IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins

Schwartz CJ, Giel JL, Patschkowski T, Luther C, Ruzicka FJ, Beinert H, Kiley PJ (2001)
Proc Natl Acad Sci U S A 98(26) 98(26): 14895-14900.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Schwartz, C.J.; Giel, J.L.; Patschkowski, ThomasUniBi; Luther, C.; Ruzicka, F.J.; Beinert, H.; Kiley, P.J.
Abstract / Bemerkung
scR (iron-sulfur cluster regulator) is encoded by an ORF located immediately upstream of genes coding for the Escherichia coli Fe-S cluster assembly proteins, IscS, IscU, and IscA. IscR shares amino acid similarity with MarA, a member of the MarA/SoxS/Rob family of transcription factors. In this study, we found that IscR functions as a repressor of the iscRSUA operon, because strains deleted for iscR have increased expression of this operon. In addition, in vitro transcription reactions established a direct role for IscR in repression of the iscR promoter. Analysis of IscR by electron paramagnetic resonance showed that the anaerobically isolated protein contains a [2Fe-2S](1+) cluster. The Fe-S cluster appears to be important for IscR function, because repression of iscR expression is significantly reduced in strains containing null mutations of the Fe-S cluster assembly genes iscS or hscA. The finding that IscR activity is decreased in strain backgrounds in which Fe-S cluster assembly is impaired suggests that this protein may be part of a novel autoregulatory mechanism that senses the Fe-S cluster assembly status of cells.
Erscheinungsjahr
2001
Zeitschriftentitel
Proc Natl Acad Sci U S A 98(26)
Band
98
Ausgabe
26
Seite(n)
14895-14900
ISSN
0027-8424
eISSN
1091-6490
Page URI
https://pub.uni-bielefeld.de/record/1864098

Zitieren

Schwartz CJ, Giel JL, Patschkowski T, et al. IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. Proc Natl Acad Sci U S A 98(26). 2001;98(26):14895-14900.
Schwartz, C. J., Giel, J. L., Patschkowski, T., Luther, C., Ruzicka, F. J., Beinert, H., & Kiley, P. J. (2001). IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. Proc Natl Acad Sci U S A 98(26), 98(26), 14895-14900. doi:10.1073/pnas.251550898
Schwartz, C. J., Giel, J. L., Patschkowski, T., Luther, C., Ruzicka, F. J., Beinert, H., and Kiley, P. J. (2001). IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. Proc Natl Acad Sci U S A 98(26) 98, 14895-14900.
Schwartz, C.J., et al., 2001. IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. Proc Natl Acad Sci U S A 98(26), 98(26), p 14895-14900.
C.J. Schwartz, et al., “IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins”, Proc Natl Acad Sci U S A 98(26), vol. 98, 2001, pp. 14895-14900.
Schwartz, C.J., Giel, J.L., Patschkowski, T., Luther, C., Ruzicka, F.J., Beinert, H., Kiley, P.J.: IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. Proc Natl Acad Sci U S A 98(26). 98, 14895-14900 (2001).
Schwartz, C.J., Giel, J.L., Patschkowski, Thomas, Luther, C., Ruzicka, F.J., Beinert, H., and Kiley, P.J. “IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins”. Proc Natl Acad Sci U S A 98(26) 98.26 (2001): 14895-14900.

