Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus).

Dawirs RR, Teuchert-Noodt G, Molthagen M (1993)
Eur J Pharmacol 241(1): 89-97.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor*in
Dawirs, R R; Teuchert-Noodt, GertraudUniBi; Molthagen, M
Abstract / Bemerkung
A single dose of methamphetamine (25 mg/kg i.p.) was administered to young adult gerbils (Meriones unguiculatus) aged 90 days and the number of spices was determined along 40-microns segments of basal, lateral and apical dendrites of pyramidal cells in layers III and V of the prefrontal cortex, after 1.5, 7, 20 and 30 days. The density of spines rapidly increased by more than 80% within 7 days after drug challenge, and subsequently returned to the original normal values within about 2 weeks. Thirty days after drug administration the density of dendritic spines was slightly, but significantly, less than control values (about 5%). The density of spines was likewise affected in layer III and V neurones, irrespective of the spatial domain of their dendritic ramifications. Since several lines of investigation indicate that methamphetamine can cause the destruction of dopaminergic nerve terminals in the mammalian forebrain, the present results are discussed against the background of current concepts about reactive synaptic reorganization and adaptive remodelling of neural circuits in the central nervous system.
Erscheinungsjahr
1993
Zeitschriftentitel
Eur J Pharmacol
Band
241
Ausgabe
1
Seite(n)
89-97
ISSN
0014-2999
Page URI
https://pub.uni-bielefeld.de/record/1668494

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Dawirs RR, Teuchert-Noodt G, Molthagen M. Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol. 1993;241(1):89-97.
Dawirs, R. R., Teuchert-Noodt, G., & Molthagen, M. (1993). Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol, 241(1), 89-97. https://doi.org/10.1016/0014-2999(93)90937-D
Dawirs, R R, Teuchert-Noodt, Gertraud, and Molthagen, M. 1993. “Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus).”. Eur J Pharmacol 241 (1): 89-97.
Dawirs, R. R., Teuchert-Noodt, G., and Molthagen, M. (1993). Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol 241, 89-97.
Dawirs, R.R., Teuchert-Noodt, G., & Molthagen, M., 1993. Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol, 241(1), p 89-97.
R.R. Dawirs, G. Teuchert-Noodt, and M. Molthagen, “Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus).”, Eur J Pharmacol, vol. 241, 1993, pp. 89-97.
Dawirs, R.R., Teuchert-Noodt, G., Molthagen, M.: Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus). Eur J Pharmacol. 241, 89-97 (1993).
Dawirs, R R, Teuchert-Noodt, Gertraud, and Molthagen, M. “Indication of methamphetamine-induced reactive synaptogenesis in the prefrontal cortex of gerbils (Meriones unguiculatus).”. Eur J Pharmacol 241.1 (1993): 89-97.

6 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Activity-dependent structural plasticity.
Butz M, Wörgötter F, van Ooyen A., Brain Res Rev 60(2), 2009
PMID: 19162072
Developmental pattern changes of prefrontal efferents in the juvenile gerbil (Meriones unguiculatus).
Witte AV, Brummelte S, Teuchert-Noodt G., J Neural Transm (Vienna) 114(11), 2007
PMID: 17557126
Long-term effects of a single adult methamphetamine challenge: minor impact on dopamine fibre density in limbic brain areas of gerbils.
Brummelte S, Grund T, Czok A, Teuchert-Noodt G, Neddens J., Behav Brain Funct 2(), 2006
PMID: 16569246
Pharmacologically induced neural plasticity in the prefrontal cortex of adult gerbils (Meriones unguiculatus).
Dawirs RR, Teuchert-Noodt G, Nossoll M., Eur J Pharmacol 327(2-3), 1997
PMID: 9200549

55 References

Daten bereitgestellt von Europe PubMed Central.

