Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils

Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR (2008)
Journal of Negative Results in BioMedicine 7(1): 2.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA
Autor*in
Brummelte, Susanne; Grund, Thorsten; Moll, Gunther H.; Teuchert-Noodt, GertraudUniBi; Dawirs, Ralph R.
Abstract / Bemerkung
It is widely believed, that environmental factors play a crucial role in the etiology and outcome of psychiatric diseases such as Attention-Deficit/Hyperactivity Disorder (ADHD). A former study from our laboratory has shown that both methylphenidate (MP) and handling have a positive effect on the dopaminergic fiber density in the prefrontal cortex (PFC) of early traumatized gerbils (Meriones unguiculatus). The current study was performed to investigate if enriched environment during MP application has an additional influence on the dopaminergic and GABAergic fiber densities in the PFC and amygdala in this animal model. Animals received a single early dose of methamphetamine (MA; 50 mg/kg; i.p.) on postnatal day (PD) 14, which is known to cause multiple changes in the subsequent development of several neurotransmitter systems including the dopaminergic systems, and were then treated with oral daily applications of MP (5 mg/kg) from PD30–60. Animals treated this way were either transferred to an enriched environment after weaning (on PD30) or were kept under impoverished rearing conditions. There was no effect of an enriched environment on the dopaminergic or GABAergic fiber density neither in the PFC nor in the amygdala. With regard to former studies these results underline the particular impact of MP in the treatment of ADHD.
Erscheinungsjahr
2008
Zeitschriftentitel
Journal of Negative Results in BioMedicine
Band
7
Ausgabe
1
Art.-Nr.
2
ISSN
1477-5751
Page URI
https://pub.uni-bielefeld.de/record/1783761

Zitieren

Brummelte S, Grund T, Moll GH, Teuchert-Noodt G, Dawirs RR. Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine. 2008;7(1): 2.
Brummelte, S., Grund, T., Moll, G. H., Teuchert-Noodt, G., & Dawirs, R. R. (2008). Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine, 7(1), 2. https://doi.org/10.1186/1477-5751-7-2
Brummelte, S., Grund, T., Moll, G. H., Teuchert-Noodt, G., and Dawirs, R. R. (2008). Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine 7:2.
Brummelte, S., et al., 2008. Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine, 7(1): 2.
S. Brummelte, et al., “Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils”, Journal of Negative Results in BioMedicine, vol. 7, 2008, : 2.
Brummelte, S., Grund, T., Moll, G.H., Teuchert-Noodt, G., Dawirs, R.R.: Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils. Journal of Negative Results in BioMedicine. 7, : 2 (2008).
Brummelte, Susanne, Grund, Thorsten, Moll, Gunther H., Teuchert-Noodt, Gertraud, and Dawirs, Ralph R. “Environmental enrichment has no effect on the development of dopaminergic and GABAergic fibers during methylphenidate treatment of early traumatized gerbils”. Journal of Negative Results in BioMedicine 7.1 (2008): 2.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Copyright Statement:
Dieses Objekt ist durch das Urheberrecht und/oder verwandte Schutzrechte geschützt. [...]
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2019-09-06T08:48:53Z
MD5 Prüfsumme
8d6577c45780c0ac3429a25bed92e651

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Oroxylin A improves attention deficit hyperactivity disorder-like behaviors in the spontaneously hypertensive rat and inhibits reuptake of dopamine in vitro.
Yoon SY, dela Peña I, Kim SM, Woo TS, Shin CY, Son KH, Park H, Lee YS, Ryu JH, Jin M, Kim KM, Cheong JH., Arch Pharm Res 36(1), 2013
PMID: 23371806
Effect of postnatal methamphetamine trauma and adolescent methylphenidate treatment on adult hippocampal neurogenesis in gerbils.
Schaefers AT, Teuchert-Noodt G, Bagorda F, Brummelte S., Eur J Pharmacol 616(1-3), 2009
PMID: 19540225

48 References

Daten bereitgestellt von Europe PubMed Central.