196 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Redox-Based Transcriptional Regulation in Prokaryotes: Revisiting Model Mechanisms.
Sevilla E, Bes MT, González A, Peleato ML, Fillat MF., Antioxid Redox Signal 30(13), 2019
PMID: 30073850
Disruption of the NlpD lipoprotein of the plague pathogen Yersinia pestis affects iron acquisition and the activity of the twin-arginine translocation system.
Tidhar A, Levy Y, Zauberman A, Vagima Y, Gur D, Aftalion M, Israeli O, Chitlaru T, Ariel N, Flashner Y, Zvi A, Mamroud E., PLoS Negl Trop Dis 13(6), 2019
PMID: 31170147
Redox-Sensing Under Hypochlorite Stress and Infection Conditions by the Rrf2-Family Repressor HypR in Staphylococcus aureus.
Loi VV, Busche T, Tedin K, Bernhardt J, Wollenhaupt J, Huyen NTT, Weise C, Kalinowski J, Wahl MC, Fulde M, Antelmann H., Antioxid Redox Signal 29(7), 2018
PMID: 29237286
Regulated Stochasticity in a Bacterial Signaling Network Permits Tolerance to a Rapid Environmental Change.
Carey JN, Mettert EL, Roggiani M, Myers KS, Kiley PJ, Goulian M., Cell 173(1), 2018
PMID: 29502970
Cysteine Desulfurase IscS2 Plays a Role in Oxygen Resistance in Clostridium difficile.
Giordano N, Hastie JL, Smith AD, Foss ED, Gutierrez-Munoz DF, Carlson PE., Infect Immun 86(8), 2018
PMID: 29866903
Iron-sulphur cluster biogenesis via the SUF pathway.
Bai Y, Chen T, Happe T, Lu Y, Sawyer A., Metallomics 10(8), 2018
PMID: 30019043
Influence of the Hfq and Crc global regulators on the control of iron homeostasis in Pseudomonas putida.
Sánchez-Hevia DL, Yuste L, Moreno R, Rojo F., Environ Microbiol 20(10), 2018
PMID: 29708644
Bacillus megaterium adapts to acid stress condition through a network of genes: Insight from a genome-wide transcriptome analysis.
Goswami G, Panda D, Samanta R, Boro RC, Modi MK, Bujarbaruah KM, Barooah M., Sci Rep 8(1), 2018
PMID: 30382109
Transcriptional profiling of the mutualistic bacterium Vibrio fischeri and an hfq mutant under modeled microgravity.
Duscher AA, Conesa A, Bishop M, Vroom MM, Zubizarreta SD, Foster JS., NPJ Microgravity 4(), 2018
PMID: 30588486
The iron-sulfur cluster sensor IscR is a negative regulator of Spi1 type III secretion system in Salmonella enterica.
Vergnes A, Viala JP, Ouadah-Tsabet R, Pocachard B, Loiseau L, Méresse S, Barras F, Aussel L., Cell Microbiol 19(4), 2017
PMID: 27704705
Identification of medaka magnetoreceptor and cryptochromes.
Wang Y, Chen J, Zhu F, Hong Y., Sci China Life Sci 60(3), 2017
PMID: 27858334
Hybrid Methods in Iron-Sulfur Cluster Biogenesis.
Prischi F, Pastore A., Front Mol Biosci 4(), 2017
PMID: 28349052
Metal homeostasis and resistance in bacteria.
Chandrangsu P, Rensing C, Helmann JD., Nat Rev Microbiol 15(6), 2017
PMID: 28344348
Crystal structures of the NO sensor NsrR reveal how its iron-sulfur cluster modulates DNA binding.
Volbeda A, Dodd EL, Darnault C, Crack JC, Renoux O, Hutchings MI, Le Brun NE, Fontecilla-Camps JC., Nat Commun 8(), 2017
PMID: 28425466
Sensing iron availability via the fragile [4Fe-4S] cluster of the bacterial transcriptional repressor RirA.
Pellicer Martinez MT, Martinez AB, Crack JC, Holmes JD, Svistunenko DA, Johnston AWB, Cheesman MR, Todd JD, Le Brun NE., Chem Sci 8(12), 2017
PMID: 29619193
O2 availability impacts iron homeostasis in Escherichia coli.
Beauchene NA, Mettert EL, Moore LJ, Keleş S, Willey ER, Kiley PJ., Proc Natl Acad Sci U S A 114(46), 2017
PMID: 29087312
Regulation of Class A β-Lactamase CzoA by CzoR and IscR in Comamonas testosteroni S44.
Zhuang W, Liu H, Li J, Chen L, Wang G., Front Microbiol 8(), 2017
PMID: 29312251
Fe-S Clusters Emerging as Targets of Therapeutic Drugs.
Vernis L, El Banna N, Baïlle D, Hatem E, Heneman A, Huang ME., Oxid Med Cell Longev 2017(), 2017
PMID: 29445445
Synthesis, delivery and regulation of eukaryotic heme and Fe-S cluster cofactors.
Barupala DP, Dzul SP, Riggs-Gelasco PJ, Stemmler TL., Arch Biochem Biophys 592(), 2016
PMID: 26785297
Differentiated, Promoter-specific Response of [4Fe-4S] NsrR DNA Binding to Reaction with Nitric Oxide.
Crack JC, Svistunenko DA, Munnoch J, Thomson AJ, Hutchings MI, Le Brun NE., J Biol Chem 291(16), 2016
PMID: 26887943
