Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease

Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C (1997)
Proc. Natl. Acad. Sci. USA 94(6): 2642-2647.

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Kaltschmidt, BarbaraUniBi; Uherek, M.; Volk, B.; Baeuerle, P.A.; Kaltschmidt, ChristianUniBi
Proc. Natl. Acad. Sci. USA
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Kaltschmidt B, Uherek M, Volk B, Baeuerle PA, Kaltschmidt C. Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA. 1997;94(6):2642-2647.
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., & Kaltschmidt, C. (1997). Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA, 94(6), 2642-2647.
Kaltschmidt, Barbara, Uherek, M., Volk, B., Baeuerle, P.A., and Kaltschmidt, Christian. 1997. “Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease”. Proc. Natl. Acad. Sci. USA 94 (6): 2642-2647.
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., and Kaltschmidt, C. (1997). Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 94, 2642-2647.
Kaltschmidt, B., et al., 1997. Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA, 94(6), p 2642-2647.
B. Kaltschmidt, et al., “Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease”, Proc. Natl. Acad. Sci. USA, vol. 94, 1997, pp. 2642-2647.
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P.A., Kaltschmidt, C.: Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA. 94, 2642-2647 (1997).
Kaltschmidt, Barbara, Uherek, M., Volk, B., Baeuerle, P.A., and Kaltschmidt, Christian. “Transcription factor NF-kB is activated in primary neurons by amyloid ß peptides and in neurons surrounding early plaques from patients with Alzheimer disease”. Proc. Natl. Acad. Sci. USA 94.6 (1997): 2642-2647.

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Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity.
Lu J, Wu DM, Zheng YL, Hu B, Zhang ZF, Shan Q, Zheng ZH, Liu CM, Wang YJ., J Pathol 222(2), 2010
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Changes in TNFα, NFκB and MnSOD protein in the vestibular nuclei after unilateral vestibular deafferentation.
Liberge M, Manrique C, Bernard-Demanze L, Lacour M., J Neuroinflammation 7(), 2010
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Mechanisms of neurodegeneration and regeneration in alcoholism.
Crews FT, Nixon K., Alcohol Alcohol 44(2), 2009
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Post-ischemic brain damage: NF-kappaB dimer heterogeneity as a molecular determinant of neuron vulnerability.
Pizzi M, Sarnico I, Lanzillotta A, Battistin L, Spano P., FEBS J 276(1), 2009
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Gene-gene interaction between CARD8 and interleukin-6 reduces Alzheimer's disease risk.
Fontalba A, Gutiérrez O, Llorca J, Mateo I, Vázquez-Higuera JL, Berciano J, Fernández-Luna JL, Combarros O., J Neurol 256(7), 2009
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Suppression of nuclear factor kappa B ameliorates astrogliosis but not amyloid burden in APPswe/PS1dE9 mice.
Zhang X, Luhrs KJ, Ryff KA, Malik WT, Driscoll MJ, Culver B., Neuroscience 161(1), 2009
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Tetanus toxin H(C) fragment reduces neuronal MPP+ toxicity.
Chaïb-Oukadour I, Gil C, Rodríguez-Alvarez J, Ortega A, Aguilera J., Mol Cell Neurosci 41(3), 2009
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Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice.
Echeverria V, Burgess S, Gamble-George J, Zeitlin R, Lin X, Cao C, Arendash GW., Neuroscience 162(4), 2009
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Tripchlorolide protects neuronal cells from microglia-mediated beta-amyloid neurotoxicity through inhibiting NF-kappaB and JNK signaling.
Pan XD, Chen XC, Zhu YG, Chen LM, Zhang J, Huang TW, Ye QY, Huang HP., Glia 57(11), 2009
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DNA methylation of Alzheimer disease and tauopathy-related genes in postmortem brain.
Barrachina M, Ferrer I., J Neuropathol Exp Neurol 68(8), 2009
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NF-kappaB in the nervous system.
Kaltschmidt B, Kaltschmidt C., Cold Spring Harb Perspect Biol 1(3), 2009
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Combination of linkage mapping and microarray-expression analysis identifies NF-kappaB signaling defect as a cause of autosomal-recessive mental retardation.
