Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs

Kretzberg J, Sejnowski T, Warzecha A-K, Egelhaaf M (2003)
Neurocomputing 52-54: 313-320.

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Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
A conductance-based model for synaptic transmission and postsynaptic integration reveals how postsynaptic responses and their variability depend on the number of synaptic inputs. With increasing number of balanced stochastic excitatory and inhibitory inputs, the postsynaptic responses and their variance first increase and then decrease again. This non-linearity can be attributed to an anti-correlation between the total excitatory and inhibitory currents. The anti-correlation, which occurs even though the conductances of the individual synapses vary independently of each other, is determined by the total synaptic conductance and grows with the number of inputs. As the number of inputs increases, the membrane potential comes increasingly closer to the resting level.
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Zeitschriftentitel
Neurocomputing
Band
52-54
Seite(n)
313-320
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Kretzberg J, Sejnowski T, Warzecha A-K, Egelhaaf M. Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs. Neurocomputing. 2003;52-54:313-320.
Kretzberg, J., Sejnowski, T., Warzecha, A. - K., & Egelhaaf, M. (2003). Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs. Neurocomputing, 52-54, 313-320. doi:10.1016/S0925-2312(02)00797-X
Kretzberg, J., Sejnowski, T., Warzecha, A. - K., and Egelhaaf, M. (2003). Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs. Neurocomputing 52-54, 313-320.
Kretzberg, J., et al., 2003. Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs. Neurocomputing, 52-54, p 313-320.
J. Kretzberg, et al., “Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs”, Neurocomputing, vol. 52-54, 2003, pp. 313-320.
Kretzberg, J., Sejnowski, T., Warzecha, A.-K., Egelhaaf, M.: Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs. Neurocomputing. 52-54, 313-320 (2003).
Kretzberg, Jutta, Sejnowski, Terrence, Warzecha, Anne-Kathrin, and Egelhaaf, Martin. “Variability of postsynaptic responses depends non-linearly on the number of synaptic inputs”. Neurocomputing 52-54 (2003): 313-320.
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2016-09-26T05:50:41Z

5 References

Daten bereitgestellt von Europe PubMed Central.

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Chance FS, Abbott LF, Reyes AD., Neuron 35(4), 2002
PMID: 12194875

Roberts, 1981
Reliability of a fly motion-sensitive neuron depends on stimulus parameters.
Warzecha AK, Kretzberg J, Egelhaaf M., J. Neurosci. 20(23), 2000
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