MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes

Vogt E, Sanhaji M, Klein W, Seidel T, Wordeman L, Eichenlaub-Ritter U (2010)
MOLECULAR HUMAN REPRODUCTION 16(9): 665-684.

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DOI
Autor*in
Vogt, E.; Sanhaji, M.; Klein, W.; Seidel, ThorstenUniBi; Wordeman, L.; Eichenlaub-Ritter, UrsulaUniBi
Einrichtung
Fakultät für Biologie > Gentechnologie/Mikrobiologie
Fakultät für Biologie > Biochemie und Physiologie der Pflanzen
Abstract / Bemerkung
Mitotic centromere-associated kinesin (MCAK) is an ATP-dependent microtubule (MT) depolymerase regulated by Aurora kinase (AURK) phosphorylation and implicated in resolution of improper MT attachments in mitosis. Distribution of MCAK was studied in oocyte maturation by anti-MCAK antibody, anti-tubulin antibody, anti-AURKB antibody and anti-centromere antibody (ACA) and by the expression of MCAK-enhanced green fluorescent protein fusion protein in maturing mouse oocytes. Function was assessed by knockdown of MCAK and Mad2, by inhibiting AURK or the proteasome, by live imaging with polarization microscope and by chromosomal analysis. The results show that MCAK is transiently recruited to the nucleus and transits to spindle poles, ACA-positive domains and chiasmata at prometaphase I. At metaphase I and II, it is present at centrosomes and centromeres next to AURKB and checkpoint proteins Mad2 and BubR1. It is retained at centromeres at telophase I and also at the midbody. Knockdown of MCAK causes a delay in chromosome congression but does not prevent bipolar spindle assembly. MCAK knockdown also induces a meiosis I arrest, which is overcome by knockdown of Mad2 resulting in chiasma resolution, chromosome separation, formation of aberrant meiosis II spindles and increased hypoploidy. In conclusion, MCAK appears to possess a unique distribution and function in oocyte maturation. It is required for meiotic progression from meiosis I to meiosis II associated with silencing of the spindle assembly checkpoint. Alterations in abundance and activity of MCAK, as implicated in aged oocytes, may therefore contribute to the loss of control of cell cycle and chromosome behaviour, thus increasing risk for errors in chromosome segregation and aneuploidy.
Stichworte
oocyte; spindle; MCAK; meiosis; aneuploidy
Erscheinungsjahr
2010
Zeitschriftentitel
MOLECULAR HUMAN REPRODUCTION
Band
16
Ausgabe
9
Seite(n)
665-684
ISSN
1360-9947
eISSN
1460-2407
Page URI
https://pub.uni-bielefeld.de/record/1793990

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Vogt E, Sanhaji M, Klein W, Seidel T, Wordeman L, Eichenlaub-Ritter U. MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes. MOLECULAR HUMAN REPRODUCTION. 2010;16(9):665-684.
Vogt, E., Sanhaji, M., Klein, W., Seidel, T., Wordeman, L., & Eichenlaub-Ritter, U. (2010). MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes. MOLECULAR HUMAN REPRODUCTION, 16(9), 665-684. https://doi.org/10.1093/molehr/gaq025
Vogt, E., Sanhaji, M., Klein, W., Seidel, Thorsten, Wordeman, L., and Eichenlaub-Ritter, Ursula. 2010. “MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes”. MOLECULAR HUMAN REPRODUCTION 16 (9): 665-684.
Vogt, E., Sanhaji, M., Klein, W., Seidel, T., Wordeman, L., and Eichenlaub-Ritter, U. (2010). MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes. MOLECULAR HUMAN REPRODUCTION 16, 665-684.
Vogt, E., et al., 2010. MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes. MOLECULAR HUMAN REPRODUCTION, 16(9), p 665-684.
E. Vogt, et al., “MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes”, MOLECULAR HUMAN REPRODUCTION, vol. 16, 2010, pp. 665-684.
