The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism

Kolassa I-T, Kolassa S, Ertl V, Papassotiropoulos A, De Quervain DJ (2010)
Biological Psychiatry 67(4): 304-308.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Kolassa, Iris-Tatjana; Kolassa, S.; Ertl, VerenaUniBi; Papassotiropoulos, A.; De Quervain, D. J.
Abstract / Bemerkung
BACKGROUND: The risk for posttraumatic stress disorder (PTSD) depends on the number of traumatic event types experienced in a dose-response relationship, but genetic factors are known to also influence the risk of PTSD. The catechol-O-methyltransferase (COMT) Val158Met polymorphism has been found to affect fear extinction and might play a role in the etiology of anxiety disorders. METHODS: Traumatic load and lifetime and current diagnosis of PTSD and COMT genotype were assessed in a sample of 424 survivors of the Rwandan Genocide living in the Nakivale refugee camp in southwestern Uganda. RESULTS: Higher numbers of different lifetime traumatic event types led to a higher prevalence of lifetime PTSD in a dose-response relationship. However, this effect was modulated by the COMT genotype: whereas Val allele carriers showed the typical dose-response relationship, Met/Met homozygotes exhibited a high risk for PTSD independently of the severity of traumatic load. CONCLUSIONS: The present findings indicate a gene-environment interaction between the human COMT Val158Met polymorphism and the number of traumatic event types experienced in the risk of developing PTSD.
Catechol O-Methyltransferase/*genetics; Chi-Square Distribution; Female; *Genetic Predisposition to Disease; Humans; Male; Life Change Events; Methionine/*genetics; Middle Aged; Single Nucleotide; *Polymorphism; Probability; Risk Factors; Aged; Africa; Adolescent; Adult; Valine/*genetics; Young Adult; Stress Disorders; Post-Traumatic/*genetics
Biological Psychiatry
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Kolassa I-T, Kolassa S, Ertl V, Papassotiropoulos A, De Quervain DJ. The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. Biological Psychiatry. 2010;67(4):304-308.
Kolassa, I. - T., Kolassa, S., Ertl, V., Papassotiropoulos, A., & De Quervain, D. J. (2010). The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. Biological Psychiatry, 67(4), 304-308.
Kolassa, Iris-Tatjana, Kolassa, S., Ertl, Verena, Papassotiropoulos, A., and De Quervain, D. J. 2010. “The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism”. Biological Psychiatry 67 (4): 304-308.
Kolassa, I. - T., Kolassa, S., Ertl, V., Papassotiropoulos, A., and De Quervain, D. J. (2010). The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. Biological Psychiatry 67, 304-308.
Kolassa, I.-T., et al., 2010. The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. Biological Psychiatry, 67(4), p 304-308.
I.-T. Kolassa, et al., “The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism”, Biological Psychiatry, vol. 67, 2010, pp. 304-308.
Kolassa, I.-T., Kolassa, S., Ertl, V., Papassotiropoulos, A., De Quervain, D.J.: The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. Biological Psychiatry. 67, 304-308 (2010).
Kolassa, Iris-Tatjana, Kolassa, S., Ertl, Verena, Papassotiropoulos, A., and De Quervain, D. J. “The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism”. Biological Psychiatry 67.4 (2010): 304-308.

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