Adaptive servoventilation improves cardiac function and respiratory stability

Oldenburg O, Bitter T, Lehmann R, Korte S, Dimitriadis Z, Faber L, Schmidt A, Westerheide N, Horstkotte D (2011)
Clinical Research in Cardiology 100(2): 107-115.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Oldenburg, Olaf; Bitter, Thomas; Lehmann, Roman; Korte, Stefan; Dimitriadis, Zisis; Faber, Lothar; Schmidt, Anke; Westerheide, NinaUniBi; Horstkotte, Dieter
Abstract / Bemerkung
Cheyne-Stokes respiration (CSR) in patients with chronic heart failure (CHF) is of major prognostic impact and expresses respiratory instability. Other parameters are daytime pCO(2), VE/VCO2-slope during exercise, exertional oscillatory ventilation (EOV), and increased sensitivity of central CO2 receptors. Adaptive servoventilation (ASV) was introduced to specifically treat CSR in CHF. Aim of this study was to investigate ASV effects on CSR, cardiac function, and respiratory stability. A total of 105 patients with CHF (NYHA >= II, left ventricular ejection fraction (EF) <= 40%) and CSR (apnoea-hypopnoea index >= 15/h) met inclusion criteria. According to adherence to ASV treatment (follow-up of 6.7 +/- 3.2 months) this group was divided into controls (rejection of ASV treatment or usage <50% of nights possible and/or <4 h/night; n = 59) and ASV (n = 56) adhered patients. In the ASV group, ventilator therapy was able to effectively treat CSR. In contrast to controls, NYHA class, EF, oxygen uptake, 6-min walking distance, and NT-proBNP improved significantly. Moreover, exclusively in these patients pCO(2), VE/VCO2-slope during exercise, EOV, and central CO2 receptor sensitivity improved. In CHF patients with CSR, ASV might be able to improve parameters of SDB, cardiac function, and respiratory stability.
Cheyne-Stokes respiration; Chronic heart failure; Sleep-disordered; breathing; Adaptive servoventilation; Respiratory instability; Cardiac; function
Clinical Research in Cardiology
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Oldenburg O, Bitter T, Lehmann R, et al. Adaptive servoventilation improves cardiac function and respiratory stability. Clinical Research in Cardiology. 2011;100(2):107-115.
Oldenburg, O., Bitter, T., Lehmann, R., Korte, S., Dimitriadis, Z., Faber, L., Schmidt, A., et al. (2011). Adaptive servoventilation improves cardiac function and respiratory stability. Clinical Research in Cardiology, 100(2), 107-115. doi:10.1007/s00392-010-0216-9
Oldenburg, O., Bitter, T., Lehmann, R., Korte, S., Dimitriadis, Z., Faber, L., Schmidt, A., Westerheide, N., and Horstkotte, D. (2011). Adaptive servoventilation improves cardiac function and respiratory stability. Clinical Research in Cardiology 100, 107-115.
Oldenburg, O., et al., 2011. Adaptive servoventilation improves cardiac function and respiratory stability. Clinical Research in Cardiology, 100(2), p 107-115.
O. Oldenburg, et al., “Adaptive servoventilation improves cardiac function and respiratory stability”, Clinical Research in Cardiology, vol. 100, 2011, pp. 107-115.
Oldenburg, O., Bitter, T., Lehmann, R., Korte, S., Dimitriadis, Z., Faber, L., Schmidt, A., Westerheide, N., Horstkotte, D.: Adaptive servoventilation improves cardiac function and respiratory stability. Clinical Research in Cardiology. 100, 107-115 (2011).
Oldenburg, Olaf, Bitter, Thomas, Lehmann, Roman, Korte, Stefan, Dimitriadis, Zisis, Faber, Lothar, Schmidt, Anke, Westerheide, Nina, and Horstkotte, Dieter. “Adaptive servoventilation improves cardiac function and respiratory stability”. Clinical Research in Cardiology 100.2 (2011): 107-115.

44 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Adaptive servo-ventilation to treat central sleep apnea in heart failure with reduced ejection fraction: the Bad Oeynhausen prospective ASV registry.
Oldenburg O, Wellmann B, Bitter T, Fox H, Buchholz A, Freiwald E, Horstkotte D, Wegscheider K., Clin Res Cardiol 107(8), 2018
PMID: 29654439
Prognostic Importance of Novel Oxygen Desaturation Metrics in Patients With Heart Failure and Central Sleep Apnea.