Vogt, E., Sanhaji, M., Klein, W., Seidel, T., Wordeman, L., Eichenlaub-Ritter, U.: MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes. MOLECULAR HUMAN REPRODUCTION. 16, 665-684 (2010).
Vogt, E., Sanhaji, M., Klein, W., Seidel, Thorsten, Wordeman, L., and Eichenlaub-Ritter, Ursula. “MCAK is present at centromeres, midspindle and chiasmata and involved in silencing of the spindle assembly checkpoint in mammalian oocytes”. MOLECULAR HUMAN REPRODUCTION 16.9 (2010): 665-684.

18 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Meiotic spindle formation in mammalian oocytes: implications for human infertility.
Namgoong S, Kim NH., Biol Reprod 98(2), 2018
PMID: 29342242
Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.
Nguyen AL, Marin D, Zhou A, Gentilello AS, Smoak EM, Cao Z, Fedick A, Wang Y, Taylor D, Scott RT, Xing J, Treff N, Schindler K., Mol Hum Reprod 23(6), 2017
PMID: 28369513
Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes.
Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fröhlich T, Arnold GJ, Grümmer R, Horsthemke B, Eichenlaub-Ritter U., Hum Reprod 31(1), 2016
PMID: 26577303
Comparative Proteomic Analysis of Buffalo Oocytes Matured in vitro Using iTRAQ Technique.
Chen L, Zhai L, Qu C, Zhang C, Li S, Wu F, Qi Y, Lu F, Xu P, Li X, Shi D., Sci Rep 6(), 2016
PMID: 27561356
Microtubule dynamics and tumor invasion involving MCAK.
Eichenlaub-Ritter U., Cell Cycle 14(21), 2015
PMID: 26375511
Expression and characterization of three Aurora kinase C splice variants found in human oocytes.
Fellmeth JE, Gordon D, Robins CE, Scott RT, Treff NR, Schindler K., Mol Hum Reprod 21(8), 2015
PMID: 25995441
Molecular insight into the regulation and function of MCAK.
Ritter A, Kreis NN, Louwen F, Wordeman L, Yuan J., Crit Rev Biochem Mol Biol 51(4), 2015
PMID: 27146484
KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly.
Connolly AA, Sugioka K, Chuang CH, Lowry JB, Bowerman B., J Cell Biol 210(6), 2015
PMID: 26370499
The effects of glial cell line-derived neurotrophic factor on the in vitro matured porcine oocyte transcriptome.
Toms D, Tsoi S, Dobrinsky J, Dyck MK, Li J., Mol Reprod Dev 81(3), 2014
PMID: 24293385
The kinesin-13 KLP10A motor regulates oocyte spindle length and affects EB1 binding without altering microtubule growth rates.
Do KK, Hoàng KL, Endow SA., Biol Open 3(7), 2014
PMID: 24907370
Spindle assembly checkpoint and its regulators in meiosis.
Sun SC, Kim NH., Hum Reprod Update 18(1), 2012
PMID: 22086113
Polar body emission.
Liu XJ., Cytoskeleton (Hoboken) 69(10), 2012
PMID: 22730245
Aurora B regulates spindle bipolarity in meiosis in vertebrate oocytes.
Shao H, Ma C, Zhang X, Li R, Miller AL, Bement WM, Liu XJ., Cell Cycle 11(14), 2012
PMID: 22751439
Microtubule-depolymerizing kinesin KLP10A restricts the length of the acentrosomal meiotic spindle in Drosophila females.
Radford SJ, Harrison AM, McKim KS., Genetics 192(2), 2012
PMID: 22865737
Environmental hazard in the aetiology of somatic and germ cell aneuploidy.
Pacchierotti F, Eichenlaub-Ritter U., Cytogenet Genome Res 133(2-4), 2011
PMID: 21228560
On the origin of crossover interference: A chromosome oscillatory movement (COM) model.
Hultén MA., Mol Cytogenet 4(), 2011
PMID: 21477316
Evidence that carbonyl stress by methylglyoxal exposure induces DNA damage and spindle aberrations, affects mitochondrial integrity in mammalian oocytes and contributes to oocyte ageing.
