LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli

Lehnen D, Blumer C, Polen T, Wackwitz B, Wendisch VF, Unden G (2002)
Molecular Microbiology 45(2): 521-532.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Lehnen, D.; Blumer, C.; Polen, T.; Wackwitz, B.; Wendisch, Volker F.UniBi ; Unden, G.
Abstract / Bemerkung
The function of the LysR-type regulator LrhA of Escherichia coli was defined by comparing whole-genome mRNA profiles from wild-type E. coli and an isogenic lrhA mutant on a DNA microarray. In the lrhA mutant, a large number (48) of genes involved in flagellation, motility and chemotaxis showed relative mRNA abundances increased by factors between 3 and 80. When a representative set of five flagellar, motility and chemotaxis genes was tested in lacZ reporter gene fusions, similar factors for derepression were found in the lrhA mutant. In gel retardation experiments, the LrhA protein bound specifically to flhD and lrhA promoter DNA (apparent K-D approximate to 20 nM), whereas the promoters of fliC , fliA and trg were not bound by LrhA. The expression of flhDC (encoding FlhD(2)C(2)) was derepressed by a factor of 3.5 in the lrhA mutant. FlhD(2)C(2) is known as the master regulator for the expression of flagellar and chemotaxis genes. By DNase I footprinting, LrhA binding sites at the flhDC and lrhA promoters were identified. The lrhA gene was under positive autoregulation by LrhA as shown by gel retardation and lrhA expression studies. It is suggested that LrhA is a key regulator controlling the transcription of flagellar, motility and chemotaxis genes by regulating the synthesis and concentration of FlhD(2)C(2).
signal; k-12; expression; co2 fixation; binding; master operon; lysr homolog; h-ns protein; acetyl phosphate; rna
Molecular Microbiology
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Lehnen D, Blumer C, Polen T, Wackwitz B, Wendisch VF, Unden G. LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli. Molecular Microbiology. 2002;45(2):521-532.
Lehnen, D., Blumer, C., Polen, T., Wackwitz, B., Wendisch, V. F., & Unden, G. (2002). LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli. Molecular Microbiology, 45(2), 521-532.
Lehnen, D., Blumer, C., Polen, T., Wackwitz, B., Wendisch, Volker F., and Unden, G. 2002. “LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli”. Molecular Microbiology 45 (2): 521-532.
Lehnen, D., Blumer, C., Polen, T., Wackwitz, B., Wendisch, V. F., and Unden, G. (2002). LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli. Molecular Microbiology 45, 521-532.
Lehnen, D., et al., 2002. LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli. Molecular Microbiology, 45(2), p 521-532.
D. Lehnen, et al., “LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli”, Molecular Microbiology, vol. 45, 2002, pp. 521-532.
Lehnen, D., Blumer, C., Polen, T., Wackwitz, B., Wendisch, V.F., Unden, G.: LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli. Molecular Microbiology. 45, 521-532 (2002).
Lehnen, D., Blumer, C., Polen, T., Wackwitz, B., Wendisch, Volker F., and Unden, G. “LrhA as a new transcriptional key regulator of flagella, motility and chemotaxis genes in Escherichia coli”. Molecular Microbiology 45.2 (2002): 521-532.

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Wendisch VF, Zimmer DP, Khodursky A, Peter B, Cozzarelli N, Kustu S., Anal. Biochem. 290(2), 2001
PMID: 11237321
Nitrogen regulatory protein C-controlled genes of Escherichia coli: scavenging as a defense against nitrogen limitation.
Zimmer DP, Soupene E, Lee HL, Wendisch VF, Khodursky AB, Peter BJ, Bender RA, Kustu S., Proc. Natl. Acad. Sci. U.S.A. 97(26), 2000
PMID: 11121068

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