Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion

Hoy B, Loewer M, Weydig C, Carra G, Tegtmeyer N, Geppert T, Schroeder P, Sewald N, Backert S, Schneider G, Wessler S (2010)
EMBO REPORTS 11(10): 798-804.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Hoy, Benjamin; Loewer, Martin; Weydig, Christiane; Carra, Gert; Tegtmeyer, Nicole; Geppert, Tim; Schroeder, Peter; Sewald, NorbertUniBi ; Backert, Steffen; Schneider, Gisbert; Wessler, Silja
Abstract / Bemerkung
Mammalian and prokaryotic high-temperature requirement A (HtrA) proteins are chaperones and serine proteases with important roles in protein quality control. Here, we describe an entirely new function of HtrA and identify it as a new secreted virulence factor from Helicobacter pylori, which cleaves the ectodomain of the cell-adhesion protein E-cadherin. E-cadherin shedding disrupts epithelial barrier functions allowing H. pylori designed to access the intercellular space. We then designed a small-molecule inhibitor that efficiently blocks HtrA activity, E-cadherin cleavage and intercellular entry of H. pylori.
Stichworte
E-cadherin; H. pylori; HtrA
Erscheinungsjahr
2010
Zeitschriftentitel
EMBO REPORTS
Band
11
Ausgabe
10
Seite(n)
798-804
ISSN
1469-221X
eISSN
1469-3178
Page URI
https://pub.uni-bielefeld.de/record/1930145

Zitieren

Hoy B, Loewer M, Weydig C, et al. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS. 2010;11(10):798-804.
Hoy, B., Loewer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Schroeder, P., et al. (2010). Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS, 11(10), 798-804. https://doi.org/10.1038/embor.2010.114
Hoy, Benjamin, Loewer, Martin, Weydig, Christiane, Carra, Gert, Tegtmeyer, Nicole, Geppert, Tim, Schroeder, Peter, et al. 2010. “Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion”. EMBO REPORTS 11 (10): 798-804.
Hoy, B., Loewer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Schroeder, P., Sewald, N., Backert, S., Schneider, G., et al. (2010). Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS 11, 798-804.
Hoy, B., et al., 2010. Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS, 11(10), p 798-804.
B. Hoy, et al., “Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion”, EMBO REPORTS, vol. 11, 2010, pp. 798-804.
Hoy, B., Loewer, M., Weydig, C., Carra, G., Tegtmeyer, N., Geppert, T., Schroeder, P., Sewald, N., Backert, S., Schneider, G., Wessler, S.: Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion. EMBO REPORTS. 11, 798-804 (2010).
Hoy, Benjamin, Loewer, Martin, Weydig, Christiane, Carra, Gert, Tegtmeyer, Nicole, Geppert, Tim, Schroeder, Peter, Sewald, Norbert, Backert, Steffen, Schneider, Gisbert, and Wessler, Silja. “Helicobacter pylori HtrA is a new secreted virulence factor that cleaves E-cadherin to disrupt intercellular adhesion”. EMBO REPORTS 11.10 (2010): 798-804.

116 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

H. pylori isolates with amino acid sequence polymorphisms as presence of both HtrA-L171 & CagL-Y58/E59 increase the risk of gastric cancer.
Yeh YC, Kuo HY, Chang WL, Yang HB, Lu CC, Cheng HC, Wu MS, Sheu BS., J Biomed Sci 26(1), 2019
PMID: 30611258
Distinct Contribution of the HtrA Protease and PDZ Domains to Its Function in Stress Resilience and Virulence of Bacillus anthracis.
Israeli M, Elia U, Rotem S, Cohen H, Tidhar A, Bercovich-Kinori A, Cohen O, Chitlaru T., Front Microbiol 10(), 2019
PMID: 30833938
Protease Activity of Campylobacter jejuni HtrA Modulates Distinct Intestinal and Systemic Immune Responses in Infected Secondary Abiotic IL-10 Deficient Mice.
