Acetate metabolism and its regulation in Corynebacterium glutamicum

Gerstmeir R, Wendisch VF, Schnicke S, Ruan H, Farwick M, Reinscheid D, Eikmanns BJ (2003)
Journal of Biotechnology 104(1-3): 99-122.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Gerstmeir, R.; Wendisch, Volker F.UniBi ; Schnicke, S.; Ruan, H.; Farwick, M.; Reinscheid, D.; Eikmanns, B. J.
Abstract / Bemerkung
The amino acid producing Corynebacterium glutamicum grows aerobically on a variety of carbohydrates and organic acids as single or combined sources of carbon and energy. Among the substrates metabolized are glucose and acetate which both can also serve as substrates for amino acid production. Based on biochemical, genetic and regulatory studies and on quantitative determination of metabolic fluxes during utilization of acetate and/or glucose, this review summarizes the present knowledge on the different steps of the fundamental pathways of acetate utilization in C glutamicum, namely, on acetate transport, acetate activation, tricarboxylic acid (TCA) cycle, glyoxylate cycle and gluconeogenesis. It becomes evident that, although the pathways of acetate utilization follow the same theme in many bacteria, important biochemical, genetic and regulatory peculiarities exist in C glutamicum. Recent genome wide and comparative expression analyses in C glutamicum cells grown on glucose and on acetate substantiated previously identified transcriptional regulation of acetate activating enzymes and of glyoxylate cycle enzymes. Additionally, a variety of genes obviously also under transcriptional control in response to the presence or absence of acetate in the growth medium were uncovered. These genes, thus also belonging to the acetate stimulon of C glutamicum, include genes coding for TCA cycle enzymes (e.g. aconitase and succinate dehydrogenase), for gluconeogenesis (phosphoenolpyruvate carboxykinase), for glycolysis (pyruvate dehydrogenase El) and genes coding for proteins with hitherto unknown function. Although the basic mechanism of transcriptional regulation of the enzymes involved in acetate metabolism is not yet understood, some recent findings led to a better understanding of the adaptation of C glutamicum to acetate at the molecular level. (C) 2003 Elsevier B.V. All rights reserved.
tricarboxylic-acid cycle; escherichia-coli k12; gram-positive bacteria; acetate metabolism; corynebacterium glutamicum; acetate activation; glyoxylate cycle; carbon flux regulation; expression profiling; phosphoenolpyruvate carboxykinase gene; cytoplasmic malate-dehydrogenases; sequence-analysis; pyruvate-carboxylase; bacillus-subtilis acetate; carbon catabolite repression; isocitrate dehydrogenase
Journal of Biotechnology
Page URI


Gerstmeir R, Wendisch VF, Schnicke S, et al. Acetate metabolism and its regulation in Corynebacterium glutamicum. Journal of Biotechnology. 2003;104(1-3):99-122.
Gerstmeir, R., Wendisch, V. F., Schnicke, S., Ruan, H., Farwick, M., Reinscheid, D., & Eikmanns, B. J. (2003). Acetate metabolism and its regulation in Corynebacterium glutamicum. Journal of Biotechnology, 104(1-3), 99-122.
Gerstmeir, R., Wendisch, Volker F., Schnicke, S., Ruan, H., Farwick, M., Reinscheid, D., and Eikmanns, B. J. 2003. “Acetate metabolism and its regulation in Corynebacterium glutamicum”. Journal of Biotechnology 104 (1-3): 99-122.
Gerstmeir, R., Wendisch, V. F., Schnicke, S., Ruan, H., Farwick, M., Reinscheid, D., and Eikmanns, B. J. (2003). Acetate metabolism and its regulation in Corynebacterium glutamicum. Journal of Biotechnology 104, 99-122.
Gerstmeir, R., et al., 2003. Acetate metabolism and its regulation in Corynebacterium glutamicum. Journal of Biotechnology, 104(1-3), p 99-122.
R. Gerstmeir, et al., “Acetate metabolism and its regulation in Corynebacterium glutamicum”, Journal of Biotechnology, vol. 104, 2003, pp. 99-122.
Gerstmeir, R., Wendisch, V.F., Schnicke, S., Ruan, H., Farwick, M., Reinscheid, D., Eikmanns, B.J.: Acetate metabolism and its regulation in Corynebacterium glutamicum. Journal of Biotechnology. 104, 99-122 (2003).
Gerstmeir, R., Wendisch, Volker F., Schnicke, S., Ruan, H., Farwick, M., Reinscheid, D., and Eikmanns, B. J. “Acetate metabolism and its regulation in Corynebacterium glutamicum”. Journal of Biotechnology 104.1-3 (2003): 99-122.