The 'liaisons dangereuses' between iron and antibiotics.
Ezraty B, Barras F., FEMS Microbiol Rev 40(3), 2016
PMID: 26945776
A New Tessera into the Interactome of the isc Operon: A Novel Interaction between HscB and IscS.
Puglisi R, Yan R, Adinolfi S, Pastore A., Front Mol Biosci 3(), 2016
PMID: 27730125
Fe-S proteins that regulate gene expression.
Mettert EL, Kiley PJ., Biochim Biophys Acta 1853(6), 2015
PMID: 25450978
How Is Fe-S Cluster Formation Regulated?
Mettert EL, Kiley PJ., Annu Rev Microbiol 69(), 2015
PMID: 26488283
The iron-binding CyaY and IscX proteins assist the ISC-catalyzed Fe-S biogenesis in Escherichia coli.
Roche B, Huguenot A, Barras F, Py B., Mol Microbiol 95(4), 2015
PMID: 25430730
An integrated approach to reconstructing genome-scale transcriptional regulatory networks.
Imam S, Noguera DR, Donohue TJ., PLoS Comput Biol 11(2), 2015
PMID: 25723545
NsrR from Streptomyces coelicolor is a nitric oxide-sensing [4Fe-4S] cluster protein with a specialized regulatory function.
Crack JC, Munnoch J, Dodd EL, Knowles F, Al Bassam MM, Kamali S, Holland AA, Cramer SP, Hamilton CJ, Johnson MK, Thomson AJ, Hutchings MI, Le Brun NE., J Biol Chem 290(20), 2015
PMID: 25771538
Silencing of DNase Colicin E8 Gene Expression by a Complex Nucleoprotein Assembly Ensures Timely Colicin Induction.
Kamenšek S, Browning DF, Podlesek Z, Busby SJ, Žgur-Bertok D, Butala M., PLoS Genet 11(6), 2015
PMID: 26114960
IscR Regulates Synthesis of Colonization Factor Antigen I Fimbriae in Response to Iron Starvation in Enterotoxigenic Escherichia coli.
Haines S, Arnaud-Barbe N, Poncet D, Reverchon S, Wawrzyniak J, Nasser W, Renauld-Mongénie G., J Bacteriol 197(18), 2015
PMID: 26124243
Yersinia Type III Secretion System Master Regulator LcrF.
Schwiesow L, Lam H, Dersch P, Auerbuch V., J Bacteriol 198(4), 2015
PMID: 26644429
Global Regulator IscR Positively Contributes to Antimonite Resistance and Oxidation in Comamonas testosteroni S44.
Liu H, Zhuang W, Zhang S, Rensing C, Huang J, Li J, Wang G., Front Mol Biosci 2(), 2015
PMID: 26734615
The iron-sulphur cluster biosynthesis regulator IscR contributes to iron homeostasis and resistance to oxidants in Pseudomonas aeruginosa.
Romsang A, Duang-Nkern J, Leesukon P, Saninjuk K, Vattanaviboon P, Mongkolsuk S., PLoS One 9(1), 2014
PMID: 24466226
Alternative FeS cluster ligands: tuning redox potentials and chemistry.
Bak DW, Elliott SJ., Curr Opin Chem Biol 19(), 2014
PMID: 24463764
Isolation and validation of an endogenous fluorescent nucleoid reporter in Salmonella Typhimurium.
Passaris I, Ghosh A, Cenens W, Michiels CW, Lammertyn J, Aertsen A., PLoS One 9(4), 2014
PMID: 24695782
The unique regulation of iron-sulfur cluster biogenesis in a Gram-positive bacterium.
Santos JA, Alonso-García N, Macedo-Ribeiro S, Pereira PJ., Proc Natl Acad Sci U S A 111(22), 2014
PMID: 24847070
Oxidative stress enhances the expression of sulfur assimilation genes: preliminary insights on the Enterococcus faecalis iron-sulfur cluster machinery regulation.
Riboldi GP, Bierhals CG, Mattos EP, Frazzon AP, d'Azevedo PA, Frazzon J., Mem Inst Oswaldo Cruz 109(4), 2014
PMID: 24936909
IscR is essential for yersinia pseudotuberculosis type III secretion and virulence.
Miller HK, Kwuan L, Schwiesow L, Bernick DL, Mettert E, Ramirez HA, Ragle JM, Chan PP, Kiley PJ, Lowe TM, Auerbuch V., PLoS Pathog 10(6), 2014
PMID: 24945271
The ins and outs of bacterial iron metabolism.
Frawley ER, Fang FC., Mol Microbiol 93(4), 2014
PMID: 25040830
Selenite reduction by the obligate aerobic bacterium Comamonas testosteroni S44 isolated from a metal-contaminated soil.
Zheng S, Su J, Wang L, Yao R, Wang D, Deng Y, Wang R, Wang G, Rensing C., BMC Microbiol 14(), 2014
PMID: 25098921
spxA2, encoding a regulator of stress resistance in Bacillus anthracis, is controlled by SaiR, a new member of the Rrf2 protein family.
Nakano MM, Kominos-Marvell W, Sane B, Nader YM, Barendt SM, Jones MB, Zuber P., Mol Microbiol 94(4), 2014
PMID: 25231235
Regulation of iron-sulphur cluster homeostasis through transcriptional control of the Isc pathway by [2Fe-2S]-IscR in Escherichia coli.
Giel JL, Nesbit AD, Mettert EL, Fleischhacker AS, Wanta BT, Kiley PJ., Mol Microbiol 87(3), 2013
