Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Kaltschmidt, Barbara; Uherek, M.; Volk, B.; Baeuerle, P.A.; Kaltschmidt, Christian

Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997)
Proc. Natl. Acad. Sci. USA 94(6): 2642-2647.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.1073/pnas.94.6.2642

Autor*in

Kaltschmidt, Barbara^UniBi; Uherek, M.; Volk, B.; Baeuerle, P.A.; Kaltschmidt, Christian^UniBi

Einrichtung

Fakultät für Biologie > Zellbiologie der Tiere

Erscheinungsjahr

1997

Zeitschriftentitel

Proc. Natl. Acad. Sci. USA

Band

94

Ausgabe

6

Seite(n)

2642-2647

ISSN

0027-8424

Page URI

https://pub.uni-bielefeld.de/record/1865447

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Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA. 1997;94(6):2642-2647.

Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., & Kaltschmidt, C. (1997). Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA, 94(6), 2642-2647. https://doi.org/10.1073/pnas.94.6.2642

Kaltschmidt, Barbara, Uherek, M., Volk, B., Baeuerle, P.A., and Kaltschmidt, Christian. 1997. “Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease”. Proc. Natl. Acad. Sci. USA 94 (6): 2642-2647.

Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., and Kaltschmidt, C. (1997). Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 94, 2642-2647.

Kaltschmidt, B., et al., 1997. Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA, 94(6), p 2642-2647.

B. Kaltschmidt, et al., “Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease”, Proc. Natl. Acad. Sci. USA, vol. 94, 1997, pp. 2642-2647.

Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P.A., Kaltschmidt, C.: Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94, 2642-2647 (1997).

Kaltschmidt, Barbara, Uherek, M., Volk, B., Baeuerle, P.A., and Kaltschmidt, Christian. “Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease”. Proc. Natl. Acad. Sci. USA 94.6 (1997): 2642-2647.

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Gemfibrozil pretreatment proved protection against acute restraint stress-induced changes in the male rats' hippocampus.
Khalaj L, Nejad SC, Mohammadi M, Zadeh SS, Pour MH, Ahmadiani A, Khodagholi F, Ashabi G, Alamdary SZ, Samami E., Brain Res 1527(), 2013
PMID: 23850768

Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells.
Marwarha G, Raza S, Prasanthi JR, Ghribi O., PLoS One 8(8), 2013
PMID: 23951005

Tropisetron attenuates amyloid-beta-induced inflammatory and apoptotic responses in rats.
Rahimian R, Fakhfouri G, Ejtemaei Mehr S, Ghia JE, Genazzani AA, Payandemehr B, Dehpour AR, Mousavizadeh K, Lim D., Eur J Clin Invest 43(10), 2013
PMID: 23937291

Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.
Chen CH, Zhou W, Liu S, Deng Y, Cai F, Tone M, Tone Y, Tong Y, Song W., Int J Neuropsychopharmacol 15(1), 2012
PMID: 21329555

Mitochondria and cell bioenergetics: increasingly recognized components and a possible etiologic cause of Alzheimer's disease.
Swerdlow RH., Antioxid Redox Signal 16(12), 2012
PMID: 21902597

Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway.
Huang X, Chen Y, Zhang H, Ma Q, Zhang YW, Xu H., Neurobiol Aging 33(5), 2012
PMID: 22056200

Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer's disease.
Sun X, Bromley-Brits K, Song W., J Neurochem 120 Suppl 1(), 2012
PMID: 22122349

Hsp70.1 and related lysosomal factors for necrotic neuronal death.
Yamashima T., J Neurochem 120(4), 2012
PMID: 22118687

Why are hippocampal CA1 neurons vulnerable but motor cortex neurons resistant to transient ischemia?
Zhu H, Yoshimoto T, Imajo-Ohmi S, Dazortsava M, Mathivanan A, Yamashima T., J Neurochem 120(4), 2012
PMID: 22017466

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology.
Ferretti MT, Allard S, Partridge V, Ducatenzeiler A, Cuello AC., J Neuroinflammation 9(), 2012
PMID: 22472085

Neuronal NF-κB ablation does not influence neuro-axonal degeneration in experimental autoimmune demyelination.
Lee DH, Kubera K, Rosenthal B, Kaltschmidt B, Kaltschmidt C, Gold R, Linker RA., J Neuroimmunol 246(1-2), 2012
PMID: 22475633

WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway.
Fakhfouri G, Ahmadiani A, Rahimian R, Grolla AA, Moradi F, Haeri A., Neuropharmacology 63(4), 2012
PMID: 22634229

Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.
Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F., J Biol Chem 287(29), 2012
PMID: 22654105

Hydrogen sulfide attenuates spatial memory impairment and hippocampal neuroinflammation in β-amyloid rat model of Alzheimer's disease.
Xuan A, Long D, Li J, Ji W, Zhang M, Hong L, Liu J., J Neuroinflammation 9(), 2012
PMID: 22898621

Late-onset Parkinsonism in NFκB/c-Rel-deficient mice.
Baiguera C, Alghisi M, Pinna A, Bellucci A, De Luca MA, Frau L, Morelli M, Ingrassia R, Benarese M, Porrini V, Pellitteri M, Bertini G, Fabene PF, Sigala S, Spillantini MG, Liou HC, Spano PF, Pizzi M., Brain 135(pt 9), 2012
PMID: 22915735

BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's disease.
Chami L, Checler F., Mol Neurodegener 7(), 2012
PMID: 23039869