98 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Modulation of acetate utilization in Komagataella phaffii by metabolic engineering of tolerance and metabolism.
Xu Q, Bai C, Liu Y, Song L, Tian L, Yan Y, Zhou J, Zhou X, Zhang Y, Cai M., Biotechnol Biofuels 12(), 2019
PMID: 30936941
Metabolic engineering of Corynebacterium glutamicum for fermentative production of chemicals in biorefinery.
Baritugo KA, Kim HT, David Y, Choi JI, Hong SH, Jeong KJ, Choi JH, Joo JC, Park SJ., Appl Microbiol Biotechnol 102(9), 2018
PMID: 29557518
The RamA regulon: complex regulatory interactions in relation to central metabolism in Corynebacterium glutamicum.
Shah A, Blombach B, Gauttam R, Eikmanns BJ., Appl Microbiol Biotechnol 102(14), 2018
PMID: 29804137
A new genome-scale metabolic model of Corynebacterium glutamicum and its application.
Zhang Y, Cai J, Shang X, Wang B, Liu S, Chai X, Tan T, Zhang Y, Wen T., Biotechnol Biofuels 10(), 2017
PMID: 28680478
Regulatory 3' Untranslated Regions of Bacterial mRNAs.
Ren GX, Guo XP, Sun YC., Front Microbiol 8(), 2017
PMID: 28740488
Regulons of global transcription factors in Corynebacterium glutamicum.
Toyoda K, Inui M., Appl Microbiol Biotechnol 100(1), 2016
PMID: 26496920
Updates on industrial production of amino acids using Corynebacterium glutamicum.
Wendisch VF, Jorge JMP, Pérez-García F, Sgobba E., World J Microbiol Biotechnol 32(6), 2016
PMID: 27116971
Application of CRISPRi in Corynebacterium glutamicum for shikimic acid production.
Zhang B, Liu ZQ, Liu C, Zheng YG., Biotechnol Lett 38(12), 2016
PMID: 27623797
Absolute quantification of Corynebacterium glutamicum glycolytic and anaplerotic enzymes by QconCAT.
Voges R, Corsten S, Wiechert W, Noack S., J Proteomics 113(), 2015
PMID: 25451015
The α-glucan phosphorylase MalP of Corynebacterium glutamicum is subject to transcriptional regulation and competitive inhibition by ADP-glucose.
Clermont L, Macha A, Müller LM, Derya SM, von Zaluskowski P, Eck A, Eikmanns BJ, Seibold GM., J Bacteriol 197(8), 2015
PMID: 25666133
Changes in protein abundance are observed in bacterial isolates from a natural host.
Rees MA, Stinear TP, Goode RJ, Coppel RL, Smith AI, Kleifeld O., Front Cell Infect Microbiol 5(), 2015
PMID: 26528441
Metabolic engineering of Corynebacterium glutamicum for 2-ketoisocaproate production.
Bückle-Vallant V, Krause FS, Messerschmidt S, Eikmanns BJ., Appl Microbiol Biotechnol 98(1), 2014
PMID: 24169948
Metabolic engineering of Corynebacterium glutamicum for glycolate production.
Zahoor A, Otten A, Wendisch VF., J Biotechnol 192 Pt B(), 2014
PMID: 24486442
Acetate kinase isozymes confer robustness in acetate metabolism.
Chan SH, Nørregaard L, Solem C, Jensen PR., PLoS One 9(3), 2014
PMID: 24638105
Production of the sesquiterpene (+)-valencene by metabolically engineered Corynebacterium glutamicum.
Frohwitter J, Heider SA, Peters-Wendisch P, Beekwilder J, Wendisch VF., J Biotechnol 191(), 2014
PMID: 24910970
The functional structure of central carbon metabolism in Pseudomonas putida KT2440.
Sudarsan S, Dethlefsen S, Blank LM, Siemann-Herzberg M, Schmid A., Appl Environ Microbiol 80(17), 2014
PMID: 24951791
Quantitative mass spectrometry reveals plasticity of metabolic networks in Mycobacterium smegmatis.
Chopra T, Hamelin R, Armand F, Chiappe D, Moniatte M, McKinney JD., Mol Cell Proteomics 13(11), 2014
PMID: 24997995
Accelerated pentose utilization by Corynebacterium glutamicum for accelerated production of lysine, glutamate, ornithine and putrescine.