PMID: 23075318
A novel endogenous induction of ColE7 expression in a csrA mutant of Escherichia coli.
Chang HW, Yang TY, Lei GS, Chak KF., Curr Microbiol 66(4), 2013
PMID: 23247769
Iron/sulfur proteins biogenesis in prokaryotes: formation, regulation and diversity.
Roche B, Aussel L, Ezraty B, Mandin P, Py B, Barras F., Biochim Biophys Acta 1827(3), 2013
PMID: 23298813
In vivo [Fe-S] cluster acquisition by IscR and NsrR, two stress regulators in Escherichia coli.
Vinella D, Loiseau L, Ollagnier de Choudens S, Fontecave M, Barras F., Mol Microbiol 87(3), 2013
PMID: 23320508
New developments in post-transcriptional regulation of operons by small RNAs.
Balasubramanian D, Vanderpool CK., RNA Biol 10(3), 2013
PMID: 23392245
Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity.
Rajagopalan S, Teter SJ, Zwart PH, Brennan RG, Phillips KJ, Kiley PJ., Nat Struct Mol Biol 20(6), 2013
PMID: 23644595
Reprint of: Iron/sulfur proteins biogenesis in prokaryotes: formation, regulation and diversity.
Roche B, Aussel L, Ezraty B, Mandin P, Py B, Barras F., Biochim Biophys Acta 1827(8-9), 2013
PMID: 23660107
Fe-S cluster biosynthesis controls uptake of aminoglycosides in a ROS-less death pathway.
Ezraty B, Vergnes A, Banzhaf M, Duverger Y, Huguenot A, Brochado AR, Su SY, Espinosa L, Loiseau L, Py B, Typas A, Barras F., Science 340(6140), 2013
PMID: 23812717
Biogenesis of [Fe-S] cluster in Firmicutes: an unexploited field of investigation.
Riboldi GP, de Mattos EP, Frazzon J., Antonie Van Leeuwenhoek 104(3), 2013
PMID: 23851716
The iron-sulfur cluster assembly machineries in plants: current knowledge and open questions.
Couturier J, Touraine B, Briat JF, Gaymard F, Rouhier N., Front Plant Sci 4(), 2013
PMID: 23898337
Global transcriptional control by NsrR in Bacillus subtilis.
Kommineni S, Lama A, Popescu B, Nakano MM., J Bacteriol 194(7), 2012
PMID: 22287527
Competing pathways control host resistance to virus via tRNA modification and programmed ribosomal frameshifting.
Maynard ND, Macklin DN, Kirkegaard K, Covert MW., Mol Syst Biol 8(), 2012
PMID: 22294093
A novel protein kinase-like domain in a selenoprotein, widespread in the tree of life.
Dudkiewicz M, Szczepińska T, Grynberg M, Pawłowski K., PLoS One 7(2), 2012
PMID: 22359664
Bacterial iron-sulfur regulatory proteins as biological sensor-switches.
Crack JC, Green J, Hutchings MI, Thomson AJ, Le Brun NE., Antioxid Redox Signal 17(9), 2012
PMID: 22239203
Pseudomonas aeruginosa thiol peroxidase protects against hydrogen peroxide toxicity and displays atypical patterns of gene regulation.
Somprasong N, Jittawuttipoka T, Duang-Nkern J, Romsang A, Chaiyen P, Schweizer HP, Vattanaviboon P, Mongkolsuk S., J Bacteriol 194(15), 2012
PMID: 22609922
Characterization of the [2Fe-2S] cluster of Escherichia coli transcription factor IscR.
Fleischhacker AS, Stubna A, Hsueh KL, Guo Y, Teter SJ, Rose JC, Brunold TC, Markley JL, Münck E, Kiley PJ., Biochemistry 51(22), 2012
PMID: 22583201
Detection of transcriptional triggers in the dynamics of microbial growth: application to the respiratorily versatile bacterium Shewanella oneidensis.
Beg QK, Zampieri M, Klitgord N, Collins SB, Altafini C, Serres MH, Segrè D., Nucleic Acids Res 40(15), 2012
PMID: 22638572
Evolution of Fe/S cluster biogenesis in the anaerobic parasite Blastocystis.
Tsaousis AD, Ollagnier de Choudens S, Gentekaki E, Long S, Gaston D, Stechmann A, Vinella D, Py B, Fontecave M, Barras F, Lukeš J, Roger AJ., Proc Natl Acad Sci U S A 109(26), 2012
PMID: 22699510
The effect of iron limitation on the transcriptome and proteome of Pseudomonas fluorescens Pf-5.
Lim CK, Hassan KA, Tetu SG, Loper JE, Paulsen IT., PLoS One 7(6), 2012
PMID: 22723948
The NsrR regulon in nitrosative stress resistance of Salmonella enterica serovar Typhimurium.
Karlinsey JE, Bang IS, Becker LA, Frawley ER, Porwollik S, Robbins HF, Thomas VC, Urbano R, McClelland M, Fang FC., Mol Microbiol 85(6), 2012
PMID: 22831173
Double locking of an Escherichia coli promoter by two repressors prevents premature colicin expression and cell lysis.
Butala M, Sonjak S, Kamenšek S, Hodošček M, Browning DF, Žgur-Bertok D, Busby SJ., Mol Microbiol 86(1), 2012
