Approaches for the Synthesis of Functionalized Cryptophycins

Sammet B, Bogner T, Nahrwold M, Weiss C, Sewald N (2010)
JOURNAL OF ORGANIC CHEMISTRY 75(20): 6953-6960.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
The first syntheses of bioactive cryptophycins functionalized at unit ID were accomplished ina one-pot Staudinger reduction/cyclization step An a/ado precursor for the lower part of the backbone was introduced to minimize protective group chemistry and enable a very convenient synthesis of cryptophycin-52 and unit D eryptophycin analogues containing an ester or a free carboxylic acid for bioconjugations Both new cryptophycin derivatives show high biological activity in cytotoxicity assays
Erscheinungsjahr
2010
Zeitschriftentitel
JOURNAL OF ORGANIC CHEMISTRY
Band
75
Ausgabe
20
Seite(n)
6953-6960
ISSN
0022-3263
eISSN
1520-6904
Page URI
https://pub.uni-bielefeld.de/record/1929773

Zitieren

Sammet B, Bogner T, Nahrwold M, Weiss C, Sewald N. Approaches for the Synthesis of Functionalized Cryptophycins. JOURNAL OF ORGANIC CHEMISTRY. 2010;75(20):6953-6960.
Sammet, B., Bogner, T., Nahrwold, M., Weiss, C., & Sewald, N. (2010). Approaches for the Synthesis of Functionalized Cryptophycins. JOURNAL OF ORGANIC CHEMISTRY, 75(20), 6953-6960. doi:10.1021/jo101563s
Sammet, B., Bogner, T., Nahrwold, M., Weiss, C., and Sewald, N. (2010). Approaches for the Synthesis of Functionalized Cryptophycins. JOURNAL OF ORGANIC CHEMISTRY 75, 6953-6960.
Sammet, B., et al., 2010. Approaches for the Synthesis of Functionalized Cryptophycins. JOURNAL OF ORGANIC CHEMISTRY, 75(20), p 6953-6960.
B. Sammet, et al., “Approaches for the Synthesis of Functionalized Cryptophycins”, JOURNAL OF ORGANIC CHEMISTRY, vol. 75, 2010, pp. 6953-6960.
Sammet, B., Bogner, T., Nahrwold, M., Weiss, C., Sewald, N.: Approaches for the Synthesis of Functionalized Cryptophycins. JOURNAL OF ORGANIC CHEMISTRY. 75, 6953-6960 (2010).
Sammet, Benedikt, Bogner, Tobias, Nahrwold, Markus, Weiss, Christine, and Sewald, Norbert. “Approaches for the Synthesis of Functionalized Cryptophycins”. JOURNAL OF ORGANIC CHEMISTRY 75.20 (2010): 6953-6960.

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