Meiswinkel TM, Gopinath V, Lindner SN, Nampoothiri KM, Wendisch VF., Microb Biotechnol 6(2), 2013
PMID: 23164409
Corynebacterium glutamicum promoters: a practical approach.
Pátek M, Holátko J, Busche T, Kalinowski J, Nešvera J., Microb Biotechnol 6(2), 2013
PMID: 23305350
The ethylmalonyl-CoA pathway is used in place of the glyoxylate cycle by Methylobacterium extorquens AM1 during growth on acetate.
Schneider K, Peyraud R, Kiefer P, Christen P, Delmotte N, Massou S, Portais JC, Vorholt JA., J Biol Chem 287(1), 2012
PMID: 22105076
Proteomic analysis on acetate metabolism in Citrobacter sp. BL-4.
Kim YM, Lee SE, Park BS, Son MK, Jung YM, Yang SO, Choi HK, Hur SH, Yum JH., Int J Biol Sci 8(1), 2012
PMID: 22211106
The variation of antioxidant defense system of Streptomyces sp. M4018 with respect to carbon sources.
Kayalı HA, Sazak A, Sahin N, Tarhan L., Prep Biochem Biotechnol 42(4), 2012
PMID: 22708810
Improved L-lysine production with Corynebacterium glutamicum and systemic insight into citrate synthase flux and activity.
van Ooyen J, Noack S, Bott M, Reth A, Eggeling L., Biotechnol Bioeng 109(8), 2012
PMID: 22392073
Metabolic engineering of Corynebacterium glutamicum aimed at alternative carbon sources and new products.
Zahoor A, Lindner SN, Wendisch VF., Comput Struct Biotechnol J 3(), 2012
PMID: 24688664
Control of adhA and sucR expression by the SucR regulator in Corynebacterium glutamicum.
Auchter M, Laslo T, Fleischer C, Schiller L, Arndt A, Gaigalat L, Kalinowski J, Eikmanns BJ., J Biotechnol 152(3), 2011
PMID: 21320555
Amino acid production from rice straw and wheat bran hydrolysates by recombinant pentose-utilizing Corynebacterium glutamicum.
Gopinath V, Meiswinkel TM, Wendisch VF, Nampoothiri KM., Appl Microbiol Biotechnol 92(5), 2011
PMID: 21796382
Structure of a highly NADP+-specific isocitrate dehydrogenase.
Sidhu NS, Delbaere LT, Sheldrick GM., Acta Crystallogr D Biol Crystallogr 67(pt 10), 2011
PMID: 21931217
Characterization of an adenylate cyclase gene (cyaB) deletion mutant of Corynebacterium glutamicum ATCC 13032.
Cha PH, Park SY, Moon MW, Subhadra B, Oh TK, Kim E, Kim JF, Lee JK., Appl Microbiol Biotechnol 85(4), 2010
PMID: 19568747
Studies on substrate utilisation in L-valine-producing Corynebacterium glutamicum strains deficient in pyruvate dehydrogenase complex.
Bartek T, Rudolf C, Kerssen U, Klein B, Blombach B, Lang S, Eikmanns BJ, Oldiges M., Bioprocess Biosyst Eng 33(7), 2010
PMID: 20204663
Molecular mechanisms of ethanol-induced pathogenesis revealed by RNA-sequencing.
Camarena L, Bruno V, Euskirchen G, Poggio S, Snyder M., PLoS Pathog 6(4), 2010
PMID: 20368969
Transcriptional regulation of the acetyl-CoA synthetase gene acsA in Pseudomonas aeruginosa.
Kretzschmar U, Khodaverdi V, Adrian L., Arch Microbiol 192(8), 2010
PMID: 20549193
Quinone-dependent D-lactate dehydrogenase Dld (Cg1027) is essential for growth of Corynebacterium glutamicum on D-lactate.
Kato O, Youn JW, Stansen KC, Matsui D, Oikawa T, Wendisch VF., BMC Microbiol 10(), 2010
PMID: 21159175
Acetohydroxyacid synthase, a novel target for improvement of L-lysine production by Corynebacterium glutamicum.
Blombach B, Hans S, Bathe B, Eikmanns BJ., Appl Environ Microbiol 75(2), 2009
PMID: 19047397
Pathway identification combining metabolic flux and functional genomics analyses: acetate and propionate activation by Corynebacterium glutamicum.
Veit A, Rittmann D, Georgi T, Youn JW, Eikmanns BJ, Wendisch VF., J Biotechnol 140(1-2), 2009
PMID: 19162097
Regulation of ldh expression during biotin-limited growth of Corynebacterium glutamicum.
