, Gastfriend D, Mathew RT, Makris N, Guimaraes A, Riorden J, Campbell T, Foley M, Hyman SE, Rosen B, Weisskoff R., J. Cereb. Blood Flow Metab. 18(7), 1998
PMID: 9663502
Biochemical changes in dementia disorders of Alzheimer type (AD/SDAT).
Gottfries CG, Adolfsson R, Aquilonius SM, Carlsson A, Eckernas SA, Nordberg A, Oreland L, Svennerholm L, Wiberg A, Winblad B., Neurobiol. Aging 4(4), 1983
PMID: 6200784

Neural activation during response competition.
Hazeltine E, Poldrack R, Gabrieli JD., J Cogn Neurosci 12 Suppl 2(), 2000
PMID: 11506652
Anterior cingulate conflict monitoring and adjustments in control.
Kerns JG, Cohen JD, MacDonald AW 3rd, Cho RY, Stenger VA, Carter CS., Science 303(5660), 2004
PMID: 14963333
Effects of bromocriptine on human subjects depend on working memory capacity.
Kimberg DY, D'Esposito M, Farah MJ., Neuroreport 8(16), 1997
PMID: 9427330

Kornblum, 1992
A comparison of label-based review and ALE meta-analysis in the Stroop task.
Laird AR, McMillan KM, Lancaster JL, Kochunov P, Turkeltaub PE, Pardo JV, Fox PT., Hum Brain Mapp 25(1), 2005
PMID: 15846823
fMRI of healthy older adults during Stroop interference.
Langenecker SA, Nielson KA, Rao SM., Neuroimage 21(1), 2004
PMID: 14741656


Effects of dextroamphetamine on cognitive performance and cortical activation.
Mattay VS, Callicott JH, Bertolino A, Heaton I, Frank JA, Coppola R, Berman KF, Goldberg TE, Weinberger DR., Neuroimage 12(3), 2000
PMID: 10944409
Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine.
Mattay VS, Goldberg TE, Fera F, Hariri AR, Tessitore A, Egan MF, Kolachana B, Callicott JH, Weinberger DR., Proc. Natl. Acad. Sci. U.S.A. 100(10), 2003
PMID: 12716966
Attentional control in the aging brain: insights from an fMRI study of the stroop task.
Milham MP, Erickson KI, Banich MT, Kramer AF, Webb A, Wszalek T, Cohen NJ., Brain Cogn 49(3), 2002
PMID: 12139955
An fMRI investigation of short-term source memory in young and older adults.
Mitchell KJ, Raye CL, Johnson MK, Greene EJ., Neuroimage 30(2), 2005
PMID: 16256377
Interference resolution: insights from a meta-analysis of neuroimaging tasks.
Nee DE, Wager TD, Jonides J., Cogn Affect Behav Neurosci 7(1), 2007
PMID: 17598730
The assessment and analysis of handedness: the Edinburgh inventory.
Oldfield RC., Neuropsychologia 9(1), 1971
PMID: 5146491
Age-related decline of dopamine synthesis in the living human brain measured by positron emission tomography with L-[beta-11C]DOPA.
Ota M, Yasuno F, Ito H, Seki C, Nozaki S, Asada T, Suhara T., Life Sci. 79(8), 2006
PMID: 16580023
Cognitive control, goal maintenance, and prefrontal function in healthy aging.
Paxton JL, Barch DM, Racine CA, Braver TS., Cereb. Cortex 18(5), 2007
PMID: 17804479
Selection requirements during verb generation: differential recruitment in older and younger adults.
Persson J, Sylvester CY, Nelson JK, Welsh KM, Jonides J, Reuter-Lorenz PA., Neuroimage 23(4), 2004
PMID: 15589102
Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans.
Pessiglione M, Seymour B, Flandin G, Dolan RJ, Frith CD., Nature 442(7106), 2006
PMID: 16929307
Attention: the mechanisms of consciousness.
Posner MI., Proc. Natl. Acad. Sci. U.S.A. 91(16), 1994
PMID: 8052596
The influence of working-memory demand and subject performance on prefrontal cortical activity.
Rypma B, Berger JS, D'Esposito M., J Cogn Neurosci 14(5), 2002
PMID: 12167257
Behavioral theories and the neurophysiology of reward.
Schultz W., Annu Rev Psychol 57(), 2006
PMID: 16318590
Lateralized cognitive processes and lateralized task control in the human brain.
Stephan KE, Marshall JC, Friston KJ, Rowe JB, Ritzl A, Zilles K, Fink GR., Science 301(5631), 2003
PMID: 12869765

Age-related changes in human D1 dopamine receptors measured by positron emission tomography.
Suhara T, Fukuda H, Inoue O, Itoh T, Suzuki K, Yamasaki T, Tateno Y., Psychopharmacology (Berl.) 103(1), 1991
PMID: 1826059
Cholinergic modulation of experience-dependent plasticity in human auditory cortex.
Thiel CM, Friston KJ, Dolan RJ., Neuron 35(3), 2002
PMID: 12165477
D2 antidopaminergic modulation of frontal lobe function in healthy human subjects.
Tost H, Meyer-Lindenberg A, Klein S, Schmitt A, Hohn F, Tenckhoff A, Ruf M, Ende G, Rietschel M, Henn FA, Braus DF., Biol. Psychiatry 60(11), 2006
PMID: 16950215
Association between age-related decline in brain dopamine activity and impairment in frontal and cingulate metabolism.
Volkow ND, Logan J, Fowler JS, Wang GJ, Gur RC, Wong C, Felder C, Gatley SJ, Ding YS, Hitzemann R, Pappas N., Am J Psychiatry 157(1), 2000
PMID: 10618016

Wechsler, 1997
Modulation of memory and visuospatial processes by biperiden and rivastigmine in elderly healthy subjects.
Wezenberg E, Verkes RJ, Sabbe BG, Ruigt GS, Hulstijn W., Psychopharmacology (Berl.) 181(3), 2005
PMID: 16041534
The relevance of behavioural measures for functional-imaging studies of cognition.
Wilkinson D, Halligan P., Nat. Rev. Neurosci. 5(1), 2004
PMID: 14708005
Modulation of memory fields by dopamine D1 receptors in prefrontal cortex.
Williams GV, Goldman-Rakic PS., Nature 376(6541), 1995
PMID: 7637804
Color-word matching stroop task: separating interference and response conflict.
Zysset S, Muller K, Lohmann G, von Cramon DY., Neuroimage 13(1), 2001
PMID: 11133306


Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®


PMID: 21254797
PubMed | Europe PMC

Suchen in

Google Scholar