Weird fingers: Functional analysis of WIP domain proteins

Appelhagen I, Huep G, Lu G-H, Strompen G, Weisshaar B, Sagasser M (2010)
FEBS Letters 584(14): 3116-3122.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Abstract / Bemerkung
WIP proteins form a plant specific subfamily of C2H2 zinc finger (ZF) proteins. In this study, we functionally characterized the WIP domain, which consists of four ZF motifs, and discuss molecular functions for WIP proteins. Mutations in each of the ZFs lead to loss of function of the TT1/WIP1 protein in Arabiopsis thaliana. SV40 type nuclear localisation signals were detected in two of the ZFs and functionally characterized using GFP fusions as well as new mutant alleles identified by TILLING. Promoter swap experiments showed that selected WIP proteins are partially able to take over TT1 function. Activity of the AtBAN promoter, a potential TT1 target, could be increased by the addition of TT1 to the TT2-TT8-TTG1 regulatory complex. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Arabidopsis thaliana; Zinc finger; Nuclear localisation signal; Proanthocyanidins; Transcription factor; Transparent testa
FEBS Letters
Page URI


Appelhagen I, Huep G, Lu G-H, Strompen G, Weisshaar B, Sagasser M. Weird fingers: Functional analysis of WIP domain proteins. FEBS Letters. 2010;584(14):3116-3122.
Appelhagen, I., Huep, G., Lu, G. - H., Strompen, G., Weisshaar, B., & Sagasser, M. (2010). Weird fingers: Functional analysis of WIP domain proteins. FEBS Letters, 584(14), 3116-3122.
Appelhagen, I., Huep, G., Lu, G. - H., Strompen, G., Weisshaar, B., and Sagasser, M. (2010). Weird fingers: Functional analysis of WIP domain proteins. FEBS Letters 584, 3116-3122.
Appelhagen, I., et al., 2010. Weird fingers: Functional analysis of WIP domain proteins. FEBS Letters, 584(14), p 3116-3122.
I. Appelhagen, et al., “Weird fingers: Functional analysis of WIP domain proteins”, FEBS Letters, vol. 584, 2010, pp. 3116-3122.
Appelhagen, I., Huep, G., Lu, G.-H., Strompen, G., Weisshaar, B., Sagasser, M.: Weird fingers: Functional analysis of WIP domain proteins. FEBS Letters. 584, 3116-3122 (2010).
Appelhagen, Ingo, Huep, Gunnar, Lu, Gui-Hua, Strompen, Georg, Weisshaar, Bernd, and Sagasser, Martin. “Weird fingers: Functional analysis of WIP domain proteins”. FEBS Letters 584.14 (2010): 3116-3122.

10 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Deposition of a cutin apoplastic barrier separating seed maternal and zygotic tissues.
Coen O, Lu J, Xu W, De Vos D, Péchoux C, Domergue F, Grain D, Lepiniec L, Magnani E., BMC Plant Biol 19(1), 2019
PMID: 31291882
One Hundred Ways to Invent the Sexes: Theoretical and Observed Paths to Dioecy in Plants.
Henry IM, Akagi T, Tao R, Comai L., Annu Rev Plant Biol 69(), 2018
PMID: 29719167
Silencing of BnTT1 family genes affects seed flavonoid biosynthesis and alters seed fatty acid composition in Brassica napus.
Lian J, Lu X, Yin N, Ma L, Lu J, Liu X, Li J, Lu J, Lei B, Wang R, Chai Y., Plant Sci 254(), 2017
PMID: 27964783
TRANSPARENT TESTA 16 and 15 act through different mechanisms to control proanthocyanidin accumulation in Arabidopsis testa.
Xu W, Bobet S, Le Gourrierec J, Grain D, De Vos D, Berger A, Salsac F, Kelemen Z, Boucherez J, Rolland A, Mouille G, Routaboul JM, Lepiniec L, Dubos C., J Exp Bot 68(11), 2017
PMID: 28830101
TRANSPARENT TESTA GLABRA 1-Dependent Regulation of Flavonoid Biosynthesis.
Zhang B, Schrader A., Plants (Basel) 6(4), 2017
PMID: 29261137
TRANSPARENT TESTA 13 is a tonoplast P3A -ATPase required for vacuolar deposition of proanthocyanidins in Arabidopsis thaliana seeds.
Appelhagen I, Nordholt N, Seidel T, Spelt K, Koes R, Quattrochio F, Sagasser M, Weisshaar B., Plant J 82(5), 2015
PMID: 25891958
Regulation of flavonoid biosynthesis involves an unexpected complex transcriptional regulation of TT8 expression, in Arabidopsis.
Xu W, Grain D, Le Gourrierec J, Harscoët E, Berger A, Jauvion V, Scagnelli A, Berger N, Bidzinski P, Kelemen Z, Salsac F, Baudry A, Routaboul JM, Lepiniec L, Dubos C., New Phytol 198(1), 2013
PMID: 23398515

23 References

Daten bereitgestellt von Europe PubMed Central.