Schmidt AM, Escher U, Mousavi S, Boehm M, Backert S, Bereswill S, Heimesaat MM., Front Cell Infect Microbiol 9(), 2019
PMID: 30984628
Properties of the HtrA Protease From Bacterium Helicobacter pylori Whose Activity Is Indispensable for Growth Under Stress Conditions.
Zarzecka U, Modrak-Wójcik A, Figaj D, Apanowicz M, Lesner A, Bzowska A, Lipinska B, Zawilak-Pawlik A, Backert S, Skorko-Glonek J., Front Microbiol 10(), 2019
PMID: 31130939
Establishment of serine protease htrA mutants in Helicobacter pylori is associated with secA mutations.
Zawilak-Pawlik A, Zarzecka U, Żyła-Uklejewicz D, Lach J, Strapagiel D, Tegtmeyer N, Böhm M, Backert S, Skorko-Glonek J., Sci Rep 9(1), 2019
PMID: 31409845
Proteases and protease inhibitors in infectious diseases.
Agbowuro AA, Huston WM, Gamble AB, Tyndall JDA., Med Res Rev 38(4), 2018
PMID: 29149530
Genetic populations and virulence factors of Helicobacter pylori.
Kabamba ET, Tuan VP, Yamaoka Y., Infect Genet Evol 60(), 2018
PMID: 29471116
Amino-Terminal Processing of Helicobacter pylori Serine Protease HtrA: Role in Oligomerization and Activity Regulation.
Albrecht N, Tegtmeyer N, Sticht H, Skórko-Glonek J, Backert S., Front Microbiol 9(), 2018
PMID: 29713313
Extracellular HtrA serine proteases: An emerging new strategy in bacterial pathogenesis.
Backert S, Bernegger S, Skórko-Glonek J, Wessler S., Cell Microbiol 20(6), 2018
PMID: 29582532
Future perspective for potential Helicobacter pylori eradication therapies.
Debraekeleer A, Remaut H., Future Microbiol 13(), 2018
PMID: 29798689
Function of Serine Protease HtrA in the Lifecycle of the Foodborne Pathogen Campylobacter jejuni.
Boehm M, Simson D, Escher U, Schmidt AM, Bereswill S, Tegtmeyer N, Backert S, Heimesaat MM., Eur J Microbiol Immunol (Bp) 8(3), 2018
PMID: 30345086
Diffuse Gastric Cancer: A Summary of Analogous Contributing Factors for Its Molecular Pathogenicity.
Ansari S, Gantuya B, Tuan VP, Yamaoka Y., Int J Mol Sci 19(8), 2018
PMID: 30115886
Afadin Downregulation by Helicobacter pylori Induces Epithelial to Mesenchymal Transition in Gastric Cells.
Marques MS, Melo J, Cavadas B, Mendes N, Pereira L, Carneiro F, Figueiredo C, Leite M., Front Microbiol 9(), 2018
PMID: 30473688
Bacterial serine protease HtrA as a promising new target for antimicrobial therapy?
Wessler S, Schneider G, Backert S., Cell Commun Signal 15(1), 2017
PMID: 28069057
Functional study of gene hp0169 in Helicobacter pylori pathogenesis.
Zhao H, Ji X, Chen X, Li J, Zhang Y, Du Z, Zhang Y, Li B., Microb Pathog 104(), 2017
PMID: 28131950
Digital PCR identifies changes in CDH1 (E-cadherin) transcription pattern in intestinal-type gastric cancer.
Abou Khouzam R, Molinari C, Salvi S, Marabelli M, Molinaro V, Orioli D, Saragoni L, Morgagni P, Calistri D, Ranzani GN., Oncotarget 8(12), 2017
PMID: 27861150
Proteolysis in Helicobacter pylori-Induced Gastric Cancer.
Posselt G, Crabtree JE, Wessler S., Toxins (Basel) 9(4), 2017
PMID: 28398251
CtHtrA: the lynchpin of the chlamydial surface and a promising therapeutic target.
Marsh JW, Ong VA, Lott WB, Timms P, Tyndall JD, Huston WM., Future Microbiol 12(), 2017
PMID: 28593794
Role of caspase-3/E-cadherin in helicobacter pylori-induced apoptosis of gastric epithelial cells.
