A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76
Di Bartolo V, Montagne B, Salek M, Jungwirth B, Carrette F, Fourtane J, Sol-Foulon N, Michel F, Schwartz O, Lehmann WD, Acuto O (2007)
J Exp Med 204(3): 681-691.
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Autor*in
Di Bartolo, Vincenzo;
Montagne, Benjamin;
Salek, Mogjiborahman;
Jungwirth, BrittaUniBi;
Carrette, Florent;
Fourtane, Julien;
Sol-Foulon, Nathalie;
Michel, Frederique;
Schwartz, Olivier;
Lehmann, Wolf D;
Acuto, Oreste
Abstract / Bemerkung
The SH2 domain-containing leukocyte protein of 76 kD (SLP-76) is a pivotal element of the signaling machinery controlling T cell receptor (TCR)-mediated activation. Here, we identify 14-3-3epsilon and zeta proteins as SLP-76 binding partners. This interaction was induced by TCR ligation and required phosphorylation of SLP-76 at serine 376. Ribonucleic acid interference and in vitro phosphorylation experiments showed that serine 376 is the target of the hematopoietic progenitor kinase 1 (HPK-1). Interestingly, either S376A mutation or HPK-1 knockdown resulted in increased TCR-induced tyrosine phosphorylation of SLP-76 and phospholipase C-gamma1. Moreover, an SLP-76-S376A mutant induced higher interleukin 2 gene transcription than wild-type SLP-76. These data reveal a novel negative feedback loop involving HPK-1-dependent serine phosphorylation of SLP-76 and 14-3-3 protein recruitment, which tunes T cell activation.
Erscheinungsjahr
2007
Zeitschriftentitel
J Exp Med
Band
204
Ausgabe
3
Seite(n)
681-691
ISSN
0022-1007
eISSN
1540-9538
Page URI
https://pub.uni-bielefeld.de/record/2092153
Zitieren
Di Bartolo V, Montagne B, Salek M, et al. A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med. 2007;204(3):681-691.
Di Bartolo, V., Montagne, B., Salek, M., Jungwirth, B., Carrette, F., Fourtane, J., Sol-Foulon, N., et al. (2007). A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med, 204(3), 681-691. https://doi.org/10.1084/jem.20062066
Di Bartolo, Vincenzo, Montagne, Benjamin, Salek, Mogjiborahman, Jungwirth, Britta, Carrette, Florent, Fourtane, Julien, Sol-Foulon, Nathalie, et al. 2007. “A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76”. J Exp Med 204 (3): 681-691.
Di Bartolo, V., Montagne, B., Salek, M., Jungwirth, B., Carrette, F., Fourtane, J., Sol-Foulon, N., Michel, F., Schwartz, O., Lehmann, W. D., et al. (2007). A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med 204, 681-691.
Di Bartolo, V., et al., 2007. A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med, 204(3), p 681-691.
V. Di Bartolo, et al., “A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76”, J Exp Med, vol. 204, 2007, pp. 681-691.
Di Bartolo, V., Montagne, B., Salek, M., Jungwirth, B., Carrette, F., Fourtane, J., Sol-Foulon, N., Michel, F., Schwartz, O., Lehmann, W.D., Acuto, O.: A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med. 204, 681-691 (2007).
Di Bartolo, Vincenzo, Montagne, Benjamin, Salek, Mogjiborahman, Jungwirth, Britta, Carrette, Florent, Fourtane, Julien, Sol-Foulon, Nathalie, Michel, Frederique, Schwartz, Olivier, Lehmann, Wolf D, and Acuto, Oreste. “A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76”. J Exp Med 204.3 (2007): 681-691.
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Royer Y, Menu C, Liu X, Constantinescu SN., DNA Cell Biol. 23(6), 2004
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Shui JW, Boomer JS, Han J, Xu J, Dement GA, Zhou G, Tan TH., Nat. Immunol. 8(1), 2006
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Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.
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Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells.
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Shevchenko A, Wilm M, Vorm O, Mann M., Anal. Chem. 68(5), 1996
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Activation-modulated association of 14-3-3 proteins with Cbl in T cells.
Liu YC, Elly C, Yoshida H, Bonnefoy-Berard N, Altman A., J. Biol. Chem. 271(24), 1996
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Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.
Motto DG, Ross SE, Wu J, Hendricks-Taylor LR, Koretzky GA., J. Exp. Med. 183(4), 1996
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Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function.