PMID: 22812562
Phenotypic repertoire of the FNR regulatory network in Escherichia coli.
Tolla DA, Savageau MA., Mol Microbiol 79(1), 2011
PMID: 21166900
Iron-containing transcription factors and their roles as sensors.
Fleischhacker AS, Kiley PJ., Curr Opin Chem Biol 15(2), 2011
PMID: 21292540
Peroxide stress elicits adaptive changes in bacterial metal ion homeostasis.
Faulkner MJ, Helmann JD., Antioxid Redox Signal 15(1), 2011
PMID: 20977351
Heme binding to the second, lower-affinity site of the global iron regulator Irr from Rhizobium leguminosarum promotes oligomerization.
White GF, Singleton C, Todd JD, Cheesman MR, Johnston AW, Le Brun NE., FEBS J 278(12), 2011
PMID: 21481185
Insights into the Rrf2 repressor family--the structure of CymR, the global cysteine regulator of Bacillus subtilis.
Shepard W, Soutourina O, Courtois E, England P, Haouz A, Martin-Verstraete I., FEBS J 278(15), 2011
PMID: 21624051
DNA-mediated charge transport in redox sensing and signaling.
Genereux JC, Boal AK, Barton JK., J Am Chem Soc 132(3), 2010
PMID: 20047321
There's NO stopping NsrR, a global regulator of the bacterial NO stress response.
Tucker NP, Le Brun NE, Dixon R, Hutchings MI., Trends Microbiol 18(4), 2010
PMID: 20167493
Dealing with oxidative stress and iron starvation in microorganisms: an overview.
Benjamin JA, Desnoyers G, Morissette A, Salvail H, Massé E., Can J Physiol Pharmacol 88(3), 2010
PMID: 20393591
Heme-responsive DNA binding by the global iron regulator Irr from Rhizobium leguminosarum.
Singleton C, White GF, Todd JD, Marritt SJ, Cheesman MR, Johnston AW, Le Brun NE., J Biol Chem 285(21), 2010
PMID: 20233710
Damped oscillations in the adaptive response of the iron homeostasis network of E. coli.
Amir A, Meshner S, Beatus T, Stavans J., Mol Microbiol 76(2), 2010
PMID: 20345668
IscR regulates RNase LS activity by repressing rnlA transcription.
Otsuka Y, Miki K, Koga M, Katayama N, Morimoto W, Takahashi Y, Yonesaki T., Genetics 185(3), 2010
PMID: 20421606
Iron-binding activity of human iron-sulfur cluster assembly protein hIscA1.
Lu J, Bitoun JP, Tan G, Wang W, Min W, Ding H., Biochem J 428(1), 2010
PMID: 20302570
Building Fe-S proteins: bacterial strategies.
Py B, Barras F., Nat Rev Microbiol 8(6), 2010
PMID: 20467446
The alr2505 (osiS) gene from Anabaena sp. strain PCC7120 encodes a cysteine desulfurase induced by oxidative stress.
Ruiz M, Bettache A, Janicki A, Vinella D, Zhang CC, Latifi A., FEBS J 277(18), 2010
PMID: 20681987
Global regulation of gene expression in response to cysteine availability in Clostridium perfringens.
André G, Haudecoeur E, Monot M, Ohtani K, Shimizu T, Dupuy B, Martin-Verstraete I., BMC Microbiol 10(), 2010
PMID: 20822510
A genetic analysis of the response of Escherichia coli to cobalt stress.
Fantino JR, Py B, Fontecave M, Barras F., Environ Microbiol 12(10), 2010
PMID: 20545747
Nitric oxide-sensitive and -insensitive interaction of Bacillus subtilis NsrR with a ResDE-controlled promoter.
Kommineni S, Yukl E, Hayashi T, Delepine J, Geng H, Moënne-Loccoz P, Nakano MM., Mol Microbiol 78(5), 2010
PMID: 21091510
High-yield expression of heterologous [FeFe] hydrogenases in Escherichia coli.
Kuchenreuther JM, Grady-Smith CS, Bingham AS, George SJ, Cramer SP, Swartz JR., PLoS One 5(11), 2010
PMID: 21124800
Functional analysis of NsrR, a nitric oxide-sensing Rrf2 repressor in Neisseria gonorrhoeae.
Isabella VM, Lapek JD, Kennedy EM, Clark VL., Mol Microbiol 71(1), 2009
PMID: 19007408
Dynamics of uptake and metabolism of small molecules in cellular response systems.
Werner M, Semsey S, Sneppen K, Krishna S., PLoS One 4(3), 2009
PMID: 19290058
Bacterial frataxin CyaY is the gatekeeper of iron-sulfur cluster formation catalyzed by IscS.
Adinolfi S, Iannuzzi C, Prischi F, Pastore C, Iametti S, Martin SR, Bonomi F, Pastore A., Nat Struct Mol Biol 16(4), 2009
PMID: 19305405
Small RNA-induced differential degradation of the polycistronic mRNA iscRSUA.
Desnoyers G, Morissette A, Prévost K, Massé E., EMBO J 28(11), 2009
PMID: 19407815
CymR, the master regulator of cysteine metabolism in Staphylococcus aureus, controls host sulphur source utilization and plays a role in biofilm formation.