Tatone C, Heizenrieder T, Di Emidio G, Treffon P, Amicarelli F, Seidel T, Eichenlaub-Ritter U., Hum Reprod 26(7), 2011
PMID: 21558076
Folliculogenesis and oogenesis: from basic science to the clinic.
Hillier SG, Smitz J, Eichenlaub-Ritter U., Mol Hum Reprod 16(9), 2010
PMID: 20693269

105 References

Daten bereitgestellt von Europe PubMed Central.

Gender differences in the induction of chromosomal aberrations and gene mutations in rodent germ cells.
Adler ID, Carere A, Eichenlaub-Ritter U, Pacchierotti F., Environ. Res. 104(1), 2006
PMID: 17052706
Aurora B regulates MCAK at the mitotic centromere.
Andrews PD, Ovechkina Y, Morrice N, Wagenbach M, Duncan K, Wordeman L, Swedlow JR., Dev. Cell 6(2), 2004
PMID: 14960279
Genome stability is ensured by temporal control of kinetochore-microtubule dynamics.
Bakhoum SF, Thompson SL, Manning AL, Compton DA., Nat. Cell Biol. 11(1), 2008
PMID: 19060894
Aneuploidy
Bond, 1983
Cytoskeleton and cell cycle control during meiotic maturation of the mouse oocyte: integrating time and space.
Brunet S, Maro B., Reproduction 130(6), 2005
PMID: 16322540
Meiotic regulation of TPX2 protein levels governs cell cycle progression in mouse oocytes.
Brunet S, Dumont J, Lee KW, Kinoshita K, Hikal P, Gruss OJ, Maro B, Verlhac MH., PLoS ONE 3(10), 2008
PMID: 18833336
Linking kinetochore-microtubule binding to the spindle checkpoint.
Burke DJ, Stukenberg PT., Dev. Cell 14(4), 2008
PMID: 18410725
Chromosome congression in the absence of kinetochore fibres.
Cai S, O'Connell CB, Khodjakov A, Walczak CE., Nat. Cell Biol. 11(7), 2009
PMID: 19525938
Centrosome and microtubule dynamics during early stages of meiosis in mouse oocytes.
Can A, Semiz O, Cinar O., Mol. Hum. Reprod. 9(12), 2003
PMID: 14614036
Sorting and reorganization of centrosomes during oocyte maturation in the mouse.
Carabatsos MJ, Combelles CM, Messinger SM, Albertini DF., Microsc. Res. Tech. 49(5), 2000
PMID: 10842370
Spatial coordination of spindle assembly by chromosome-mediated signaling gradients.
Caudron M, Bunt G, Bastiaens P, Karsenti E., Science 309(5739), 2005
PMID: 16123300
Aurora kinase promotes turnover of kinetochore microtubules to reduce chromosome segregation errors.
Cimini D, Wan X, Hirel CB, Salmon ED., Curr. Biol. 16(17), 2006
PMID: 16950108
Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling.
Cleveland DW, Mao Y, Sullivan KF., Cell 112(4), 2003
PMID: 12600307
Dual roles of Incenp crucial to the assembly of the acentrosomal metaphase spindle in female meiosis.
Colombie N, Cullen CF, Brittle AL, Jang JK, Earnshaw WC, Carmena M, McKim K, Ohkura H., Development 135(19), 2008
PMID: 18755775
Localization of CENP-E in the fibrous corona and outer plate of mammalian kinetochores from prometaphase through anaphase.
Cooke CA, Schaar B, Yen TJ, Earnshaw WC., Chromosoma 106(7), 1997
PMID: 9391217
Aurora-A and ch-TOG act in a common pathway in control of spindle pole integrity.
De Luca M, Brunetto L, Asteriti IA, Giubettini M, Lavia P, Guarguaglini G., Oncogene 27(51), 2008
PMID: 18663358
Kinetochore-independent chromosome poleward movement during anaphase of meiosis II in mouse eggs.
Deng M, Gao J, Suraneni P, Li R., PLoS ONE 4(4), 2009
PMID: 19365562
Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores.