Transcriptional and post-transcriptional regulation of β-secretase.
Tamagno E, Guglielmotto M, Monteleone D, Vercelli A, Tabaton M., IUBMB Life 64(12), 2012
PMID: 23180460

Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity.
Chan KH, Lam KS, Cheng OY, Kwan JS, Ho PW, Cheng KK, Chung SK, Ho JW, Guo VY, Xu A., PLoS One 7(12), 2012
PMID: 23300647

Effects of Fructus mume Extract on MAPK and NF-κB Signaling and the Resultant Improvement in the Cognitive Deficits Induced by Chronic Cerebral Hypoperfusion.
Jeon WK, Ma J, Choi BR, Han SH, Jin Q, Hwang BY, Han JS., Evid Based Complement Alternat Med 2012(), 2012
PMID: 23346201

APOE dependent-association of PPAR-γ genetic variants with Alzheimer's disease risk.
Combarros O, Rodríguez-Rodríguez E, Mateo I, Vázquez-Higuera JL, Infante J, Berciano J, Sánchez-Juan P., Neurobiol Aging 32(3), 2011
PMID: 19660836

Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system.
Yakovleva T, Bazov I, Watanabe H, Hauser KF, Bakalkin G., Brain Behav Immun 25 Suppl 1(), 2011
PMID: 21195164

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease.
Nijholt DA, de Graaf TR, van Haastert ES, Oliveira AO, Berkers CR, Zwart R, Ovaa H, Baas F, Hoozemans JJ, Scheper W., Cell Death Differ 18(6), 2011
PMID: 21252911

Tetrandrine attenuates spatial memory impairment and hippocampal neuroinflammation via inhibiting NF-κB activation in a rat model of Alzheimer's disease induced by amyloid-β(1-42).
He FQ, Qiu BY, Zhang XH, Li TK, Xie Q, Cui DJ, Huang XL, Gan HT., Brain Res 1384(), 2011
PMID: 21300035

Tetrandrine suppresses amyloid-β-induced inflammatory cytokines by inhibiting NF-κB pathway in murine BV2 microglial cells.
He FQ, Qiu BY, Li TK, Xie Q, Cui DJ, Huang XL, Gan HT., Int Immunopharmacol 11(9), 2011
PMID: 21496499

The miRNA pathway in neurological and skeletal muscle disease: implications for pathogenesis and therapy.
Sibley CR, Wood MJ., J Mol Med (Berl) 89(11), 2011
PMID: 21751030

Development of spontaneous neuropathy in NF-κBp50-deficient mice by calcineurin-signal involving impaired NF-κB activation.
Nakamura-Yanagidaira T, Takahashi Y, Sano K, Murata T, Hayashi T., Mol Vis 17(), 2011
PMID: 21850191

Characterisation of amyloid-induced inflammatory responses in the rat retina.
Howlett DR, Bate ST, Collier S, Lawman A, Chapman T, Ashmeade T, Marshall I, Anderson PJ, Philpott KL, Richardson JC, Hille CJ., Exp Brain Res 214(2), 2011
PMID: 21850448

Formation and signaling actions of electrophilic lipids.
Schopfer FJ, Cipollina C, Freeman BA., Chem Rev 111(10), 2011
PMID: 21928855

Gallic acid, a histone acetyltransferase inhibitor, suppresses β-amyloid neurotoxicity by inhibiting microglial-mediated neuroinflammation.
Kim MJ, Seong AR, Yoo JY, Jin CH, Lee YH, Kim YJ, Lee J, Jun WJ, Yoon HG., Mol Nutr Food Res 55(12), 2011
PMID: 22038937

NF-kappaB signaling in neurite growth and neuronal survival.
Teng FY, Tang BL., Rev Neurosci 21(4), 2010
PMID: 21086762

The consequences of mitochondrial amyloid beta-peptide in Alzheimer's disease.
Muirhead KE, Borger E, Aitken L, Conway SJ, Gunn-Moore FJ., Biochem J 426(3), 2010
PMID: 20175748

TAp63 is a transcriptional target of NF-kappaB.
Wu J, Bergholz J, Lu J, Sonenshein GE, Xiao ZX., J Cell Biochem 109(4), 2010
PMID: 20052674

Transcriptional regulation of UCP4 by NF-kappaB and its role in mediating protection against MPP+ toxicity.
Ho JW, Ho PW, Zhang WY, Liu HF, Kwok KH, Yiu DC, Chan KH, Kung MH, Ramsden DB, Ho SL., Free Radic Biol Med 49(2), 2010
PMID: 20385226

Neuroprotective herbs and foods from different traditional medicines and diets.
Iriti M, Vitalini S, Fico G, Faoro F., Molecules 15(5), 2010
PMID: 20657497

Control of transferrin expression by β-amyloid through the CP2 transcription factor.
Jang SM, Kim JW, Kim CH, An JH, Kang EJ, Kim CG, Kim HJ, Choi KH., FEBS J 277(19), 2010
PMID: 20796026

The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells.
Dasari B, Prasanthi JR, Marwarha G, Singh BB, Ghribi O., BMC Ophthalmol 10(), 2010
PMID: 20836858

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity.
Lu J, Wu DM, Zheng YL, Hu B, Zhang ZF, Shan Q, Zheng ZH, Liu CM, Wang YJ., J Pathol 222(2), 2010
PMID: 20690163

Changes in TNFα, NFκB and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation.
Liberge M, Manrique C, Bernard-Demanze L, Lacour M., J Neuroinflammation 7(), 2010
PMID: 21143912

