Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery

Widera D, Grimm W-D, Moebius J, Mikenberg I, Piechaczek C, Gassmann G, Wolff N, Thevenod F, Kaltschmidt C, Kaltschmidt B (2007)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Widera, DariusUniBi ; Grimm, Wolf-Dieter; Moebius, Jeannette; Mikenberg, Ilja; Piechaczek, Christoph; Gassmann, Georg; Wolff, Natascha; Thevenod, Frank; Kaltschmidt, ChristianUniBi; Kaltschmidt, BarbaraUniBi
Page URI


Widera D, Grimm W-D, Moebius J, et al. Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery. STEM CELLS AND DEVELOPMENT. 2007;16(3):447-460.
Widera, D., Grimm, W. - D., Moebius, J., Mikenberg, I., Piechaczek, C., Gassmann, G., Wolff, N., et al. (2007). Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery. STEM CELLS AND DEVELOPMENT, 16(3), 447-460. https://doi.org/10.1089/scd.2006.0068
Widera, D., Grimm, W. - D., Moebius, J., Mikenberg, I., Piechaczek, C., Gassmann, G., Wolff, N., Thevenod, F., Kaltschmidt, C., and Kaltschmidt, B. (2007). Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery. STEM CELLS AND DEVELOPMENT 16, 447-460.
Widera, D., et al., 2007. Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery. STEM CELLS AND DEVELOPMENT, 16(3), p 447-460.
D. Widera, et al., “Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery”, STEM CELLS AND DEVELOPMENT, vol. 16, 2007, pp. 447-460.
Widera, D., Grimm, W.-D., Moebius, J., Mikenberg, I., Piechaczek, C., Gassmann, G., Wolff, N., Thevenod, F., Kaltschmidt, C., Kaltschmidt, B.: Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery. STEM CELLS AND DEVELOPMENT. 16, 447-460 (2007).
Widera, Darius, Grimm, Wolf-Dieter, Moebius, Jeannette, Mikenberg, Ilja, Piechaczek, Christoph, Gassmann, Georg, Wolff, Natascha, Thevenod, Frank, Kaltschmidt, Christian, and Kaltschmidt, Barbara. “Highly efficient neural differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery”. STEM CELLS AND DEVELOPMENT 16.3 (2007): 447-460.

