"Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue

Nahrwold M, Bogner T, Eissler S, Verma S, Sewald N (2010)
Organic Letters 12(5): 1064-1067.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Nahrwold, Markus; Bogner, Tobias; Eissler, Stefan; Verma, Spart; Sewald, NorbertUniBi
Einrichtung
Centrum für Biotechnologie > Institut für Biochemie und Biotechnik
Centrum für Biotechnologie > Arbeitsgruppe N. Sewald
Fakultät für Chemie > Organische Chemie III
Abstract / Bemerkung
An endocyclic trans-amide linkage within the macrocyclic antitumor agent cryptophycin-52 was replaced by a 1,4-disubstituted 1H-1,2,3-triazole ring. Macrocyclisation of the triazole analogue was accomplished by macrolactamization as well as by Cu(I)-mediated "click"-cyclization. Compared to cryptophycin-52, in vitro cytotoxicity of "clicktophycin-52" against the multidrug resistant human cancer cell line KB-V1 is only slightly reduced.
Erscheinungsjahr
2010
Zeitschriftentitel
Organic Letters
Band
12
Ausgabe
5
Seite(n)
1064-1067
ISSN
1523-7060
eISSN
1523-7052
Page URI
https://pub.uni-bielefeld.de/record/1796707

Zitieren

Nahrwold M, Bogner T, Eissler S, Verma S, Sewald N. "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. Organic Letters. 2010;12(5):1064-1067.
Nahrwold, M., Bogner, T., Eissler, S., Verma, S., & Sewald, N. (2010). "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. Organic Letters, 12(5), 1064-1067. https://doi.org/10.1021/ol1000473
Nahrwold, Markus, Bogner, Tobias, Eissler, Stefan, Verma, Spart, and Sewald, Norbert. 2010. “"Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue”. Organic Letters 12 (5): 1064-1067.
Nahrwold, M., Bogner, T., Eissler, S., Verma, S., and Sewald, N. (2010). "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. Organic Letters 12, 1064-1067.
Nahrwold, M., et al., 2010. "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. Organic Letters, 12(5), p 1064-1067.
M. Nahrwold, et al., “"Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue”, Organic Letters, vol. 12, 2010, pp. 1064-1067.
Nahrwold, M., Bogner, T., Eissler, S., Verma, S., Sewald, N.: "Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue. Organic Letters. 12, 1064-1067 (2010).
Nahrwold, Markus, Bogner, Tobias, Eissler, Stefan, Verma, Spart, and Sewald, Norbert. “"Clicktophycin-52": A Bioactive Cryptophycin-52 Triazole Analogue”. Organic Letters 12.5 (2010): 1064-1067.

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