Mechanisms of neurodegeneration and regeneration in alcoholism.
Crews FT, Nixon K., Alcohol Alcohol 44(2), 2009
PMID: 18940959

Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability.
Pizzi M, Sarnico I, Lanzillotta A, Battistin L, Spano P., FEBS J 276(1), 2009
PMID: 19087197

Gene-gene interaction between CARD8 and interleukin-6 reduces Alzheimer's disease risk.
Fontalba A, Gutiérrez O, Llorca J, Mateo I, Vázquez-Higuera JL, Berciano J, Fernández-Luna JL, Combarros O., J Neurol 256(7), 2009
PMID: 19252766

Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice.
Zhang X, Luhrs KJ, Ryff KA, Malik WT, Driscoll MJ, Culver B., Neuroscience 161(1), 2009
PMID: 19286451

Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity.
Chaïb-Oukadour I, Gil C, Rodríguez-Alvarez J, Ortega A, Aguilera J., Mol Cell Neurosci 41(3), 2009
PMID: 19344769

Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice.
Echeverria V, Burgess S, Gamble-George J, Zeitlin R, Lin X, Cao C, Arendash GW., Neuroscience 162(4), 2009
PMID: 19447162

Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling.
Pan XD, Chen XC, Zhu YG, Chen LM, Zhang J, Huang TW, Ye QY, Huang HP., Glia 57(11), 2009
PMID: 19170180

DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain.
Barrachina M, Ferrer I., J Neuropathol Exp Neurol 68(8), 2009
PMID: 19606065

NF-kappaB in the nervous system.
Kaltschmidt B, Kaltschmidt C., Cold Spring Harb Perspect Biol 1(3), 2009
PMID: 20066105

Neuroprotective effects of the new diterpene, CBNU06 against beta-amyloid-induced toxicity through the inhibition of NF-kappaB signaling pathway in PC12 cells.
Kim HS, Lim JY, Sul D, Hwang BY, Won TJ, Hwang KW, Park SY., Eur J Pharmacol 622(1-3), 2009
PMID: 19765580

Ectodomain shedding of the receptor for advanced glycation end products: a novel therapeutic target for Alzheimer's disease.
Zhang L, Postina R, Wang Y., Cell Mol Life Sci 66(24), 2009
PMID: 19672558

Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation.
Philippe O, Rio M, Carioux A, Plaza JM, Guigue P, Molinari F, Boddaert N, Bole-Feysot C, Nitschke P, Smahi A, Munnich A, Colleaux L., Am J Hum Genet 85(6), 2009
PMID: 20004764

Converging concepts: adaptive response, preconditioning, and the Yerkes-Dodson Law are manifestations of hormesis.
Calabrese EJ., Ageing Res Rev 7(1), 2008
PMID: 17768095

Effect on memory of acute administration of naturally secreted fibrils and synthetic amyloid-beta peptides in an invertebrate model.
Feld M, Galli C, Piccini A, Romano A., Neurobiol Learn Mem 89(4), 2008
PMID: 17920304

Anti-inflammatory interventions of NF-kappaB signaling: potential applications and risks.
Uwe S., Biochem Pharmacol 75(8), 2008
PMID: 18070616

Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of Ranvier.
Politi C, Del Turco D, Sie JM, Golinski PA, Tegeder I, Deller T, Schultz C., Neuropathol Appl Neurobiol 34(3), 2008
PMID: 17986183

Pharmacological enhancement of neuronal survival.
Calabrese EJ., Crit Rev Toxicol 38(4), 2008
PMID: 18432420

NF-kappaB signaling pathway and its therapeutic implications in human diseases.
Sarkar FH, Li Y, Wang Z, Kong D., Int Rev Immunol 27(5), 2008
PMID: 18853341

Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytes.
Sarnico I, Boroni F, Benarese M, Alghisi M, Valerio A, Battistin L, Spano P, Pizzi M., J Neural Transm (Vienna) 115(5), 2008
PMID: 18197358

Amyloid beta-peptide activates nuclear factor-kappaB through an N-methyl-D-aspartate signaling pathway in cultured cerebellar cells.
Kawamoto EM, Lepsch LB, Boaventura MF, Munhoz CD, Lima LS, Yshii LM, Avellar MC, Curi R, Mattson MP, Scavone C., J Neurosci Res 86(4), 2008
PMID: 17969100

Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture.
Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M, Hong JS., Neurochem Res 33(10), 2008
PMID: 18368483

Induction of heat shock proteins and the proteasome system by casein-N epsilon-(carboxymethyl)lysine and N epsilon-(carboxymethyl)lysine in Caco-2 cells.
Schmid K, Haslbeck M, Buchner J, Somoza V., Ann N Y Acad Sci 1126(), 2008
PMID: 18448826

Flavanols, mild cognitive impairment, and Alzheimer's dementia.
Patel AK, Rogers JT, Huang X., Int J Clin Exp Med 1(2), 2008
PMID: 19079672

p75(NTR) activation of NF-kappaB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells.
Bai Y, Li Q, Yang J, Zhou X, Yin X, Zhao D., Neurosci Res 62(1), 2008
PMID: 18602709

Activation of nuclear factor-kappaB during retinal degeneration in rd mice.
Zeng HY, Tso MO, Lai S, Lai H., Mol Vis 14(), 2008
PMID: 18552981