Soutourina O, Poupel O, Coppée JY, Danchin A, Msadek T, Martin-Verstraete I., Mol Microbiol 73(2), 2009
PMID: 19508281
Cellular defenses against superoxide and hydrogen peroxide.
Imlay JA., Annu Rev Biochem 77(), 2008
PMID: 18173371
Fe-S cluster assembly pathways in bacteria.
Ayala-Castro C, Saini A, Outten FW., Microbiol Mol Biol Rev 72(1), 2008
PMID: 18322036
Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus.
Hochgräfe F, Wolf C, Fuchs S, Liebeke M, Lalk M, Engelmann S, Hecker M., J Bacteriol 190(14), 2008
PMID: 18487332
In vivo iron-sulfur cluster formation.
Raulfs EC, O'Carroll IP, Dos Santos PC, Unciuleac MC, Dean DR., Proc Natl Acad Sci U S A 105(25), 2008
PMID: 18562278
Bacterial ApbC can bind and effectively transfer iron-sulfur clusters.
Boyd JM, Pierik AJ, Netz DJ, Lill R, Downs DM., Biochemistry 47(31), 2008
PMID: 18616280
Regulation of Escherichia coli IscS desulfurase activity by ferrous iron and cysteine.
Wu G, Li P, Wu X., Biochem Biophys Res Commun 374(2), 2008
PMID: 18639525
Iron-sulfur cluster biogenesis systems and their crosstalk.
Xu XM, Møller SG., Chembiochem 9(15), 2008
PMID: 18798211
The impact of O(2) on the Fe-S cluster biogenesis requirements of Escherichia coli FNR.
Mettert EL, Outten FW, Wanta B, Kiley PJ., J Mol Biol 384(4), 2008
PMID: 18938178
The transcriptional repressor protein NsrR senses nitric oxide directly via a [2Fe-2S] cluster.
Tucker NP, Hicks MG, Clarke TA, Crack JC, Chandra G, Le Brun NE, Dixon R, Hutchings MI., PLoS One 3(11), 2008
PMID: 18989365
Transcription Factor NsrR from Bacillus subtilis Senses Nitric Oxide with a 4Fe-4S Cluster (†).
Yukl ET, Elbaz MA, Nakano MM, Moënne-Loccoz P., Biochemistry 47(49), 2008
PMID: 19006327
Iron-sulfur cluster biosynthesis.
Bandyopadhyay S, Chandramouli K, Johnson MK., Biochem Soc Trans 36(pt 6), 2008
PMID: 19021507
Regulation of denitrification genes in Neisseria meningitidis by nitric oxide and the repressor NsrR.
Rock JD, Thomson MJ, Read RC, Moir JW., J Bacteriol 189(3), 2007
PMID: 17122348
Nitric oxide in chemostat-cultured Escherichia coli is sensed by Fnr and other global regulators: unaltered methionine biosynthesis indicates lack of S nitrosation.
Pullan ST, Gidley MD, Jones RA, Barrett J, Stevanin TM, Read RC, Green J, Poole RK., J Bacteriol 189(5), 2007
PMID: 17189370
Regulators of bacterial responses to nitric oxide.
Spiro S., FEMS Microbiol Rev 31(2), 2007
PMID: 17313521
Gyrase inhibitors induce an oxidative damage cellular death pathway in Escherichia coli.
Dwyer DJ, Kohanski MA, Hayete B, Collins JJ., Mol Syst Biol 3(), 2007
PMID: 17353933
Bioinformatic prediction and experimental verification of Fur-regulated genes in the extreme acidophile Acidithiobacillus ferrooxidans.
Quatrini R, Lefimil C, Veloso FA, Pedroso I, Holmes DS, Jedlicki E., Nucleic Acids Res 35(7), 2007
PMID: 17355989
ROS as signalling molecules: mechanisms that generate specificity in ROS homeostasis.
D'Autréaux B, Toledano MB., Nat Rev Mol Cell Biol 8(10), 2007
PMID: 17848967
Global control of cysteine metabolism by CymR in Bacillus subtilis.
Even S, Burguière P, Auger S, Soutourina O, Danchin A, Martin-Verstraete I., J Bacteriol 188(6), 2006
PMID: 16513748
Genes of Escherichia coli O157:H7 that are involved in high-pressure resistance.
Malone AS, Chung YK, Yousef AE., Appl Environ Microbiol 72(4), 2006
PMID: 16597971
YfhJ, a molecular adaptor in iron-sulfur cluster formation or a frataxin-like protein?
Pastore C, Adinolfi S, Huynen MA, Rybin V, Martin S, Mayer M, Bukau B, Pastore A., Structure 14(5), 2006
PMID: 16698547
Beyond the Fur paradigm: iron-controlled gene expression in rhizobia.
Rudolph G, Hennecke H, Fischer HM., FEMS Microbiol Rev 30(4), 2006
PMID: 16774589
The nitric oxide-responsive regulator NsrR controls ResDE-dependent gene expression.
Nakano MM, Geng H, Nakano S, Kobayashi K., J Bacteriol 188(16), 2006
PMID: 16885456
Genetic regulation of fluxes: iron homeostasis of Escherichia coli.
Semsey S, Andersson AM, Krishna S, Jensen MH, Massé E, Sneppen K., Nucleic Acids Res 34(17), 2006
PMID: 16982641
Computational reconstruction of iron- and manganese-responsive transcriptional networks in alpha-proteobacteria.