54 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Physiological Expression of Ion Channel Receptors in Human Periodontal Ligament Stem Cells.
Chiricosta L, Diomede F, Trubiani O, Bramanti P, Mazzon E., Cells 8(3), 2019
PMID: 30845727
Human Dental Pulp Stem Cells Grown in Neurogenic Media Differentiate Into Endothelial Cells and Promote Neovasculogenesis in the Mouse Brain.
Luzuriaga J, Pastor-Alonso O, Encinas JM, Unda F, Ibarretxe G, Pineda JR., Front Physiol 10(), 2019
PMID: 30984027
Neural crest stem cells from human epidermis of aged donors maintain their multipotency in vitro and in vivo.
Moghadasi Boroujeni S, Koontz A, Tseropoulos G, Kerosuo L, Mehrotra P, Bajpai VK, Selvam SR, Lei P, Bronner ME, Andreadis ST., Sci Rep 9(1), 2019
PMID: 31278326
Isolation and Characterization of Neural Crest-Derived Stem Cells From Adult Ovine Palatal Tissue.
Zeuner MT, Didenko NN, Humphries D, Stergiadis S, Morash TM, Patel K, Grimm WD, Widera D., Front Cell Dev Biol 6(), 2018
PMID: 29696142
Dental pulp stem cells in regenerative medicine.
Hollands P, Aboyeji D, Orcharton M., Br Dent J (), 2018
PMID: 29725075
NF-κB p65 directs sex-specific neuroprotection in human neurons.
Ruiz-Perera LM, Schneider L, Windmöller BA, Müller J, Greiner JFW, Kaltschmidt C, Kaltschmidt B., Sci Rep 8(1), 2018
PMID: 30375448
Human dental follicle cells express embryonic, mesenchymal and neural stem cells markers.
Lima RL, Holanda-Afonso RC, Moura-Neto V, Bolognese AM, DosSantos MF, Souza MM., Arch Oral Biol 73(), 2017
PMID: 27764680
Effect of gingival fibroblasts and ultrasound on dogs' root resorption during orthodontic treatment.
Crossman J, Hassan AH, Saleem A, Felemban N, Aldaghreer S, Fawzi E, Farid M, Abdel-Ghaffar K, Gargoum A, El-Bialy T., J Orthod Sci 6(1), 2017
PMID: 28197400
Mesenchymal Stem Cells Derived from Dental Pulp: A Review.
Ledesma-Martínez E, Mendoza-Núñez VM, Santiago-Osorio E., Stem Cells Int 2016(), 2016
PMID: 26779263
Alternative source of stem cells derived from human periodontal ligament: a new treatment for experimental autoimmune encephalomyelitis.
Trubiani O, Giacoppo S, Ballerini P, Diomede F, Piattelli A, Bramanti P, Mazzon E., Stem Cell Res Ther 7(), 2016
PMID: 26729060
Nuclear translocation of PKCα isoenzyme is involved in neurogenic commitment of human neural crest-derived periodontal ligament stem cells.
Trubiani O, Guarnieri S, Diomede F, Mariggiò MA, Merciaro I, Morabito C, Cavalcanti MF, Cocco L, Ramazzotti G., Cell Signal 28(11), 2016
PMID: 27478064
Applicability of tooth derived stem cells in neural regeneration.
Parisi L, Manfredi E., Neural Regen Res 11(11), 2016
PMID: 28123398
Neural crest stem cells from hair follicles and boundary cap have different effects on pancreatic islets in vitro.
Kosykh A, Ngamjariyawat A, Vasylovska S, Konig N, Trolle C, Lau J, Mikaelyan A, Panchenko M, Carlsson PO, Vorotelyak E, Kozlova EN., Int J Neurosci 125(7), 2015
PMID: 25077520
Neurogenic maturation of human dental pulp stem cells following neurosphere generation induces morphological and electrophysiological characteristics of functional neurons.
Gervois P, Struys T, Hilkens P, Bronckaers A, Ratajczak J, Politis C, Brône B, Lambrichts I, Martens W., Stem Cells Dev 24(3), 2015
PMID: 25203005
Intrastriatal transplantation of adult human neural crest-derived stem cells improves functional outcome in parkinsonian rats.