Dynein light chain LC8 negatively regulates NF-kappaB through the redox-dependent interaction with IkappaBalpha.
Jung Y, Kim H, Min SH, Rhee SG, Jeong W., J Biol Chem 283(35), 2008
PMID: 18579519

Raf inhibition protects cortical cells against beta-amyloid toxicity.
Echeverria V, Burgess S, Gamble-George J, Arendash GW, Citron BA., Neurosci Lett 444(1), 2008
PMID: 18706973

The role and regulation of the nuclear factor kappa B signalling pathway in human labour.
Lappas M, Rice GE., Placenta 28(5-6), 2007
PMID: 16843526

Inhibition of Abeta production by NF-kappaB inhibitors.
Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan M., Neurosci Lett 415(1), 2007
PMID: 17223266

Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus.
Müller GJ, Lassmann H, Johansen FF., Neurobiol Dis 25(3), 2007
PMID: 17207631

NF-kappa B as a therapeutic target in neurodegenerative diseases.
Camandola S, Mattson MP., Expert Opin Ther Targets 11(2), 2007
PMID: 17227229

CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway.
Ait-Ghezala G, Volmar CH, Frieling J, Paris D, Tweed M, Bakshi P, Mullan M., Eur J Neurosci 25(6), 2007
PMID: 17432959

Nuclear factor kappa-B p50 and p65 subunits expression in dementia with Lewy bodies.
Saldaña M, Mullol J, Aguilar E, Bonastre M, Marin C., Neuropathol Appl Neurobiol 33(3), 2007
PMID: 17442064

Hydrogen peroxide induces the death of astrocytes through the down-regulation of the constitutive nuclear factor-kappaB activity.
Choi JJ, Choi J, Kang CD, Chen X, Wu CF, Ko KH, Kim WK., Free Radic Res 41(5), 2007
PMID: 17454138

Over-expression of amyloid precursor protein in HEK cells alters p53 conformational state and protects against doxorubicin.
Uberti D, Cenini G, Olivari L, Ferrari-Toninelli G, Porrello E, Cecchi C, Pensalfini A, Liguri G, Govoni S, Racchi M, Maurizio M., J Neurochem 103(1), 2007
PMID: 17608641

Chronic treatment of rats with sodium valproate downregulates frontal cortex NF-kappaB DNA binding activity and COX-2 mRNA.
Rao JS, Bazinet RP, Rapoport SI, Lee HJ., Bipolar Disord 9(5), 2007
PMID: 17680922

Assessment of the astrogliotic responses of three human astrocytoma cell lines to ethanol, trimethyltin chloride and acrylamide.
Holden LJ, Coleman MD., Toxicology 241(1-2), 2007
PMID: 17875352

Nuclear factor-kappa B regulates seizure threshold and gene transcription following convulsant stimulation.
Lubin FD, Ren Y, Xu X, Anderson AE., J Neurochem 103(4), 2007
PMID: 17727632

Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system.
Okvist A, Johansson S, Kuzmin A, Bazov I, Merino-Martinez R, Ponomarev I, Mayfield RD, Harris RA, Sheedy D, Garrick T, Harper C, Hurd YL, Terenius L, Ekström TJ, Bakalkin G, Yakovleva T., PLoS One 2(9), 2007
PMID: 17895971

Oxidative stress and transcriptional regulation in Alzheimer disease.
Shi Q, Gibson GE., Alzheimer Dis Assoc Disord 21(4), 2007
PMID: 18090434

Dual roles of NF-kappaB in cell survival and implications of NF-kappaB inhibitors in neuroprotective therapy.
Qin ZH, Tao LY, Chen X., Acta Pharmacol Sin 28(12), 2007
PMID: 18031598

Biphasic role of nuclear factor-kappa B on cell survival and COX-2 expression in SOD1 Tg astrocytes after oxygen glucose deprivation.
Lee YS, Song YS, Giffard RG, Chan PH., J Cereb Blood Flow Metab 26(8), 2006
PMID: 16395278

Potential role of NF-kappaB in adult neural stem cells: the underrated steersman?
Widera D, Mikenberg I, Kaltschmidt B, Kaltschmidt C., Int J Dev Neurosci 24(2-3), 2006
PMID: 16413989

Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.
Tao Y, Yan D, Yang Q, Zeng R, Wang Y., Mol Cell Biol 26(3), 2006
PMID: 16428456

Effect of Abeta exposure on the mRNA expression patterns of voltage-sensitive calcium channel alpha 1 subunits (alpha 1A-alpha 1D) in human SK-N-SH neuroblastoma.
Chiou WF., Neurochem Int 49(3), 2006
PMID: 16574279

NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production.
Valerio A, Boroni F, Benarese M, Sarnico I, Ghisi V, Bresciani LG, Ferrario M, Borsani G, Spano P, Pizzi M., Eur J Neurosci 23(7), 2006
PMID: 16623827

Effects of pyrrolidine dithiocarbamate on beta-amyloid (25-35)-induced inflammatory responses and memory deficits in the rat.
Cheng G, Whitehead SN, Hachinski V, Cechetto DF., Neurobiol Dis 23(1), 2006
PMID: 16624564

Roles for NF-kappaB in nerve cell survival, plasticity, and disease.
Mattson MP, Meffert MK., Cell Death Differ 13(5), 2006
PMID: 16397579

Pharmacological studies on fullerene (C60), a novel carbon allotrope, and its derivatives.
Satoh M, Takayanagi I., J Pharmacol Sci 100(5), 2006
PMID: 16682790