DNA recognition by Cys2His2 zinc finger proteins.
Wolfe SA, Nekludova L, Pabo CO., Annu Rev Biophys Biomol Struct 29(), 2000
PMID: 10940247
Zinc finger proteins: getting a grip on RNA.
Brown RS., Curr. Opin. Struct. Biol. 15(1), 2005
PMID: 15718139
Zinc finger proteins: new insights into structural and functional diversity.
Laity JH, Lee BM, Wright PE., Curr. Opin. Struct. Biol. 11(1), 2001
PMID: 11179890
The NTT gene is required for transmitting-tract development in carpels of Arabidopsis thaliana.
Crawford BC, Ditta G, Yanofsky MF., Curr. Biol. 17(13), 2007
PMID: 17600712
A transposon-induced epigenetic change leads to sex determination in melon.
Martin A, Troadec C, Boualem A, Rajab M, Fernandez R, Morin H, Pitrat M, Dogimont C, Bendahmane A., Nature 461(7267), 2009
PMID: 19847267
Genome-wide insertional mutagenesis of Arabidopsis thaliana.
Alonso JM, Stepanova AN, Leisse TJ, Kim CJ, Chen H, Shinn P, Stevenson DK, Zimmerman J, Barajas P, Cheuk R, Gadrinab C, Heller C, Jeske A, Koesema E, Meyers CC, Parker H, Prednis L, Ansari Y, Choy N, Deen H, Geralt M, Hazari N, Hom E, Karnes M, Mulholland C, Ndubaku R, Schmidt I, Guzman P, Aguilar-Henonin L, Schmid M, Weigel D, Carter DE, Marchand T, Risseeuw E, Brogden D, Zeko A, Crosby WL, Berry CC, Ecker JR., Science 301(5633), 2003
PMID: 12893945
Transactivation properties of parsley proline-rich bZIP transcription factors.
Sprenger-Haussels M, Weisshaar B., Plant J. 22(1), 2000
PMID: 10792815
TT2, TT8, and TTG1 synergistically specify the expression of BANYULS and proanthocyanidin biosynthesis in Arabidopsis thaliana.
Baudry A, Heim MA, Dubreucq B, Caboche M, Weisshaar B, Lepiniec L., Plant J. 39(3), 2004
PMID: 15255866
Influence of the testa on seed dormancy, germination, and longevity in Arabidopsis.
Debeaujon I, Leon-Kloosterziel KM, Koornneef M., Plant Physiol. 122(2), 2000
PMID: 10677433
The promoter of the Arabidopsis thaliana BAN gene is active in proanthocyanidin-accumulating cells of the Brassica napus seed coat.
Nesi N, Lucas MO, Auger B, Baron C, Lecureuil A, Guerche P, Kronenberger J, Lepiniec L, Debeaujon I, Renard M., Plant Cell Rep. 28(4), 2009
PMID: 19153740
Proanthocyanidin-accumulating cells in Arabidopsis testa: regulation of differentiation and role in seed development.
Debeaujon I, Nesi N, Perez P, Devic M, Grandjean O, Caboche M, Lepiniec L., Plant Cell 15(11), 2003
PMID: 14555692
Tannin analysis of food products.
Deshpande SS, Cheryan M, Salunkhe DK., Crit Rev Food Sci Nutr 24(4), 1986
PMID: 3536314
The nuclear pore complex: from molecular architecture to functional dynamics.
Stoffler D, Fahrenkrog B, Aebi U., Curr. Opin. Cell Biol. 11(3), 1999
PMID: 10395558
Dissection of a nuclear localization signal.
Hodel MR, Corbett AH, Hodel AE., J. Biol. Chem. 276(2), 2001
PMID: 11038364
MEME SUITE: tools for motif discovery and searching.
Bailey TL, Boden M, Buske FA, Frith M, Grant CE, Clementi L, Ren J, Li WW, Noble WS., Nucleic Acids Res. 37(Web Server issue), 2009
PMID: 19458158
Role of anthocyanidin reductase, encoded by BANYULS in plant flavonoid biosynthesis.
Xie DY, Sharma SB, Paiva NL, Ferreira D, Dixon RA., Science 299(5605), 2003
PMID: 12532018
Zinc fingers as protein recognition motifs: structural basis for the GATA-1/friend of GATA interaction.
Liew CK, Simpson RJ, Kwan AH, Crofts LA, Loughlin FE, Matthews JM, Crossley M, Mackay JP., Proc. Natl. Acad. Sci. U.S.A. 102(3), 2005
PMID: 15644435


Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®


PMID: 20541552
PubMed | Europe PMC

Suchen in

Google Scholar