Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14
Fuchs S, Resch K, Thiel C, Ulbrich-Lesner M, Platzer M, Jockusch H, Schmitt-John T (2002)
BMC Genetics 3(1): 14.
Zeitschriftenaufsatz
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Autor*in
Fuchs, Sonja;
Resch, Karin;
Thiel, Cora;
Ulbrich-Lesner, MichaelUniBi;
Platzer, Matthias;
Jockusch, HaraldUniBi;
Schmitt-John, Thomas
Einrichtung
Abstract / Bemerkung
Background: To support the positional cloning of the mouse mutation wobbler (wr) the corresponding regions on human Chr2p13-14 and mouse Chr11 were analyzed in detail and compared with respect to gene content, order, and orientation. Results: The gene content of the investigated regions was highly conserved between the two species: 20 orthologous genes were identified on our BAC/YAC contig comprising 4.5 Mb between REL/Rel and RAB1A/Rab1a. Exceptions were pseudogenes ELP and PX19 whose mouse counterparts were not located within the analyzed region. Two independently isolated genomic clones indicate an inversion between man and mouse with the inverted segment being identical to the wobbler critical interval. We investigated the wobbler critical region by extensive STS/EST mapping and genomic sequencing. Additionally, the full-length cDNA sequences of four newly mapped genes as well as the previously mapped gene Otx1 were established and subjected to mutation analysis. Our data indicate that all genes in the wr critical region have been identified. Conclusion: Unexpectedly, neither mutation analysis of cDNAs nor levels of mRNAs indicated which of the candidate genes might be affected by the wr mutation. The possibility arises that there might be hitherto unknown effects of mutations, in addition to structural changes of the mRNA or regulatory abnormalities.
Erscheinungsjahr
2002
Zeitschriftentitel
BMC Genetics
Band
3
Ausgabe
1
Art.-Nr.
14
ISSN
1471-2156
Page URI
https://pub.uni-bielefeld.de/record/1773792
Zitieren
Fuchs S, Resch K, Thiel C, et al. Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genetics. 2002;3(1): 14.
Fuchs, S., Resch, K., Thiel, C., Ulbrich-Lesner, M., Platzer, M., Jockusch, H., & Schmitt-John, T. (2002). Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genetics, 3(1), 14. https://doi.org/10.1186/1471-2156-3-14
Fuchs, Sonja, Resch, Karin, Thiel, Cora, Ulbrich-Lesner, Michael, Platzer, Matthias, Jockusch, Harald, and Schmitt-John, Thomas. 2002. “Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14”. BMC Genetics 3 (1): 14.
Fuchs, S., Resch, K., Thiel, C., Ulbrich-Lesner, M., Platzer, M., Jockusch, H., and Schmitt-John, T. (2002). Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genetics 3:14.
Fuchs, S., et al., 2002. Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genetics, 3(1): 14.
S. Fuchs, et al., “Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14”, BMC Genetics, vol. 3, 2002, : 14.
Fuchs, S., Resch, K., Thiel, C., Ulbrich-Lesner, M., Platzer, M., Jockusch, H., Schmitt-John, T.: Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14. BMC Genetics. 3, : 14 (2002).
Fuchs, Sonja, Resch, Karin, Thiel, Cora, Ulbrich-Lesner, Michael, Platzer, Matthias, Jockusch, Harald, and Schmitt-John, Thomas. “Comparative transcription map of the wobbler critical region on mouse chromosome 11 and the homologous region on human chromosome 2p13-14”. BMC Genetics 3.1 (2002): 14.
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EMBL
5 Einträge gefunden, die diesen Artikel zitieren
Mus musculus Otx1 (Otx1) gene, complete cds. (EMBL: AF424700)
Sequence length: 4182
Download in FASTA format
Sequence length: 4182
Download in FASTA format
Mus musculus homoloc-13 mRNA, complete cds. (EMBL: AF424701)
Sequence length: 2357
Download in FASTA format
Sequence length: 2357
Download in FASTA format
Mus musculus Hcc8 mRNA, complete cds. (EMBL: AF424699)
Sequence length: 4328
Download in FASTA format
Sequence length: 4328
Download in FASTA format
UNIPROT
72 Einträge gefunden, die diesen Artikel zitieren von denen 10 angezeigt werden
Peroxisomal membrane protein PEX13 (UNIPROT: D6RH41)
Organism: Mus musculus
Download in FASTA format
Organism: Mus musculus
Download in FASTA format
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