Urinary neopterin concentrations vs total neopterins for clinical utility

Fuchs D, Milstien S, Krämer A, Reibnegger G, Werner ER, Goedert JJ, Kaufman S, Wachter H (1989)
Clinical Chemistry 35(12): 2305-2307.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA
Autor*in
Fuchs, Dietmar; Milstien, Sheldon; Krämer, AlexanderUniBi ; Reibnegger, Gilbert; Werner, Ernst R.; Goedert, James J.; Kaufman, Seymour; Wachter, Helmut
Abstract / Bemerkung
Neopterin measurements are especially useful as an early marker in (e.g.) allograft rejections and in patients infected with human immunodeficiency virus type 1 (HIV-1). An increased concentration of total neopterins (neopterin + dihydroneopterin) is also a significant marker in patients with HIV-1 infection. In this study we compared concentrations of neopterin and total neopterins in urine samples from 77 homosexual men with and 73 without established HIV-1 infection. HIV- 1-seropositive homosexual men had higher concentrations of neopterin and total neopterins (and 7,8-dihydroneopterin) in their urine than did those who were HIV-1-seronegative, and there was a close correlation between neopterin and total neopterins. Both neopterin variables correlated inversely with CD4 + T-cell counts and CD4 +/CD8 + T-cell ratios but not with CD8+ T-cell counts in the HIV-1-seropositive men. Our data indicate that measurements of neopterin and total neopterins are of almost equal potential for clinical diagnosis. However, when measuring total neopterins, which includes oxidation of 7,8- dihydroneopterin to neopterin, more strict requirements of sample collection and handling are necessary to avoid degradation of the 7,8- dihydro derivative.
Erscheinungsjahr
1989
Zeitschriftentitel
Clinical Chemistry
Band
35
Ausgabe
12
Seite(n)
2305-2307
Page URI
https://pub.uni-bielefeld.de/record/1784165

Zitieren

Fuchs D, Milstien S, Krämer A, et al. Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry. 1989;35(12):2305-2307.
Fuchs, D., Milstien, S., Krämer, A., Reibnegger, G., Werner, E. R., Goedert, J. J., Kaufman, S., et al. (1989). Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry, 35(12), 2305-2307.
Fuchs, D., Milstien, S., Krämer, A., Reibnegger, G., Werner, E. R., Goedert, J. J., Kaufman, S., and Wachter, H. (1989). Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry 35, 2305-2307.
Fuchs, D., et al., 1989. Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry, 35(12), p 2305-2307.
D. Fuchs, et al., “Urinary neopterin concentrations vs total neopterins for clinical utility”, Clinical Chemistry, vol. 35, 1989, pp. 2305-2307.
Fuchs, D., Milstien, S., Krämer, A., Reibnegger, G., Werner, E.R., Goedert, J.J., Kaufman, S., Wachter, H.: Urinary neopterin concentrations vs total neopterins for clinical utility. Clinical Chemistry. 35, 2305-2307 (1989).
Fuchs, Dietmar, Milstien, Sheldon, Krämer, Alexander, Reibnegger, Gilbert, Werner, Ernst R., Goedert, James J., Kaufman, Seymour, and Wachter, Helmut. “Urinary neopterin concentrations vs total neopterins for clinical utility”. Clinical Chemistry 35.12 (1989): 2305-2307.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Copyright Statement:
Dieses Objekt ist durch das Urheberrecht und/oder verwandte Schutzrechte geschützt. [...]
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2019-09-06T08:48:54Z
MD5 Prüfsumme
aa677b8bbbaf06c0b4f34712c3e44da8

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Suchen in

Google Scholar