Structural heterogeneity of membrane receptors and GTP-binding proteins and its functional consequences for signal transduction

Boege F, Neumann E, Helmreich EJM (1991)
European Journal of Biochemistry 199(1): 1-15.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Abstract / Bemerkung
Recent information obtained, mainly by recombinant cDNA technology, on structural heterogeneity of hormone and transmitter receptors, of GTP-binding proteins (G-proteins) and, especially, of G-protein-linked receptors is reviewed and the implications of structural heterogeneity for diversity of hormone and transmitter actions is discussed. For the future, three-dimensional structural analysis of membrane proteins participating in signal transmission and transduction pathways is needed in order to understand the molecular basis of allosteric regulatory mechanisms governing the interactions between these proteins including hysteretic properties and cell-cybernetic aspects.
Stichworte
NUCLEOTIDE REGULATORY PROTEINS; BETA-ADRENERGIC-RECEPTOR; AMINO-ACID SEQUENCE; NICOTINIC ACETYLCHOLINE-RECEPTOR; MUSCARINIC K+-CHANNEL
Erscheinungsjahr
1991
Zeitschriftentitel
European Journal of Biochemistry
Band
199
Ausgabe
1
Seite(n)
1-15
ISSN
0014-2956
eISSN
1432-1033
Page URI
https://pub.uni-bielefeld.de/record/1774560

Zitieren

Boege F, Neumann E, Helmreich EJM. Structural heterogeneity of membrane receptors and GTP-binding proteins and its functional consequences for signal transduction. European Journal of Biochemistry. 1991;199(1):1-15.
Boege, F., Neumann, E., & Helmreich, E. J. M. (1991). Structural heterogeneity of membrane receptors and GTP-binding proteins and its functional consequences for signal transduction. European Journal of Biochemistry, 199(1), 1-15. doi:10.1111/j.1432-1033.1991.tb16085.x
Boege, F., Neumann, E., and Helmreich, E. J. M. (1991). Structural heterogeneity of membrane receptors and GTP-binding proteins and its functional consequences for signal transduction. European Journal of Biochemistry 199, 1-15.
Boege, F., Neumann, E., & Helmreich, E.J.M., 1991. Structural heterogeneity of membrane receptors and GTP-binding proteins and its functional consequences for signal transduction. European Journal of Biochemistry, 199(1), p 1-15.
F. Boege, E. Neumann, and E.J.M. Helmreich, “Structural heterogeneity of membrane receptors and GTP-binding proteins and its functional consequences for signal transduction”, European Journal of Biochemistry, vol. 199, 1991, pp. 1-15.
Boege, F., Neumann, E., Helmreich, E.J.M.: Structural heterogeneity of membrane receptors and GTP-binding proteins and its functional consequences for signal transduction. European Journal of Biochemistry. 199, 1-15 (1991).
Boege, Fritz, Neumann, Eberhard, and Helmreich, Ernst J. M. “Structural heterogeneity of membrane receptors and GTP-binding proteins and its functional consequences for signal transduction”. European Journal of Biochemistry 199.1 (1991): 1-15.
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