Philippe O, Rio M, Carioux A, Plaza JM, Guigue P, Molinari F, Boddaert N, Bole-Feysot C, Nitschke P, Smahi A, Munnich A, Colleaux L., Am J Hum Genet 85(6), 2009
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Accumulation of phosphorylated I kappaB alpha and activated IKK in nodes of Ranvier.
Politi C, Del Turco D, Sie JM, Golinski PA, Tegeder I, Deller T, Schultz C., Neuropathol Appl Neurobiol 34(3), 2008
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Pharmacological enhancement of neuronal survival.
Calabrese EJ., Crit Rev Toxicol 38(4), 2008
PMID: 18432420
NF-kappaB signaling pathway and its therapeutic implications in human diseases.
Sarkar FH, Li Y, Wang Z, Kong D., Int Rev Immunol 27(5), 2008
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Targeting IKK2 by pharmacological inhibitor AS602868 prevents excitotoxic injury to neurons and oligodendrocytes.
Sarnico I, Boroni F, Benarese M, Alghisi M, Valerio A, Battistin L, Spano P, Pizzi M., J Neural Transm (Vienna) 115(5), 2008
PMID: 18197358
Amyloid beta-peptide activates nuclear factor-kappaB through an N-methyl-D-aspartate signaling pathway in cultured cerebellar cells.
Kawamoto EM, Lepsch LB, Boaventura MF, Munhoz CD, Lima LS, Yshii LM, Avellar MC, Curi R, Mattson MP, Scavone C., J Neurosci Res 86(4), 2008
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Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture.
Yang S, Zhang D, Yang Z, Hu X, Qian S, Liu J, Wilson B, Block M, Hong JS., Neurochem Res 33(10), 2008
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Flavanols, mild cognitive impairment, and Alzheimer's dementia.
Patel AK, Rogers JT, Huang X., Int J Clin Exp Med 1(2), 2008
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p75(NTR) activation of NF-kappaB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells.
Bai Y, Li Q, Yang J, Zhou X, Yin X, Zhao D., Neurosci Res 62(1), 2008
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Activation of nuclear factor-kappaB during retinal degeneration in rd mice.
Zeng HY, Tso MO, Lai S, Lai H., Mol Vis 14(), 2008
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Raf inhibition protects cortical cells against beta-amyloid toxicity.
Echeverria V, Burgess S, Gamble-George J, Arendash GW, Citron BA., Neurosci Lett 444(1), 2008
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Inhibition of Abeta production by NF-kappaB inhibitors.
Paris D, Patel N, Quadros A, Linan M, Bakshi P, Ait-Ghezala G, Mullan M., Neurosci Lett 415(1), 2007
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Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus.
Müller GJ, Lassmann H, Johansen FF., Neurobiol Dis 25(3), 2007
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NF-kappa B as a therapeutic target in neurodegenerative diseases.
Camandola S, Mattson MP., Expert Opin Ther Targets 11(2), 2007
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CD40 promotion of amyloid beta production occurs via the NF-kappaB pathway.
Ait-Ghezala G, Volmar CH, Frieling J, Paris D, Tweed M, Bakshi P, Mullan M., Eur J Neurosci 25(6), 2007
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Nuclear factor kappa-B p50 and p65 subunits expression in dementia with Lewy bodies.
Saldaña M, Mullol J, Aguilar E, Bonastre M, Marin C., Neuropathol Appl Neurobiol 33(3), 2007
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Hydrogen peroxide induces the death of astrocytes through the down-regulation of the constitutive nuclear factor-kappaB activity.
Choi JJ, Choi J, Kang CD, Chen X, Wu CF, Ko KH, Kim WK., Free Radic Res 41(5), 2007
PMID: 17454138
Over-expression of amyloid precursor protein in HEK cells alters p53 conformational state and protects against doxorubicin.
Uberti D, Cenini G, Olivari L, Ferrari-Toninelli G, Porrello E, Cecchi C, Pensalfini A, Liguri G, Govoni S, Racchi M, Maurizio M., J Neurochem 103(1), 2007
PMID: 17608641
Neuroadaptations in human chronic alcoholics: dysregulation of the NF-kappaB system.
