Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology
Tinnefeld P, Sauer M (2005)
Angew Chem Int Ed Engl 44(18): 2642-2671.
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Autor*in
Tinnefeld, Philip;
Sauer, MarkusUniBi
Einrichtung
Abstract / Bemerkung
In the last decade emerging single-molecule fluorescence-spectroscopy tools have been developed and adapted to analyze individual molecules under various conditions. Single-molecule-sensitive optical techniques are now well established and help to increase our understanding of complex problems in different disciplines ranging from materials science to cell biology. Previous dreams, such as the monitoring of the motility and structural changes of single motor proteins in living cells or the detection of single-copy genes and the determination of their distance from polymerase molecules in transcription factories in the nucleus of a living cell, no longer constitute unsolvable problems. In this Review we demonstrate that single-molecule fluorescence spectroscopy has become an independent discipline capable of solving problems in molecular biology. We outline the challenges and future prospects for optical single-molecule techniques which can be used in combination with smart labeling strategies to yield quantitative three-dimensional information about the dynamic organization of living cells.
Erscheinungsjahr
2005
Zeitschriftentitel
Angew Chem Int Ed Engl
Band
44
Ausgabe
18
Seite(n)
2642-2671
ISSN
1433-7851
eISSN
1521-3773
Page URI
https://pub.uni-bielefeld.de/record/1666274
Zitieren
Tinnefeld P, Sauer M. Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology. Angew Chem Int Ed Engl. 2005;44(18):2642-2671.
Tinnefeld, P., & Sauer, M. (2005). Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology. Angew Chem Int Ed Engl, 44(18), 2642-2671. https://doi.org/10.1002/anie.200300647
Tinnefeld, Philip, and Sauer, Markus. 2005. “Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology”. Angew Chem Int Ed Engl 44 (18): 2642-2671.
Tinnefeld, P., and Sauer, M. (2005). Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology. Angew Chem Int Ed Engl 44, 2642-2671.
Tinnefeld, P., & Sauer, M., 2005. Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology. Angew Chem Int Ed Engl, 44(18), p 2642-2671.
P. Tinnefeld and M. Sauer, “Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology”, Angew Chem Int Ed Engl, vol. 44, 2005, pp. 2642-2671.
Tinnefeld, P., Sauer, M.: Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology. Angew Chem Int Ed Engl. 44, 2642-2671 (2005).
Tinnefeld, Philip, and Sauer, Markus. “Branching out of single-molecule fluorescence spectroscopy: challenges for chemistry and influence on biology”. Angew Chem Int Ed Engl 44.18 (2005): 2642-2671.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
54 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Breaking the Concentration Barrier for Single-Molecule Fluorescence Measurements.
Peng S, Wang W, Chen C., Chemistry 24(5), 2018
PMID: 29044746
Peng S, Wang W, Chen C., Chemistry 24(5), 2018
PMID: 29044746
Three-Dimensional Localization of Single Molecules for Super-Resolution Imaging and Single-Particle Tracking.
von Diezmann A, Shechtman Y, Moerner WE., Chem Rev 117(11), 2017
PMID: 28151646
von Diezmann A, Shechtman Y, Moerner WE., Chem Rev 117(11), 2017
PMID: 28151646
Covalent dye attachment influences the dynamics and conformational properties of flexible peptides.
Luitz MP, Barth A, Crevenna AH, Bomblies R, Lamb DC, Zacharias M., PLoS One 12(5), 2017
PMID: 28542243
Luitz MP, Barth A, Crevenna AH, Bomblies R, Lamb DC, Zacharias M., PLoS One 12(5), 2017
PMID: 28542243
Design and validation of a new ratiometric intracellular pH imaging probe using lanthanide-doped upconverting nanoparticles.
Du S, Hernández-Gil J, Dong H, Zheng X, Lyu G, Bañobre-López M, Gallo J, Sun LD, Yan CH, Long NJ., Dalton Trans 46(40), 2017
PMID: 28972616
Du S, Hernández-Gil J, Dong H, Zheng X, Lyu G, Bañobre-López M, Gallo J, Sun LD, Yan CH, Long NJ., Dalton Trans 46(40), 2017
PMID: 28972616
Direct observation of structural properties and fluorescent trapping sites in macrocyclic porphyrin arrays at the single-molecule level.