Watanabe E, Kiyono K, Matsui S, Somers VK, Sano K, Hayano J, Ichikawa T, Kawai M, Harada M, Ozaki Y., J Card Fail 23(2), 2017
PMID: 27615064
Long-Term Experience with First-Generation Implantable Neurostimulation Device in Central Sleep Apnea Treatment.
Fox H, Bitter T, Horstkotte D, Oldenburg O, Gutleben KJ., Pacing Clin Electrophysiol 40(5), 2017
PMID: 28211952
Impact of SERVE-HF on management of sleep disordered breathing in heart failure: a call for further studies.
Linz D, Fox H, Bitter T, Spießhöfer J, Schöbel C, Skobel E, Türoff A, Böhm M, Cowie MR, Arzt M, Oldenburg O., Clin Res Cardiol 105(7), 2016
PMID: 26872963
Transvenous stimulation of the phrenic nerve for the treatment of central sleep apnoea: 12 months' experience with the remedē® System.
Jagielski D, Ponikowski P, Augostini R, Kolodziej A, Khayat R, Abraham WT., Eur J Heart Fail 18(11), 2016
PMID: 27373452
Noninvasive ventilation improves cardiac function in patients with chronic heart failure.
Cheng J, Liu Y, Li G, Zhang Z, Ma L, Yang X, Yang J, Zhang K, Kong J, Dong M, Zhang M, Xu X, Sui W, Wang J, Shang R, Ji X, Zhang Y, Zhang C, Hao P., Oncotarget 7(31), 2016
PMID: 27391436
Association of Central Sleep Apnea with Impaired Heart Structure and Cardiovascular Hemodynamics in Patients with Chronic Heart Failure.
Kazimierczak A, Krzesiński P, Gielerak G, Uziębło-Życzkowska B, Smurzyński P, Ryczek R, Cwetsch A, Skrobowski A., Med Sci Monit 22(), 2016
PMID: 27558771
Noninvasive Positive Pressure Ventilation in Chronic Heart Failure.
Jiang H, Han Y, Xu C, Pu J, He B., Can Respir J 2016(), 2016
PMID: 27891061
Defining the system: contributors to exercise limitations in heart failure.
Phillips SA, Vuckovic K, Cahalin LP, Baynard T., Heart Fail Clin 11(1), 2015
PMID: 25432470
Breathing exercises and inspiratory muscle training in heart failure.
Cahalin LP, Arena RA., Heart Fail Clin 11(1), 2015
PMID: 25432483
Altered breathing syndrome in heart failure: newer insights and treatment options.
Tomita Y, Kasai T, Kisaka T, Rossiter HB, Kihara Y, Wasserman K, Daida H., Curr Heart Fail Rep 12(2), 2015
PMID: 25576448
Sleep-disordered Breathing in Heart Failure - Current State of the Art.
Cowie MR, Woehrle H, Oldenburg O, Damy T, van der Meer P, Erdman E, Metra M, Zannad F, Trochu JN, Gullestad L, Fu M, Böhm M, Auricchio A, Levy P., Card Fail Rev 1(1), 2015
PMID: 28785426
Heart failure: Central sleep apnoea in HF--what can we learn from SERVE-HF?
Oldenburg O, Horstkotte D., Nat Rev Cardiol 12(12), 2015
PMID: 26525541
[Sleep-related breathing disorders and (resulting) cardiovascular diseases].
Oldenburg O, Bitter T, Fox H, Horstkotte D., Herz 39(1), 2014
PMID: 24477634
Novel cardiac pacemaker-based human model of periodic breathing to develop real-time, pre-emptive technology for carbon dioxide stabilisation.
Baruah R, Giannoni A, Willson K, Manisty CH, Mebrate Y, Kyriacou A, Yadav H, Unsworth B, Sutton R, Mayet J, Hughes AD, Francis DP., Open Heart 1(1), 2014
PMID: 25332798
Clinical applications of adaptive servoventilation devices: part 2.
Javaheri S, Brown LK, Randerath WJ., Chest 146(3), 2014
PMID: 25180729
Targeting Sleep Disordered Breathing to Prevent Heart Failure: What is the Evidence?
