Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate

Kato O, Youn J-W, Stansen KC, Matsui D, Oikawa T, Wendisch VF (2010)
BMC Microbiology 10(1): 321.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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URN
urn:nbn:de:0070-pub-19246665
Autor*in
Kato, Osamu; Youn, Jung-WonUniBi; Stansen, K. C.; Matsui, Daisuke; Oikawa, Tadao; Wendisch, Volker F.UniBi
Einrichtung
Fakultät für Biologie > Genetik der Prokaryoten
Centrum für Biotechnologie > Arbeitsgruppe V. Wendisch
Centrum für Biotechnologie > Institut für Genomforschung und Systembiologie
Abstract / Bemerkung
Background: Corynebacterium glutamicum is able to grow with lactate as sole or combined carbon and energy source. Quinone-dependent L-lactate dehydrogenase LldD is known to be essential for utilization of L-lactate by C. glutamicum. D-lactate also serves as sole carbon source for C. glutamicum ATCC 13032. Results: Here, the gene cg1027 was shown to encode the quinone-dependent D-lactate dehydrogenase (Dld) by enzymatic analysis of the protein purified from recombinant E. coli. The absorption spectrum of purified Dld indicated the presence of FAD as bound cofactor. Inactivation of dld resulted in the loss of the ability to grow with D-lactate, which could be restored by plasmid-borne expression of dld. Heterologous expression of dld from C. glutamicum ATCC 13032 in C. efficiens enabled this species to grow with D-lactate as sole carbon source. Homologs of dld of C. glutamicum ATCC 13032 are not encoded in the sequenced genomes of other corynebacteria and mycobacteria. However, the dld locus of C. glutamicum ATCC 13032 shares 2367 bp of 2372 bp identical nucleotides with the dld locus of Propionibacterium freudenreichii subsp. shermanii, a bacterium used in Swiss-type cheese making. Both loci are flanked by insertion sequences of the same family suggesting a possible event of horizontal gene transfer. Conclusions: Cg1067 encodes quinone-dependent D-lactate dehydrogenase Dld of Corynebacterium glutamicum. Dld is essential for growth with D-lactate as sole carbon source. The genomic region of dld likely has been acquired by horizontal gene transfer.
Erscheinungsjahr
2010
Zeitschriftentitel
BMC Microbiology
Band
10
Ausgabe
1
Art.-Nr.
321
ISSN
1471-2180
Finanzierungs-Informationen
Open-Access-Publikationskosten wurden durch die Deutsche Forschungsgemeinschaft und die Universität Bielefeld gefördert.
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https://pub.uni-bielefeld.de/record/1924666

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Kato O, Youn J-W, Stansen KC, Matsui D, Oikawa T, Wendisch VF. Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate. BMC Microbiology. 2010;10(1): 321.
Kato, O., Youn, J. - W., Stansen, K. C., Matsui, D., Oikawa, T., & Wendisch, V. F. (2010). Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate. BMC Microbiology, 10(1), 321. https://doi.org/10.1186/1471-2180-10-321
Kato, Osamu, Youn, Jung-Won, Stansen, K. C., Matsui, Daisuke, Oikawa, Tadao, and Wendisch, Volker F. 2010. “Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate”. BMC Microbiology 10 (1): 321.
Kato, O., Youn, J. - W., Stansen, K. C., Matsui, D., Oikawa, T., and Wendisch, V. F. (2010). Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate. BMC Microbiology 10:321.
Kato, O., et al., 2010. Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate. BMC Microbiology, 10(1): 321.
O. Kato, et al., “Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate”, BMC Microbiology, vol. 10, 2010, : 321.
Kato, O., Youn, J.-W., Stansen, K.C., Matsui, D., Oikawa, T., Wendisch, V.F.: Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate. BMC Microbiology. 10, : 321 (2010).
Kato, Osamu, Youn, Jung-Won, Stansen, K. C., Matsui, Daisuke, Oikawa, Tadao, and Wendisch, Volker F. “Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate”. BMC Microbiology 10.1 (2010): 321.
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