Ditchfield C, Johnson VL, Tighe A, Ellston R, Haworth C, Johnson T, Mortlock A, Keen N, Taylor SS., J. Cell Biol. 161(2), 2003
PMID: 12719470
Chromosome missegregation and apoptosis in mice lacking the mitotic checkpoint protein Mad2.
Dobles M, Liberal V, Scott ML, Benezra R, Sorger PK., Cell 101(6), 2000
PMID: 10892650
Chloral hydrate induced spindle aberrations, metaphase I arrest and aneuploidy in mouse oocytes.
Eichenlaub-Ritter U, Betzendahl I., Mutagenesis 10(6), 1995
PMID: 8596466
Nocodazole sensitivity, age-related aneuploidy, and alterations in the cell cycle during maturation of mouse oocytes.
Eichenlaub-Ritter U, Boll I., Cytogenet. Cell Genet. 52(3-4), 1989
PMID: 2535312
2-methoxyestradiol induces spindle aberrations, chromosome congression failure, and nondisjunction in mouse oocytes.
Eichenlaub-Ritter U, Winterscheidt U, Vogt E, Shen Y, Tinneberg HR, Sorensen R., Biol. Reprod. 76(5), 2007
PMID: 17229934
The interplay of the N- and C-terminal domains of MCAK control microtubule depolymerization activity and spindle assembly.
Ems-McClung SC, Hertzer KM, Zhang X, Miller MW, Walczak CE., Mol. Biol. Cell 18(1), 2006
PMID: 17093055
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient.
Fuller BG, Lampson MA, Foley EA, Rosasco-Nitcher S, Le KV, Tobelmann P, Brautigan DL, Stukenberg PT, Kapoor TM., Nature 453(7198), 2008
PMID: 18463638
A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex.
Gassmann R, Essex A, Hu JS, Maddox PS, Motegi F, Sugimoto A, O'Rourke SM, Bowerman B, McLeod I, Yates JR 3rd, Oegema K, Cheeseman IM, Desai A., Genes Dev. 22(17), 2008
PMID: 18765790
The 3Ms of central spindle assembly: microtubules, motors and MAPs.
Glotzer M., Nat. Rev. Mol. Cell Biol. 10(1), 2009
PMID: 19197328
Functional overlap of microtubule assembly factors in chromatin-promoted spindle assembly.
Groen AC, Maresca TJ, Gatlin JC, Salmon ED, Mitchison TJ., Mol. Biol. Cell 20(11), 2009
PMID: 19369413
Gene expression profiles of single human mature oocytes in relation to age.
Grondahl ML, Yding Andersen C, Bogstad J, Nielsen FC, Meinertz H, Borup R., Hum. Reprod. 25(4), 2010
PMID: 20147335
Age-associated alteration of gene expression patterns in mouse oocytes.
Hamatani T, Falco G, Carter MG, Akutsu H, Stagg CA, Sharov AA, Dudekula DB, VanBuren V, Ko MS., Hum. Mol. Genet. 13(19), 2004
PMID: 15317747
The depolymerizing kinesin MCAK uses lattice diffusion to rapidly target microtubule ends.
Helenius J, Brouhard G, Kalaidzidis Y, Diez S, Howard J., Nature 441(7089), 2006
PMID: 16672973
Simultaneous analysis of chromosomes and chromosome-associated proteins in mammalian oocytes and embryos.
Hodges CA, Hunt PA., Chromosoma 111(3), 2002
PMID: 12355205
Control of homologous chromosome division in the mammalian oocyte.
Holt JE, Jones KT., Mol. Hum. Reprod. 15(3), 2009
PMID: 19179408
Mad2 is required for inhibiting securin and cyclin B degradation following spindle depolymerisation in meiosis I mouse oocytes.
Homer HA, McDougall A, Levasseur M, Murdoch AP, Herbert M., Reproduction 130(6), 2005
PMID: 16322543
RNA interference in meiosis I human oocytes: towards an understanding of human aneuploidy.