Okvist A, Johansson S, Kuzmin A, Bazov I, Merino-Martinez R, Ponomarev I, Mayfield RD, Harris RA, Sheedy D, Garrick T, Harper C, Hurd YL, Terenius L, Ekström TJ, Bakalkin G, Yakovleva T., PLoS One 2(9), 2007
PMID: 17895971
Oxidative stress and transcriptional regulation in Alzheimer disease.
Shi Q, Gibson GE., Alzheimer Dis Assoc Disord 21(4), 2007
PMID: 18090434
Potential role of NF-kappaB in adult neural stem cells: the underrated steersman?
Widera D, Mikenberg I, Kaltschmidt B, Kaltschmidt C., Int J Dev Neurosci 24(2-3), 2006
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Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.
Tao Y, Yan D, Yang Q, Zeng R, Wang Y., Mol Cell Biol 26(3), 2006
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NF-kappaB pathway: a target for preventing beta-amyloid (Abeta)-induced neuronal damage and Abeta42 production.
Valerio A, Boroni F, Benarese M, Sarnico I, Ghisi V, Bresciani LG, Ferrario M, Borsani G, Spano P, Pizzi M., Eur J Neurosci 23(7), 2006
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Roles for NF-kappaB in nerve cell survival, plasticity, and disease.
Mattson MP, Meffert MK., Cell Death Differ 13(5), 2006
PMID: 16397579
Anti-inflammatory effect of jeongshintang through suppression of p38 activation in human astrocytoma, U373MG cells.
Kim SJ, Jeong HJ, Kim BK, Kim NH, Kim JS, Choi KS, Lee HJ, Kang ST, Shin SS, Kim WI, Eom HS, Lee KM, Um JY, Hong SH, Kim HM., Exp Mol Pathol 81(1), 2006
PMID: 16698013
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.
Rossner S, Sastre M, Bourne K, Lichtenthaler SF., Prog Neurobiol 79(2), 2006
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Pin1 in Alzheimer's disease.
Butterfield DA, Abdul HM, Opii W, Newman SF, Joshi G, Ansari MA, Sultana R., J Neurochem 98(6), 2006
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Interaction of interleukin-1beta with muscarinic acetylcholine receptor-mediated signaling cascade in cholinergically differentiated SH-SY5Y cells.
Schliebs R, Heidel K, Apelt J, Gniezdzinska M, Kirazov L, Szutowicz A., Brain Res 1122(1), 2006
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Protein oxidation and degradation during aging: role in skin aging and neurodegeneration.
Widmer R, Ziaja I, Grune T., Free Radic Res 40(12), 2006
PMID: 17090415
NF-kappaB precursor, p105, and NF-kappaB inhibitor, IkappaBgamma, are both elevated in Alzheimer disease brain.
Huang Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX., Neurosci Lett 373(2), 2005
PMID: 15567564
Altered transcriptional regulators in response to serum in immortalized lymphocytes from Alzheimer's disease patients.
de las Cuevas N, Muñoz U, Hermida OG, Martín-Requero A., Neurobiol Aging 26(5), 2005
PMID: 15708436
NF-kappaB in the survival and plasticity of neurons.
Mattson MP., Neurochem Res 30(6-7), 2005
PMID: 16187223
NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity.
Pizzi M, Sarnico I, Boroni F, Benarese M, Steimberg N, Mazzoleni G, Dietz GP, Bähr M, Liou HC, Spano PF., Cell Death Differ 12(7), 2005
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Signaling via NF-kappaB in the nervous system.
Kaltschmidt B, Widera D, Kaltschmidt C., Biochim Biophys Acta 1745(3), 2005
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Selenium reduces the proapoptotic signaling associated to NF-kappaB pathway and stimulates glutathione peroxidase activity during excitotoxic damage produced by quinolinate in rat corpus striatum.
Santamaría A, Vázquez-Román B, La Cruz VP, González-Cortés C, Trejo-Solís MC, Galván-Arzate S, Jara-Prado A, Guevara-Fonseca J, Ali SF., Synapse 58(4), 2005
PMID: 16206188
Differential MnSOD and HO-1 expression in cerebral endothelial cells in response to sublethal oxidative stress.
Méthy D, Bertrand N, Prigent-Tessier A, Stanimirovic D, Beley A, Marie C., Brain Res 1003(1-2), 2004
PMID: 15019574
Beta-amyloid25-35 inhibits glutamate uptake in cultured neurons and astrocytes: modulation of uptake as a survival mechanism.