Yang Y, Du J, Liu F, Wang X, Li X, Li Y., Oncotarget 8(35), 2017
PMID: 28938629
Pseudomonas aeruginosa ExlA and Serratia marcescens ShlA trigger cadherin cleavage by promoting calcium influx and ADAM10 activation.
Reboud E, Bouillot S, Patot S, Béganton B, Attrée I, Huber P., PLoS Pathog 13(8), 2017
PMID: 28832671
Helicobacter pylori Makes a Molecular Incision to Gain Epithelial Entry.
Noto JM, Peek RM., Cell Host Microbe 22(4), 2017
PMID: 29024639
Growth phase-dependent composition of the Helicobacter pylori exoproteome.
Snider CA, Voss BJ, McDonald WH, Cover TL., J Proteomics 130(), 2016
PMID: 26363098
Pathobiology of Helicobacter pylori-Induced Gastric Cancer.
Amieva M, Peek RM., Gastroenterology 150(1), 2016
PMID: 26385073
Borrelia burgdorferi HtrA: evidence for twofold proteolysis of outer membrane protein p66.
Coleman JL, Toledo A, Benach JL., Mol Microbiol 99(1), 2016
PMID: 26370492
The salt-sensitive structure and zinc inhibition of Borrelia burgdorferi protease BbHtrA.
Russell TM, Tang X, Goldstein JM, Bagarozzi D, Johnson BJ., Mol Microbiol 99(3), 2016
PMID: 26480895
Characterisation of worldwide Helicobacter pylori strains reveals genetic conservation and essentiality of serine protease HtrA.
Tegtmeyer N, Moodley Y, Yamaoka Y, Pernitzsch SR, Schmidt V, Traverso FR, Schmidt TP, Rad R, Yeoh KG, Bow H, Torres J, Gerhard M, Schneider G, Wessler S, Backert S., Mol Microbiol 99(5), 2016
PMID: 26568477
Beyond a tumor suppressor: Soluble E-cadherin promotes the progression of cancer.
Hu QP, Kuang JY, Yang QK, Bian XW, Yu SC., Int J Cancer 138(12), 2016
PMID: 26704932
Downregulated Expression of E-cadherin and TP53 in Patients with Gastric Diseases: the Involvement of H. pylori Infection and Its Virulence Markers.
Ferraz MA, Zabaglia LM, Pereira WN, Orcini WA, de Labio RW, Caleman Neto A, Wisnieski F, Calcagno DQ, Santos LC, Assumpção PP, Burbano RR, Artigiani R, Smith Mde A, Payão SL, Rasmussen LT., J Gastrointest Cancer 47(1), 2016
PMID: 26585943
Identification of E-cadherin signature motifs functioning as cleavage sites for Helicobacter pylori HtrA.
Schmidt TP, Perna AM, Fugmann T, Böhm M, Jan Hiss, Haller S, Götz C, Tegtmeyer N, Hoy B, Rau TT, Neri D, Backert S, Schneider G, Wessler S., Sci Rep 6(), 2016
PMID: 26983597
Insights into the Cyanobacterial Deg/HtrA Proteases.
Cheregi O, Wagner R, Funk C., Front Plant Sci 7(), 2016
PMID: 27252714
Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA.
Schmidt TP, Goetz C, Huemer M, Schneider G, Wessler S., Gut Pathog 8(), 2016
PMID: 27274359
HtrA Is Important for Stress Resistance and Virulence in Haemophilus parasuis.
Zhang L, Li Y, Wen Y, Lau GW, Huang X, Wu R, Yan Q, Huang Y, Zhao Q, Ma X, Wen X, Cao S., Infect Immun 84(8), 2016
PMID: 27217419
HtrA, a Temperature- and Stationary Phase-Activated Protease Involved in Maturation of a Key Microbial Virulence Determinant, Facilitates Borrelia burgdorferi Infection in Mammalian Hosts.