Anti-inflammatory effect of jeongshintang through suppression of p38 activation in human astrocytoma, U373MG cells.
Kim SJ, Jeong HJ, Kim BK, Kim NH, Kim JS, Choi KS, Lee HJ, Kang ST, Shin SS, Kim WI, Eom HS, Lee KM, Um JY, Hong SH, Kim HM., Exp Mol Pathol 81(1), 2006
PMID: 16698013

Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.
Rossner S, Sastre M, Bourne K, Lichtenthaler SF., Prog Neurobiol 79(2), 2006
PMID: 16904810

Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system.
Hewett SJ, Bell SC, Hewett JA., Pharmacol Ther 112(2), 2006
PMID: 16750270

Distinct roles of diverse nuclear factor-kappaB complexes in neuropathological mechanisms.
Pizzi M, Spano P., Eur J Pharmacol 545(1), 2006
PMID: 16854410

Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets.
Ramassamy C., Eur J Pharmacol 545(1), 2006
PMID: 16904103

Pin1 in Alzheimer's disease.
Butterfield DA, Abdul HM, Opii W, Newman SF, Joshi G, Ansari MA, Sultana R., J Neurochem 98(6), 2006
PMID: 16945100

NF-kappaB functions in the nervous system: from development to disease.
Mémet S., Biochem Pharmacol 72(9), 2006
PMID: 16997282

Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.
Schliebs R, Heidel K, Apelt J, Gniezdzinska M, Kirazov L, Szutowicz A., Brain Res 1122(1), 2006
PMID: 17026971

The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration.
Alberghina L, Colangelo AM., BMC Neurosci 7 Suppl 1(), 2006
PMID: 17118156

Protein oxidation and degradation during aging: role in skin aging and neurodegeneration.
Widmer R, Ziaja I, Grune T., Free Radic Res 40(12), 2006
PMID: 17090415

NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain.
Huang Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX., Neurosci Lett 373(2), 2005
PMID: 15567564

TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition.
Zou JY, Crews FT., Brain Res 1034(1-2), 2005
PMID: 15713255

Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients.
de las Cuevas N, Muñoz U, Hermida OG, Martín-Requero A., Neurobiol Aging 26(5), 2005
PMID: 15708436

Endogenous oxidative stress in sporadic Alzheimer's disease neuronal cybrids reduces viability by increasing apoptosis through pro-death signaling pathways and is mimicked by oxidant exposure of control cybrids.
Onyango IG, Bennett JP, Tuttle JB., Neurobiol Dis 19(1-2), 2005
PMID: 15837587

NF-kappaB in the survival and plasticity of neurons.
Mattson MP., Neurochem Res 30(6-7), 2005
PMID: 16187223

NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity.
Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazzoleni G, Dietz GP, Bähr M, Liou HC, Spano PF., Cell Death Differ 12(7), 2005
PMID: 15818410

Signaling via NF-kappaB in the nervous system.
Kaltschmidt B, Widera D, Kaltschmidt C., Biochim Biophys Acta 1745(3), 2005
PMID: 15993497

Distinct nuclear factor-kappaB/Rel proteins have opposing modulatory effects in glutamate-induced cell death in HT22 cells.
Ishige K, Tanaka M, Arakawa M, Saito H, Ito Y., Neurochem Int 47(8), 2005
PMID: 16183169

Selenium reduces the proapoptotic signaling associated to NF-kappaB pathway and stimulates glutathione peroxidase activity during excitotoxic damage produced by quinolinate in rat corpus striatum.
Santamaría A, Vázquez-Román B, La Cruz VP, González-Cortés C, Trejo-Solís MC, Galván-Arzate S, Jara-Prado A, Guevara-Fonseca J, Ali SF., Synapse 58(4), 2005
PMID: 16206188

Responses of Cultured Astrocytes, C6 Glioma and 1321NI Astrocytoma Cells to Amyloid beta-Peptide Fragments.
Pentreath VW, Mead C., Nonlinearity Biol Toxicol Med 2(1), 2004
PMID: 19330108

Effects of beta-AP peptides on activation of the transcription factor NF-kappaB and in cell proliferation in glial cell cultures.
Casal C, Serratosa J, Tusell JM., Neurosci Res 48(3), 2004
PMID: 15154677

Differential MnSOD and HO-1 expression in cerebral endothelial cells in response to sublethal oxidative stress.
Méthy D, Bertrand N, Prigent-Tessier A, Stanimirovic D, Beley A, Marie C., Brain Res 1003(1-2), 2004
PMID: 15019574

Overexpression of receptor of advanced glycation end products hypersensitizes cells for amyloid beta peptide-induced cell death.
Hadding A, Kaltschmidt B, Kaltschmidt C., Biochim Biophys Acta 1691(1), 2004
PMID: 15053925

Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism.
Fernández-Tomé P, Brera B, Arévalo MA, de Ceballos ML., Neurobiol Dis 15(3), 2004
PMID: 15056466

Effect of cell density on intracellular levels of the Alzheimer's amyloid precursor protein.
Rebelo S, Henriques AG, da Cruz e Silva EF, da Cruz e Silva OA., J Neurosci Res 76(3), 2004
PMID: 15079870

N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.
Maruyama W, Nitta A, Shamoto-Nagai M, Hirata Y, Akao Y, Yodim M, Furukawa S, Nabeshima T, Naoi M., Neurochem Int 44(6), 2004
PMID: 14687604

