Adipose gene expression response of lean and obese mice to short-term dietary restriction

van Schothorst EM, Keijer J, Pennings JLA, Opperhuizen A, van den Brom CE, Kohl T, Franssen-van Hal NLW, Hoebee B (2006)
Obesity (Silver Spring) 14(6): 974-979.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
van Schothorst, Evert M; Keijer, Jaap; Pennings, Jeroen L A; Opperhuizen, Antoon; van den Brom, Charissa E; Kohl, ThomasUniBi; Franssen-van Hal, Nicole L W; Hoebee, Barbara
Abstract / Bemerkung
Overweight and obesity lead to higher morbidity risks, which are alleviated even by mild weight loss. To gain insight in the molecular effects of weight loss in adipose tissue, we analyzed the effects of short-term dietary restriction (DR) on mice fed a low-fat diet (lean mice) or a high-fat diet (obese mice). Female C57Bl6/J mice on both diets were on DR until an average body weight loss of 20%, which was achieved in 8 to 12 days depending on body weight at the start of DR. Plasma free fatty acids and blood glucose levels decreased significantly on DR. In the (restricted) low-fat diet groups, gene expression analysis using adipose-enriched cDNA microarrays revealed only two transcripts to be significant differentially expressed by DR: up-regulation of malic enzyme (Mod1) and down-regulation of major urinary protein 1 (Mup1). Real-time polymerase chain reaction analysis confirmed these findings and showed, for the high-fat diet groups, an identical expression pattern for Mup1, whereas Mod1 showed an opposed gene expression pattern for the high-fat diet groups. In conclusion, initial weight loss induces transcriptional changes only in a very small number of adipose genes, which also depends on the (restricted) diet used.
Erscheinungsjahr
2006
Zeitschriftentitel
Obesity (Silver Spring)
Band
14
Ausgabe
6
Seite(n)
974-979
ISSN
1930-7381
eISSN
1930-739X
Page URI
https://pub.uni-bielefeld.de/record/2092165

Zitieren

van Schothorst EM, Keijer J, Pennings JLA, et al. Adipose gene expression response of lean and obese mice to short-term dietary restriction. Obesity (Silver Spring). 2006;14(6):974-979.
van Schothorst, E. M., Keijer, J., Pennings, J. L. A., Opperhuizen, A., van den Brom, C. E., Kohl, T., Franssen-van Hal, N. L. W., et al. (2006). Adipose gene expression response of lean and obese mice to short-term dietary restriction. Obesity (Silver Spring), 14(6), 974-979. https://doi.org/10.1038/oby.2006.111
van Schothorst, Evert M, Keijer, Jaap, Pennings, Jeroen L A, Opperhuizen, Antoon, van den Brom, Charissa E, Kohl, Thomas, Franssen-van Hal, Nicole L W, and Hoebee, Barbara. 2006. “Adipose gene expression response of lean and obese mice to short-term dietary restriction”. Obesity (Silver Spring) 14 (6): 974-979.
van Schothorst, E. M., Keijer, J., Pennings, J. L. A., Opperhuizen, A., van den Brom, C. E., Kohl, T., Franssen-van Hal, N. L. W., and Hoebee, B. (2006). Adipose gene expression response of lean and obese mice to short-term dietary restriction. Obesity (Silver Spring) 14, 974-979.
van Schothorst, E.M., et al., 2006. Adipose gene expression response of lean and obese mice to short-term dietary restriction. Obesity (Silver Spring), 14(6), p 974-979.
E.M. van Schothorst, et al., “Adipose gene expression response of lean and obese mice to short-term dietary restriction”, Obesity (Silver Spring), vol. 14, 2006, pp. 974-979.
van Schothorst, E.M., Keijer, J., Pennings, J.L.A., Opperhuizen, A., van den Brom, C.E., Kohl, T., Franssen-van Hal, N.L.W., Hoebee, B.: Adipose gene expression response of lean and obese mice to short-term dietary restriction. Obesity (Silver Spring). 14, 974-979 (2006).
van Schothorst, Evert M, Keijer, Jaap, Pennings, Jeroen L A, Opperhuizen, Antoon, van den Brom, Charissa E, Kohl, Thomas, Franssen-van Hal, Nicole L W, and Hoebee, Barbara. “Adipose gene expression response of lean and obese mice to short-term dietary restriction”. Obesity (Silver Spring) 14.6 (2006): 974-979.