Müller J, Ossig C, Greiner JF, Hauser S, Fauser M, Widera D, Kaltschmidt C, Storch A, Kaltschmidt B., Stem Cells Transl Med 4(1), 2015
PMID: 25479965
CXCR4/CXCR7 molecular involvement in neuronal and neural progenitor migration: focus in CNS repair.
Merino JJ, Bellver-Landete V, Oset-Gasque MJ, Cubelos B., J Cell Physiol 230(1), 2015
PMID: 24913264
Controversial Role of Toll-like Receptor 4 in Adult Stem Cells.
Zeuner M, Bieback K, Widera D., Stem Cell Rev Rep 11(4), 2015
PMID: 25865145
Comparative Assessment of Oral Mesenchymal Stem Cells Isolated from Healthy and Diseased Tissues.
Páll E, Florea A, Soriţău O, Cenariu M, Petruţiu AS, Roman A., Microsc Microanal 21(5), 2015
PMID: 26315895
Neurogenic potential of dental pulp stem cells isolated from murine incisors.
Ellis KM, O'Carroll DC, Lewis MD, Rychkov GY, Koblar SA., Stem Cell Res Ther 5(1), 2014
PMID: 24572146
Culture bag systems for clinical applications of adult human neural crest-derived stem cells.
Greiner JF, Grunwald LM, Müller J, Sudhoff H, Widera D, Kaltschmidt C, Kaltschmidt B., Stem Cell Res Ther 5(2), 2014
PMID: 24629140
Translational Research: Palatal-derived Ecto-mesenchymal Stem Cells from Human Palate: A New Hope for Alveolar Bone and Cranio-Facial Bone Reconstruction.
Grimm WD, Dannan A, Giesenhagen B, Schau I, Varga G, Vukovic MA, Sirak SV., Int J Stem Cells 7(1), 2014
PMID: 24921024
Interaction of adult human neural crest-derived stem cells with a nanoporous titanium surface is sufficient to induce their osteogenic differentiation.
Schürmann M, Wolff A, Widera D, Hauser S, Heimann P, Hütten A, Kaltschmidt C, Kaltschmidt B., Stem Cell Res 13(1), 2014
PMID: 24858494
The stemness of neural crest cells and their derivatives.
Kunisada T, Tezulka K, Aoki H, Motohashi T., Birth Defects Res C Embryo Today 102(3), 2014
PMID: 25219876
Today prospects for tissue engineering therapeutic approach in dentistry.
Bossù M, Pacifici A, Carbone D, Tenore G, Ierardo G, Pacifici L, Polimeni A., ScientificWorldJournal 2014(), 2014
PMID: 25379516
Characterization and analysis of migration patterns of dentospheres derived from periodontal tissue and the palate.
Keeve PL, Dittmar T, Gassmann G, Grimm WD, Niggemann B, Friedmann A., J Periodontal Res 48(3), 2013
PMID: 23030636
Human adult periodontal ligament-derived cells integrate and differentiate after implantation into the adult mammalian brain.
Bueno C, Ramirez C, Rodríguez-Lozano FJ, Tabarés-Seisdedos R, Rodenas M, Moraleda JM, Jones JR, Martinez S, Martinez S., Cell Transplant 22(11), 2013
PMID: 23043788
Gingiva as a source of stem cells with therapeutic potential.
Fournier BP, Larjava H, Häkkinen L., Stem Cells Dev 22(24), 2013
PMID: 23944935
Human periodontal ligament stem cells repair mental nerve injury.
Li B, Jung HJ, Kim SM, Kim MJ, Jahng JW, Lee JH., Neural Regen Res 8(30), 2013
PMID: 25206604
Isolation of novel multipotent neural crest-derived stem cells from adult human inferior turbinate.
Hauser S, Widera D, Qunneis F, Müller J, Zander C, Greiner J, Strauss C, Lüningschrör P, Heimann P, Schwarze H, Ebmeyer J, Sudhoff H, Araúzo-Bravo MJ, Greber B, Zaehres H, Schöler H, Kaltschmidt C, Kaltschmidt B., Stem Cells Dev 21(5), 2012
PMID: 22128806
Osteoblastic/cementoblastic and neural differentiation of dental stem cells and their applications to tissue engineering and regenerative medicine.