Interference effect of epigallocatechin-3-gallate on targets of nuclear factor kappaB signal transduction pathways activated by EB virus encoded latent membrane protein 1.
Yan Z, Yong-Guang T, Fei-Jun L, Fa-Qing T, Min T, Ya C., Int J Biochem Cell Biol 36(8), 2004
PMID: 15147726

GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.
Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M., J Biol Chem 279(44), 2004
PMID: 15322108

RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS., EMBO J 23(20), 2004
PMID: 15457210

Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease.
Grune T, Jung T, Merker K, Davies KJ., Int J Biochem Cell Biol 36(12), 2004
PMID: 15325589

Protective effects of oligomers of grape seed polyphenols against beta-amyloid-induced oxidative cell death.
Li MH, Jang JH, Sun B, Surh YJ., Ann N Y Acad Sci 1030(), 2004
PMID: 15659813

Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning.
Aggarwal BB, Shishodia S., Ann N Y Acad Sci 1030(), 2004
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Genes and genomics of autoimmune inflammation: from Rel to TRAIL.
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Pyrrolidine dithiocarbamate-induced neuronal cell death is mediated by Akt, casein kinase 2, c-Jun N-terminal kinase, and IkappaB kinase in embryonic hippocampal progenitor cells.
Min YK, Park JH, Chong SA, Kim YS, Ahn YS, Seo JT, Bae YS, Chung KC., J Neurosci Res 71(5), 2003
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Lithium inhibits Abeta-induced stress in endoplasmic reticulum of rabbit hippocampus but does not prevent oxidative damage and tau phosphorylation.
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From calcium to NF-kappa B signaling pathways in neurons.
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Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy.
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Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.
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Inhibition of NF-kB renders cells more vulnerable to apoptosis induced by amyloid beta peptides.
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Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway.
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Is DNA repair compromised in Alzheimer's disease?
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Water-soluble chitosan inhibits the production of pro-inflammatory cytokine in human astrocytoma cells activated by amyloid beta peptide and interleukin-1beta.
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[The Rel/NF-kappa-B transcription factors: complex role in cell regulation].
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Growing old with nuclear factor-kappaB.
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NF-kappaB-mediated up-regulation of Bcl-X(S) and Bax contributes to cytochrome c release in cyanide-induced apoptosis.
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Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappaB activation.
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Transcriptional activation and increase in expression of Alzheimer's beta-amyloid precursor protein gene is mediated by TGF-beta in normal human astrocytes.
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Transforming growth factor-beta-induced transcription of the Alzheimer beta-amyloid precursor protein gene involves interaction between the CTCF-complex and Smads.
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Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer's disease amyloid.
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Nutritional approaches to combat oxidative stress in Alzheimer's disease.
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Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation.
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Abeta[25-35] peptide and iron promote apoptosis in lymphocytes by an oxidative stress mechanism: involvement of H2O2, caspase-3, NF-kappaB, p53 and c-Jun.
Velez-Pardo C, Ospina GG, Jimenez del Rio M., Neurotoxicology 23(3), 2002
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NF-kappaB mediates IL-1beta-induced synthesis/release of alpha2-macroglobulin in a human glial cell line.
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Hypoxia signaling to genes: significance in Alzheimer's disease.
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Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide.
Rogers J, Strohmeyer R, Kovelowski CJ, Li R., Glia 40(2), 2002
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Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases.
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Cyclooxygenase-2 is a neuronal target gene of NF-kappaB.
Kaltschmidt B, Linker RA, Deng J, Kaltschmidt C., BMC Mol Biol 3(), 2002
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Neuroprotection from glutamate toxicity with ultra-low dose glutamate.
Jonas W, Lin Y, Tortella F., Neuroreport 12(2), 2001
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Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure.
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Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate.
Rodrigues CM, Solá S, Brito MA, Brondino CD, Brites D, Moura JJ., Biochem Biophys Res Commun 281(2), 2001
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NF-kappaB is involved in the survival of cerebellar granule neurons: association of IkappaBbeta [correction of Ikappabeta] phosphorylation with cell survival.
Koulich E, Nguyen T, Johnson K, Giardina C, D'mello S., J Neurochem 76(4), 2001
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DNA array analysis of the developing rat cerebellum: transforming growth factor-beta2 inhibits constitutively activated NF-kappaB in granule neurons.
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Intracellular pathways involved in TNF-alpha and superoxide anion release by Abeta(1-42)-stimulated primary human macrophages.
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Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity.
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Amyloid beta-peptide: biphasic dose responses.
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From theory to therapy: implications from an in vitro model of ramified microglia.
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Enhanced expression of I-kappaB with neurofibrillary pathology in Alzheimer's disease.
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Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease.
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Microglial chemotaxis, activation, and phagocytosis of amyloid beta-peptide as linked phenomena in Alzheimer's disease.
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Abeta(1-42) and aluminum induce stress in the endoplasmic reticulum in rabbit hippocampus, involving nuclear translocation of gadd 153 and NF-kappaB.
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Altered subcellular distribution of transcriptional regulators in response to Abeta peptide and during Alzheimer's disease.
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S100beta induction of the proinflammatory cytokine interleukin-6 in neurons.
Li Y, Barger SW, Liu L, Mrak RE, Griffin WS., J Neurochem 74(1), 2000
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Overexpression of neurotrophin receptor p75 contributes to the excitotoxin-induced cholinergic neuronal death in rat basal forebrain.
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Model for aging in the basal forebrain cholinergic system.
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Roles of nuclear factor kappaB in neuronal survival and plasticity.
