Theoretical implication of liganding reactions in axonal sodium channel gating

Dorogi PL, Neumann E (1980)
Neurochemistry International 2: 45-51.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
OA
Autor/in
;
Abstract / Bemerkung
Mathematical simulation models for measured permeability properties of axonal Na+ channels point to the presence of bimolecular, as well as net-membrane-field-dependent intramolecular, reaction steps in channel gating reactions. An abstract chemical reaction model is presented, which postulates ligand binding reactions in both Na+ channel activation and subsequent desensitization as observed in voltage-clamp experiments. Membrane capacitance currents due to the movement of charged or dipolar gating structures also indicate that the early phase of the gating charge movement is dictated by local, rather than net-membrane-field-driven reactions, and therefore reflect energy input from chemical sources which are an integral part of the membrane.
Stichworte
Asymmetric membrane capacitance; Electrochemical gating model
Erscheinungsjahr
1980
Zeitschriftentitel
Neurochemistry International
Band
2
Seite(n)
45-51
ISSN
ARRAY(0x9011a60)
Page URI
https://pub.uni-bielefeld.de/record/1774434

Zitieren

Dorogi PL, Neumann E. Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International. 1980;2:45-51.
Dorogi, P. L., & Neumann, E. (1980). Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International, 2, 45-51. doi:10.1016/0197-0186(80)90010-8
Dorogi, P. L., and Neumann, E. (1980). Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International 2, 45-51.
Dorogi, P.L., & Neumann, E., 1980. Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International, 2, p 45-51.
P.L. Dorogi and E. Neumann, “Theoretical implication of liganding reactions in axonal sodium channel gating”, Neurochemistry International, vol. 2, 1980, pp. 45-51.
Dorogi, P.L., Neumann, E.: Theoretical implication of liganding reactions in axonal sodium channel gating. Neurochemistry International. 2, 45-51 (1980).
Dorogi, Peter L., and Neumann, Eberhard. “Theoretical implication of liganding reactions in axonal sodium channel gating”. Neurochemistry International 2 (1980): 45-51.
Alle Dateien verfügbar unter der/den folgenden Lizenz(en):
Copyright Statement:
This Item is protected by copyright and/or related rights. [...]
Volltext(e)
Access Level
OA Open Access
Zuletzt Hochgeladen
2019-09-06T08:48:11Z
MD5 Prüfsumme
0a53e4283e6628ae975caaf8a4fde0ca

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Suchen in

Google Scholar