Kim BC, Bae H, Kwon IK, Lee EJ, Park JH, Khademhosseini A, Khademhosseini A, Hwang YS., Tissue Eng Part B Rev 18(3), 2012
PMID: 22224548
Osteogenic differentiation of human periodontal ligament stem cells expressing lentiviral NEL-like protein 1.
Chen CY, Liu YJ, Shi SG, Chen FM, Cai C, Li B, Wang J, Shi L, Li Y, Liu ZY, Niu ZY., Int J Mol Med 30(4), 2012
PMID: 22767336
Adult craniofacial stem cells: sources and relation to the neural crest.
Kaltschmidt B, Kaltschmidt C, Widera D., Stem Cell Rev Rep 8(3), 2012
PMID: 22170630
Origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells.
Widera D, Hauser S, Kaltschmidt C, Kaltschmidt B., Anat Res Int 2012(), 2012
PMID: 23082250
Knockdown of IKK1/2 promotes differentiation of mouse embryonic stem cells into neuroectoderm at the expense of mesoderm.
Lüningschrör P, Kaltschmidt B, Kaltschmidt C., Stem Cell Rev Rep 8(4), 2012
PMID: 22833419
Differentiation and neuro-protective properties of immortalized human tooth germ stem cells.
Yalvaç ME, Yilmaz A, Mercan D, Aydin S, Dogan A, Arslan A, Demir Z, Salafutdinov II, Shafigullina AK, Sahin F, Rizvanov AA, Palotás A., Neurochem Res 36(12), 2011
PMID: 21785835
Comparison of human dental follicle cells (DFCs) and stem cells from human exfoliated deciduous teeth (SHED) after neural differentiation in vitro.
Morsczeck C, Völlner F, Saugspier M, Brandl C, Reichert TE, Driemel O, Schmalz G., Clin Oral Investig 14(4), 2010
PMID: 19590907
A multipotent neural crest-derived progenitor cell population is resident within the oral mucosa lamina propria.
Davies LC, Locke M, Webb RD, Roberts JT, Langley M, Thomas DW, Archer CW, Stephens P., Stem Cells Dev 19(6), 2010
PMID: 20132052
Simultaneous PKC and cAMP activation induces differentiation of human dental pulp stem cells into functionally active neurons.
Király M, Porcsalmy B, Pataki A, Kádár K, Jelitai M, Molnár B, Hermann P, Gera I, Grimm WD, Ganss B, Zsembery A, Varga G., Neurochem Int 55(5), 2009
PMID: 19576521
A two-step strategy for neuronal differentiation in vitro of human dental follicle cells.
Völlner F, Ernst W, Driemel O, Morsczeck C., Differentiation 77(5), 2009
PMID: 19394129
Adult palatum as a novel source of neural crest-related stem cells.
Widera D, Zander C, Heidbreder M, Kasperek Y, Noll T, Seitz O, Saldamli B, Sudhoff H, Sader R, Kaltschmidt C, Kaltschmidt B., Stem Cells 27(8), 2009
PMID: 19544446
Plasticity of stem cells derived from adult periodontal ligament.
Huang CY, Pelaez D, Dominguez-Bendala J, Garcia-Godoy F, Cheung HS., Regen Med 4(6), 2009
PMID: 19903001
Cultivation and differentiation characteristics of human limbal progenitor cells.
Vossmerbaeumer U, Kuehl S, Bieback K, Klüter H, Jonas JB., Tissue Cell 40(2), 2008
PMID: 18061639
Human periodontal ligament: a niche of neural crest stem cells.
Coura GS, Garcez RC, de Aguiar CB, Alvarez-Silva M, Magini RS, Trentin AG., J Periodontal Res 43(5), 2008
PMID: 18624954
Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas.
Qiu J, Ai L, Ramachandran C, Yao B, Gopalakrishnan S, Fields CR, Delmas AL, Dyer LM, Melnick SJ, Yachnis AT, Schwartz PH, Fine HA, Brown KD, Robertson KD., Lab Invest 88(9), 2008
PMID: 18607344
Current approaches and challenges in making a bio-tooth.
Yu J, Shi J, Jin Y., Tissue Eng Part B Rev 14(3), 2008
PMID: 18665759

