Digression on membrane electroporation for drug and gene delivery.

Neumann E, Kakorin S (2002)
Technol Cancer Res Treat 1(5).

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Abstract / Bemerkung
Membrane electroporation (ME) defines an electrical technique to render lipid membranes porous and permeable, transiently and reversibly, by external voltage pulses. Although there are numerous applications of ME to manipulate cells, organelles and tissues in cell biology, biotechnology and medicine, yet the molecular mechanism of ME is only slowly being understood. A general chemical- thermodynamical approach for the quantitative description of cell membrane electroporation has been developed to provide the framework to quantitatively rationalize electroporative cell transformation and electroporative uptake of drug-like dyes into cells, as well as electrolyte efflux from salt-filled electroporated vesicles. Mechanistically, the electroporative transfer of gene and drug-like dyes involves the coupling between an interactive contact formation of the permeates with the cell surface membrane and the structural electroporation-resealing cycle C <--> (P) where C is the closed and (P) represents a number of different porated membrane states, respectively. The experimentally accessible concentration fraction f(p) = [(P)] / ([C] + [(P)]) of porous states is related to thermodynamic and electro-mechanic parameters such as temperature and the electric field strength, membrane rigidity or curvature. The results of the theoretical approach, mainly based on electrooptical data of lipid vesicles, have been successfully used to analyze single cells and to specify conditions for the practical purpose of direct electroporative gene transfer and drug delivery, in particular in the new medical disciplines of electroporative chemotherapy and electroporative gene vaccination.
Erscheinungsjahr
Zeitschriftentitel
Technol Cancer Res Treat
Band
1
Ausgabe
5
ISSN
PUB-ID

Zitieren

Neumann E, Kakorin S. Digression on membrane electroporation for drug and gene delivery. Technol Cancer Res Treat. 2002;1(5).
Neumann, E., & Kakorin, S. (2002). Digression on membrane electroporation for drug and gene delivery. Technol Cancer Res Treat, 1(5). doi:10.1177/153303460200100503
Neumann, E., and Kakorin, S. (2002). Digression on membrane electroporation for drug and gene delivery. Technol Cancer Res Treat 1.
Neumann, E., & Kakorin, S., 2002. Digression on membrane electroporation for drug and gene delivery. Technol Cancer Res Treat, 1(5).
E. Neumann and S. Kakorin, “Digression on membrane electroporation for drug and gene delivery.”, Technol Cancer Res Treat, vol. 1, 2002.
Neumann, E., Kakorin, S.: Digression on membrane electroporation for drug and gene delivery. Technol Cancer Res Treat. 1, (2002).
Neumann, Eberhard, and Kakorin, Sergej. “Digression on membrane electroporation for drug and gene delivery.”. Technol Cancer Res Treat 1.5 (2002).

5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes.
Yang Q, Larsen SK, Mi Z, Robbins PD, Basse PH., AAPS J 10(4), 2008
PMID: 19104945
Transdermal transport of India ink by electromagnetic electroporation in Guinea pigs: an ultrastructural study.
Ortega VV, Martínez AF, Gascón JY, Sánchez NA, Baños MA, Rubiales FC., Ultrastruct Pathol 30(1), 2006
PMID: 16517472
Effect of GDNF gene transfer into axotomized retinal ganglion cells using in vivo electroporation with a contact lens-type electrode.
Ishikawa H, Takano M, Matsumoto N, Sawada H, Ide C, Mimura O, Dezawa M., Gene Ther 12(4), 2005
PMID: 15616607
Electroporation of subcutaneous mouse tumors by rectangular and trapezium high voltage pulses.
Pliquett U, Elez R, Piiper A, Neumann E., Bioelectrochemistry 62(1), 2004
PMID: 14990329

49 References

Daten bereitgestellt von Europe PubMed Central.


AUTHOR UNKNOWN, 0
Electrochemotherapy of tumours resistant to cisplatin: a study in a murine tumour model.
Cemazar M, Miklavcic D, Mir LM, Belehradek J Jr, Bonnay M, Fourcault D, Sersa G., Eur. J. Cancer 37(9), 2001
PMID: 11378348
Vascular reactions to in vivo electroporation: characterization and consequences for drug and gene delivery.
Gehl J, Skovsgaard T, Mir LM., Biochim. Biophys. Acta 1569(1-3), 2002
PMID: 11853957
Mechanisms of in vivo DNA electrotransfer: respective contributions of cell electropermeabilization and DNA electrophoresis.
Satkauskas S, Bureau MF, Puc M, Mahfoudi A, Scherman D, Miklavcic D, Mir LM., Mol. Ther. 5(2), 2002
PMID: 11829520
Permeability changes induced by electric impulses in vesicular membranes.
Neumann E, Rosenheck K., J. Membr. Biol. 10(3), 1972
PMID: 4667921
Gene transfer into mouse lyoma cells by electroporation in high electric fields.
Neumann E, Schaefer-Ridder M, Wang Y, Hofschneider PH., EMBO J. 1(7), 1982
PMID: 6329708