Fernández-Tomé P, Brera B, Arévalo MA, de Ceballos ML., Neurobiol Dis 15(3), 2004
PMID: 15056466
Effect of cell density on intracellular levels of the Alzheimer's amyloid precursor protein.
Rebelo S, Henriques AG, da Cruz e Silva EF, da Cruz e Silva OA., J Neurosci Res 76(3), 2004
PMID: 15079870
N-Propargyl-1 (R)-aminoindan, rasagiline, increases glial cell line-derived neurotrophic factor (GDNF) in neuroblastoma SH-SY5Y cells through activation of NF-kappaB transcription factor.
Maruyama W, Nitta A, Shamoto-Nagai M, Hirata Y, Akao Y, Yodim M, Furukawa S, Nabeshima T, Naoi M., Neurochem Int 44(6), 2004
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GEFT, a Rho family guanine nucleotide exchange factor, regulates neurite outgrowth and dendritic spine formation.
Bryan B, Kumar V, Stafford LJ, Cai Y, Wu G, Liu M., J Biol Chem 279(44), 2004
PMID: 15322108
RAGE potentiates Abeta-induced perturbation of neuronal function in transgenic mice.
Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue LF, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Du Yan SS., EMBO J 23(20), 2004
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From calcium to NF-kappa B signaling pathways in neurons.
Lilienbaum A, Israël A., Mol Cell Biol 23(8), 2003
PMID: 12665571
Mutational study of the nuclear factor kappa B inducing kinase gene in patients with progressive supranuclear palsy.
Campdelacreu J, Ezquerra M, Muñoz E, Oliva R, Tolosa E., Neurosci Lett 340(2), 2003
PMID: 12668260
Noradrenergic depletion increases inflammatory responses in brain: effects on IkappaB and HSP70 expression.
Heneka MT, Gavrilyuk V, Landreth GE, O'Banion MK, Weinberg G, Feinstein DL., J Neurochem 85(2), 2003
PMID: 12675915
H2O2 and 4-hydroxynonenal mediate amyloid beta-induced neuronal apoptosis by activating JNKs and p38MAPK.
Tamagno E, Robino G, Obbili A, Bardini P, Aragno M, Parola M, Danni O., Exp Neurol 180(2), 2003
PMID: 12684028
Amyloid beta peptide (Abeta42) activates PLC-delta1 promoter through the NF-kappaB binding site.
Kim JY, Kim H, Lee SG, Choi BH, Kim YH, Huh PW, Lee KH, Han H, Rha HK., Biochem Biophys Res Commun 310(3), 2003
PMID: 14550290
Is DNA repair compromised in Alzheimer's disease?
Davydov V, Hansen LA, Shackelford DA., Neurobiol Aging 24(7), 2003
PMID: 12928056
MK-801 and 7-Ni attenuate the activation of brain NF-kappa B induced by LPS.
Glezer I, Munhoz CD, Kawamoto EM, Marcourakis T, Avellar MC, Avellar MC, Scavone C., Neuropharmacology 45(8), 2003
PMID: 14614955
Stimulus-dependent activation of NF-kappaB specifies apoptosis or neuroprotection in cerebellar granule cells.
Kaltschmidt B, Heinrich M, Kaltschmidt C., Neuromolecular Med 2(3), 2002
PMID: 12622408
[The Rel/NF-kappa-B transcription factors: complex role in cell regulation].
Bottex-Gauthier C, Pollet S, Favier A, Vidal DR., Pathol Biol (Paris) 50(3), 2002
PMID: 11980335
Growing old with nuclear factor-kappaB.
Giardina C, Hubbard AK., Cell Stress Chaperones 7(2), 2002
PMID: 12380689
Acetaminophen protects hippocampal neurons and PC12 cultures from amyloid beta-peptides induced oxidative stress and reduces NF-kappaB activation.
Bisaglia M, Venezia V, Piccioli P, Stanzione S, Porcile C, Russo C, Mancini F, Milanese C, Schettini G., Neurochem Int 41(1), 2002
PMID: 11918971
Generation of reactive oxygen species and activation of NF-kappaB by non-Abeta component of Alzheimer's disease amyloid.