13 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Update on the human and mouse lipocalin (LCN) gene family, including evidence the mouse Mup cluster is result of an "evolutionary bloom".
Charkoftaki G, Wang Y, McAndrews M, Bruford EA, Thompson DC, Vasiliou V, Nebert DW., Hum Genomics 13(1), 2019
PMID: 30782214
The Effects of Graded Levels of Calorie Restriction: X. Transcriptomic Responses of Epididymal Adipose Tissue.
Derous D, Mitchell SE, Green CL, Wang Y, Han JDJ, Chen L, Promislow DEL, Lusseau D, Douglas A, Speakman JR., J Gerontol A Biol Sci Med Sci 73(3), 2018
PMID: 28575190
Changes in gene expression associated with FTO overexpression in mice.
Merkestein M, McTaggart JS, Lee S, Kramer HB, McMurray F, Lafond M, Boutens L, Cox R, Ashcroft FM., PLoS One 9(5), 2014
PMID: 24842286
Liver and adipose expression associated SNPs are enriched for association to type 2 diabetes.
Zhong H, Beaulaurier J, Lum PY, Molony C, Yang X, Macneil DJ, Weingarth DT, Zhang B, Greenawalt D, Dobrin R, Hao K, Woo S, Fabre-Suver C, Qian S, Tota MR, Keller MP, Kendziorski CM, Yandell BS, Castro V, Attie AD, Kaplan LM, Schadt EE., PLoS Genet 6(5), 2010
PMID: 20463879
Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.
Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, Karlsson J, Castellani LW, Mumick S, Wang K, Xie T, Coon M, Zhang C, Estrada-Smith D, Farber CR, Wang SS, van Nas A, Ghazalpour A, Zhang B, Macneil DJ, Lamb JR, Dipple KM, Reitman ML, Mehrabian M, Lum PY, Schadt EE, Lusis AJ, Drake TA., Nat Genet 41(4), 2009
PMID: 19270708
Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet.
van Schothorst EM, Flachs P, Franssen-van Hal NL, Kuda O, Bunschoten A, Molthoff J, Vink C, Hooiveld GJ, Kopecky J, Keijer J., BMC Genomics 10(), 2009
PMID: 19284886
The effects of apelin treatment on skeletal muscle mitochondrial content.
Frier BC, Williams DB, Wright DC., Am J Physiol Regul Integr Comp Physiol 297(6), 2009
PMID: 19793954
Deficiency in cytosolic malic enzyme does not increase acetaminophen-induced hepato-toxicity.
Qian S, Mumick S, Nizner P, Tota MR, Menetski J, Reitman ML, Macneil DJ., Basic Clin Pharmacol Toxicol 103(1), 2008
PMID: 18346052

18 References

Daten bereitgestellt von Europe PubMed Central.

Obesity as a medical problem.
Kopelman PG., Nature 404(6778), 2000
PMID: 10766250

AUTHOR UNKNOWN, 0
Beneficial health effects of modest weight loss.
Goldstein DJ., Int. J. Obes. Relat. Metab. Disord. 16(6), 1992
PMID: 1322866

Van, Int J Obes Relat Metab Disord. 21(), 1997
Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans.
Fontana L, Meyer TE, Klein S, Holloszy JO., Proc. Natl. Acad. Sci. U.S.A. 101(17), 2004
PMID: 15096581

Van, Obes Res. 13(), 2005
Adipose tissue energy metabolism: altered gene expression profile of mice subjected to long-term caloric restriction.
Higami Y, Pugh TD, Page GP, Allison DB, Prolla TA, Weindruch R., FASEB J. 18(2), 2003
PMID: 14688200
Gene expression profile of rat adipose tissue at the onset of high-fat-diet obesity.
Li J, Yu X, Pan W, Unger RH., Am. J. Physiol. Endocrinol. Metab. 282(6), 2002
PMID: 12006364
DNA microarray analysis of genes differentially expressed in diet-induced (cafeteria) obese rats.
Lopez IP, Marti A, Milagro FI, Zulet Md Mde L, Moreno-Aliaga MJ, Martinez JA, De Miguel C., Obes. Res. 11(2), 2003
PMID: 12582213
Temporal linkage between the phenotypic and genomic responses to caloric restriction.
Dhahbi JM, Kim HJ, Mote PL, Beaver RJ, Spindler SR., Proc. Natl. Acad. Sci. U.S.A. 101(15), 2004
PMID: 15044709
Gene expression patterns in calorically restricted mice: partial overlap with long-lived mutant mice.
Miller RA, Chang Y, Galecki AT, Al-Regaiey K, Kopchick JJ, Bartke A., Mol. Endocrinol. 16(11), 2002
PMID: 12403853
The expression of adipogenic genes is decreased in obesity and diabetes mellitus.
Nadler ST, Stoehr JP, Schueler KL, Tanimoto G, Yandell BS, Attie AD., Proc. Natl. Acad. Sci. U.S.A. 97(21), 2000
PMID: 11027337
Major urinary proteins, alpha(2U)-globulins and aphrodisin.
Cavaggioni A, Mucignat-Caretta C., Biochim. Biophys. Acta 1482(1-2), 2000
PMID: 11058763
Distinct transcriptional profiles of adipogenesis in vivo and in vitro.
Soukas A, Socci ND, Saatkamp BD, Novelli S, Friedman JM., J. Biol. Chem. 276(36), 2001
PMID: 11445576
Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects.
Clement K, Viguerie N, Poitou C, Carette C, Pelloux V, Curat CA, Sicard A, Rome S, Benis A, Zucker JD, Vidal H, Laville M, Barsh GS, Basdevant A, Stich V, Cancello R, Langin D., FASEB J. 18(14), 2004
PMID: 15522911
Molecular and morphometric description of adipose tissue during weight changes: a quantitative tool for assessment of tissue texture.
Pagano C, Calcagno A, Giacomelli L, Poletti A, Macchi V, Vettor R, De Caro R, Federspil G., Int. J. Mol. Med. 14(5), 2004
PMID: 15492863
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 16861601
PubMed | Europe PMC

Suchen in

Google Scholar