Homer HA, McDougall A, Levasseur M, Murdoch AP, Herbert M., Mol. Hum. Reprod. 11(6), 2005
PMID: 15908454
Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes.
Homer HA, McDougall A, Levasseur M, Yallop K, Murdoch AP, Herbert M., Genes Dev. 19(2), 2005
PMID: 15655110
Tripin/hSgo2 recruits MCAK to the inner centromere to correct defective kinetochore attachments.
Huang H, Feng J, Famulski J, Rattner JB, Liu ST, Kao GD, Muschel R, Chan GK, Yen TJ., J. Cell Biol. 177(3), 2007
PMID: 17485487
Sex matters in meiosis.
Hunt PA, Hassold TJ., Science 296(5576), 2002
PMID: 12077403
Chromosome cohesion in mitosis and meiosis.
Ishiguro K, Watanabe Y., J. Cell. Sci. 120(Pt 3), 2007
PMID: 17251376
TIP150 interacts with and targets MCAK at the microtubule plus ends.
Jiang K, Wang J, Liu J, Ward T, Wordeman L, Davidson A, Wang F, Yao X., EMBO Rep. 10(8), 2009
PMID: 19543227
The proteasome is involved in the first metaphase-to-anaphase transition of meiosis in rat oocytes.
Josefsberg LB, Galiani D, Dantes A, Amsterdam A, Dekel N., Biol. Reprod. 62(5), 2000
PMID: 10775176
Inhibition of aurora B kinase blocks chromosome segregation, overrides the spindle checkpoint, and perturbs microtubule dynamics in mitosis.
Kallio MJ, McCleland ML, Stukenberg PT, Gorbsky GJ., Curr. Biol. 12(11), 2002
PMID: 12062053
Comparative analysis of meiotic progression in female mice bearing mutations in genes of the DNA mismatch repair pathway.
Kan R, Sun X, Kolas NK, Avdievich E, Kneitz B, Edelmann W, Cohen PE., Biol. Reprod. 78(3), 2007
PMID: 18057311
Successful inactivation of endogenous Oct-3/4 and c-mos genes in mouse preimplantation embryos and oocytes using short interfering RNAs.
Kim MH, Yuan X, Okumura S, Ishikawa F., Biochem. Biophys. Res. Commun. 296(5), 2002
PMID: 12207927
CENP-E combines a slow, processive motor and a flexible coiled coil to produce an essential motile kinetochore tether.
Kim Y, Heuser JE, Waterman CM, Cleveland DW., J. Cell Biol. 181(3), 2008
PMID: 18443223
Dynein is a transient kinetochore component whose binding is regulated by microtubule attachment, not tension.
King JM, Hays TS, Nicklas RB., J. Cell Biol. 151(4), 2000
PMID: 11076960
The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells.
Kline-Smith SL, Walczak CE., Mol. Biol. Cell 13(8), 2002
PMID: 12181341
Depletion of centromeric MCAK leads to chromosome congression and segregation defects due to improper kinetochore attachments.
Kline-Smith SL, Khodjakov A, Hergert P, Walczak CE., Mol. Biol. Cell 15(3), 2003
PMID: 14699064
Sex-specific differences in meiotic chromosome segregation revealed by dicentric bridge resolution in mice.
Koehler KE, Millie EA, Cherry JP, Burgoyne PS, Evans EP, Hunt PA, Hassold TJ., Genetics 162(3), 2002
PMID: 12454080
Aurora B phosphorylates centromeric MCAK and regulates its localization and microtubule depolymerization activity.
Lan W, Zhang X, Kline-Smith SL, Rosasco SE, Barrett-Wilt GA, Shabanowitz J, Hunt DF, Walczak CE, Stukenberg PT., Curr. Biol. 14(4), 2004
PMID: 14972678
Proteasome inhibitors: valuable new tools for cell biologists.
Lee DH, Goldberg AL., Trends Cell Biol. 8(10), 1998
PMID: 9789328
Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells.