EINAQ -- a European educational initiative on Attention-Deficit Hyperactivity Disorder and associated problems.
Rothenberger A, Danckaerts M, Dopfner M, Sergeant J, Steinhausen HC., Eur Child Adolesc Psychiatry 13 Suppl 1(), 2004
PMID: 15322954
Affinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters.
Gatley SJ, Pan D, Chen R, Chaturvedi G, Ding YS., Life Sci. 58(12), 1996
PMID: 8786705
Dopamine reuptake by norepinephrine neurons: exception or rule?
Carboni E, Silvagni A., Crit Rev Neurobiol 16(1-2), 2004
PMID: 15581407
Therapeutic doses of oral methylphenidate significantly increase extracellular dopamine in the human brain.
Volkow ND, Wang G, Fowler JS, Logan J, Gerasimov M, Maynard L, Ding Y, Gatley SJ, Gifford A, Franceschi D., J. Neurosci. 21(2), 2001
PMID: 11160455
Atomoxetine increases extracellular levels of norepinephrine and dopamine in prefrontal cortex of rat: a potential mechanism for efficacy in attention deficit/hyperactivity disorder.
Bymaster FP, Katner JS, Nelson DL, Hemrick-Luecke SK, Threlkeld PG, Heiligenstein JH, Morin SM, Gehlert DR, Perry KW., Neuropsychopharmacology 27(5), 2002
PMID: 12431845
Animal models of attention-deficit hyperactivity disorder.
Russell VA, Sagvolden T, Johansen EB., Behav Brain Funct 1(), 2005
PMID: 16022733
High midbrain [18F]DOPA accumulation in children with attention deficit hyperactivity disorder.
Ernst M, Zametkin AJ, Matochik JA, Pascualvaca D, Jons PH, Cohen RM., Am J Psychiatry 156(8), 1999
PMID: 10450262
Toward a pathophysiology of attention-deficit/hyperactivity disorder.
Castellanos FX., Clin Pediatr (Phila) 36(7), 1997
PMID: 9241475
Influence of methylphenidate on brain development--an update of recent animal experiments.
Grund T, Lehmann K, Bock N, Rothenberger A, Teuchert-Noodt G., Behav Brain Funct 2(), 2006
PMID: 16403217
Developmentally induced imbalance of dopaminergic fibre densities in limbic brain regions of gerbils ( Meriones unguiculatus).
Busche A, Polascheck D, Lesting J, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 111(4), 2004
PMID: 15057515
Relationship of family environment and parental psychiatric diagnosis to impairment in ADHD.
Pressman LJ, Loo SK, Carpenter EM, Asarnow JR, Lynn D, McCracken JT, McGough JJ, Lubke GH, Yang MH, Smalley SL., J Am Acad Child Adolesc Psychiatry 45(3), 2006
PMID: 16540820
Family-environment risk factors for attention-deficit hyperactivity disorder. A test of Rutter's indicators of adversity.
Biederman J, Milberger S, Faraone SV, Kiely K, Guite J, Mick E, Ablon S, Warburton R, Reed E., Arch. Gen. Psychiatry 52(6), 1995
PMID: 7771916
Can inattention/overactivity be an institutional deprivation syndrome?
Kreppner JM, O'Connor TG, Rutter M; English and Romanian Adoptees Study Team., J Abnorm Child Psychol 29(6), 2001
PMID: 11761285
Dopamine presynaptically and heterogeneously modulates nucleus accumbens medium-spiny neuron GABA synapses in vitro.
Geldwert D, Norris JM, Feldman IG, Schulman JJ, Joyce MP, Rayport S., BMC Neurosci 7(), 2006
PMID: 16813648
Direct protein-protein coupling enables cross-talk between dopamine D5 and gamma-aminobutyric acid A receptors.
Liu F, Wan Q, Pristupa ZB, Yu XM, Wang YT, Niznik HB., Nature 403(6767), 2000
PMID: 10659839
Alteration in the GABAergic network of the prefrontal cortex in a potential animal model of psychosis.
Brummelte S, Neddens J, Teuchert-Noodt G., J Neural Transm (Vienna) 114(5), 2007
PMID: 17195918
Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).
Dawirs RR, Teuchert-Noodt G, Nossoll M., Eur. J. Pharmacol. 327(2-3), 1997
PMID: 9200549
Ontogeny of the dopamine innervation in the nucleus accumbens of gerbils.
Lesting J, Neddens J, Teuchert-Noodt G., Brain Res. 1066(1-2), 2005
PMID: 16343448
Early methylphenidate administration to young rats causes a persistent reduction in the density of striatal dopamine transporters.
Moll GH, Hause S, Ruther E, Rothenberger A, Huether G., J Child Adolesc Psychopharmacol 11(1), 2001
PMID: 11322741
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
ADHD - beyond core symptoms. Not only a European perspective.
Rothenberger A, Dopfner M, Sergeant J, Steinhausen HC., 2004
Attention and behavioural problems of Finnish adolescents may be related to the family environment.
Hurtig T, Taanila A, Ebeling H, Miettunen J, Moilanen I., Eur Child Adolesc Psychiatry 14(8), 2005
PMID: 16341505
European clinical guidelines for hyperkinetic disorder -- first upgrade.
Taylor E, Dopfner M, Sergeant J, Asherson P, Banaschewski T, Buitelaar J, Coghill D, Danckaerts M, Rothenberger A, Sonuga-Barke E, Steinhausen HC, Zuddas A., Eur Child Adolesc Psychiatry 13 Suppl 1(), 2004
PMID: 15322953
Long-acting medications for the hyperkinetic disorders. A systematic review and European treatment guideline.
Banaschewski T, Coghill D, Santosh P, Zuddas A, Asherson P, Buitelaar J, Danckaerts M, Dopfner M, Faraone SV, Rothenberger A, Sergeant J, Steinhausen HC, Sonuga-Barke EJ, Taylor E., Eur Child Adolesc Psychiatry 15(8), 2006
PMID: 16680409
Differential environment alters ontogeny of dopamine innervation of the orbital prefrontal cortex in gerbils.
Neddens J, Brandenburg K, Teuchert-Noodt G, Dawirs RR., J. Neurosci. Res. 63(2), 2001
PMID: 11169631
Acute handling stress modulates methylphenidate-induced catecholamine overflow in the medial prefrontal cortex.
Marsteller DA, Gerasimov MR, Schiffer WK, Geiger JM, Barnett CR, Schaich Borg J, Scott S, Ceccarelli J, Volkow ND, Molina PE, Alexoff DL, Dewey SL., Neuropsychopharmacology 27(2), 2002
PMID: 12093590
The effects of neonatal handling on the development of the adrenocortical response to stress: implications for neuropathology and cognitive deficits in later life.
Meaney MJ, Mitchell JB, Aitken DH, Bhatnagar S, Bodnoff SR, Iny LJ, Sarrieau A., Psychoneuroendocrinology 16(1-3), 1991
PMID: 1961847
Effects of neonatal handling on the behavior and prolactin stress response in male and female rats at various ages and estrous cycle phases of females.
Severino GS, Fossati IA, Padoin MJ, Gomes CM, Trevizan L, Sanvitto GL, Franci CR, Anselmo-Franci JA, Lucion AB., Physiol. Behav. 81(3), 2004
PMID: 15135021

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Quellen

PMID: 18485211
PubMed | Europe PMC

Suchen in

Google Scholar