Ham S, Lee JE, Song S, Peng X, Hori T, Aratani N, Osuka A, Sim E, Kim D., Phys Chem Chem Phys 18(5), 2016
PMID: 26765482
Ham S, Lee JE, Song S, Peng X, Hori T, Aratani N, Osuka A, Sim E, Kim D., Phys Chem Chem Phys 18(5), 2016
PMID: 26765482
From single-molecule spectroscopy to super-resolution imaging of the neuron: a review.
Laine RF, Kaminski Schierle GS, van de Linde S, Kaminski CF., Methods Appl Fluoresc 4(2), 2016
PMID: 28809165
Laine RF, Kaminski Schierle GS, van de Linde S, Kaminski CF., Methods Appl Fluoresc 4(2), 2016
PMID: 28809165
Single Molecule Nanospectroscopy Visualizes Proton-Transfer Processes within a Zeolite Crystal.
Ristanović Z, Kubarev AV, Hofkens J, Roeffaers MB, Weckhuysen BM., J Am Chem Soc 138(41), 2016
PMID: 27709925
Ristanović Z, Kubarev AV, Hofkens J, Roeffaers MB, Weckhuysen BM., J Am Chem Soc 138(41), 2016
PMID: 27709925
Quantifying molecular colocalization in live cell fluorescence microscopy.
Humpert F, Yahiatène I, Lummer M, Sauer M, Huser T., J Biophotonics 8(1-2), 2015
PMID: 24375988
Humpert F, Yahiatène I, Lummer M, Sauer M, Huser T., J Biophotonics 8(1-2), 2015
PMID: 24375988
Artificial Molecular Machines.
Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL., Chem Rev 115(18), 2015
PMID: 26346838
Erbas-Cakmak S, Leigh DA, McTernan CT, Nussbaumer AL., Chem Rev 115(18), 2015
PMID: 26346838
Dissecting pigment architecture of individual photosynthetic antenna complexes in solution.
Wang Q, Moerner WE., Proc Natl Acad Sci U S A 112(45), 2015
PMID: 26438850
Wang Q, Moerner WE., Proc Natl Acad Sci U S A 112(45), 2015
PMID: 26438850
Single-molecule spectroscopy and imaging over the decades.
Moerner WE, Shechtman Y, Wang Q., Faraday Discuss 184(), 2015
PMID: 26616210
Moerner WE, Shechtman Y, Wang Q., Faraday Discuss 184(), 2015
PMID: 26616210
Enhancing single-molecule fluorescence with nanophotonics.
Acuna G, Grohmann D, Tinnefeld P., FEBS Lett 588(19), 2014
PMID: 24928436
Acuna G, Grohmann D, Tinnefeld P., FEBS Lett 588(19), 2014
PMID: 24928436
Single-enzyme kinetics with fluorogenic substrates: lessons learnt and future directions.
Turunen P, Rowan AE, Blank K., FEBS Lett 588(19), 2014
PMID: 24931376
Turunen P, Rowan AE, Blank K., FEBS Lett 588(19), 2014
PMID: 24931376
Shedding light on protein folding, structural and functional dynamics by single molecule studies.
Bavishi K, Hatzakis NS., Molecules 19(12), 2014
PMID: 25429564
Bavishi K, Hatzakis NS., Molecules 19(12), 2014
PMID: 25429564
A common diaryl ether intermediate for the gram-scale synthesis of oxazine and xanthene fluorophores.
Anzalone AV, Wang TY, Chen Z, Cornish VW., Angew Chem Int Ed Engl 52(2), 2013
PMID: 23169599
Anzalone AV, Wang TY, Chen Z, Cornish VW., Angew Chem Int Ed Engl 52(2), 2013
PMID: 23169599
Investigating cellular structures at the nanoscale with organic fluorophores.
van de Linde S, Aufmkolk S, Franke C, Holm T, Klein T, Löschberger A, Proppert S, Wolter S, Sauer M., Chem Biol 20(1), 2013
PMID: 23352135
van de Linde S, Aufmkolk S, Franke C, Holm T, Klein T, Löschberger A, Proppert S, Wolter S, Sauer M., Chem Biol 20(1), 2013
PMID: 23352135
Beta-barrel scaffold of fluorescent proteins: folding, stability and role in chromophore formation.
