Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms

Brinke M, Hoess S, Fink G, Ternes TA, Heininger P, Traunspurger W (2010)
AQUATIC TOXICOLOGY 99(2): 126-137.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Brinke, MarvinUniBi; Hoess, Sebastian; Fink, Guido; Ternes, Thomas A.; Heininger, Peter; Traunspurger, WalterUniBi
Abstract / Bemerkung
Ivermectin is a widely applied veterinary pharmaceutical that is highly toxic to several non-target organisms. So far, little is known about its impact on benthic freshwater species, although its rapid sorption to sediment particles and high persistence in aquatic sediments have raised concerns about the risk for benthic organisms. In the present study, indoor microcosms were used to assess the impact of ivermectin on freshwater meiobenthic communities over a period of 224 days. Microcosm sediments were directly spiked with ivermectin to achieve nominal concentrations of 0.9, 9, and 45 mu g kg(-1) dw. Initially measured ivermectin concentrations (day 0) were 0.6, 6.2, and 31 mu g kg(-1) dw. In addition to abundance of major meiobenthic organism groups, the nematode community was assessed on the species level, assuming a high risk for free-living nematodes due to their close phylogenetic relationship to the main target organisms of ivermectin, parasitic nematodes. Benthic microcrustaceans (cladocerans, ostracods) and nematodes showed the most sensitive response to ivermectin, while tardigrades profited from the presence of the pharmaceutical. The most pronounced effects on the meiofauna community composition occurred at the highest treatment level (31 mu g kg(-1) dw), leading to a no observed effect concentration (NOECcommunity) of 6.2 mu g kg(-1) dw. However, the nematode community was already seriously affected at a concentration of 6.2 mu g kg(-1) dw with two bacterivorous genera, Monhystera and Eumonhystera, being the most sensitive, whereas species of omnivorous genera (Tripyla, Tobrilus) increased in abundance after the application of ivermectin. Thus, a NOECcommunity of 0.6 mu g kg(-1) dw was derived for nematodes. Direct and indirect effects of ivermectin on meiobenthic communities could be demonstrated. The pharmaceutical is likely to pose a high risk, because its NOECs are close to predicted environmental concentrations (PECs) in sediments (0.45-2.17 mu g kg(-1) dw), resulting in worst case risk quotients (RQs) of 1.05-36.2. This observation lends support to efforts aimed at preventing the repeated entry of ivermectin in aquatic environments and thus its accumulation in sediments. Moreover, this study points out that model ecosystem studies should be part of environmental risk assessments (ERAs) of veterinary medicinal products (VMPs). (C) 2010 Elsevier B.V. All rights reserved.
Stichworte
Pharmaceutical; Ivermectin; Meiofauna; Nematodes; Community; Microcosm
Erscheinungsjahr
2010
Zeitschriftentitel
AQUATIC TOXICOLOGY
Band
99
Ausgabe
2
Seite(n)
126-137
ISSN
0166-445X
Page URI
https://pub.uni-bielefeld.de/record/1794440

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Brinke M, Hoess S, Fink G, Ternes TA, Heininger P, Traunspurger W. Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms. AQUATIC TOXICOLOGY. 2010;99(2):126-137.
Brinke, M., Hoess, S., Fink, G., Ternes, T. A., Heininger, P., & Traunspurger, W. (2010). Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms. AQUATIC TOXICOLOGY, 99(2), 126-137. https://doi.org/10.1016/j.aquatox.2010.04.008
Brinke, Marvin, Hoess, Sebastian, Fink, Guido, Ternes, Thomas A., Heininger, Peter, and Traunspurger, Walter. 2010. “Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms”. AQUATIC TOXICOLOGY 99 (2): 126-137.
Brinke, M., Hoess, S., Fink, G., Ternes, T. A., Heininger, P., and Traunspurger, W. (2010). Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms. AQUATIC TOXICOLOGY 99, 126-137.
Brinke, M., et al., 2010. Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms. AQUATIC TOXICOLOGY, 99(2), p 126-137.
M. Brinke, et al., “Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms”, AQUATIC TOXICOLOGY, vol. 99, 2010, pp. 126-137.
Brinke, M., Hoess, S., Fink, G., Ternes, T.A., Heininger, P., Traunspurger, W.: Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms. AQUATIC TOXICOLOGY. 99, 126-137 (2010).
Brinke, Marvin, Hoess, Sebastian, Fink, Guido, Ternes, Thomas A., Heininger, Peter, and Traunspurger, Walter. “Assessing effects of the pharmaceutical ivermectin on meiobenthic communities using freshwater microcosms”. AQUATIC TOXICOLOGY 99.2 (2010): 126-137.

14 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Is Caenorhabditis elegans representative of freshwater nematode species in toxicity testing?
Haegerbaeumer A, Höss S, Heininger P, Traunspurger W., Environ Sci Pollut Res Int 25(3), 2018
PMID: 29143265
Effects of ivermectin on Danio rerio: a multiple endpoint approach: behaviour, weight and subcellular markers.
Domingues I, Oliveira R, Soares AM, Amorim MJ., Ecotoxicology 25(3), 2016
PMID: 26769347
Effect of ivermectin on the larvae of Anopheles gambiae and Culex quinquefasciatus.
Derua YA, Malongo BB, Simonsen PE., Parasit Vectors 9(), 2016
PMID: 26951712
A comparative approach using ecotoxicological methods from single-species bioassays to model ecosystems.
Haegerbaeumer A, Höss S, Ristau K, Claus E, Möhlenkamp C, Heininger P, Traunspurger W., Environ Toxicol Chem 35(12), 2016
PMID: 27155316
Experimental studies with nematodes in ecotoxicology: an overview.
Hägerbäumer A, Höss S, Heininger P, Traunspurger W., J Nematol 47(1), 2015
PMID: 25861113
Response of bacteria and meiofauna to iron oxide colloids in sediments of freshwater microcosms.
Höss S, Frank-Fahle B, Lueders T, Traunspurger W., Environ Toxicol Chem 34(11), 2015
PMID: 26031573
Sediment contact tests as a tool for the assessment of sediment quality in German waters.
Feiler U, Höss S, Ahlf W, Gilberg D, Hammers-Wirtz M, Hollert H, Meller M, Neumann-Hensel H, Ottermanns R, Seiler TB, Spira D, Heininger P., Environ Toxicol Chem 32(1), 2013
PMID: 23027525
Ozonation of trimethoprim in aqueous solution: identification of reaction products and their toxicity.
Kuang J, Huang J, Wang B, Cao Q, Deng S, Yu G., Water Res 47(8), 2013
PMID: 23541309
A review on the toxicity and non-target effects of macrocyclic lactones in terrestrial and aquatic environments.
Lumaret JP, Errouissi F, Floate K, Römbke J, Wardhaugh K., Curr Pharm Biotechnol 13(6), 2012
PMID: 22039795
Using meiofauna to assess pollutants in freshwater sediments: a microcosm study with cadmium.
Brinke M, Ristau K, Bergtold M, Höss S, Claus E, Heininger P, Traunspurger W., Environ Toxicol Chem 30(2), 2011
PMID: 21038433
Nematode species at risk--a metric to assess pollution in soft sediments of freshwaters.
Höss S, Claus E, Von der Ohe PC, Brinke M, Güde H, Heininger P, Traunspurger W., Environ Int 37(5), 2011
PMID: 21482435
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