Ye M, Sharma K, Thakur M, Smith AA, Buyuktanir O, Xiang X, Yang X, Promnares K, Lou Y, Yang XF, Pal U., Infect Immun 84(8), 2016
PMID: 27271745
Impact of Helicobacter pylori on the healing process of the gastric barrier.
Mnich E, Kowalewicz-Kulbat M, Sicińska P, Hinc K, Obuchowski M, Gajewski A, Moran AP, Chmiela M., World J Gastroenterol 22(33), 2016
PMID: 27672275
HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens.
Abfalter CM, Schubert M, Götz C, Schmidt TP, Posselt G, Wessler S., Cell Commun Signal 14(1), 2016
PMID: 27931258
Linkages between oral commensal bacteria and atherosclerotic plaques in coronary artery disease patients.
Chhibber-Goel J, Singhal V, Bhowmik D, Vivek R, Parakh N, Bhargava B, Sharma A., NPJ Biofilms Microbiomes 2(), 2016
PMID: 28649401
Helicobacter pylori bacteria alter the p53 stress response via ERK-HDM2 pathway.
Bhardwaj V, Noto JM, Wei J, Andl C, El-Rifai W, Peek RM, Zaika AI., Oncotarget 6(3), 2015
PMID: 25605238
Microevolution of Virulence-Related Genes in Helicobacter pylori Familial Infection.
Furuta Y, Konno M, Osaki T, Yonezawa H, Ishige T, Imai M, Shiwa Y, Shibata-Hatta M, Kanesaki Y, Yoshikawa H, Kamiya S, Kobayashi I., PLoS One 10(5), 2015
PMID: 25978460
Fragment-Based De Novo Design Reveals a Small-Molecule Inhibitor of Helicobacter Pylori HtrA.
Perna AM, Rodrigues T, Schmidt TP, Böhm M, Stutz K, Reker D, Pfeiffer B, Altmann KH, Backert S, Wessler S, Schneider G., Angew Chem Int Ed Engl 54(35), 2015
PMID: 26069090
Outer membrane vesicles of Tannerella forsythia: biogenesis, composition, and virulence.
Friedrich V, Gruber C, Nimeth I, Pabinger S, Sekot G, Posch G, Altmann F, Messner P, Andrukhov O, Schäffer C., Mol Oral Microbiol 30(6), 2015
PMID: 25953484
Production, secretion and purification of a correctly folded staphylococcal antigen in Lactococcus lactis.
Samazan F, Rokbi B, Seguin D, Telles F, Gautier V, Richarme G, Chevret D, Varela PF, Velours C, Poquet I., Microb Cell Fact 14(), 2015
PMID: 26178240
Structural and functional aspects of the Helicobacter pylori secretome.
Zanotti G, Cendron L., World J Gastroenterol 20(6), 2014
PMID: 24587618
Dynamic monitoring of Salmonella typhimurium infection of polarized epithelia using organic transistors.
Tria SA, Ramuz M, Huerta M, Leleux P, Rivnay J, Jimison LH, Hama A, Malliaras GG, Owens RM., Adv Healthc Mater 3(7), 2014
PMID: 24497469
Helicobacter pylori-induced posttranscriptional regulation of H-K-ATPase α-subunit gene expression by miRNA.
Zhang YM, Noto JM, Hammond CE, Barth JL, Argraves WS, Backert S, Peek RM, Smolka AJ., Am J Physiol Gastrointest Liver Physiol 306(7), 2014
PMID: 24503769
Peptide lineup against Gram-negative bacterial infection – first-in-class peptide inhibitor of H. pylori HtrA.
Perna AM, Schmidt T, Fugmann T, Tegtmeyer N, Backert S, Wessler S, Schneider G., J Cheminform 6(suppl 1), 2014
PMID: PMC3980066
Proteomic analysis of Vibrio cholerae outer membrane vesicles.
Altindis E, Fu Y, Mekalanos JJ., Proc Natl Acad Sci U S A 111(15), 2014
PMID: 24706774
The LA loop as an important regulatory element of the HtrA (DegP) protease from Escherichia coli: structural and functional studies.