Tanaka S, Takehashi M, Matoh N, Iida S, Suzuki T, Futaki S, Hamada H, Masliah E, Sugiura Y, Ueda K., J Neurochem 82(2), 2002
PMID: 12124431
Nutritional approaches to combat oxidative stress in Alzheimer's disease.
Butterfield D, Castegna A, Pocernich C, Drake J, Scapagnini G, Calabrese V., J Nutr Biochem 13(8), 2002
PMID: 12165357
Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation.
Hilliard BA, Mason N, Xu L, Sun J, Lamhamedi-Cherradi SE, Liou HC, Hunter C, Chen YH., J Clin Invest 110(6), 2002
PMID: 12235116
NF-kappaB mediates IL-1beta-induced synthesis/release of alpha2-macroglobulin in a human glial cell line.
Gao F, Bales KR, Dodel RC, Liu J, Chen X, Hample H, Farlow MR, Paul SM, Du Y., Brain Res Mol Brain Res 105(1-2), 2002
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Hypoxia signaling to genes: significance in Alzheimer's disease.
Bazan NG, Palacios-Pelaez R, Lukiw WJ., Mol Neurobiol 26(2-3), 2002
PMID: 12428761
Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide.
Rogers J, Strohmeyer R, Kovelowski CJ, Li R., Glia 40(2), 2002
PMID: 12379913
Oxidative modulation of nuclear factor-kappaB in human cells expressing mutant fALS-typical superoxide dismutases.
Casciati A, Ferri A, Cozzolino M, Celsi F, Nencini M, Rotilio G, Carrì MT., J Neurochem 83(5), 2002
PMID: 12437573
Cyclooxygenase-2 is a neuronal target gene of NF-kappaB.
Kaltschmidt B, Linker RA, Deng J, Kaltschmidt C., BMC Mol Biol 3(), 2002
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Neuroprotection from glutamate toxicity with ultra-low dose glutamate.
Jonas W, Lin Y, Tortella F., Neuroreport 12(2), 2001
PMID: 11209946
Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure.
Lucassen PJ, Müller MB, Holsboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF., Am J Pathol 158(2), 2001
PMID: 11159183
Amyloid beta-peptide disrupts mitochondrial membrane lipid and protein structure: protective role of tauroursodeoxycholate.
Rodrigues CM, Solá S, Brito MA, Brondino CD, Brites D, Moura JJ., Biochem Biophys Res Commun 281(2), 2001
PMID: 11181071
Intracellular pathways involved in TNF-alpha and superoxide anion release by Abeta(1-42)-stimulated primary human macrophages.
Smits HA, de Vos NM, Wat JW, van der Bruggen T, Verhoef J, Nottet HS., J Neuroimmunol 115(1-2), 2001
PMID: 11282164
Nuclear factor-kappaB activation is not involved in a MPTP model of Parkinson's disease.
Teismann P, Schwaninger M, Weih F, Ferger B., Neuroreport 12(5), 2001
PMID: 11303744
Mitochondrial involvement in brain function and dysfunction: relevance to aging, neurodegenerative disorders and longevity.
Calabrese V, Scapagnini G, Giuffrida Stella AM, Bates TE, Clark JB., Neurochem Res 26(6), 2001
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C-terminal fragment of amyloid precursor protein induces astrocytosis.
Bach JH, Chae HS, Rah JC, Lee MW, Park CH, Choi SH, Choi JK, Lee SH, Kim YS, Kim KY, Lee WB, Suh YH, Kim SS., J Neurochem 78(1), 2001
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Amyloid beta-peptide: biphasic dose responses.
Calabrese EJ., Crit Rev Toxicol 31(4-5), 2001
PMID: 11504184
From theory to therapy: implications from an in vitro model of ramified microglia.
Rosenstiel P, Lucius R, Deuschl G, Sievers J, Wilms H., Microsc Res Tech 54(1), 2001
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6-hydroxydopamine-induced nuclear factor-kappa B activation in PC12 cells.
Blum D, Torch S, Nissou MF, Verna JM., Biochem Pharmacol 62(4), 2001
PMID: 11448458
The amyloid peptide induces early genotoxic damage in human preneuron NT2.