Rodionov DA, Gelfand MS, Todd JD, Curson AR, Johnston AW., PLoS Comput Biol 2(12), 2006
PMID: 17173478
A novel endoribonuclease, RNase LS, in Escherichia coli.
Otsuka Y, Yonesaki T., Genetics 169(1), 2005
PMID: 15677746
Structure, function, and formation of biological iron-sulfur clusters.
Johnson DC, Dean DR, Smith AD, Johnson MK., Annu Rev Biochem 74(), 2005
PMID: 15952888
Sulfur and nitrogen limitation in Escherichia coli K-12: specific homeostatic responses.
Gyaneshwar P, Paliy O, McAuliffe J, Popham DL, Jordan MI, Kustu S., J Bacteriol 187(3), 2005
PMID: 15659685
Parasite plastids: approaching the endgame.
Wilson RJ., Biol Rev Camb Philos Soc 80(1), 2005
PMID: 15727041
Regulation of the Bacillus subtilis ytmI operon, involved in sulfur metabolism.
Burguière P, Fert J, Guillouard I, Auger S, Danchin A, Martin-Verstraete I., J Bacteriol 187(17), 2005
PMID: 16109943
Effect of RyhB small RNA on global iron use in Escherichia coli.
Massé E, Vanderpool CK, Gottesman S., J Bacteriol 187(20), 2005
PMID: 16199566
Role of the regulatory gene rirA in the transcriptional response of Sinorhizobium meliloti to iron limitation.
Chao TC, Buhrmester J, Hansmeier N, Pühler A, Weidner S., Appl Environ Microbiol 71(10), 2005
PMID: 16204511
Dissimilatory metabolism of nitrogen oxides in bacteria: comparative reconstruction of transcriptional networks.
Rodionov DA, Dubchak IL, Arkin AP, Alm EJ, Gelfand MS., PLoS Comput Biol 1(5), 2005
PMID: 16261196
Crystal structure of IscA, an iron-sulfur cluster assembly protein from Escherichia coli.
Cupp-Vickery JR, Silberg JJ, Ta DT, Vickery LE., J Mol Biol 338(1), 2004
PMID: 15050828
Transcription of the yeast iron regulon does not respond directly to iron but rather to iron-sulfur cluster biosynthesis.
Chen OS, Crisp RJ, Valachovic M, Bard M, Winge DR, Kaplan J., J Biol Chem 279(28), 2004
PMID: 15123701
Staphylococcal NreB: an O(2)-sensing histidine protein kinase with an O(2)-labile iron-sulphur cluster of the FNR type.
Kamps A, Achebach S, Fedtke I, Unden G, Götz F., Mol Microbiol 52(3), 2004
PMID: 15101978
Transcriptional analysis of biofilm formation processes in the anaerobic, hyperthermophilic bacterium Thermotoga maritima.
Pysz MA, Conners SB, Montero CI, Shockley KR, Johnson MR, Ward DE, Kelly RM., Appl Environ Microbiol 70(10), 2004
PMID: 15466556
Bacterial redox sensors.
Green J, Paget MS., Nat Rev Microbiol 2(12), 2004
PMID: 15550941
Escherichia coli endoribonucleases involved in cleavage of bacteriophage T4 mRNAs.
Otsuka Y, Ueno H, Yonesaki T., J Bacteriol 185(3), 2003
PMID: 12533474
The role of Fe-S proteins in sensing and regulation in bacteria.
Kiley PJ, Beinert H., Curr Opin Microbiol 6(2), 2003
PMID: 12732309
The fdxA ferredoxin gene can down-regulate frxA nitroreductase gene expression and is essential in many strains of Helicobacter pylori.
Mukhopadhyay AK, Jeong JY, Dailidiene D, Hoffman PS, Berg DE., J Bacteriol 185(9), 2003
PMID: 12700272
Xenorhabdus nematophila requires an intact iscRSUA-hscBA-fdx operon to colonize Steinernema carpocapsae nematodes.
Martens EC, Gawronski-Salerno J, Vokal DL, Pellitteri MC, Menard ML, Goodrich-Blair H., J Bacteriol 185(12), 2003
PMID: 12775707
Bacterial iron homeostasis.
Andrews SC, Robinson AK, Rodríguez-Quiñones F., FEMS Microbiol Rev 27(2-3), 2003
PMID: 12829269
Thermotoga maritima IscU. Structural characterization and dynamics of a new class of metallochaperone.
Bertini I, Cowan JA, Del Bianco C, Luchinat C, Mansy SS., J Mol Biol 331(4), 2003
PMID: 12909018
The Geobacillus stearothermophilus V iscS gene, encoding cysteine desulfurase, confers resistance to potassium tellurite in Escherichia coli K-12.
Tantaleán JC, Araya MA, Saavedra CP, Fuentes DE, Pérez JM, Calderón IL, Youderian P, Vásquez CC., J Bacteriol 185(19), 2003
PMID: 13129955
Recombinant Escherichia coli biotin synthase is a [2Fe-2S](2+) protein in whole cells.
Cosper MM, Jameson GN, Eidsness MK, Huynh BH, Johnson MK., FEBS Lett 529(2-3), 2002
PMID: 12372623
Feedback regulation of iron-sulfur cluster biosynthesis.
Frazzon J, Dean DR., Proc Natl Acad Sci U S A 98(26), 2001
PMID: 11752417