Lee J, Kitajima TS, Tanno Y, Yoshida K, Morita T, Miyano T, Miyake M, Watanabe Y., Nat. Cell Biol. 10(1), 2007
PMID: 18084284
Modulating multidrug resistance gene in leukaemia cells by short interfering RNA.
Lim MN, Lau NS, Chang KM, Leong CF, Zakaria Z., Singapore Med J 48(10), 2007
PMID: 17909680
Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates.
Liu D, Vader G, Vromans MJ, Lampson MA, Lens SM., Science 323(5919), 2009
PMID: 19150808
Nuclear localization of NORs and centromeres in mouse oocytes during folliculogenesis.
Longo F, Garagna S, Merico V, Orlandini G, Gatti R, Scandroglio R, Redi CA, Zuccotti M., Mol. Reprod. Dev. 66(3), 2003
PMID: 14502607
Mitotic centromere-associated kinesin is important for anaphase chromosome segregation.
Maney T, Hunter AW, Wagenbach M, Wordeman L., J. Cell Biol. 142(3), 1998
PMID: 9700166
The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells.
Manning AL, Ganem NJ, Bakhoum SF, Wagenbach M, Wordeman L, Compton DA., Mol. Biol. Cell 18(8), 2007
PMID: 17538014
The human kinesin Kif18A is a motile microtubule depolymerase essential for chromosome congression.
Mayr MI, Hummer S, Bormann J, Gruner T, Adio S, Woehlke G, Mayer TU., Curr. Biol. 17(6), 2007
PMID: 17346968
Centrosome and microtubule dynamics during meiotic progression in the mouse oocyte.
Messinger SM, Albertini DF., J. Cell. Sci. 100 ( Pt 2)(), 1991
PMID: 1721916
MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells.
Michel LS, Liberal V, Chatterjee A, Kirchwegger R, Pasche B, Gerald W, Dobles M, Sorger PK, Murty VV, Benezra R., Nature 409(6818), 2001
PMID: 11201745
MCAK associates with the tips of polymerizing microtubules.
Moore AT, Rankin KE, von Dassow G, Peris L, Wagenbach M, Ovechkina Y, Andrieux A, Job D, Wordeman L., J. Cell Biol. 169(3), 2005
PMID: 15883193
Not all germ cells are created equal: aspects of sexual dimorphism in mammalian meiosis.
Morelli MA, Cohen PE., Reproduction 130(6), 2005
PMID: 16322537
Bub1 and aurora B cooperate to maintain BubR1-mediated inhibition of APC/CCdc20.
Morrow CJ, Tighe A, Johnson VL, Scott MI, Ditchfield C, Taylor SS., J. Cell. Sci. 118(Pt 16), 2005
PMID: 16046481
The kinase activity of aurora B is required for kinetochore-microtubule interactions during mitosis.
Murata-Hori M, Wang YL., Curr. Biol. 12(11), 2002
PMID: 12062052
The spindle-assembly checkpoint in space and time.
Musacchio A, Salmon ED., Nat. Rev. Mol. Cell Biol. 8(5), 2007
PMID: 17426725
Disseminating the genome: joining, resolving, and separating sister chromatids during mitosis and meiosis.
Nasmyth K., Annu. Rev. Genet. 35(), 2001
PMID: 11700297
Changing Mad2 levels affects chromosome segregation and spindle assembly checkpoint control in female mouse meiosis I.
Niault T, Hached K, Sotillo R, Sorger PK, Maro B, Benezra R, Wassmann K., PLoS ONE 2(11), 2007
PMID: 18043727
Differentiation of cytoplasmic and meiotic spindle assembly MCAK functions by Aurora B-dependent phosphorylation.
Ohi R, Sapra T, Howard J, Mitchison TJ., Mol. Biol. Cell 15(6), 2004
PMID: 15064354
Gender effects on the incidence of aneuploidy in mammalian germ cells.
Pacchierotti F, Adler ID, Eichenlaub-Ritter U, Mailhes JB., Environ. Res. 104(1), 2007
PMID: 17292877
Age-associated increase in aneuploidy and changes in gene expression in mouse eggs.
