Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study

Labudda K, Brand M, Mertens M, Ebner A, Markowitsch HJ, Woermann FG (2010)
NEUROCASE 16(1): 59-73.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Labudda, KirstenUniBi; Brand, MatthiasUniBi; Mertens, Markus; Ebner, Alois; Markowitsch, Hans J.UniBi; Woermann, Friedrich G.
Abstract / Bemerkung
We investigated the impact of a congenital prefrontal lesion and its resection on decision making under risk and under ambiguity in a patient with right mediofrontal cortical dysplasia. Both kinds of decision making are normally associated with the medial prefrontal cortex. We additionally studied pre- and postsurgical fMRI activations when processing information relevant for risky decision making. Results indicate selective impairments of ambiguous decision making pre- and postsurgically. Decision making under risk was intact. In contrast to healthy subjects the patient exhibited no activation within the dysplastic anterior cingulate cortex but left-sided orbitofrontal activation on the fMRI task suggesting early reorganization processes.
Frontal lobe; Congenital lesion; Neuropsychology; fMRI; Decision making; Malformation of cortical development
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Labudda K, Brand M, Mertens M, Ebner A, Markowitsch HJ, Woermann FG. Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study. NEUROCASE. 2010;16(1):59-73.
Labudda, K., Brand, M., Mertens, M., Ebner, A., Markowitsch, H. J., & Woermann, F. G. (2010). Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study. NEUROCASE, 16(1), 59-73.
Labudda, K., Brand, M., Mertens, M., Ebner, A., Markowitsch, H. J., and Woermann, F. G. (2010). Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study. NEUROCASE 16, 59-73.
Labudda, K., et al., 2010. Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study. NEUROCASE, 16(1), p 59-73.
K. Labudda, et al., “Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study”, NEUROCASE, vol. 16, 2010, pp. 59-73.
Labudda, K., Brand, M., Mertens, M., Ebner, A., Markowitsch, H.J., Woermann, F.G.: Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study. NEUROCASE. 16, 59-73 (2010).
Labudda, Kirsten, Brand, Matthias, Mertens, Markus, Ebner, Alois, Markowitsch, Hans J., and Woermann, Friedrich G. “Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study”. NEUROCASE 16.1 (2010): 59-73.

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