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Neuron-specific localisation of the TR3 death receptor in Alzheimer's disease.
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Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia.
Stephenson D, Yin T, Smalstig EB, Hsu MA, Panetta J, Little S, Clemens J., J Cereb Blood Flow Metab 20(3), 2000
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Cyanide-induced apoptosis involves oxidative-stress-activated NF-kappaB in cortical neurons.
Shou Y, Gunasekar PG, Borowitz JL, Isom GE., Toxicol Appl Pharmacol 164(2), 2000
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Anti-inflammatory drugs: a hope for Alzheimer's disease?
Hüll M, Lieb K, Fiebich BL., Expert Opin Investig Drugs 9(4), 2000
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The heat shock response inhibits NF-kappaB activation, nitric oxide synthase type 2 expression, and macrophage/microglial activation in brain.
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Inflammation and Alzheimer's disease.
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The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus.
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Pro-apoptotic action of PAR-4 involves inhibition of NF-kappaB activity and suppression of BCL-2 expression.
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beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress.
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The Rel/NF-kappa B family: friend and foe.
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Neuroinflammatory signaling upregulation in Alzheimer's disease.
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NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: the role of oxidant/antioxidant balance.
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Interleukin-1beta induces cyclooxygenase-2 and prostaglandin E(2) synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-kappaB.
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Dehydroepiandrosterone inhibits microglial nitric oxide production in a stimulus-specific manner.
Barger SW, Chavis JA, Drew PD., J Neurosci Res 62(4), 2000
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The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease.
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NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival.
Denk A, Wirth T, Baumann B., Cytokine Growth Factor Rev 11(4), 2000
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Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative.
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The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons.
Camandola S, Poli G, Mattson MP., Brain Res Mol Brain Res 85(1-2), 2000
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Tumor necrosis factor and reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-kappaB.
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Activation of NF-kappa B by reactive oxygen intermediates in the nervous system.
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Nuclear factor-kappaB/Rel proteins: a point of convergence of signalling pathways relevant in neuronal function and dysfunction.
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Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches.
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Regulation of amyloid precursor protein cleavage.
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The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages.
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NF-kappaB is activated and promotes cell death in focal cerebral ischemia.
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Repression of NF-kappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators.
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Loss of NF-kappaB activity during cerebral ischemia and TNF cytotoxicity.
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Anti-inflammatory substances - a new therapeutic option in Alzheimer's disease.
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Activation of nuclear factor kappaB by nitric oxide in rat striatal neurones: differential inhibition of the p50 and p65 subunits by dexamethasone.
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Is NF-kappaB the sensor of oxidative stress?
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Differential regulation of major histocompatibility complex class II expression and nitric oxide release by beta-amyloid in rat astrocyte and microglia.
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Identification of beta-amyloid-responsive genes by RNA differential display: early induction of a DNA damage-inducible gene, gadd45.
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Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis.
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cDNA cloning of a novel secreted isoform of the human receptor for advanced glycation end products and characterization of cells co-expressing cell-surface scavenger receptors and Swedish mutant amyloid precursor protein.
Malherbe P, Richards JG, Gaillard H, Thompson A, Diener C, Schuler A, Huber G., Brain Res Mol Brain Res 71(2), 1999
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Sodium salicylate and 17beta-estradiol attenuate nuclear transcription factor NF-kappaB translocation in cultured rat astroglial cultures following exposure to amyloid A beta(1-40) and lipopolysaccharides.
Dodel RC, Du Y, Bales KR, Gao F, Paul SM., J Neurochem 73(4), 1999
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Optimized protocol for biolistic transfection of brain slices and dissociated cultured neurons with a hand-held gene gun.
Wellmann H, Kaltschmidt B, Kaltschmidt C., J Neurosci Methods 92(1-2), 1999
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Interleukin-17 stimulates the expression of IkappaB alpha mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines.
Kehlen A, Thiele K, Riemann D, Rainov N, Langner J., J Neuroimmunol 101(1), 1999
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Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice.
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Control of apoptosis by Rel/NF-kappaB transcription factors.
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Alzheimer's disease and brain development: common molecular pathways.
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Early glycoxidation damage in brains from Down's syndrome.
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NF-kappaB modulates lipopolysaccharide-induced microglial nerve growth factor expression.
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Amyloid beta-peptide stimulates nitric oxide production in astrocytes through an NFkappaB-dependent mechanism.
Akama KT, Albanese C, Pestell RG, Van Eldik LJ., Proc Natl Acad Sci U S A 95(10), 1998
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NF-kB immunoreactivity is observed in association with beta A4 diffuse plaques in patients with Alzheimer's disease.
Ferrer I, Martí E, López E, Tortosa A., Neuropathol Appl Neurobiol 24(4), 1998
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Upregulation of amyloid precursor protein gene promoter in rat primary hippocampal neurons by phorbol ester, IL-1 and retinoic acid, but not by reactive oxygen species.
Yang Y, Quitschke WW, Brewer GJ., Brain Res Mol Brain Res 60(1), 1998
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Immunolocalization of transcription factor NF-kappaB in inclusion-body myositis muscle and at normal human neuromuscular junctions.
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Expression of FAC1 in activated microglia during Alzheimer's disease.