Pan H, Ma P, Zhu W, Schultz RM., Dev. Biol. 316(2), 2008
PMID: 18342300
A perikinetochoric ring defined by MCAK and Aurora-B as a novel centromere domain.
Parra MT, Gomez R, Viera A, Page J, Calvente A, Wordeman L, Rufas JS, Suja JA., PLoS Genet. 2(6), 2006
PMID: 16741559
Sequential assembly of centromeric proteins in male mouse meiosis.
Parra MT, Gomez R, Viera A, Llano E, Pendas AM, Rufas JS, Suja JA., PLoS Genet. 5(3), 2009
PMID: 19283064
Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR.
Pfaffl MW, Horgan GW, Dempfle L., Nucleic Acids Res. 30(9), 2002
PMID: 11972351
Egg activation at fertilization: where it all begins.
Runft LL, Jaffe LA, Mehlmann LM., Dev. Biol. 245(2), 2002
PMID: 11977978
The chromosomal passenger complex is required for chromatin-induced microtubule stabilization and spindle assembly.
Sampath SC, Ohi R, Leismann O, Salic A, Pozniakovski A, Funabiki H., Cell 118(2), 2004
PMID: 15260989
Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes.
Schuh M, Ellenberg J., Cell 130(3), 2007
PMID: 17693257
Cytoplasmic dynein is required for poleward chromosome movement during mitosis in Drosophila embryos.
Sharp DJ, Rogers GC, Scholey JM., Nat. Cell Biol. 2(12), 2000
PMID: 11146657
Non-invasive method to assess genotoxicity of nocodazole interfering with spindle formation in mammalian oocytes.
Shen Y, Betzendahl I, Sun F, Tinneberg HR, Eichenlaub-Ritter U., Reprod. Toxicol. 19(4), 2005
PMID: 15749259
Enhanced polarizing microscopy as a new tool in aneuploidy research in oocytes.
Shen Y, Betzendahl I, Tinneberg HR, Eichenlaub-Ritter U., Mutat. Res. 651(1-2), 2007
PMID: 18160331
Aurora kinase B modulates chromosome alignment in mouse oocytes.
Shuda K, Schindler K, Ma J, Schultz RM, Donovan PJ., Mol. Reprod. Dev. 76(11), 2009
PMID: 19565641
Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint.
Sivaram MV, Wadzinski TL, Redick SD, Manna T, Doxsey SJ., EMBO J. 28(7), 2009
PMID: 19229290
Mad2 overexpression promotes aneuploidy and tumorigenesis in mice.
Sotillo R, Hernando E, Diaz-Rodriguez E, Teruya-Feldstein J, Cordon-Cardo C, Lowe SW, Benezra R., Cancer Cell 11(1), 2006
PMID: 17189715
Association between spindle assembly checkpoint expression and maternal age in human oocytes.
Steuerwald N, Cohen J, Herrera RJ, Sandalinas M, Brenner CA., Mol. Hum. Reprod. 7(1), 2001
PMID: 11134360
Maternal age-related differential global expression profiles observed in human oocytes.
Steuerwald NM, Bermudez MG, Wells D, Munne S, Cohen J., Reprod. Biomed. Online 14(6), 2007
PMID: 17579982
Regulation of spindle and chromatin dynamics during early and late stages of oocyte maturation by aurora kinases.
Swain JE, Ding J, Wu J, Smith GD., Mol. Hum. Reprod. 14(5), 2008
PMID: 18353803
Kif15 cooperates with eg5 to promote bipolar spindle assembly.
Tanenbaum ME, Macurek L, Janssen A, Geers EF, Alvarez-Fernandez M, Medema RH., Curr. Biol. 19(20), 2009
PMID: 19818618
The meiosis I-to-meiosis II transition in mouse oocytes requires separase activity.
Terret ME, Wassmann K, Waizenegger I, Maro B, Peters JM, Verlhac MH., Curr. Biol. 13(20), 2003
PMID: 14561405
Kinetochore stretching inactivates the spindle assembly checkpoint.