Dietrich C, Nato A, Bost B, Le Maréchal P, Guyonvarch A., Microbiology 155(pt 4), 2009
PMID: 19332837
Characterization of the dicarboxylate transporter DctA in Corynebacterium glutamicum.
Youn JW, Jolkver E, Krämer R, Marin K, Wendisch VF., J Bacteriol 191(17), 2009
PMID: 19581365
Role of the transcriptional regulator RamB (Rv0465c) in the control of the glyoxylate cycle in Mycobacterium tuberculosis.
Micklinghoff JC, Breitinger KJ, Schmidt M, Geffers R, Eikmanns BJ, Bange FC., J Bacteriol 191(23), 2009
PMID: 19767422
Function and transcriptional regulation of the isocitrate lyase in Pseudomonas aeruginosa.
Kretzschmar U, Khodaverdi V, Jeoung JH, Görisch H., Arch Microbiol 190(2), 2008
PMID: 18574579
Engineering of a glycerol utilization pathway for amino acid production by Corynebacterium glutamicum.
Rittmann D, Lindner SN, Wendisch VF., Appl Environ Microbiol 74(20), 2008
PMID: 18757581
Response of the cytoplasmic and membrane proteome of Corynebacterium glutamicum ATCC 13032 to pH changes.
Barriuso-Iglesias M, Schluesener D, Barreiro C, Poetsch A, Martín JF., BMC Microbiol 8(), 2008
PMID: 19091079
Effect of elevated dissolved carbon dioxide concentrations on growth of Corynebacterium glutamicum on D-glucose and L-lactate.
Bäumchen C, Knoll A, Husemann B, Seletzky J, Maier B, Dietrich C, Amoabediny G, Büchs J., J Biotechnol 128(4), 2007
PMID: 17275119
Transcriptionally regulated adhA gene encodes alcohol dehydrogenase required for ethanol and n-propanol utilization in Corynebacterium glutamicum R.
Kotrbova-Kozak A, Kotrba P, Inui M, Sajdok J, Yukawa H., Appl Microbiol Biotechnol 76(6), 2007
PMID: 17646983
CoryneCenter - an online resource for the integrated analysis of corynebacterial genome and transcriptome data.
Neuweger H, Baumbach J, Albaum S, Bekel T, Dondrup M, Hüser AT, Kalinowski J, Oehm S, Pühler A, Rahmann S, Weile J, Goesmann A., BMC Syst Biol 1(), 2007
PMID: 18034885
Emerging Corynebacterium glutamicum systems biology.
Wendisch VF, Bott M, Kalinowski J, Oldiges M, Wiechert W., J Biotechnol 124(1), 2006
PMID: 16406159
Utilization of soluble starch by a recombinant Corynebacterium glutamicum strain: growth and lysine production.
Seibold G, Auchter M, Berens S, Kalinowski J, Eikmanns BJ., J Biotechnol 124(2), 2006
PMID: 16488498
Control of carbon flux through enzymes of central and intermediary metabolism during growth of Escherichia coli on acetate.
El-Mansi M, Cozzone AJ, Shiloach J, Eikmanns BJ., Curr Opin Microbiol 9(2), 2006
PMID: 16530464
The acetate switch.
Wolfe AJ., Microbiol Mol Biol Rev 69(1), 2005
PMID: 15755952
Gene expression systems in corynebacteria.
Srivastava P, Deb JK., Protein Expr Purif 40(2), 2005
PMID: 15766862
The amrG1 gene is involved in the activation of acetate in Corynebacterium glutamicum.
Ruan H, Gerstmeir R, Schnicke S, Eikmanns BJ., Sci China C Life Sci 48(2), 2005
PMID: 15986882
Adaptation of Corynebacterium glutamicum to ammonium limitation: a global analysis using transcriptome and proteome techniques.
Silberbach M, Schäfer M, Hüser AT, Kalinowski J, Pühler A, Krämer R, Burkovski A., Appl Environ Microbiol 71(5), 2005
PMID: 15870326
DNA microarray analysis of the nitrogen starvation response of Corynebacterium glutamicum.
Silberbach M, Hüser A, Kalinowski J, Pühler A, Walter B, Krämer R, Burkovski A., J Biotechnol 119(4), 2005
PMID: 15935503
Characterization of a Corynebacterium glutamicum lactate utilization operon induced during temperature-triggered glutamate production.
Stansen C, Uy D, Delaunay S, Eggeling L, Goergen JL, Wendisch VF., Appl Environ Microbiol 71(10), 2005
PMID: 16204505
RamB, a novel transcriptional regulator of genes involved in acetate metabolism of Corynebacterium glutamicum.