Kusunose K, Mehra R., Curr Cardiovasc Risk Rep 8(10), 2014
PMID: 25215169
Importance and management of chronic sleep apnoea in cardiology.
Jaffe LM, Kjekshus J, Gottlieb SS., Eur Heart J 34(11), 2013
PMID: 22427382
Adaptive servo-ventilation in cardiac function and neurohormonal status in patients with heart failure and central sleep apnea nonresponsive to continuous positive airway pressure.
Kasai T, Kasagi S, Maeno K, Dohi T, Kawana F, Kato M, Naito R, Ishiwata S, Ohno M, Yamaguchi T, Narui K, Momomura S., JACC Heart Fail 1(1), 2013
PMID: 24621799
Trilevel adaptive servoventilation for the treatment of central and mixed sleep apnea in chronic heart failure patients.
Oldenburg O, Bitter T, Wellmann B, Fischbach T, Efken C, Schmidt A, Horstkotte D., Sleep Med 14(5), 2013
PMID: 23453905
Portable recording for detecting sleep disorder breathing in patients under the care of a heart failure clinic.
Dolliner P, Brammen L, Graf S, Huelsmann M, Stiebellehner L, Gleiss A, Ubl P, Steurer G., Clin Res Cardiol 102(7), 2013
PMID: 23579765
Electrical myostimulation improves left ventricular function and peak oxygen consumption in patients with chronic heart failure: results from the exEMS study comparing different stimulation strategies.
van Buuren F, Mellwig KP, Prinz C, Körber B, Fründ A, Fritzsche D, Faber L, Kottmann T, Bogunovic N, Dahm J, Horstkotte D., Clin Res Cardiol 102(7), 2013
PMID: 23579764
Treatment of Cheyne-Stokes respiration reduces arrhythmic events in chronic heart failure.
Bitter T, Gutleben KJ, Nölker G, Westerheide N, Prinz C, Dimitriadis Z, Horstkotte D, Vogt J, Oldenburg O., J Cardiovasc Electrophysiol 24(10), 2013
PMID: 23844935
Influence of algorithm-based analgesia and sedation in patients after sudden cardiac arrest.
Abanador-Kamper N, Kamper L, Wolfertz J, Dinh W, Thürmann P, Seyfarth M., Clin Res Cardiol 101(3), 2012
PMID: 22048697
The treatment of central sleep apnea syndromes in adults: practice parameters with an evidence-based literature review and meta-analyses.
Aurora RN, Chowdhuri S, Ramar K, Bista SR, Casey KR, Lamm CI, Kristo DA, Mallea JM, Rowley JA, Zak RS, Tracy SL., Sleep 35(1), 2012
PMID: 22215916
Therapy for sleep hypoventilation and central apnea syndromes.
Selim BJ, Junna MR, Morgenthaler TI., Curr Treat Options Neurol 14(5), 2012
PMID: 22923141
Adaptive servoventilation for treatment of sleep-disordered breathing in heart failure: a systematic review and meta-analysis.
Sharma BK, Bakker JP, McSharry DG, Desai AS, Javaheri S, Malhotra A., Chest 142(5), 2012
PMID: 22722232
Comparison of acute and chronic impact of adaptive servo-ventilation on left chamber geometry and function in patients with chronic heart failure.
Haruki N, Takeuchi M, Kaku K, Yoshitani H, Kuwaki H, Tamura M, Abe H, Okazaki M, Tsutsumi A, Otsuji Y., Eur J Heart Fail 13(10), 2011
PMID: 21831914
Loop gain: can it help close the heart failure-periodic breathing loop?
Basner RC., Am J Respir Crit Care Med 184(9), 2011
PMID: 22045747
Sleep disordered breathing in patients with heart failure: pathophysiology and management.
Sharma B, McSharry D, Malhotra A., Curr Treat Options Cardiovasc Med 13(6), 2011
PMID: 21894522
Phosphinic peptides as zinc metalloproteinase inhibitors.
Dive V, Georgiadis D, Matziari M, Makaritis A, Beau F, Cuniasse P, Yiotakis A., Cell Mol Life Sci 61(16), 2004
PMID: 15316651

37 References

Daten bereitgestellt von Europe PubMed Central.

The six-minute walk test.
Enright PL., Respir Care 48(8), 2003
PMID: 12890299
Long-term survival in patients hospitalized with congestive heart failure: relation to preserved and reduced left ventricular systolic function.