Figaj D, Gieldon A, Polit A, Sobiecka-Szkatula A, Koper T, Denkiewicz M, Banecki B, Lesner A, Ciarkowski J, Lipinska B, Skorko-Glonek J., J Biol Chem 289(22), 2014
PMID: 24737328
Analysis of surface-exposed outer membrane proteins in Helicobacter pylori.
Voss BJ, Gaddy JA, McDonald WH, Cover TL., J Bacteriol 196(13), 2014
PMID: 24769695
How Listeria monocytogenes organizes its surface for virulence.
Carvalho F, Sousa S, Cabanes D., Front Cell Infect Microbiol 4(), 2014
PMID: 24809022
The impact of serine protease HtrA in apoptosis, intestinal immune responses and extra-intestinal histopathology during Campylobacter jejuni infection of infant mice.
Heimesaat MM, Fischer A, Alutis M, Grundmann U, Boehm M, Tegtmeyer N, Göbel UB, Kühl AA, Bereswill S, Backert S., Gut Pathog 6(), 2014
PMID: 24883112
Inhibiting Helicobacter pylori HtrA protease by addressing a computationally predicted allosteric ligand binding site.
Perna AM, Reisen F, Schmidt TP, Geppert T, Pillong M, Weisel M, Hoy B, Simister PC, Feller SM, Wessler S, Schneider G., Chem Sci 5(), 2014
PMID: 26819700
The role of serine protease HtrA in acute ulcerative enterocolitis and extra-intestinal immune responses during Campylobacter jejuni infection of gnotobiotic IL-10 deficient mice.
Heimesaat MM, Alutis M, Grundmann U, Fischer A, Tegtmeyer N, Böhm M, Kühl AA, Göbel UB, Backert S, Bereswill S., Front Cell Infect Microbiol 4(), 2014
PMID: 24959425
Comparative proteomic analysis of the membrane proteins of two Haemophilus parasuis strains to identify proteins that may help in habitat adaptation and pathogenesis.
Zhang L, Wen Y, Li Y, Wei X, Yan X, Wen X, Wu R, Huang X, Huang Y, Yan Q, Liu M, Cao S., Proteome Sci 12(), 2014
PMID: 25057263
Effect of Helicobacter pylori on gastric epithelial cells.
Alzahrani S, Lina TT, Gonzalez J, Pinchuk IV, Beswick EJ, Reyes VE., World J Gastroenterol 20(36), 2014
PMID: 25278677
Draft genome sequences of six enterohepatic helicobacter species isolated from humans and one from rhesus macaques.
Shen Z, Sheh A, Young SK, Abouelliel A, Ward DV, Earl AM, Fox JG., Genome Announc 2(5), 2014
PMID: 25212613
The stability and activity of recombinant Helicobacter pylori HtrA under stress conditions.
Hoy B, Brandstetter H, Wessler S., J Basic Microbiol 53(5), 2013
PMID: 22736569
Adherens junctions as targets of microorganisms: a focus on Helicobacter pylori.
Costa AM, Leite M, Seruca R, Figueiredo C., FEBS Lett 587(3), 2013
PMID: 23262219
Thermosensing to adjust bacterial virulence in a fluctuating environment.
Steinmann R, Dersch P., Future Microbiol 8(1), 2013
PMID: 23252495
Helicobacter pylori in gastric carcinogenesis: mechanisms.
Wroblewski LE, Peek RM., Gastroenterol Clin North Am 42(2), 2013
PMID: 23639641
Why can't we make an effective vaccine against Helicobacter pylori?
Sutton P, Chionh YT., Expert Rev Vaccines 12(4), 2013
PMID: 23560923
The HtrA protease of Borrelia burgdorferi degrades outer membrane protein BmpD and chemotaxis phosphatase CheX.
Coleman JL, Crowley JT, Toledo AM, Benach JL., Mol Microbiol 88(3), 2013
PMID: 23565798
Genome-wide association analysis of avian resistance to Campylobacter jejuni colonization identifies risk locus spanning the CDH13 gene.