Gerstmeir R, Cramer A, Dangel P, Schaffer S, Eikmanns BJ., J Bacteriol 186(9), 2004
PMID: 15090522
Roles of pyruvate kinase and malic enzyme in Corynebacterium glutamicum for growth on carbon sources requiring gluconeogenesis.
Netzer R, Krause M, Rittmann D, Peters-Wendisch PG, Eggeling L, Wendisch VF, Sahm H., Arch Microbiol 182(5), 2004
PMID: 15375646

108 References

Daten bereitgestellt von Europe PubMed Central.

Regulation of isocitrate lyase in Rhodobacter capsulatus E1F1
Blasco, Curr. Microbiol. 22(), 1991
Uncoupling by Acetic Acid Limits Growth of and Acetogenesis by Clostridium thermoaceticum.
Baronofsky JJ, Schreurs WJ, Kashket ER., Appl. Environ. Microbiol. 48(6), 1984
PMID: 16346677
The enzymic interconversion of acetate and acetyl-coenzyme A in Escherichia coli.
Brown TD, Jones-Mortimer MC, Kornberg HL., J. Gen. Microbiol. 102(2), 1977
PMID: 21941
A highly specific monomeric isocitrate dehydrogenase from Corynebacterium glutamicum.
Chen R, Yang H., Arch. Biochem. Biophys. 383(2), 2000
PMID: 11185559
Inhibition of Escherichia coli K12 by short-chain organic acids: lack of evidence for induction of the SOS response.
Cherrington CA, Hinton M, Pearson GR, Chopra I., J. Appl. Bacteriol. 70(2), 1991
PMID: 2019550
Glyoxylate bypass operon of Escherichia coli: cloning and determination of the functional map.
Chung T, Klumpp DJ, LaPorte DC., J. Bacteriol. 170(1), 1988
PMID: 2826399
Two-carbon compounds and fatty acids as carbon sources
Clark, 1996
Batch kinetics of Corynebacterium glutamicum during growth on various substrates: use of substrate mixtures to localize metabolic bottlenecks
Cocaign, Appl. Microbiol. Biotechnol. 40(), 1993
Control site location and transcriptional regulation in Escherichia coli.
Collado-Vides J, Magasanik B, Gralla JD., Microbiol. Rev. 55(3), 1991
PMID: 1943993
The direct synthesis of phosphoenolpyruvate from pyruvate by Escherichia coli.
Cooper RA, Kornberg HL., Proc. R. Soc. Lond., B, Biol. Sci. 168(1012), 1967
PMID: 4383554
Utilization of acetate in Escherichia coli: structural organization and differential expression of the ace operon.
Cortay JC, Bleicher F, Duclos B, Cenatiempo Y, Gautier C, Prato JL, Cozzone AJ., Biochimie 71(9-10), 1989
PMID: 2512996
Tricarboxylic acid cycle and glyoxylate bypass
Cronan, 1996
Simultaneous consumption of glucose and fructose from sugar mixtures during batch growth of Corynebacterium glutamicum
Dominguez, Appl. Microbiol. Biotechnol. 47(), 1993
Carrier-mediated acetate uptake in Corynebacterium glutamicum
Ebbighausen, Arch. Microbiol. 155(), 1991
Amplification of three threonine biosynthesis genes in Corynebacterium glutamicum and its influence on carbon flux in different strains.
Eikmanns BJ, Metzger M, Reinscheid D, Kircher M, Sahm H., Appl. Microbiol. Biotechnol. 34(5), 1991
PMID: 1369320
Nucleotide sequence, expression and transcriptional analysis of the Corynebacterium glutamicum gltA gene encoding citrate synthase.
Eikmanns BJ, Thum-Schmitz N, Eggeling L, Ludtke KU, Sahm H., Microbiology (Reading, Engl.) 140 ( Pt 8)(), 1994
PMID: 7522844
Yeast carbon catabolite repression.
Gancedo JM., Microbiol. Mol. Biol. Rev. 62(2), 1998
PMID: 9618445
Phosphorylation of Isocitrate dehydrogenase of Escherichia coli.
Garnak M, Reeves HC., Science 203(4385), 1979
PMID: 34215
Cloning of the malic enzyme gene from Corynebacterium glutamicum and role of the enzyme in lactate metabolism.
Gourdon P, Baucher MF, Lindley ND, Guyonvarch A., Appl. Environ. Microbiol. 66(7), 2000
PMID: 10877795
Regulation of the Bacillus subtilis acetate kinase gene by CcpA.