Gustafsson F, Torp-Pedersen C, Brendorp B, Seibaek M, Burchardt H, Kober L; DIAMOND Study Group., Eur. Heart J. 24(9), 2003
PMID: 12727154
[Adaptive servoventilation: effect on Cheyne-Stokes-Respiration and on quality of life]
Topfer V, El-Sebai M, Wessendorf TE, Moraidis I, Teschler H., Pneumologie 58(1), 2004
PMID: 14732897
Metoprolol CR/XL improves systolic and diastolic left ventricular function in patients with chronic heart failure.
Hole T, Froland G, Gullestad L, Offstad J, Skjaerpe T., Echocardiography 21(3), 2004
PMID: 15053783
Effects of nasal CPAP on sympathetic activity in patients with heart failure and central sleep apnea.
Naughton MT, Benard DC, Liu PP, Rutherford R, Rankin F, Bradley TD., Am. J. Respir. Crit. Care Med. 152(2), 1995
PMID: 7633695
Hypocapnia and increased ventilatory responsiveness in patients with idiopathic central sleep apnea.
Xie A, Rutherford R, Rankin F, Wong B, Bradley TD., Am. J. Respir. Crit. Care Med. 152(6 Pt 1), 1995
PMID: 8520761
Ventilatory response to exercise and to carbon dioxide in patients with heart failure.
Andreas S, Morguet AJ, Werner GS, Kreuzer H., Eur. Heart J. 17(5), 1996
PMID: 8737106
Effects of cardiac dysfunction on non-hypercapnic central sleep apnea.
Solin P, Roebuck T, Swieca J, Walters EH, Naughton MT., Chest 113(1), 1998
PMID: 9440576
Influence of pulmonary capillary wedge pressure on central apnea in heart failure.
Solin P, Bergin P, Richardson M, Kaye DM, Walters EH, Naughton MT., Circulation 99(12), 1999
PMID: 10096933
A mechanism of central sleep apnea in patients with heart failure.
Javaheri S., N. Engl. J. Med. 341(13), 1999
PMID: 10498490
Nocturnal continuous positive airway pressure improves ventilatory efficiency during exercise in patients with chronic heart failure.
Arzt M, Schulz M, Wensel R, Montalvan S, Blumberg FC, Riegger GA, Pfeifer M., Chest 127(3), 2005
PMID: 15764759
Influence of ejection fraction on cardiovascular outcomes in a broad spectrum of heart failure patients.
Solomon SD, Anavekar N, Skali H, McMurray JJ, Swedberg K, Yusuf S, Granger CB, Michelson EL, Wang D, Pocock S, Pfeffer MA; Candesartan in Heart Failure Reduction in Mortality (CHARM) Investigators., Circulation 112(24), 2005
PMID: 16330684
Compliance with and effectiveness of adaptive servoventilation versus continuous positive airway pressure in the treatment of Cheyne-Stokes respiration in heart failure over a six month period.
Philippe C, Stoica-Herman M, Drouot X, Raffestin B, Escourrou P, Hittinger L, Michel PL, Rouault S, d'Ortho MP., Heart 92(3), 2005
PMID: 15964943
Sleep-disordered breathing in patients with symptomatic heart failure: a contemporary study of prevalence in and characteristics of 700 patients.
Oldenburg O, Lamp B, Faber L, Teschler H, Horstkotte D, Topfer V., Eur. J. Heart Fail. 9(3), 2006
PMID: 17027333
Influence of obstructive sleep apnea on mortality in patients with heart failure.
Wang H, Parker JD, Newton GE, Floras JS, Mak S, Chiu KL, Ruttanaumpawan P, Tomlinson G, Bradley TD., J. Am. Coll. Cardiol. 49(15), 2007
PMID: 17433953
Sleep apnoea in heart failure.
Schulz R, Blau A, Borgel J, Duchna HW, Fietze I, Koper I, Prenzel R, Schadlich S, Schmitt J, Tasci S, Andreas S; working group Kreislauf und Schlaf of the German Sleep Society (DGSM)., Eur. Respir. J. 29(6), 2007
PMID: 17360729
Efficacy of adaptive servoventilation in treatment of complex and central sleep apnea syndromes.