Contributions of dendritic spines and perforated synapses to synaptic plasticity.
Calverley RK, Jones DG., Brain Res. Brain Res. Rev. 15(3), 1990
PMID: 2289086
The tangential organization of the visual cortex
Colonnier, J. Anat. (London) 98(), 1964
5,6-Dihydroxytryptamine, a serotonergic neurotoxin, is formed endogenously in the rat brain.
Commins DL, Axt KJ, Vosmer G, Seiden LS., Brain Res. 403(1), 1987
PMID: 2435369
The function of dendritic spines: a review of theoretical issues.
Coss RG, Perkel DH., Behav. Neural Biol. 44(2), 1985
PMID: 2415102
Reactive synaptogenesis in the hippocampus
Cotman, 1978
Cell biology of synaptic plasticity.
Cotman CW, Nieto-Sampedro M., Science 225(4668), 1984
PMID: 6382610
The determinants of stress-in-induced activation of the prefrontal cortical dopamine system
Deutch, 1990
Perforated synapses on double-headed dendritic spines: a possible structural substrate of synaptic plasticity.
Geinisman Y, Morrell F, deToledo-Morrell L., Brain Res. 480(1-2), 1989
PMID: 2713659
The anatomy of a memory: convergence of results across a diversity of tests
Greenough, Trends Neurosci. 11(), 1988
Noradrenaline neuron plasticity in developing rat brain: effects of neonatal 6-hydroxy-dopamine demonstrated by dopamine-β-hydroxylase immunocytochemistry
Gustafson, Dev. Brain Res. 37(), 1987
Spine density on neostriatal neurones changes with 6-hydroxydopamine lesions and with age.
Ingham CA, Hood SH, Arbuthnott GW., Brain Res. 503(2), 1989
PMID: 2514009
The integrative properties of spiny distal dendrites.
Jaslove SW., Neuroscience 47(3), 1992
PMID: 1584406
Neonatal thermal lesions of the mesolimbocortical dopaminergic projection decrease food-hoarding behavior.
Kalsbeek A, De Bruin JP, Feenstra MG, Matthijssen MA, Uylings HB., Brain Res. 475(1), 1988
PMID: 3214729
Organization of mesencephalic dopamine neurons projecting to neocortex and septum
Lindvall, Adv. Biochem. Pyschopharmacol. 16(), 1977
Locus coeruleus projections to cortex: topography, morphology and collateralization.
Loughlin SE, Foote SL, Fallon JH., Brain Res. Bull. 9(1-6), 1982
PMID: 7172032
Spine loss and regrowth in hippocampus following deafferentation.
Parnavelas JG, Lynch G, Brecha N, Cotman CW, Globus A., Nature 248(5443), 1974
PMID: 4818565
Reaction of central catecholaminergic neurons to injury: Model systems of central regeneration and sprouting
Reis, 1978
Angewandte Statistik
Sachs, 1974
Neurotoxicity of methamphetamine and related drugs
Seiden, 1987
Dopaminergic A10 neurones are involved in cognitive functions.
Simon H, Scatton B, Moal ML., Nature 286(5769), 1980
PMID: 7402306
Purkinje cell ontogeny: formation and maintenance of spines.
Sotelo C., Prog. Brain Res. 48(), 1978
PMID: 746152
Influence of the mesocortical dopaminergic system on activity, food hoarding, social-agonistic behavior, and spatial delayed alternation in male rats.
Stam CJ, de Bruin JP, van Haelst AM, van der Gugten J, Kalsbeek A., Behav. Neurosci. 103(1), 1989
PMID: 2923675
Disappearance of hoarding and disorganization of eating behavior after ventral mesencephalic tegmentum lesions in rats.
Stinus L, Gaffori O, Simon H, Le Moal M., J Comp Physiol Psychol 92(2), 1978
PMID: 670455
Selective activation of mesocortical DA system by stress.
Thierry AM, Tassin JP, Blanc G, Glowinski J., Nature 263(5574), 1976
PMID: 958479
Synaptic remodelling during primaru and reactive synaptogenesis
Wolff, 1989
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