Connell S, Meade KG, Allan B, Lloyd AT, Downing T, O'Farrelly C, Bradley DG., G3 (Bethesda) 3(5), 2013
PMID: 23550144
Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis.
Gloeckl S, Ong VA, Patel P, Tyndall JD, Timms P, Beagley KW, Allan JA, Armitage CW, Turnbull L, Whitchurch CB, Merdanovic M, Ehrmann M, Powers JC, Oleksyszyn J, Verdoes M, Bogyo M, Huston WM., Mol Microbiol 89(4), 2013
PMID: 23796320
Electron microscopic, genetic and protein expression analyses of Helicobacter acinonychis strains from a Bengal tiger.
Tegtmeyer N, Rivas Traverso F, Rohde M, Oyarzabal OA, Lehn N, Schneider-Brachert W, Ferrero RL, Fox JG, Berg DE, Backert S., PLoS One 8(8), 2013
PMID: 23940723
Borrelia burgdorferi HtrA may promote dissemination and irritation.
Gherardini FC., Mol Microbiol 90(2), 2013
PMID: 23998919
Extracellular secretion of protease HtrA from Campylobacter jejuni is highly efficient and independent of its protease activity and flagellum.
Boehm M, Haenel I, Hoy B, Brøndsted L, Smith TG, Hoover T, Wessler S, Tegtmeyer N., Eur J Microbiol Immunol (Bp) 3(3), 2013
PMID: 24265934
Digestion of epithelial tight junction proteins by the commensal Clostridium perfringens.
Pruteanu M, Shanahan F., Am J Physiol Gastrointest Liver Physiol 305(10), 2013
PMID: 24072681
Lipopolysaccharide increases the incidence of collagen-induced arthritis in mice through induction of protease HTRA-1 expression.
Hou Y, Lin H, Zhu L, Liu Z, Hu F, Shi J, Yang T, Shi X, Zhu M, Godley BF, Wang Q, Li Z, Zhao Y., Arthritis Rheum 65(11), 2013
PMID: 23982886
The protease inhibitor JO146 demonstrates a critical role for CtHtrA for Chlamydia trachomatis reversion from penicillin persistence.
Ong VA, Marsh JW, Lawrence A, Allan JA, Timms P, Huston WM., Front Cell Infect Microbiol 3(), 2013
PMID: 24392355
From Virtual Screening to Bioactive Compounds by Visualizing and Clustering of Chemical Space.
Klenner A, Hähnke V, Geppert T, Schneider P, Zettl H, Haller S, Rodrigues T, Reisen F, Hoy B, Schaible AM, Werz O, Wessler S, Schneider G., Mol Inform 31(1), 2012
PMID: 27478174
Helicobacter pylori defense against oxidative attack.
Stent A, Every AL, Sutton P., Am J Physiol Gastrointest Liver Physiol 302(6), 2012
PMID: 22194421
Distinct roles of secreted HtrA proteases from gram-negative pathogens in cleaving the junctional protein and tumor suppressor E-cadherin.
Hoy B, Geppert T, Boehm M, Reisen F, Plattner P, Gadermaier G, Sewald N, Ferreira F, Briza P, Schneider G, Backert S, Wessler S., J Biol Chem 287(13), 2012
PMID: 22337879
the active site residue V266 of Chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions.
Gloeckl S, Tyndall JD, Stansfield SH, Timms P, Huston WM., J Mol Microbiol Biotechnol 22(1), 2012
PMID: 22353774
A role for altered phagosome maturation in the long-term persistence of Helicobacter pylori infection.
Borlace GN, Keep SJ, Prodoehl MJ, Jones HF, Butler RN, Brooks DA., Am J Physiol Gastrointest Liver Physiol 303(2), 2012
PMID: 22575220
E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions.
Carneiro P, Fernandes MS, Figueiredo J, Caldeira J, Carvalho J, Pinheiro H, Leite M, Melo S, Oliveira P, Simões-Correia J, Oliveira MJ, Carneiro F, Figueiredo C, Paredes J, Oliveira C, Seruca R., FEBS Lett 586(18), 2012
PMID: 22841718
The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide.