Uchida KS, Takagaki K, Kumada K, Hirayama Y, Noda T, Hirota T., J. Cell Biol. 184(3), 2009
PMID: 19188492
Chromosomal passengers: the four-dimensional regulation of mitotic events.
Vagnarelli P, Earnshaw WC., Chromosoma 113(5), 2004
PMID: 15351889
Spindle formation, chromosome segregation and the spindle checkpoint in mammalian oocytes and susceptibility to meiotic error.
Vogt E, Kirsch-Volders M, Parry J, Eichenlaub-Ritter U., Mutat. Res. 651(1-2), 2007
PMID: 18096427
Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes.
Vogt E, Kipp A, Eichenlaub-Ritter U., Reprod. Biomed. Online 19(3), 2009
PMID: 19778480
Multiple mechanisms of chromosome movement in vertebrate cells mediated through the Ndc80 complex and dynein/dynactin.
Vorozhko VV, Emanuele MJ, Kallio MJ, Stukenberg PT, Gorbsky GJ., Chromosoma 117(2), 2007
PMID: 18057949
XKCM1: a Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly.
Walczak CE, Mitchison TJ, Desai A., Cell 84(1), 1996
PMID: 8548824
The microtubule-destabilizing kinesin XKCM1 is required for chromosome positioning during spindle assembly.
Walczak CE, Gan EC, Desai A, Mitchison TJ, Kline-Smith SL., Curr. Biol. 12(21), 2002
PMID: 12419191
Inhibition of Aurora kinases perturbs chromosome alignment and spindle checkpoint signaling in rat spermatocytes.
Wang Y, Toppari J, Parvinen M, Kallio MJ., Exp. Cell Res. 312(18), 2006
PMID: 16962097
Does aneuploidy cause cancer?
Weaver BA, Cleveland DW., Curr. Opin. Cell Biol. 18(6), 2006
PMID: 17046232
Specific interference with gene function by double-stranded RNA in early mouse development.
Wianny F, Zernicka-Goetz M., Nat. Cell Biol. 2(2), 2000
PMID: 10655585
CENP-E is a plus end-directed kinetochore motor required for metaphase chromosome alignment.
Wood KW, Sakowicz R, Goldstein LS, Cleveland DW., Cell 91(3), 1997
PMID: 9363944
Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis.
Wordeman L, Mitchison TJ., J. Cell Biol. 128(1-2), 1995
PMID: 7822426
MCAK facilitates chromosome movement by promoting kinetochore microtubule turnover.
Wordeman L, Wagenbach M, von Dassow G., J. Cell Biol. 179(5), 2007
PMID: 18039936
Across the meiotic divide - CSF activity in the post-Emi2/XErp1 era.
Wu JQ, Kornbluth S., J. Cell. Sci. 121(Pt 21), 2008
PMID: 18946022
Mitotic requirement for aurora A kinase is bypassed in the absence of aurora B kinase.
Yang H, Burke T, Dempsey J, Diaz B, Collins E, Toth J, Beckmann R, Ye X., FEBS Lett. 579(16), 2005
PMID: 15922328
Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function.
Zhang X, Lan W, Ems-McClung SC, Stukenberg PT, Walczak CE., Mol. Biol. Cell 18(9), 2007
PMID: 17567953
Cytoplasmic dynein participates in meiotic checkpoint inactivation in mouse oocytes by transporting cytoplasmic mitotic arrest-deficient (Mad) proteins from kinetochores to spindle poles.
Zhang D, Yin S, Jiang MX, Ma W, Hou Y, Liang CG, Yu LZ, Wang WH, Sun QY., Reproduction 133(4), 2007
PMID: 17504913
Aurora A phosphorylates MCAK to control ran-dependent spindle bipolarity.
Zhang X, Ems-McClung SC, Walczak CE., Mol. Biol. Cell 19(7), 2008
PMID: 18434591
Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference.
Zhu C, Zhao J, Bibikova M, Leverson JD, Bossy-Wetzel E, Fan JB, Abraham RT, Jiang W., Mol. Biol. Cell 16(7), 2005
PMID: 15843429
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