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The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease.
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Familial Alzheimer's disease: oxidative stress, beta-amyloid, presenilins, and cell death.
Velez-Pardo C, Jimenez Del Rio M, Lopera F., Gen Pharmacol 31(5), 1998
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Nuclear factor kappa B: important transcription factor and therapeutic target.
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NF-kappa B: a crucial transcription factor for glial and neuronal cell function.
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Gene expression induced by cerebral ischemia: an apoptotic perspective.
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Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration.
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Antioxidant defense of the brain: a role for astrocytes.
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Alteration of transcription factors NF-kappaB and STAT1 in Alzheimer's disease brains.
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Kaltschmidt C, Kaltschmidt B, Baeuerle PA., Mech. Dev. 43(2-3), 1993
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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.
Hensley K, Carney JM, Mattson MP, Aksenova M, Harris M, Wu JF, Floyd RA, Butterfield DA., Proc. Natl. Acad. Sci. U.S.A. 91(8), 1994
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Constitutive NF-kappa B activity in neurons.
Kaltschmidt C, Kaltschmidt B, Neumann H, Wekerle H, Baeuerle PA., Mol. Cell. Biol. 14(6), 1994
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Hydrogen peroxide mediates amyloid beta protein toxicity.
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Function and activation of NF-kappa B in the immune system.
Baeuerle PA, Henkel T., Annu. Rev. Immunol. 12(), 1994
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Sequential induction of NF-kappa B/Rel family proteins during B-cell terminal differentiation.
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Inflammatory mechanisms in Alzheimer's disease: implications for therapy.
Aisen PS, Davis KL., Am J Psychiatry 151(8), 1994
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Expression of inducible nitric oxide synthase by neurones following exposure to endotoxin and cytokine.
Minc-Golomb D, Tsarfaty I, Schwartz JP., Br. J. Pharmacol. 112(3), 1994
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Transcription factor NF-kappa B is activated in microglia during experimental autoimmune encephalomyelitis.
Kaltschmidt C, Kaltschmidt B, Lannes-Vieira J, Kreutzberg GW, Wekerle H, Baeuerle PA, Gehrmann J., J. Neuroimmunol. 55(1), 1994
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Behavioral and anatomical deficits in mice homozygous for a modified beta-amyloid precursor protein gene.
Muller U, Cristina N, Li ZW, Wolfer DP, Lipp HP, Rulicke T, Brandner S, Aguzzi A, Weissmann C., Cell 79(5), 1994
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Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein.
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F., Nature 373(6514), 1995
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Interleukin-1 expression in different plaque types in Alzheimer's disease: significance in plaque evolution.
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Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ.
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beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity.
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Reciprocal control of inflammatory cytokines, IL-1 and IL-6, and beta-amyloid production in cultures.
Del Bo R, Angeretti N, Lucca E, De Simoni MG, Forloni G., Neurosci. Lett. 188(1), 1995
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Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B.
Beg AA, Sha WC, Bronson RT, Ghosh S, Baltimore D., Nature 376(6536), 1995
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Selective recognition of the activated form of transcription factor NF-kappa B by a monoclonal antibody.
Kaltschmidt C, Kaltschmidt B, Henkel T, Stockinger H, Baeuerle PA., Biol. Chem. Hoppe-Seyler 376(1), 1995
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Induction of MHC class I genes in neurons.
Neumann H, Cavalie A, Jenne DE, Wekerle H., Science 269(5223), 1995
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Glial cytokines in Alzheimer's disease: review and pathogenic implications.
Mrak RE, Sheng JG, Griffin WS., Hum. Pathol. 26(8), 1995
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Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.
Kaltschmidt C, Kaltschmidt B, Baeuerle PA., Proc. Natl. Acad. Sci. U.S.A. 92(21), 1995
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Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro.
Guerrini L, Blasi F, Denis-Donini S., Proc. Natl. Acad. Sci. U.S.A. 92(20), 1995
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Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.
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Identification and characterization of a kappa B/Rel binding site in the regulatory region of the amyloid precursor protein gene.
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Induction of oxidative stress by okadaic acid is required for activation of transcription factor NF-kappa B.
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Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein.
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Amyloid plaque core protein in Alzheimer disease and Down syndrome.
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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor.
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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.
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Intracellular thiols regulate activation of nuclear factor kappa B and transcription of human immunodeficiency virus.
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Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage.
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Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.
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Is amyloidogenesis during Alzheimer's disease due to an IL-1-/IL-6-mediated 'acute phase response' in the brain?
Vandenabeele P, Fiers W., Immunol. Today 12(7), 1991
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Detection of interleukin-6 and alpha 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients.
Strauss S, Bauer J, Ganter U, Jonas U, Berger M, Volk B., Lab. Invest. 66(2), 1992
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Rel/NF-kappa B/I kappa B family: intimate tales of association and dissociation.
Verma IM, Stevenson JK, Schwarz EM, Van Antwerp D, Miyamoto S., Genes Dev. 9(22), 1995
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Selective activation of NF-kappa B by nerve growth factor through the neurotrophin receptor p75.
Carter BD, Kaltschmidt C, Kaltschmidt B, Offenhauser N, Bohm-Matthaei R, Baeuerle PA, Barde YA., Science 272(5261), 1996
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TrkA activation is sufficient to rescue axotomized cholinergic neurons.
Lucidi-Phillipi CA, Clary DO, Reichardt LF, Gage FH., Neuron 16(3), 1996
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Generation of mice with a 200-kb amyloid precursor protein gene deletion by Cre recombinase-mediated site-specific recombination in embryonic stem cells.
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The NF-kappa B p65 promoter.
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