Santiard-Baron D, Lacoste A, Ellouk-Achard S, Soulié C, Nicole A, Sarasin A, Ceballos-Picot I., Mutat Res 479(1-2), 2001
PMID: 11470486
Enhanced expression of I-kappaB with neurofibrillary pathology in Alzheimer's disease.
Yoshiyama Y, Arai K, Hattori T., Neuroreport 12(12), 2001
PMID: 11522940
Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease.
Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM., Prog Neurobiol 65(2), 2001
PMID: 11403877
S100beta induction of the proinflammatory cytokine interleukin-6 in neurons.
Li Y, Barger SW, Liu L, Mrak RE, Griffin WS., J Neurochem 74(1), 2000
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Model for aging in the basal forebrain cholinergic system.
Gu Z, Wortwein G, Yu J, Perez-Polo JR., Antioxid Redox Signal 2(3), 2000
PMID: 11229357
Roles of nuclear factor kappaB in neuronal survival and plasticity.
Mattson MP, Culmsee C, Yu Z, Camandola S., J Neurochem 74(2), 2000
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Neuron-specific localisation of the TR3 death receptor in Alzheimer's disease.
Newman SJ, Bond B, Crook B, Darker J, Edge C, Maycox PR., Brain Res 857(1-2), 2000
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Transcription factor nuclear factor-kappa B is activated in neurons after focal cerebral ischemia.
Stephenson D, Yin T, Smalstig EB, Hsu MA, Panetta J, Little S, Clemens J., J Cereb Blood Flow Metab 20(3), 2000
PMID: 10724123
Cyanide-induced apoptosis involves oxidative-stress-activated NF-kappaB in cortical neurons.
Shou Y, Gunasekar PG, Borowitz JL, Isom GE., Toxicol Appl Pharmacol 164(2), 2000
PMID: 10764633
Anti-inflammatory drugs: a hope for Alzheimer's disease?
Hüll M, Lieb K, Fiebich BL., Expert Opin Investig Drugs 9(4), 2000
PMID: 11060701
The heat shock response inhibits NF-kappaB activation, nitric oxide synthase type 2 expression, and macrophage/microglial activation in brain.
Heneka MT, Sharp A, Klockgether T, Gavrilyuk V, Feinstein DL., J Cereb Blood Flow Metab 20(5), 2000
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Inflammation and Alzheimer's disease.
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WS, Hampel H, Hull M, Landreth G, Lue L, Mrak R, Mackenzie IR, McGeer PL, O'Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T., Neurobiol Aging 21(3), 2000
PMID: 10858586
The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus.
Kaltschmidt B, Kaltschmidt C, Hofmann TG, Hehner SP, Dröge W, Schmitz ML., Eur J Biochem 267(12), 2000
PMID: 10849002
beta-amyloid peptides are cytotoxic to astrocytes in culture: a role for oxidative stress.
Brera B, Serrano A, de Ceballos ML., Neurobiol Dis 7(4), 2000
PMID: 10964610
The Rel/NF-kappa B family: friend and foe.
Perkins ND., Trends Biochem Sci 25(9), 2000
PMID: 10973057
Neuroinflammatory signaling upregulation in Alzheimer's disease.
Lukiw WJ, Bazan NG., Neurochem Res 25(9-10), 2000
PMID: 11059791
The role of oxidative stress in the toxicity induced by amyloid beta-peptide in Alzheimer's disease.
Miranda S, Opazo C, Larrondo LF, Muñoz FJ, Ruiz F, Leighton F, Inestrosa NC., Prog Neurobiol 62(6), 2000
PMID: 10880853
NF-kappaB transcription factors: critical regulators of hematopoiesis and neuronal survival.
Denk A, Wirth T, Baumann B., Cytokine Growth Factor Rev 11(4), 2000
PMID: 10959078
Association of a haplotype for tumor necrosis factor in siblings with late-onset Alzheimer disease: the NIMH Alzheimer Disease Genetics Initiative.
Collins JS, Perry RT, Watson B, Harrell LE, Acton RT, Blacker D, Albert MS, Tanzi RE, Bassett SS, McInnis MG, Campbell RD, Go RC., Am J Med Genet 96(6), 2000
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Differential induction of NF-kappaB activity and neural cell death by antidepressants in vitro.