Cassone M, Gagne AL, Spruce LA, Seeholzer SH, Sebert ME., J Biol Chem 287(46), 2012
PMID: 23012372
Bacterial proteolytic complexes as therapeutic targets.
Raju RM, Goldberg AL, Rubin EJ., Nat Rev Drug Discov 11(10), 2012
PMID: 23023677
Bacterial outer membrane vesicles in disease and preventive medicine.
Unal CM, Schaar V, Riesbeck K., Semin Immunopathol 33(5), 2011
PMID: 21153593
Protein quality control in the bacterial periplasm.
Merdanovic M, Clausen T, Kaiser M, Huber R, Ehrmann M., Annu Rev Microbiol 65(), 2011
PMID: 21639788
HTRA proteases: regulated proteolysis in protein quality control.
Clausen T, Kaiser M, Huber R, Ehrmann M., Nat Rev Mol Cell Biol 12(3), 2011
PMID: 21326199
Context-based identification of protein-protein interfaces and "hot-spot" residues.
Geppert T, Hoy B, Wessler S, Schneider G., Chem Biol 18(3), 2011
PMID: 21439479
Comparative whole genome sequence analysis of the carcinogenic bacterial model pathogen Helicobacter felis.
Arnold IC, Zigova Z, Holden M, Lawley TD, Rad R, Dougan G, Falkow S, Bentley SD, Müller A., Genome Biol Evol 3(), 2011
PMID: 21402865
Inhibitors of Helicobacter pylori protease HtrA found by 'virtual ligand' screening combat bacterial invasion of epithelia.
Löwer M, Geppert T, Schneider P, Hoy B, Wessler S, Schneider G., PLoS One 6(3), 2011
PMID: 21483848
Structure-Based Pharmacophores for Virtual Screening.
Löwer M, Proschak E., Mol Inform 30(5), 2011
PMID: 27467085
HtrA is a major virulence determinant of Bacillus anthracis.
Chitlaru T, Zaide G, Ehrlich S, Inbar I, Cohen O, Shafferman A., Mol Microbiol 81(6), 2011
PMID: 21801240
Pathogenesis of Helicobacter pylori infection.
Backert S, Clyne M., Helicobacter 16 Suppl 1(), 2011
PMID: 21896081
"Targeted disruption of the epithelial-barrier by Helicobacter pylori".
Wroblewski LE, Peek RM., Cell Commun Signal 9(1), 2011
PMID: 22044698
Protease-activated receptor-2 (PAR2) in human gastric mucosa as mediator of proinflammatory effects in Helicobacter pylori infection.
Kandulski A, Kuester D, Mönkemüller K, Fry L, Malfertheiner P, Wex T., Helicobacter 16(6), 2011
PMID: 22059396

23 References

Daten bereitgestellt von Europe PubMed Central.

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1.
Noe V, Fingleton B, Jacobs K, Crawford HC, Vermeulen S, Steelant W, Bruyneel E, Matrisian LM, Mareel M., J. Cell. Sci. 114(Pt 1), 2001
PMID: 11112695
Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA.
Amieva MR, Vogelmann R, Covacci A, Tompkins LS, Nelson WJ, Falkow S., Science 300(5624), 2003
PMID: 12775840
Helicobacter pylori VacA, a paradigm for toxin multifunctionality.
Cover TL, Blanke SR., Nat. Rev. Microbiol. 3(4), 2005
PMID: 15759043
ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.
Maretzky T, Reiss K, Ludwig A, Buchholz J, Scholz F, Proksch E, de Strooper B, Hartmann D, Saftig P., Proc. Natl. Acad. Sci. U.S.A. 102(26), 2005
PMID: 15958533
The role of human HtrA1 in arthritic disease.
Grau S, Richards PJ, Kerr B, Hughes C, Caterson B, Williams AS, Junker U, Jones SA, Clausen T, Ehrmann M., J. Biol. Chem. 281(10), 2005
PMID: 16377621
Intracellular, intercellular, and stromal invasion of gastric mucosa, preneoplastic lesions, and cancer by Helicobacter pylori.
