Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls

Schlosser N, Wolf OT, Fernando SC, Riedesel K, Otte C, Muhtz C, Beblo T, Driessen M, Lowe B, Wingenfeld K (2010)
Psychoneuroendocrinology 35(2): 316-320.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Schlosser, Nicole; Wolf, Oliver Tobias; Fernando, Silvia Carvalho; Riedesel, Kirsten; Otte, Christian; Muhtz, Christoph; Beblo, ThomasUniBi; Driessen, MartinUniBi ; Lowe, Bernd; Wingenfeld, Katja
Abstract / Bemerkung
OBJECTIVE: Overgeneral autobiographical memory has become a well established phenomenon within major depressive disorder (MDD). Neuroendocrinologically, MDD is often characterized by a dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, i.e. hypercortisolemia and reduced feedback sensitivity. In healthy participants cortisol administration has been found to impair autobiographical memory retrieval. The purpose of this study was to compare the effects of acute cortisol administration on autobiographical memory in MDD patients with the effects observed in healthy controls. We hypothesized that in contrast to healthy control subjects acute cortisol administration would not affect autobiographical memory performance in MDD due to reduced central glucocorticoid sensitivity. METHODS: In a placebo-controlled, double-blind crossover study, 16 patients with MDD and 16 healthy control subjects received a placebo or 10mg of hydrocortisone orally before autobiographical memory testing (AMT). RESULTS: In the placebo condition depressed patients performed poorer than controls. After hydrocortisone intake, healthy subjects reported significantly fewer specific memories on the AMT compared to placebo treatment. In contrast, memory specificity of MDD patients was not affected by hydrocortisone treatment. CONCLUSIONS: The present findings replicate previous findings of impaired autobiographical memory retrieval after hydrocortisone treatment in healthy subjects and of impaired AMT performance in depressed patients. We speculate that the missing acute impairing effect of hydrocortisone on autobiographical memory in depressed patients might reflect reduced central glucocorticoid sensitivity. However alternative explanations cannot be ruled out. 2009 Elsevier Ltd. All rights reserved.
Erscheinungsjahr
2010
Zeitschriftentitel
Psychoneuroendocrinology
Band
35
Ausgabe
2
Seite(n)
316-320
ISSN
1873-3360
Page URI
https://pub.uni-bielefeld.de/record/1945338

Zitieren

Schlosser N, Wolf OT, Fernando SC, et al. Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls. Psychoneuroendocrinology. 2010;35(2):316-320.
Schlosser, N., Wolf, O. T., Fernando, S. C., Riedesel, K., Otte, C., Muhtz, C., Beblo, T., et al. (2010). Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls. Psychoneuroendocrinology, 35(2), 316-320. https://doi.org/10.1016/j.psyneuen.2009.06.015
Schlosser, N., Wolf, O. T., Fernando, S. C., Riedesel, K., Otte, C., Muhtz, C., Beblo, T., Driessen, M., Lowe, B., and Wingenfeld, K. (2010). Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls. Psychoneuroendocrinology 35, 316-320.
Schlosser, N., et al., 2010. Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls. Psychoneuroendocrinology, 35(2), p 316-320.
N. Schlosser, et al., “Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls”, Psychoneuroendocrinology, vol. 35, 2010, pp. 316-320.
Schlosser, N., Wolf, O.T., Fernando, S.C., Riedesel, K., Otte, C., Muhtz, C., Beblo, T., Driessen, M., Lowe, B., Wingenfeld, K.: Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls. Psychoneuroendocrinology. 35, 316-320 (2010).
Schlosser, Nicole, Wolf, Oliver Tobias, Fernando, Silvia Carvalho, Riedesel, Kirsten, Otte, Christian, Muhtz, Christoph, Beblo, Thomas, Driessen, Martin, Lowe, Bernd, and Wingenfeld, Katja. “Effects of acute cortisol administration on autobiographical memory in patients with major depression and healthy controls”. Psychoneuroendocrinology 35.2 (2010): 316-320.

12 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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