Proteolytically stable peptides by incorporation of α-Tfm amino acids

Koksch B, Sewald N, Hofmann H-J, Burger K, Jakubke H-D (1997)
J. Pept. Sci. 3(3): 157-167.

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Zeitschriftentitel
J. Pept. Sci.
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3
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3
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157-167
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Koksch B, Sewald N, Hofmann H-J, Burger K, Jakubke H-D. Proteolytically stable peptides by incorporation of α-Tfm amino acids. J. Pept. Sci. 1997;3(3):157-167.
Koksch, B., Sewald, N., Hofmann, H. - J., Burger, K., & Jakubke, H. - D. (1997). Proteolytically stable peptides by incorporation of α-Tfm amino acids. J. Pept. Sci., 3(3), 157-167. doi:10.1002/(SICI)1099-1387(199705)3:3<157::AID-PSC94>3.0.CO;2-W
Koksch, B., Sewald, N., Hofmann, H. - J., Burger, K., and Jakubke, H. - D. (1997). Proteolytically stable peptides by incorporation of α-Tfm amino acids. J. Pept. Sci. 3, 157-167.
Koksch, B., et al., 1997. Proteolytically stable peptides by incorporation of α-Tfm amino acids. J. Pept. Sci., 3(3), p 157-167.
B. Koksch, et al., “Proteolytically stable peptides by incorporation of α-Tfm amino acids”, J. Pept. Sci., vol. 3, 1997, pp. 157-167.
Koksch, B., Sewald, N., Hofmann, H.-J., Burger, K., Jakubke, H.-D.: Proteolytically stable peptides by incorporation of α-Tfm amino acids. J. Pept. Sci. 3, 157-167 (1997).
Koksch, Beate, Sewald, Norbert, Hofmann, Hans-Jörg, Burger, Klaus, and Jakubke, Hans-Dieter. “Proteolytically stable peptides by incorporation of α-Tfm amino acids”. J. Pept. Sci. 3.3 (1997): 157-167.

16 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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PMID: 29513394
Enantioselective synthesis of α-perfluoroalkylated prolines, their 6,7-membered homologues and derivatives.
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Position-dependent impact of hexafluoroleucine and trifluoroisoleucine on protease digestion.
Huhmann S, Stegemann AK, Folmert K, Klemczak D, Moschner J, Kube M, Koksch B., Beilstein J Org Chem 13(), 2017
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Synthesis of α,ω-polyfluorinated α-amino acid derivatives and δ,δ-difluoronorvaline.
Ulbrich D, Daniliuc CG, Haufe G., Org Biomol Chem 14(9), 2016
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(R)-α-trifluoromethylalanine containing short peptide in the inhibition of amyloid peptide fibrillation.
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Stabilization of β-peptide helices by direct attachment of trifluoromethyl groups to peptide backbones.
Cho J, Sawaki K, Hanashima S, Yamaguchi Y, Shiro M, Saigo K, Ishida Y., Chem Commun (Camb) 50(69), 2014
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Impact of fluorination on proteolytic stability of peptides in human blood plasma.
Asante V, Mortier J, Schlüter H, Koksch B., Bioorg Med Chem 21(12), 2013
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Efficient asymmetric synthesis of trifluoromethylated β-aminophosphonates and their incorporation into dipeptides.
Turcheniuk KV, Poliashko KO, Kukhar VP, Rozhenko AB, Soloshonok VA, Sorochinsky AE., Chem Commun (Camb) 48(94), 2012
PMID: 23090101
Domino reactions with fluorinated five-membered heterocycles. alpha-Trifluoromethyl alpha-amino acids with unsaturated side-chains.
Burger K, Hennig L, Tsouker P, Spengler J, Albericio F, Koksch B., Amino Acids 31(4), 2006
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The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity.
Giménez D, Andreu C, del Olmo Ml, Varea T, Diaz D, Asensio G., Bioorg Med Chem 14(20), 2006
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Methyltrifluoropyruvate imines possessing N-oxalyl and N-phosphonoformyl groups--precursors to a variety of alpha-CF3-alpha-amino acid derivatives.
Skarpos H, Vorob'eva DV, Osipov SN, Odinets IL, Breuer E, Röschenthaler GV., Org Biomol Chem 4(19), 2006
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Evaluation of the molecular interactions of fluorinated amino acids with native polypeptides.
Jäckel C, Seufert W, Thust S, Koksch B., Chembiochem 5(5), 2004
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Microsomal triglyceride transfer protein inhibitors: discovery and synthesis of alkyl phosphonates as potent MTP inhibitors and cholesterol lowering agents.
Magnin DR, Biller SA, Wetterau J, Robl JA, Dickson JK, Taunk P, Harrity TW, Lawrence RM, Sun CQ, Wang T, Logan J, Fryszman O, Connolly F, Jolibois K, Kunselman L., Bioorg Med Chem Lett 13(7), 2003
PMID: 12657277

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