Grundy FJ, Waters DA, Allen SH, Henkin TM., J. Bacteriol. 175(22), 1993
PMID: 8226682
Identification of genes involved in utilization of acetate and acetoin in Bacillus subtilis.
Grundy FJ, Waters DA, Takova TY, Henkin TM., Mol. Microbiol. 10(2), 1993
PMID: 7934817
Catabolite regulation of Bacillus subtilis acetate and acetoin utilization genes by CcpA.
Grundy FJ, Turinsky AJ, Henkin TM., J. Bacteriol. 176(15), 1994
PMID: 7913927
Two routes for synthesis of phosphoenolpyruvate from C4-dicarboxylic acids in Escherichia coli.
Hansen EJ, Juni E., Biochem. Biophys. Res. Commun. 59(4), 1974
PMID: 4370531
Strategies of mixed substrate utilization in microorganisms.
Harder W, Dijkhuizen L., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 297(1088), 1982
PMID: 6180444
Transcriptome analysis of acetate metabolism in Corynebacterium glutamicum using a newly developed metabolic array.
Hayashi M, Mizoguchi H, Shiraishi N, Obayashi M, Nakagawa S, Imai J, Watanabe S, Ota T, Ikeda M., Biosci. Biotechnol. Biochem. 66(6), 2002
PMID: 12162556
Proteome analysis of Corynebacterium glutamicum.
Hermann T, Pfefferle W, Baumann C, Busker E, Schaffer S, Bott M, Sahm H, Dusch N, Kalinowski J, Puhler A, Bendt AK, Kramer R, Burkovski A., Electrophoresis 22(9), 2001
PMID: 11425227
Mycobacterial persistence: adaptation to a changing environment.
Honer zu Bentrup K, Russell DG., Trends Microbiol. 9(12), 2001
PMID: 11728873
Analysis of a cis-active sequence mediating catabolite repression in gram-positive bacteria.
Hueck CJ, Hillen W, Saier MH Jr., Res. Microbiol. 145(7), 1994
PMID: 7855437
Cloning, expression and functional analyses of the catabolite control protein CcpA from Bacillus megaterium.
Hueck CJ, Kraus A, Schmiedel D, Hillen W., Mol. Microbiol. 16(5), 1995
PMID: 7476184
Characterization of phosphoenolpyruvate carboxykinase from Corynebacterium glutamicum
Jetten, FEMS Microbiol. Lett. 111(), 1993
Purification and properties of oxaloacetate decarboxylase from Corynebacterium glutamicum.
Jetten MS, Sinskey AJ., Antonie Van Leeuwenhoek 67(2), 1995
PMID: 7771770
Transport of carboxylic acids
Kay, 1978
On the permeability to weak acids and bases of the cytoplasmic membrane of Clostridium pasteurianum.
Kell DB, Peck MW, Rodger G, Morris JG., Biochem. Biophys. Res. Commun. 99(1), 1981
PMID: 7236271
Fancy meeting you here! A fresh look at "prokaryotic" protein phosphorylation.
Kennelly PJ, Potts M., J. Bacteriol. 178(16), 1996
PMID: 8759835
Glutamic acid
Kinoshita, 1972
Anaplerotic sequences and their role in metabolism
Kornberg, 1966
Uptake of glutamate in Corynebacterium glutamicum. 1. Kinetic properties and regulation by internal pH and potassium.
Kramer R, Lambert C, Hoischen C, Ebbighausen H., Eur. J. Biochem. 194(3), 1990
PMID: 1980106
Structure of the gluABCD cluster encoding the glutamate uptake system of Corynebacterium glutamicum.
Kronemeyer W, Peekhaus N, Kramer R, Sahm H, Eggeling L., J. Bacteriol. 177(5), 1995
PMID: 7868586
Regulation of acetyl coenzyme A synthetase in Escherichia coli.
Kumari S, Beatty CM, Browning DF, Busby SJ, Simel EJ, Hovel-Miner G, Wolfe AJ., J. Bacteriol. 182(15), 2000
PMID: 10894724
Amino acids—technical production and use
Leuchtenberger, 1996
The genus Corynebacterium—nonmedical
Liebl, 1991
Development and validation of corynebacterium DNA microarrays.
Loos A, Glanemann C, Willis LB, O'Brien XM, Lessard PA, Gerstmeir R, Guillouet S, Sinskey AJ., Appl. Environ. Microbiol. 67(5), 2001
PMID: 11319117
Microarrays for microbiologists.