AUTHOR UNKNOWN, 0
Electro-insertion of xeno-glycophorin into the red blood cell membrane.
Mouneimne Y, Tosi PF, Gazitt Y, Nicolau C., Biochem. Biophys. Res. Commun. 159(1), 1989
PMID: 2493789
Perturbation of human skin due to application of high voltage.
Pliquett UF, Gusbeth CA., Bioelectrochemistry 51(1), 2000
PMID: 10790779
Non-linearity of molecular transport through human skin due to electric stimulus.
Pliquett UF, Gusbeth CA, Weaver JC., J Control Release 68(3), 2000
PMID: 10974391
Changes in skin structure and electrical properties following high voltage exposure.
Gowrishankar TR, Pliquett U, Weaver JC., Ann. N. Y. Acad. Sci. 888(), 1999
PMID: 10842633

AUTHOR UNKNOWN, 0
Bleomycin: revival of an old drug.
Mir LM, Tounekti O, Orlowski S., Gen. Pharmacol. 27(5), 1996
PMID: 8842674
Phase I/II trial for the treatment of cutaneous and subcutaneous tumors using electrochemotherapy.
Heller R, Jaroszeski MJ, Glass LF, Messina JL, Rapaport DP, DeConti RC, Fenske NA, Gilbert RA, Mir LM, Reintgen DS., Cancer 77(5), 1996
PMID: 8608491

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0
Mechanism of electroinduced ionic species transport through a multilamellar lipid system.
Chizmadzhev YA, Zarnitsin VG, Weaver JC, Potts RO., Biophys. J. 68(3), 1995
PMID: 7756542
Mechanism of electroporative dye uptake by mouse B cells.
Neumann E, Toensing K, Kakorin S, Budde P, Frey J., Biophys. J. 74(1), 1998
PMID: 9449314
Reversible electrical breakdown of lipid bilayers: formation and evolution of pores.
Glaser RW, Leikin SL, Chernomordik LV, Pastushenko VF, Sokirko AI., Biochim. Biophys. Acta 940(2), 1988
PMID: 2453213

AUTHOR UNKNOWN, 0

Neumann, Radiol. Oncol. 32(), 1998

AUTHOR UNKNOWN, 0

AUTHOR UNKNOWN, 0

Pastushenko, Biol. Mem. 6(), 1992

AUTHOR UNKNOWN, 0
Electro-optics of membrane electroporation in diphenylhexatriene-doped lipid bilayer vesicles.
Kakorin S, Stoylov SP, Neumann E., Biophys. Chem. 58(1-2), 1996
PMID: 8679914

AUTHOR UNKNOWN, 0

Kakorin, Phys. Chem. 102(), 1998

AUTHOR UNKNOWN, 0
Annexin V and vesicle membrane electroporation.
Tonsing K, Kakorin S, Neumann E, Liemann S, Huber R., Eur. Biophys. J. 26(4), 1997
PMID: 9378099
Gerhard schwarz: scientist and colleague
Neuman E, Winterhalter M., Biophys. Chem. 85(2-3), 2000
PMID: 10961499

Chang, 1992
Ionic conductivity of electroporated lipid bilayer membranes.
Kakorin S, Neumann E., Bioelectrochemistry 56(1-2), 2002
PMID: 12009466

AUTHOR UNKNOWN, 0
Effect of n-alcohols on the electrotransformation and permeability of Saccharomyces cerevisiae.
Ganeva VJ, Tsoneva IC., Appl. Microbiol. Biotechnol. 38(6), 1993
PMID: 7763536

Maniatis, 1982
Biological functions of human Fc gamma RIIa/Fc gamma RIIc in B cells.
Budde P, Bewarder N, Weinrich V, Frey J., Eur. J. Cell Biol. 64(1), 1994
PMID: 7957312

Neumann, 1999

AUTHOR UNKNOWN, 0
Fundamentals of electroporative delivery of drugs and genes.
Neumann E, Kakorin S, Toensing K., Bioelectrochem Bioenerg 48(1), 1999
PMID: 10228565
Calcium-mediated DNA adsorption to yeast cells and kinetics of cell transformation by electroporation.
Neumann E, Kakorin S, Tsoneva I, Nikolova B, Tomov T., Biophys. J. 71(2), 1996
PMID: 8842225
Dip patch clamp currents suggest electrodiffusive transport of the polyelectrolyte DNA through lipid bilayers.
Spassova M, Tsoneva I, Petrov AG, Petkova JI, Neumann E., Biophys. Chem. 52(3), 1994
PMID: 7999976
Importance of association between permeabilization and electrophoretic forces for intramuscular DNA electrotransfer.
Bureau MF, Gehl J, Deleuze V, Mir LM, Scherman D., Biochim. Biophys. Acta 1474(3), 2000
PMID: 10779687
Mechanisms of in vivo DNA electrotransfer: respective contributions of cell electropermeabilization and DNA electrophoresis.
Satkauskas S, Bureau MF, Puc M, Mahfoudi A, Scherman D, Miklavcic D, Mir LM., Mol. Ther. 5(2), 2002
PMID: 11829520
Light scattering by a core-mantle spheroidal particle.
Farafonov VG, Voshchinnikov NV, Somsikov VV., Appl Opt 35(27), 1996
PMID: 21127540

AUTHOR UNKNOWN, 0

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 12625758
PubMed | Europe PMC

Suchen in

Google Scholar