Stepanenko OV, Stepanenko OV, Kuznetsova IM, Verkhusha VV, Turoverov KK., Int Rev Cell Mol Biol 302(), 2013
PMID: 23351712
Stepanenko OV, Stepanenko OV, Kuznetsova IM, Verkhusha VV, Turoverov KK., Int Rev Cell Mol Biol 302(), 2013
PMID: 23351712
Modern biophysical approaches probe transcription-factor-induced DNA bending and looping.
Gietl A, Grohmann D., Biochem Soc Trans 41(1), 2013
PMID: 23356313
Gietl A, Grohmann D., Biochem Soc Trans 41(1), 2013
PMID: 23356313
Enhanced accuracy of single-molecule diffusion measurements with a photocleavable energy-transfer dyad.
Dill M, Baier MC, Mecking S, Wöll D., Angew Chem Int Ed Engl 52(47), 2013
PMID: 24222580
Dill M, Baier MC, Mecking S, Wöll D., Angew Chem Int Ed Engl 52(47), 2013
PMID: 24222580
Opportunities and challenges in single-molecule and single-particle fluorescence microscopy for mechanistic studies of chemical reactions.
Cordes T, Blum SA., Nat Chem 5(12), 2013
PMID: 24256861
Cordes T, Blum SA., Nat Chem 5(12), 2013
PMID: 24256861
DNA origami as biocompatible surface to match single-molecule and ensemble experiments.
Gietl A, Holzmeister P, Grohmann D, Tinnefeld P., Nucleic Acids Res 40(14), 2012
PMID: 22523083
Gietl A, Holzmeister P, Grohmann D, Tinnefeld P., Nucleic Acids Res 40(14), 2012
PMID: 22523083
Fluorescence enhancement at docking sites of DNA-directed self-assembled nanoantennas.
Acuna GP, Möller FM, Holzmeister P, Beater S, Lalkens B, Tinnefeld P., Science 338(6106), 2012
PMID: 23112329
Acuna GP, Möller FM, Holzmeister P, Beater S, Lalkens B, Tinnefeld P., Science 338(6106), 2012
PMID: 23112329
FRET (fluorescence resonance energy transfer) sheds light on transcription.
Grohmann D, Klose D, Fielden D, Werner F., Biochem Soc Trans 39(1), 2011
PMID: 21265759
Grohmann D, Klose D, Fielden D, Werner F., Biochem Soc Trans 39(1), 2011
PMID: 21265759
Improving FRET-based monitoring of single chemomechanical rotary motors at work.
Börsch M, Wrachtrup J., Chemphyschem 12(3), 2011
PMID: 21305683
Börsch M, Wrachtrup J., Chemphyschem 12(3), 2011
PMID: 21305683
Design and synthesis of a new class of membrane-permeable triazaborolopyridinium fluorescent probes.
Hapuarachchige S, Montaño G, Ramesh C, Rodriguez D, Henson LH, Williams CC, Kadavakkollu S, Johnson DL, Shuster CB, Arterburn JB., J Am Chem Soc 133(17), 2011
PMID: 21473622
Hapuarachchige S, Montaño G, Ramesh C, Rodriguez D, Henson LH, Williams CC, Kadavakkollu S, Johnson DL, Shuster CB, Arterburn JB., J Am Chem Soc 133(17), 2011
PMID: 21473622
Effects of a self-assembled molecular capsule on the ultrafast photodynamics of a photochromic salicylideneaniline guest.
Sliwa M, Naumov P, Choi HJ, Nguyen QT, Debus B, Delbaere S, Ruckebusch C., Chemphyschem 12(9), 2011
PMID: 21598375
Sliwa M, Naumov P, Choi HJ, Nguyen QT, Debus B, Delbaere S, Ruckebusch C., Chemphyschem 12(9), 2011
PMID: 21598375
The role of electronic coupling in linear porphyrin arrays probed by single-molecule fluorescence spectroscopy.