Post A, Crochemore C, Uhr M, Holsboer F, Behl C., Eur J Neurosci 12(12), 2000
PMID: 11122343
Tumor necrosis factor and reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-kappaB.
Ginis I, Hallenbeck JM, Liu J, Spatz M, Jaiswal R, Shohami E., Mol Med 6(12), 2000
PMID: 11474119
Activation of NF-kappa B by reactive oxygen intermediates in the nervous system.
Kaltschmidt B, Sparna T, Kaltschmidt C., Antioxid Redox Signal 1(2), 1999
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Regulation of amyloid precursor protein cleavage.
Mills J, Reiner PB., J Neurochem 72(2), 1999
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Activation of nuclear factor-kappaB in the rat brain after transient focal ischemia.
Gabriel C, Justicia C, Camins A, Planas AM., Brain Res Mol Brain Res 65(1), 1999
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Mechanisms of apoptosis in PC12 cells irreversibly differentiated with nerve growth factor and cyclic AMP.
Lambeng N, Michel PP, Brugg B, Agid Y, Ruberg M., Brain Res 821(1), 1999
PMID: 10064788
Characterization of a neuronal kappaB-binding factor distinct from NF-kappaB.
Moerman AM, Mao X, Lucas MM, Barger SW., Brain Res Mol Brain Res 67(2), 1999
PMID: 10216229
The amino-terminus of the amyloid-beta protein is critical for the cellular binding and consequent activation of the respiratory burst of human macrophages.
Van Muiswinkel FL, Raupp SF, de Vos NM, Smits HA, Verhoef J, Eikelenboom P, Nottet HS., J Neuroimmunol 96(1), 1999
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NF-kappaB is activated and promotes cell death in focal cerebral ischemia.
Schneider A, Martin-Villalba A, Weih F, Vogel J, Wirth T, Schwaninger M., Nat Med 5(5), 1999
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Repression of NF-kappaB impairs HeLa cell proliferation by functional interference with cell cycle checkpoint regulators.
Kaltschmidt B, Kaltschmidt C, Hehner SP, Dröge W, Schmitz ML., Oncogene 18(21), 1999
PMID: 10359527
Loss of NF-kappaB activity during cerebral ischemia and TNF cytotoxicity.
Botchkina GI, Geimonen E, Bilof ML, Villarreal O, Tracey KJ., Mol Med 5(6), 1999
PMID: 10415162
Anti-inflammatory substances - a new therapeutic option in Alzheimer's disease.
Hüll M, Fiebich BL, Schumann G, Lieb K, Bauer J., Drug Discov Today 4(6), 1999
PMID: 10354542
Is NF-kappaB the sensor of oxidative stress?
Li N, Karin M., FASEB J 13(10), 1999
PMID: 10385605
Identification of beta-amyloid-responsive genes by RNA differential display: early induction of a DNA damage-inducible gene, gadd45.
Santiard-Baron D, Gosset P, Nicole A, Sinet PM, Christen Y, Ceballos-Picot I., Exp Neurol 158(1), 1999
PMID: 10448433
Inhibition of NF-kappaB potentiates amyloid beta-mediated neuronal apoptosis.
Kaltschmidt B, Uherek M, Wellmann H, Volk B, Kaltschmidt C., Proc Natl Acad Sci U S A 96(16), 1999
PMID: 10430956
Interleukin-17 stimulates the expression of IkappaB alpha mRNA and the secretion of IL-6 and IL-8 in glioblastoma cell lines.
Kehlen A, Thiele K, Riemann D, Rainov N, Langner J., J Neuroimmunol 101(1), 1999
PMID: 10580807
Expression of cytokine genes and increased nuclear factor-kappa B activity in the brains of scrapie-infected mice.
Kim JI, Ju WK, Choi JH, Choi E, Carp RI, Wisniewski HM, Kim YS., Brain Res Mol Brain Res 73(1-2), 1999
PMID: 10581394
Control of apoptosis by Rel/NF-kappaB transcription factors.
Barkett M, Gilmore TD., Oncogene 18(49), 1999
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Alzheimer's disease and brain development: common molecular pathways.
Jordan-Sciutto K, Bowser R., Front Biosci 3(), 1998
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