Lucchini S, Thompson A, Hinton JC., Microbiology (Reading, Engl.) 147(Pt 6), 2001
PMID: 11390672
Response of the central metabolism in Corynebacterium glutamicum to the use of an NADH-dependent glutamate dehydrogenase.
Marx A, Eikmanns BJ, Sahm H, de Graaf AA, Eggeling L., Metab. Eng. 1(1), 1999
PMID: 10935753
Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase.
McKinney JD, Honer zu Bentrup K, Munoz-Elias EJ, Miczak A, Chen B, Chan WT, Swenson D, Sacchettini JC, Jacobs WR Jr, Russell DG., Nature 406(6797), 2000
PMID: 10963599
Molecular characterization of Escherichia coli malate synthase G. Differentiation with the malate synthase A isoenzyme.
Molina I, Pellicer MT, Badia J, Aguilar J, Baldoma L., Eur. J. Biochem. 224(2), 1994
PMID: 7925370
The growth of bacterial cultures
Monod, Annu. Rev. Microbiol. 3(), 1949
Genome-wide transcription profiling of Corynebacterium glutamicum after heat shock and during growth on acetate and glucose.
Muffler A, Bettermann S, Haushalter M, Horlein A, Neveling U, Schramm M, Sorgenfrei O., J. Biotechnol. 98(2-3), 2002
PMID: 12141991
High resolution two-dimensional electrophoresis of proteins.
O'Farrell PH., J. Biol. Chem. 250(10), 1975
PMID: 236308
Global expression profiling of acetate-grown Escherichia coli.
Oh MK, Rohlin L, Kao KC, Liao JC., J. Biol. Chem. 277(15), 2002
PMID: 11815613
Regulation of the TCA and glyoxylate cycles in Brevibacterium flavum
Ozaki, J. Biochem. 66(), 1968
In vivo quantification of parallel and bidirectional fluxes in the anaplerosis of Corynebacterium glutamicum.
Petersen S, de Graaf AA, Eggeling L, Mollney M, Wiechert W, Sahm H., J. Biol. Chem. 275(46), 2000
PMID: 10946002
Phosphoenolpyruvate carboxylase in Corynebacterium glutamicum is dispensable for growth and lysine production
Peters-Wendisch, FEMS Microbiol. Lett. 112(), 1993
Pyruvate carboxylase as anaplerotic enzyme in Corynebacterium glutamicum
Peters-Wendisch, Microbiology 143(), 1997
Pyruvate carboxylase from Corynebacterium glutamicum: characterization, expression and inactivation of the pyc gene.
Peters-Wendisch PG, Kreutzer C, Kalinowski J, Patek M, Sahm H, Eikmanns BJ., Microbiology (Reading, Engl.) 144 ( Pt 4)(), 1998
PMID: 9579065
Pyruvate carboxylase is a major bottleneck for glutamate and lysine production by Corynebacterium glutamicum.
Peters-Wendisch PG, Schiel B, Wendisch VF, Katsoulidis E, Mockel B, Sahm H, Eikmanns BJ., J. Mol. Microbiol. Biotechnol. 3(2), 2001
PMID: 11321586
Catabolite regulation of the pta gene as part of carbon flow pathways in Bacillus subtilis.
Presecan-Siedel E, Galinier A, Longin R, Deutscher J, Danchin A, Glaser P, Martin-Verstraete I., J. Bacteriol. 181(22), 1999
PMID: 10559153
Propionate metabolism in Saccharomyces cerevisiae: implications for the metabolon hypothesis.
Pronk JT, van der Linden-Beuman A, Verduyn C, Scheffers WA, van Dijken JP., Microbiology (Reading, Engl.) 140 ( Pt 4)(), 1994
PMID: 7912143
Phosphotransacetylase from Bacillus subtilis: purification and physiological studies.
Rado TA, Hoch JA., Biochim. Biophys. Acta 321(1), 1973
PMID: 4201530
Malate synthase from Corynebacterium glutamicum: sequence analysis of the gene and biochemical characterization of the enzyme.
Reinscheid DJ, Eikmanns BJ, Sahm H., Microbiology (Reading, Engl.) 140 ( Pt 11)(), 1994
PMID: 7812449
Cloning, sequence analysis, expression and inactivation of the Corynebacterium glutamicum pta-ack operon encoding phosphotransacetylase and acetate kinase.
Reinscheid DJ, Schnicke S, Rittmann D, Zahnow U, Sahm H, Eikmanns BJ., Microbiology (Reading, Engl.) 145 ( Pt 2)(), 1999
PMID: 10075432
Characterization of the phosphoenolpyruvate carboxykinase gene from Corynebacterium glutamicum and significance of the enzyme for growth and amino acid production.