Yang J, Lee JE, Lee CY, Aratani N, Osuka A, Hupp JT, Kim D., Chemistry 17(33), 2011
PMID: 21732433
Yang J, Lee JE, Lee CY, Aratani N, Osuka A, Hupp JT, Kim D., Chemistry 17(33), 2011
PMID: 21732433
Room temperature excitation spectroscopy of single quantum dots.
Blum C, Schleifenbaum F, Stopel M, Peter S, Sackrow M, Subramaniam V, Meixner AJ., Beilstein J Nanotechnol 2(), 2011
PMID: 22003458
Blum C, Schleifenbaum F, Stopel M, Peter S, Sackrow M, Subramaniam V, Meixner AJ., Beilstein J Nanotechnol 2(), 2011
PMID: 22003458
Single molecule experimentation in biological physics: exploring the living component of soft condensed matter one molecule at a time.
Harriman OL, Leake MC., J Phys Condens Matter 23(50), 2011
PMID: 22067659
Harriman OL, Leake MC., J Phys Condens Matter 23(50), 2011
PMID: 22067659
Fluorescence correlation spectroscopy: past, present, future.
Elson EL., Biophys J 101(12), 2011
PMID: 22208184
Elson EL., Biophys J 101(12), 2011
PMID: 22208184
Fluorescent probes and delivery methods for single-molecule experiments.
Lymperopoulos K, Kiel A, Seefeld A, Stöhr K, Herten DP., Chemphyschem 11(1), 2010
PMID: 19960557
Lymperopoulos K, Kiel A, Seefeld A, Stöhr K, Herten DP., Chemphyschem 11(1), 2010
PMID: 19960557
High-resolution single-turnover mapping reveals intraparticle diffusion limitation in Ti-MCM-41-catalyzed epoxidation.
De Cremer G, Roeffaers MB, Bartholomeeusen E, Lin K, Dedecker P, Pescarmona PP, Jacobs PA, De Vos DE, Hofkens J, Sels BF., Angew Chem Int Ed Engl 49(5), 2010
PMID: 20029861
De Cremer G, Roeffaers MB, Bartholomeeusen E, Lin K, Dedecker P, Pescarmona PP, Jacobs PA, De Vos DE, Hofkens J, Sels BF., Angew Chem Int Ed Engl 49(5), 2010
PMID: 20029861
Single molecules as optical nanoprobes for soft and complex matter.
Kulzer F, Xia T, Orrit M., Angew Chem Int Ed Engl 49(5), 2010
PMID: 20052698
Kulzer F, Xia T, Orrit M., Angew Chem Int Ed Engl 49(5), 2010
PMID: 20052698
Single-molecule spectroscopy: caught in a trap.
Dedecker P, Hofkens J., Nat Chem 2(3), 2010
PMID: 21124467
Dedecker P, Hofkens J., Nat Chem 2(3), 2010
PMID: 21124467
Probability distributions of molecular observables computed from Markov models. II. Uncertainties in observables and their time-evolution.
Chodera JD, Noé F., J Chem Phys 133(10), 2010
PMID: 20849191
Chodera JD, Noé F., J Chem Phys 133(10), 2010
PMID: 20849191
Optically monitoring the mechanical assembly of single molecules.
Kufer SK, Strackharn M, Stahl SW, Gumpp H, Puchner EM, Gaub HE., Nat Nanotechnol 4(1), 2009
PMID: 19119282
Kufer SK, Strackharn M, Stahl SW, Gumpp H, Puchner EM, Gaub HE., Nat Nanotechnol 4(1), 2009
PMID: 19119282
Fluorescent amino acids: advances in protein-extrinsic fluorophores.
Katritzky AR, Narindoshvili T., Org Biomol Chem 7(4), 2009
PMID: 19194572
Katritzky AR, Narindoshvili T., Org Biomol Chem 7(4), 2009
PMID: 19194572
High power light emitting diode based setup for photobleaching fluorescent impurities.
Herman TK, Mackowiak SA, Kaufman LJ., Rev Sci Instrum 80(1), 2009
PMID: 19191468
Herman TK, Mackowiak SA, Kaufman LJ., Rev Sci Instrum 80(1), 2009
PMID: 19191468
Fluorescence-based analysis of enzymes at the single-molecule level.