Allam JS, Olson EJ, Gay PC, Morgenthaler TI., Chest 132(6), 2007
PMID: 18079219
Adaptive servoventilation improves cardiac function in patients with chronic heart failure and Cheyne-Stokes respiration.
Oldenburg O, Schmidt A, Lamp B, Bitter T, Muntean BG, Langer C, Horstkotte D., Eur. J. Heart Fail. 10(6), 2008
PMID: 18486550
Long-term prognosis after cardiac resynchronization therapy is related to the extent of left ventricular reverse remodeling at midterm follow-up.
Ypenburg C, van Bommel RJ, Borleffs CJ, Bleeker GB, Boersma E, Schalij MJ, Bax JJ., J. Am. Coll. Cardiol. 53(6), 2009
PMID: 19195605
Relationship between sleep apnoea and mortality in patients with ischaemic heart failure.
Yumino D, Wang H, Floras JS, Newton GE, Mak S, Ruttanaumpawan P, Parker JD, Bradley TD., Heart 95(10), 2009
PMID: 19131443
Pulmonary capillary wedge pressure and pulmonary arterial pressure in heart failure patients with sleep-disordered breathing.
Oldenburg O, Bitter T, Wiemer M, Langer C, Horstkotte D, Piper C., Sleep Med. 10(7), 2009
PMID: 19135413
Long-term time-course of nocturnal breathing disorders in heart failure patients.
Pinna GD, Maestri R, Mortara A, Johnson P, Andrews D, Ponikowski P, Witkowski T, La Rovere MT, Sleight P., Eur. Respir. J. 35(2), 2009
PMID: 19574330
Cheyne-Stokes respiration in heart failure: cycle length is dependent on left ventricular ejection fraction.
Wedewardt J, Bitter T, Prinz C, Faber L, Horstkotte D, Oldenburg O., Sleep Med. 11(2), 2010
PMID: 20064744
Shift in sleep apnoea type in heart failure patients in the CANPAP trial.
Ryan CM, Floras JS, Logan AG, Kimoff RJ, Series F, Morrison D, Ferguson KA, Belenkie I, Pfeifer M, Fleetham J, Hanly PJ, Smilovitch M, Arzt M, Bradley TD; CANPAP Investigators, Belenkie I, Whitelaw W, Heule M, Morrison D, Howlett J, Ferguson KA, Kimoff RJ, Smilovitch M, Series F, Leblanc MH, Bradley TD, Logan AG, Floras JS, Ross H, Delgado D, Leung RS, Hanly PJ, Fleetham J, Gin K, Wilson J, Corne S, Azevedo E, Pfeifer M, Montalvan-Dobmayr S, Schichtl T., Eur. Respir. J. 35(3), 2010
PMID: 20190331
Adaptive servoventilation in diastolic heart failure and Cheyne-Stokes respiration.
Bitter T, Westerheide N, Faber L, Hering D, Prinz C, Langer C, Horstkotte D, Oldenburg O., Eur. Respir. J. 36(2), 2009
PMID: 20032021
Peripheral and central ventilatory responses in central sleep apnea with and without congestive heart failure.
Solin P, Roebuck T, Johns DP, Walters EH, Naughton MT., Am. J. Respir. Crit. Care Med. 162(6), 2000
PMID: 11112137
Acute effects of continuous positive airway pressure on cardiac sympathetic tone in congestive heart failure.
Kaye DM, Mansfield D, Aggarwal A, Naughton MT, Esler MD., Circulation 103(19), 2001
PMID: 11352880
Adaptive pressure support servo-ventilation: a novel treatment for Cheyne-Stokes respiration in heart failure.
Teschler H, Dohring J, Wang YM, Berthon-Jones M., Am. J. Respir. Crit. Care Med. 164(4), 2001
PMID: 11520725
Oscillatory ventilation during exercise in patients with chronic heart failure: clinical correlates and prognostic implications.
Corra U, Giordano A, Bosimini E, Mezzani A, Piepoli M, Coats AJ, Giannuzzi P., Chest 121(5), 2002
PMID: 12006446
A randomized controlled trial of adaptive ventilation for Cheyne-Stokes breathing in heart failure.
Pepperell JC, Maskell NA, Jones DR, Langford-Wiley BA, Crosthwaite N, Stradling JR, Davies RJ., Am. J. Respir. Crit. Care Med. 168(9), 2003
PMID: 12928310


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