Riedel C, Rittmann D, Dangel P, Mockel B, Petersen S, Sahm H, Eikmanns BJ., J. Mol. Microbiol. Biotechnol. 3(4), 2001
PMID: 11565516
Inhibition of Escherichia coli growth by acetic acid: a problem with methionine biosynthesis and homocysteine toxicity.
Roe AJ, O'Byrne C, McLaggan D, Booth IR., Microbiology (Reading, Engl.) 148(Pt 7), 2002
PMID: 12101308
Cyclic AMP-independent catabolite repression in bacteria.
Saier MH Jr., FEMS Microbiol. Lett. 138(2-3), 1996
PMID: 9026456
Multiple mechanisms controlling carbon metabolism in bacteria.
Saier MH Jr., Biotechnol. Bioeng. 58(2-3), 1998
PMID: 10191387
A high-resolution reference map for cytoplasmic and membrane-associated proteins of Corynebacterium glutamicum.
Schaffer S, Weil B, Nguyen VD, Dongmann G, Gunther K, Nickolaus M, Hermann T, Bott M., Electrophoresis 22(20), 2001
PMID: 11824608
Quantitative monitoring of gene expression patterns with a complementary DNA microarray.
Schena M, Shalon D, Davis RW, Brown PO., Science 270(5235), 1995
PMID: 7569999
Transcriptional analysis of the gap-pgk-tpi-ppc gene cluster of Corynebacterium glutamicum.
Schwinde JW, Thum-Schmitz N, Eikmanns BJ, Sahm H., J. Bacteriol. 175(12), 1993
PMID: 7685337
Genetic and biochemical studies on bacterial formation of l-glutamate I. Relationship between isocitrate lyase, acetate kinase, and phosphate acetyltranferase levels and glutamate production in Brevibacterium flavum
Shiio, J. Gen. Appl. Microbiol. 15(), 1969
Phosphotransacetylase of Escherichia coli B, purification and properties.
Shimizu M, Suzuki T, Kameda KY, Abiko Y., Biochim. Biophys. Acta 191(3), 1969
PMID: 4903502
Regulation of the Bacillus subtilis phosphotransacetylase gene.
Shin BS, Choi SK, Park SH., J. Biochem. 126(2), 1999
PMID: 10423526
Biochemical and structural studies of malate synthase from Mycobacterium tuberculosis.
Smith CV, Huang CC, Miczak A, Russell DG, Sacchettini JC, Honer zu Bentrup K., J. Biol. Chem. 278(3), 2002
PMID: 12393860
13C NMR studies of the fluxes in the central metabolism of Corynebacterium glutamicum during growth and overproduction of amino acids in batch cultures
Sonntag, Appl. Microbiol. Biotechnol. 44(), 1995
Regulation of carbon catabolism in Bacillus species.
Stulke J, Hillen W., Annu. Rev. Microbiol. 54(), 2000
PMID: 11018147
Strategy to sequence the genome of Corynebacterium glutamicum ATCC 13032: use of a cosmid and a bacterial artificial chromosome library.
Tauch A, Homann I, Mormann S, Ruberg S, Billault A, Bathe B, Brand S, Brockmann-Gretza O, Ruckert C, Schischka N, Wrenger C, Hoheisel J, Mockel B, Huthmacher K, Pfefferle W, Puhler A, Kalinowski J., J. Biotechnol. 95(1), 2002
PMID: 11879709
Propionate oxidation in Escherichia coli: evidence for operation of a methylcitrate cycle in bacteria.
Textor S, Wendisch VF, De Graaf AA, Muller U, Linder MI, Linder D, Buckel W., Arch. Microbiol. 168(5), 1997
PMID: 9325432
Energy conservation in chemotrophic anaerobic bacteria.
Thauer RK, Jungermann K, Decker K., Bacteriol Rev 41(1), 1977
PMID: 860983
Formation of oxaloacetate by CO2 fixation on phosphoenolpyruvate
Utter, 1972

Regulation of acetate metabolism in Corynebacterium glutamicum: transcriptional control of the isocitrate lyase and malate synthase genes.
Wendisch VF, Spies M, Reinscheid DJ, Schnicke S, Sahm H, Eikmanns BJ., Arch. Microbiol. 168(4), 1997
PMID: 9297462

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

PMID: 12948633
PubMed | Europe PMC

Suchen in

Google Scholar