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Mutation of tyrosines 492/493 in the kinase domain of ZAP-70 affects multiple T-cell receptor signaling pathways.
Mege D, Di Bartolo V, Germain V, Tuosto L, Michel F, Acuto O., J. Biol. Chem. 271(51), 1996
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HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway.
Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NN., EMBO J. 15(24), 1996
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Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NN., EMBO J. 15(24), 1996
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Serine phosphorylation of Cbl induced by phorbol ester enhances its association with 14-3-3 proteins in T cells via a novel serine-rich 14-3-3-binding motif.
Liu YC, Liu Y, Elly C, Yoshida H, Lipkowitz S, Altman A., J. Biol. Chem. 272(15), 1997
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Liu YC, Liu Y, Elly C, Yoshida H, Lipkowitz S, Altman A., J. Biol. Chem. 272(15), 1997
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14-3-3 (epsilon) interacts with the insulin-like growth factor I receptor and insulin receptor substrate I in a phosphoserine-dependent manner.
Craparo A, Freund R, Gustafson TA., J. Biol. Chem. 272(17), 1997
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Craparo A, Freund R, Gustafson TA., J. Biol. Chem. 272(17), 1997
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14-3-3 protein binds to insulin receptor substrate-1, one of the binding sites of which is in the phosphotyrosine binding domain.
Ogihara T, Isobe T, Ichimura T, Taoka M, Funaki M, Sakoda H, Onishi Y, Inukai K, Anai M, Fukushima Y, Kikuchi M, Yazaki Y, Oka Y, Asano T., J. Biol. Chem. 272(40), 1997
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LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
Zhang W, Sloan-Lancaster J, Kitchen J, Trible RP, Samelson LE., Cell 92(1), 1998
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Uncoupling of nonreceptor tyrosine kinases from PLC-gamma1 in an SLP-76-deficient T cell.
Yablonski D, Kuhne MR, Kadlecek T, Weiss A., Science 281(5375), 1998
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Yablonski D, Kuhne MR, Kadlecek T, Weiss A., Science 281(5375), 1998
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The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors.
Liu SK, Fang N, Koretzky GA, McGlade CJ., Curr. Biol. 9(2), 1999
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Ser/Thr phosphorylation of IRS proteins: a molecular basis for insulin resistance.
Zick Y., Sci. STKE 2005(268), 2005
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Zick Y., Sci. STKE 2005(268), 2005
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Sequence tag scanning: a new explorative strategy for recognition of unexpected protein alterations by nanoelectrospray ionization-tandem mass spectrometry.
Salek M, Di Bartolo V, Cittaro D, Borsotti D, Wei J, Acuto O, Rappsilber J, Lehmann WD., Proteomics 5(3), 2005
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Salek M, Di Bartolo V, Cittaro D, Borsotti D, Wei J, Acuto O, Rappsilber J, Lehmann WD., Proteomics 5(3), 2005
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CD28 costimulatory signal induces protein arginine methylation in T cells.
Blanchet F, Cardona A, Letimier FA, Hershfield MS, Acuto O., J. Exp. Med. 202(3), 2005
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Blanchet F, Cardona A, Letimier FA, Hershfield MS, Acuto O., J. Exp. Med. 202(3), 2005
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Early phosphorylation kinetics of proteins involved in proximal TCR-mediated signaling pathways.
Houtman JC, Houghtling RA, Barda-Saad M, Toda Y, Samelson LE., J. Immunol. 175(4), 2005
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Houtman JC, Houghtling RA, Barda-Saad M, Toda Y, Samelson LE., J. Immunol. 175(4), 2005
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CD8 T cell sensory adaptation dependent on TCR avidity for self-antigens.
Marquez ME, Ellmeier W, Sanchez-Guajardo V, Freitas AA, Acuto O, Di Bartolo V., J. Immunol. 175(11), 2005
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Marquez ME, Ellmeier W, Sanchez-Guajardo V, Freitas AA, Acuto O, Di Bartolo V., J. Immunol. 175(11), 2005
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SLP76 and SLP65: complex regulation of signalling in lymphocytes and beyond.
Koretzky GA, Abtahian F, Silverman MA., Nat. Rev. Immunol. 6(1), 2006
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Koretzky GA, Abtahian F, Silverman MA., Nat. Rev. Immunol. 6(1), 2006
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