48 References

Daten bereitgestellt von Europe PubMed Central.

Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.
Doetsch F, Caille I, Lim DA, Garcia-Verdugo JM, Alvarez-Buylla A., Cell 97(6), 1999
PMID: 10380923
Identification of a neural stem cell in the adult mammalian central nervous system.
Johansson CB, Momma S, Clarke DL, Risling M, Lendahl U, Frisen J., Cell 96(1), 1999
PMID: 9989494
Stem cells in the central nervous system.
McKay R., Science 276(5309), 1997
PMID: 9082987
Mammalian neural stem cells.
Gage FH., Science 287(5457), 2000
PMID: 10688783
Isolation and characterization of neural stem cells from the adult human olfactory bulb.
Pagano SF, Impagnatiello F, Girelli M, Cova L, Grioni E, Onofri M, Cavallaro M, Etteri S, Vitello F, Giombini S, Solero CL, Parati EA., Stem Cells 18(4), 2000
PMID: 10924096
In vitro neurogenesis by progenitor cells isolated from the adult human hippocampus.
Roy NS, Wang S, Jiang L, Kang J, Benraiss A, Harrison-Restelli C, Fraser RA, Couldwell WT, Kawaguchi A, Okano H, Nedergaard M, Goldman SA., Nat. Med. 6(3), 2000
PMID: 10700228
Neural stem cells in the adult human brain.
Johansson CB, Svensson M, Wallstedt L, Janson AM, Frisen J., Exp. Cell Res. 253(2), 1999
PMID: 10585297
Efficient generation of neural precursors from adult human skin: astrocytes promote neurogenesis from skin-derived stem cells.
Joannides A, Gaughwin P, Schwiening C, Majed H, Sterling J, Compston A, Chandran S., Lancet 364(9429), 2004
PMID: 15246730
Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice.
Eglitis MA, Mezey E., Proc. Natl. Acad. Sci. U.S.A. 94(8), 1997
PMID: 9108108
Generalized potential of adult neural stem cells.
Clarke DL, Johansson CB, Wilbertz J, Veress B, Nilsson E, Karlstrom H, Lendahl U, Frisen J., Science 288(5471), 2000
PMID: 10834848
Neuroectodermal differentiation from mouse multipotent adult progenitor cells.
Jiang Y, Henderson D, Blackstad M, Chen A, Miller RF, Verfaillie CM., Proc. Natl. Acad. Sci. U.S.A. 100 Suppl 1(), 2003
PMID: 12925733
Pluripotency of mesenchymal stem cells derived from adult marrow.
Jiang Y, Jahagirdar BN, Reinhardt RL, Schwartz RE, Keene CD, Ortiz-Gonzalez XR, Reyes M, Lenvik T, Lund T, Blackstad M, Du J, Aldrich S, Lisberg A, Low WC, Largaespada DA, Verfaillie CM., Nature 418(6893), 2002
PMID: 12077603
Stem cell plasticity.
Martin-Rendon E, Watt SM., Br. J. Haematol. 122(6), 2003
PMID: 12956757
Postnatal astrocytes promote neural induction from adult human bone marrow-derived stem cells.
Joannides A, Gaughwin P, Scott M, Watt S, Compston A, Chandran S., J. Hematother. Stem Cell Res. 12(6), 2003
PMID: 14977477
Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo.
Gronthos S, Mankani M, Brahim J, Robey PG, Shi S., Proc. Natl. Acad. Sci. U.S.A. 97(25), 2000
PMID: 11087820
SHED: stem cells from human exfoliated deciduous teeth.
Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, Shi S., Proc. Natl. Acad. Sci. U.S.A. 100(10), 2003
PMID: 12716973
Investigation of multipotent postnatal stem cells from human periodontal ligament.
Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S., Lancet 364(9429), 2004
PMID: 15246727
The efficacy of mesenchymal stem cells to regenerate and repair dental structures.
Shi S, Bartold PM, Miura M, Seo BM, Robey PG, Gronthos S., Orthod Craniofac Res 8(3), 2005
PMID: 16022721

Gassmann, Dent Implantol 10(), 2006
Differentiation of mouse embryonic stem cells into a defined neuronal lineage.
Bibel M, Richter J, Schrenk K, Tucker KL, Staiger V, Korte M, Goetz M, Barde YA., Nat. Neurosci. 7(9), 2004
PMID: 15332090