Necchi V, Candusso ME, Tava F, Luinetti O, Ventura U, Fiocca R, Ricci V, Solcia E., Gastroenterology 132(3), 2007
PMID: 17383424
Structural basis for the regulated protease and chaperone function of DegP.
Krojer T, Sawa J, Schafer E, Saibil HR, Ehrmann M, Clausen T., Nature 453(7197), 2008
PMID: 18496527
p120 and Kaiso regulate Helicobacter pylori-induced expression of matrix metalloproteinase-7.
Ogden SR, Wroblewski LE, Weydig C, Romero-Gallo J, O'Brien DP, Israel DA, Krishna US, Fingleton B, Reynolds AB, Wessler S, Peek RM Jr., Mol. Biol. Cell 19(10), 2008
PMID: 18653469
Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins.
Jiang J, Zhang X, Chen Y, Wu Y, Zhou ZH, Chang Z, Sui SF., Proc. Natl. Acad. Sci. U.S.A. 105(33), 2008
PMID: 18697939
Prediction of extracellular proteases of the human pathogen Helicobacter pylori reveals proteolytic activity of the Hp1018/19 protein HtrA.
Lower M, Weydig C, Metzler D, Reuter A, Starzinski-Powitz A, Wessler S, Schneider G., PLoS ONE 3(10), 2008
PMID: 18946507
Helicobacter pylori dysregulation of gastric epithelial tight junctions by urease-mediated myosin II activation.
Wroblewski LE, Shen L, Ogden S, Romero-Gallo J, Lapierre LA, Israel DA, Turner JR, Peek RM Jr., Gastroenterology 136(1), 2008
PMID: 18996125
Structure, function and regulation of the conserved serine proteases DegP and DegS of Escherichia coli.
Meltzer M, Hasenbein S, Mamant N, Merdanovic M, Poepsel S, Hauske P, Kaiser M, Huber R, Krojer T, Clausen T, Ehrmann M., Res. Microbiol. 160(9), 2009
PMID: 19695325
Proteases in bacterial pathogenesis.
Ingmer H, Brondsted L., Res. Microbiol. 160(9), 2009
PMID: 19778606
Basic local alignment search tool.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ., J. Mol. Biol. 215(3), 1990
PMID: 2231712
Selective increase of the permeability of polarized epithelial cell monolayers by Helicobacter pylori vacuolating toxin.
Papini E, Satin B, Norais N, de Bernard M, Telford JL, Rappuoli R, Montecucco C., J. Clin. Invest. 102(4), 1998
PMID: 9710450
Global transposon mutagenesis and essential gene analysis of Helicobacter pylori.
Salama NR, Shepherd B, Falkow S., J. Bacteriol. 186(23), 2004
PMID: 15547264
E-cadherin in gastric cancer.
Chan AO., World J. Gastroenterol. 12(2), 2006
PMID: 16482618
Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells.
Murata-Kamiya N, Kurashima Y, Teishikata Y, Yamahashi Y, Saito Y, Higashi H, Aburatani H, Akiyama T, Peek RM Jr, Azuma T, Hatakeyama M., Oncogene 26(32), 2007
PMID: 17237808
Molecular mechanisms of epithelial-barrier disruption by Helicobacter pylori.
Wessler S, Backert S., Trends Microbiol. 16(8), 2008
PMID: 18619844
Ectodomain shedding of E-cadherin and c-Met is induced by Helicobacter pylori infection.
Schirrmeister W, Gnad T, Wex T, Higashiyama S, Wolke C, Naumann M, Lendeckel U., Exp. Cell Res. 315(20), 2009
PMID: 19665015
Helicobacter pylori and gastrointestinal tract adenocarcinomas.
Peek RM Jr, Blaser MJ., Nat. Rev. Cancer 2(1), 2002
PMID: 11902583
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 20814423
PubMed | Europe PMC

Suchen in

Google Scholar