Urinary neopterin concentrations and T-cell subset data in HIV-1 infection

Reibnegger G, Fuchs D, Goedert JJ, Hausen A, Krämer A, Werner ER, Werner-Felmayer G, Dierich MP, Wachter H (1990)
Journal of Molecular Medicine 68(1): 43-48.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
URN
urn:nbn:de:0070-pub-17840537
Autor*in
Reibnegger, Gilbert; Fuchs, Dietmar; Goedert, James J.; Hausen, A.; Krämer, AlexanderUniBi ; Werner, Ernst R.; Werner-Felmayer, G.; Dierich, M. P.; Wachter, Helmut
Einrichtung
Fakultät für Gesundheitswissenschaften > AG 2 Bevölkerungsmedizin und Versorgungsforschung
Abstract / Bemerkung
We investigated the ability of urinary neopterin concentrations and T-cell subset data, and their ratios to discriminate between anti-HIV-1 seronegatives, seropositives, and AIDS cases. Using receiver-operated-characteristics curves, neopterin levels were shown to provide the best discrimination. Of the ratios derived from the single variables, neopterin per CD4+ cell counts and neopterin per CD4+/CD8+ cell ratio were superior to the CD4+/CD8+ cell ratio. Multivariate analyses were performed using a generalized likelihood ratio approach as well as linear discriminant analysis. The combination of neopterin concentration and CD4+ T-cell count is well suited to discriminate between various stages of HIV-1 infection and, therefore, we recommend using more than one assay to evaluate disease progression.
Stichworte
HIV infection; Generalized likelihood ratio technique; Classification; T-cell subsets; Neopterin
Erscheinungsjahr
1990
Zeitschriftentitel
Journal of Molecular Medicine
Band
68
Ausgabe
1
Seite(n)
43-48
ISSN
0023-2173
eISSN
1432-1440
Page URI
https://pub.uni-bielefeld.de/record/1784053

Zitieren

Reibnegger G, Fuchs D, Goedert JJ, et al. Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine. 1990;68(1):43-48.
Reibnegger, G., Fuchs, D., Goedert, J. J., Hausen, A., Krämer, A., Werner, E. R., Werner-Felmayer, G., et al. (1990). Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine, 68(1), 43-48. https://doi.org/10.1007/BF01648890
Reibnegger, Gilbert, Fuchs, Dietmar, Goedert, James J., Hausen, A., Krämer, Alexander, Werner, Ernst R., Werner-Felmayer, G., Dierich, M. P., and Wachter, Helmut. 1990. “Urinary neopterin concentrations and T-cell subset data in HIV-1 infection”. Journal of Molecular Medicine 68 (1): 43-48.
Reibnegger, G., Fuchs, D., Goedert, J. J., Hausen, A., Krämer, A., Werner, E. R., Werner-Felmayer, G., Dierich, M. P., and Wachter, H. (1990). Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine 68, 43-48.
Reibnegger, G., et al., 1990. Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine, 68(1), p 43-48.
G. Reibnegger, et al., “Urinary neopterin concentrations and T-cell subset data in HIV-1 infection”, Journal of Molecular Medicine, vol. 68, 1990, pp. 43-48.
Reibnegger, G., Fuchs, D., Goedert, J.J., Hausen, A., Krämer, A., Werner, E.R., Werner-Felmayer, G., Dierich, M.P., Wachter, H.: Urinary neopterin concentrations and T-cell subset data in HIV-1 infection. Journal of Molecular Medicine. 68, 43-48 (1990).
Reibnegger, Gilbert, Fuchs, Dietmar, Goedert, James J., Hausen, A., Krämer, Alexander, Werner, Ernst R., Werner-Felmayer, G., Dierich, M. P., and Wachter, Helmut. “Urinary neopterin concentrations and T-cell subset data in HIV-1 infection”. Journal of Molecular Medicine 68.1 (1990): 43-48.
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1 Zitation in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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PMID: 1710305

15 References

Daten bereitgestellt von Europe PubMed Central.

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