A simple method for organotypic cultures of nervous tissue.
Stoppini L, Buchs PA, Muller D., J. Neurosci. Methods 37(2), 1991
PMID: 1715499
SOX2 functions to maintain neural progenitor identity.
Graham V, Khudyakov J, Ellis P, Pevny L., Neuron 39(5), 2003
PMID: 12948443
MCP-1 induces migration of adult neural stem cells.
Widera D, Holtkamp W, Entschladen F, Niggemann B, Zanker K, Kaltschmidt B, Kaltschmidt C., Eur. J. Cell Biol. 83(8), 2004
PMID: 15506562
Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway.
Imitola J, Raddassi K, Park KI, Mueller FJ, Nieto M, Teng YD, Frenkel D, Li J, Sidman RL, Walsh CA, Snyder EY, Khoury SJ., Proc. Natl. Acad. Sci. U.S.A. 101(52), 2004
PMID: 15608062
Gene therapy: can neural stem cells deliver?
Muller FJ, Snyder EY, Loring JF., Nat. Rev. Neurosci. 7(1), 2006
PMID: 16371952
The therapeutic potential of neural stem cells.
Martino G, Pluchino S., Nat. Rev. Neurosci. 7(5), 2006
PMID: 16760919
Neural progenitor cells from postmortem adult human retina.
Mayer EJ, Carter DA, Ren Y, Hughes EH, Rice CM, Halfpenny CA, Scolding NJ, Dick AD., Br J Ophthalmol 89(1), 2005
PMID: 15615756
Comparative analysis of neuroectodermal differentiation capacity of human bone marrow stromal cells using various conversion protocols.
Hermann A, Liebau S, Gastl R, Fickert S, Habisch HJ, Fiedler J, Schwarz J, Brenner R, Storch A., J. Neurosci. Res. 83(8), 2006
PMID: 16612831
Plasticity of cultured mesenchymal stem cells: switch from nestin-positive to excitable neuron-like phenotype.
Wislet-Gendebien S, Hans G, Leprince P, Rigo JM, Moonen G, Rogister B., Stem Cells 23(3), 2005
PMID: 15749934
Astrocytic and neuronal fate of mesenchymal stem cells expressing nestin.
Wislet-Gendebien S, Wautier F, Leprince P, Rogister B., Brain Res. Bull. 68(1-2), 2005
PMID: 16325009
The capacity of mesenchymal stem cells for neural differentiation in vitro.
Zemchikhina VN, Golubeva ON., Tsitologiia 47(7), 2005
PMID: 16706229
Mesenchymal stem cells spontaneously express neural proteins in culture and are neurogenic after transplantation.
Deng J, Petersen BE, Steindler DA, Jorgensen ML, Laywell ED., Stem Cells 24(4), 2005
PMID: 16322639
Nestin expression in odontoblasts and odontogenic ectomesenchymal tissue of odontogenic tumours.
Fujita S, Hideshima K, Ikeda T., J. Clin. Pathol. 59(3), 2006
PMID: 16505272
Expression of the intermediate filament nestin during rodent tooth development.
Terling C, Rass A, Mitsiadis TA, Fried K, Lendahl U, Wroblewski J., Int. J. Dev. Biol. 39(6), 1995
PMID: 8901197
Nestin expression in embryonic and adult human teeth under normal and pathological conditions.
About I, Laurent-Maquin D, Lendahl U, Mitsiadis TA., Am. J. Pathol. 157(1), 2000
PMID: 10880398
Teeth and tooth nerves.
Hildebrand C, Fried K, Tuisku F, Johansson CS., Prog. Neurobiol. 45(3), 1995
PMID: 7777672
Neural crest as the source of adult stem cells.
Pierret C, Spears K, Maruniak JA, Kirk MD., Stem Cells Dev. 15(2), 2006
PMID: 16646675
Expression of neural cell-adhesion molecule mRNA during mouse molar tooth development.
Obara N, Suzuki Y, Nagai Y, Nishiyama H, Mizoguchi I, Takeda M., Arch. Oral Biol. 47(11), 2002
PMID: 12446188
Expression patterns of neurotrophic factor mRNAs in developing human teeth.
Nosrat I, Seiger A, Olson L, Nosrat CA., Cell Tissue Res. 310(2), 2002
PMID: 12397373
Principles and applications of cell delivery systems for periodontal regeneration.
Bartold PM, Xiao Y, Lyngstaadas SP, Paine ML, Snead ML., Periodontol. 2000 41(), 2006
PMID: 16686930


Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®


PMID: 17610375
PubMed | Europe PMC

Suchen in

Google Scholar