Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum
Veit A, Rittmann D, Georgi T, Youn J-W, Eikmanns BJ, Wendisch VF (2009)
Journal of Biotechnology 140(1-2): 75-83.
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Einrichtung
Abstract / Bemerkung
Corynebacterium glutamicum call utilize acetic acid and propionic acid for growth and amino acid production. Growth on acetate as sole carbon source requires acetate activation by acetate kinase (AK) and phosphotransacetylase (PTA), encoded in the pta-ack operon. Genetic and enzymatic Studies, showed that these enzymes also catalyze propionate activation and were required for growth oil propionate as sole carbon source. However, when glucose was present as a co-substrate Strain lacking the AK-PTA pathway was still able to utilize acetate or propionate for growth indicating that an alternative activation pathway exists. As shown by C-13-labelling experiments, the carbon skeleton of acetate is conserved during activation to acetyl-CoA in this pathway. Metabolic flux analysis during growth on an acetate-glucose Mixture revealed that in the absence of the AK-PTA pathway carbon fluxes in glycolysis, the tricarboxylic acid (TCA) cycle and anaplerosis via PEP carboxylase and/or pyruvate carboxylase were increased, while the glyoxylate cycle flux was decreased. DNA microarray experiments identified cg2840 as a constitutively and highly expressed gene putatively encoding a CoA transferase. Purified His-tagged Cg2840 Protein was active as CoA transferase interconverting acetyl-, propionyl- and succinyl-moieties as CoA acceptors and donors. Strains lacking both the CoA transferase and the AK-PTA pathway could neither activate acetate nor propionate in the presence or absence of glucose. Thus, when these short-chain fatty acids are co-metabolized with other carbon Sources, CoA transferase and the AK-PTA pathway constitute a redundant system for activation of acetate and propionate. (C) 2008 Elsevier B.V. All rights reserved.
Stichworte
clostridium-kluyveri;
carbon-flux;
biochemical-characterization;
escherichia-coli;
nuclear-magnetic-resonance;
bidirectional reaction steps;
coa transferase;
acetate activation;
propionate activation;
corynebacterium glutamicum;
amino acid production;
expression analysis;
sequence-analysis;
isocitrate lyase;
lysine production
Erscheinungsjahr
2009
Zeitschriftentitel
Journal of Biotechnology
Band
140
Ausgabe
1-2
Seite(n)
75-83
ISSN
0168-1656
Page URI
https://pub.uni-bielefeld.de/record/1895306
Zitieren
Veit A, Rittmann D, Georgi T, Youn J-W, Eikmanns BJ, Wendisch VF. Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum. Journal of Biotechnology. 2009;140(1-2):75-83.
Veit, A., Rittmann, D., Georgi, T., Youn, J. - W., Eikmanns, B. J., & Wendisch, V. F. (2009). Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum. Journal of Biotechnology, 140(1-2), 75-83. https://doi.org/10.1016/j.jbiotec.2008.12.014
Veit, A., Rittmann, D., Georgi, T., Youn, Jung-Won, Eikmanns, B. J., and Wendisch, Volker F. 2009. “Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum”. Journal of Biotechnology 140 (1-2): 75-83.
Veit, A., Rittmann, D., Georgi, T., Youn, J. - W., Eikmanns, B. J., and Wendisch, V. F. (2009). Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum. Journal of Biotechnology 140, 75-83.
Veit, A., et al., 2009. Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum. Journal of Biotechnology, 140(1-2), p 75-83.
A. Veit, et al., “Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum”, Journal of Biotechnology, vol. 140, 2009, pp. 75-83.
Veit, A., Rittmann, D., Georgi, T., Youn, J.-W., Eikmanns, B.J., Wendisch, V.F.: Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum. Journal of Biotechnology. 140, 75-83 (2009).
Veit, A., Rittmann, D., Georgi, T., Youn, Jung-Won, Eikmanns, B. J., and Wendisch, Volker F. “Pathway identification combining metabolic flux and functional genomics analyses: Acetate and propionate activation by Corynebacterium glutamicum”. Journal of Biotechnology 140.1-2 (2009): 75-83.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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Quantitative determination of metabolic fluxes during coutilization of two carbon sources: comparative analyses with Corynebacterium glutamicum during growth on acetate and/or glucose.
Wendisch VF, de Graaf AA, Sahm H, Eikmanns BJ., J. Bacteriol. 182(11), 2000
PMID: 10809686
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PMID: 10809686
Regulation of acetate metabolism in Corynebacterium glutamicum: transcriptional control of the isocitrate lyase and malate synthase genes.
Wendisch VF, Spies M, Reinscheid DJ, Schnicke S, Sahm H, Eikmanns BJ., Arch. Microbiol. 168(4), 1997
PMID: 9297462
Wendisch VF, Spies M, Reinscheid DJ, Schnicke S, Sahm H, Eikmanns BJ., Arch. Microbiol. 168(4), 1997
PMID: 9297462
Bidirectional reaction steps in metabolic networks: I. Modeling and simulation of carbon isotope labeling experiments.
Wiechert W, de Graaf AA., Biotechnol. Bioeng. 55(1), 1997
PMID: 18636449
Wiechert W, de Graaf AA., Biotechnol. Bioeng. 55(1), 1997
PMID: 18636449
Bidirectional reaction steps in metabolic networks: II. Flux estimation and statistical analysis.
Wiechert W, Siefke C, de Graaf AA, Marx A., Biotechnol. Bioeng. 55(1), 1997
PMID: 18636450
Wiechert W, Siefke C, de Graaf AA, Marx A., Biotechnol. Bioeng. 55(1), 1997
PMID: 18636450
The l-Lysine Story: From Metabolic Pathways to Industrial Production
Wittmann, 2007
Wittmann, 2007
Analyses of the acetate-producing pathways in Corynebacterium glutamicum under oxygen-deprived conditions.
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PMID: 17909785
Yasuda K, Jojima T, Suda M, Okino S, Inui M, Yukawa H., Appl. Microbiol. Biotechnol. 77(4), 2007
PMID: 17909785
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