Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum

Youn J-W, Jolkver E, Kramer R, Marin K, Wendisch VF (2008)
Journal of Bacteriology 190(19): 6458-6466.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Youn, Jung-WonUniBi; Jolkver, E.; Kramer, R.; Marin, K.; Wendisch, Volker F.UniBi
Einrichtung
Fakultät für Biologie > Genetik der Prokaryoten
Centrum für Biotechnologie > Arbeitsgruppe V. Wendisch
Abstract / Bemerkung
Many bacteria can utilize C-4-carboxylates as carbon and energy sources. However, Corynebacterium glutamicum ATCC 13032 is not able to use tricarboxylic acid cycle intermediates such as succinate, fumarate, and L-malate as sole carbon sources. Upon prolonged incubation, spontaneous mutants which had gained the ability to grow on succinate, fumarate, and L-malate could be isolated. DNA microarray analysis showed higher mRNA levels of cg0277, which subsequently was named dccT, in the mutants than in the wild type, and transcriptional fusion analysis revealed that a point mutation in the promoter region of dccT was responsible for increased expression. The overexpression of dccT was sufficient to enable the C. glutamicum wild type to grow on succinate, fumarate, and L-malate as the sole carbon sources. Biochemical analyses revealed that DccT, which is a member of the divalent anion/Na+ symporter family, catalyzes the effective uptake of dicarboxylates like succinate, fumarate, L-malate, and likely also oxaloacetate in a sodium-dependent manner.
Stichworte
biochemical-characterization; transport-system; phosphoenolpyruvate carboxylase; pyruvate-carboxylase; escherichia-coli; bacillus-subtilis; homologous proteins; carrier protein; sequence-analysis; staphylococcus-aureus
Erscheinungsjahr
2008
Zeitschriftentitel
Journal of Bacteriology
Band
190
Ausgabe
19
Seite(n)
6458-6466
ISSN
0021-9193
Page URI
https://pub.uni-bielefeld.de/record/1895401

Zitieren

Youn J-W, Jolkver E, Kramer R, Marin K, Wendisch VF. Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum. Journal of Bacteriology. 2008;190(19):6458-6466.
Youn, J. - W., Jolkver, E., Kramer, R., Marin, K., & Wendisch, V. F. (2008). Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum. Journal of Bacteriology, 190(19), 6458-6466. https://doi.org/10.1128/Jb.00780-08
Youn, Jung-Won, Jolkver, E., Kramer, R., Marin, K., and Wendisch, Volker F. 2008. “Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum”. Journal of Bacteriology 190 (19): 6458-6466.
Youn, J. - W., Jolkver, E., Kramer, R., Marin, K., and Wendisch, V. F. (2008). Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum. Journal of Bacteriology 190, 6458-6466.
Youn, J.-W., et al., 2008. Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum. Journal of Bacteriology, 190(19), p 6458-6466.
J.-W. Youn, et al., “Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum”, Journal of Bacteriology, vol. 190, 2008, pp. 6458-6466.
Youn, J.-W., Jolkver, E., Kramer, R., Marin, K., Wendisch, V.F.: Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum. Journal of Bacteriology. 190, 6458-6466 (2008).
Youn, Jung-Won, Jolkver, E., Kramer, R., Marin, K., and Wendisch, Volker F. “Identification and characterization of the dicarboxylate uptake system DccT in Corynebacterium glutamicum”. Journal of Bacteriology 190.19 (2008): 6458-6466.

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