36 References

Daten bereitgestellt von Europe PubMed Central.

The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli.
Schwartz CJ, Djaman O, Imlay JA, Kiley PJ., Proc. Natl. Acad. Sci. U.S.A. 97(16), 2000
PMID: 10908675

Agar J, Zheng L, Cash V, Dean D, Johnson M., 2000
IscU as a scaffold for iron-sulfur cluster biosynthesis: sequential assembly of [2Fe-2S] and [4Fe-4S] clusters in IscU.
Agar JN, Krebs C, Frazzon J, Huynh BH, Dean DR, Johnson MK., Biochemistry 39(27), 2000
PMID: 10891064
Iron-sulfur cluster assembly: characterization of IscA and evidence for a specific and functional complex with ferredoxin.
Ollagnier-de-Choudens S, Mattioli T, Takahashi Y, Fontecave M., J. Biol. Chem. 276(25), 2001
PMID: 11319236
Modular organization and identification of a mononuclear iron-binding site within the NifU protein.
Agar JN, Yuvaniyama P, Jack RF, Cash VL, Smith AD, Dean DR, Johnson MK., J. Biol. Inorg. Chem. 5(2), 2000
PMID: 10819462

Patschkowski T, Bates D, Kiley P., 2000
Oxidative stress.
Storz G, Imlay JA., Curr. Opin. Microbiol. 2(2), 1999
PMID: 10322176
The AraC transcriptional activators.
Martin RG, Rosner JL., Curr. Opin. Microbiol. 4(2), 2001
PMID: 11282467
Ter, a function which generates the ends of the mature lambda chromosome.
Mousset S, Thomas R., Nature 221(5177), 1969
PMID: 5763077
One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.
Datsenko KA, Wanner BL., Proc. Natl. Acad. Sci. U.S.A. 97(12), 2000
PMID: 10829079
A collection of strains containing genetically linked alternating antibiotic resistance elements for genetic mapping of Escherichia coli.
Singer M, Baker TA, Schnitzler G, Deischel SM, Goel M, Dove W, Jaacks KJ, Grossman AD, Erickson JW, Gross CA., Microbiol. Rev. 53(1), 1989
PMID: 2540407

Miller J., 1972
Identification of a contact site for different transcription activators in region 4 of the Escherichia coli RNA polymerase sigma70 subunit.
Lonetto MA, Rhodius V, Lamberg K, Kiley P, Busby S, Gross C., J. Mol. Biol. 284(5), 1998
PMID: 9878355
Substitution of leucine 28 with histidine in the Escherichia coli transcription factor FNR results in increased stability of the [4Fe-4S](2+) cluster to oxygen.
Bates DM, Popescu CV, Khoroshilova N, Vogt K, Beinert H, Munck E, Kiley PJ., J. Biol. Chem. 275(9), 2000
PMID: 10692418
Evidence for the formation of a linear [3Fe-4S] cluster in partially unfolded aconitase.
Kennedy MC, Kent TA, Emptage M, Merkle H, Beinert H, Munck E., J. Biol. Chem. 259(23), 1984
PMID: 6094558
Iron-sulfur cluster disassembly in the FNR protein of Escherichia coli by O2: [4Fe-4S] to [2Fe-2S] conversion with loss of biological activity.
Khoroshilova N, Popescu C, Munck E, Beinert H, Kiley PJ., Proc. Natl. Acad. Sci. U.S.A. 94(12), 1997
PMID: 9177174

Beinert H, Orme-Johnson W, Palmer G., 1978

Palmer G., 1973
A gene encoding a DnaK/hsp70 homolog in Escherichia coli.
Seaton BL, Vickery LE., Proc. Natl. Acad. Sci. U.S.A. 91(6), 1994
PMID: 8134349
Redox signal transduction via iron-sulfur clusters in the SoxR transcription activator.
Hidalgo E, Ding H, Demple B., Trends Biochem. Sci. 22(6), 1997
PMID: 9204707
DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide.
Zheng M, Wang X, Templeton LJ, Smulski DR, LaRossa RA, Storz G., J. Bacteriol. 183(15), 2001
PMID: 11443091

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 11742080
PubMed | Europe PMC

Suchen in

Google Scholar