Blank K, De Cremer G, Hofkens J., Biotechnol J 4(4), 2009
PMID: 19229885
Blank K, De Cremer G, Hofkens J., Biotechnol J 4(4), 2009
PMID: 19229885
Single-molecule Förster resonance energy transfer studies of RNA structure, dynamics and function.
Helm M, Kobitski AY, Nienhaus GU., Biophys Rev 1(4), 2009
PMID: 28510027
Helm M, Kobitski AY, Nienhaus GU., Biophys Rev 1(4), 2009
PMID: 28510027
Single-molecule cut-and-paste surface assembly.
Kufer SK, Puchner EM, Gumpp H, Liedl T, Gaub HE., Science 319(5863), 2008
PMID: 18239119
Kufer SK, Puchner EM, Gumpp H, Liedl T, Gaub HE., Science 319(5863), 2008
PMID: 18239119
Do-it-yourself guide: how to use the modern single-molecule toolkit.
Walter NG, Huang CY, Manzo AJ, Sobhy MA., Nat Methods 5(6), 2008
PMID: 18511916
Walter NG, Huang CY, Manzo AJ, Sobhy MA., Nat Methods 5(6), 2008
PMID: 18511916
Synthesis of BODIPY-labeled alkylphosphocholines with leishmanicidal activity, as fluorescent analogues of miltefosine.
Hornillos V, Carrillo E, Rivas L, Amat-Guerri F, Acuña AU., Bioorg Med Chem Lett 18(24), 2008
PMID: 18990566
Hornillos V, Carrillo E, Rivas L, Amat-Guerri F, Acuña AU., Bioorg Med Chem Lett 18(24), 2008
PMID: 18990566
Single-molecule tracking in eukaryotic cell nuclei.
Siebrasse JP, Grünwald D, Kubitscheck U., Anal Bioanal Chem 387(1), 2007
PMID: 17033772
Siebrasse JP, Grünwald D, Kubitscheck U., Anal Bioanal Chem 387(1), 2007
PMID: 17033772
Enhanced Förster Resonance Energy Transfer (FRET) on Single Metal Particle.
Zhang J, Fu Y, Lakowicz JR., J Phys Chem C Nanomater Interfaces 111(1), 2007
PMID: 19079780
Zhang J, Fu Y, Lakowicz JR., J Phys Chem C Nanomater Interfaces 111(1), 2007
PMID: 19079780
Fluorescence detection with high time resolution: from optical microscopy to simultaneous force and fluorescence spectroscopy.
Gaiduk A, Kühnemuth R, Felekyan S, Antonik M, Becker W, Kudryavtsev V, Sandhagen C, Seidel CA., Microsc Res Tech 70(5), 2007
PMID: 17393495
Gaiduk A, Kühnemuth R, Felekyan S, Antonik M, Becker W, Kudryavtsev V, Sandhagen C, Seidel CA., Microsc Res Tech 70(5), 2007
PMID: 17393495
Kinetics of complexin binding to the SNARE complex: correcting single molecule FRET measurements for hidden events.
Li Y, Augustine GJ, Weninger K., Biophys J 93(6), 2007
PMID: 17513363
Li Y, Augustine GJ, Weninger K., Biophys J 93(6), 2007
PMID: 17513363
Fluorescence from diffusing single molecules illuminates biomolecular structure and dynamics.
Mukhopadhyay S, Deniz AA., J Fluoresc 17(6), 2007
PMID: 17641956
Mukhopadhyay S, Deniz AA., J Fluoresc 17(6), 2007
PMID: 17641956
The fluorescent protein color palette.
Olenych SG, Claxton NS, Ottenberg GK, Davidson MW., Curr Protoc Cell Biol Chapter 21(), 2007
PMID: 18228502
Olenych SG, Claxton NS, Ottenberg GK, Davidson MW., Curr Protoc Cell Biol Chapter 21(), 2007
PMID: 18228502
Direct observation of single protein molecules in aqueous solution.
Grünwald D, Hoekstra A, Dange T, Buschmann V, Kubitscheck U., Chemphyschem 7(4), 2006
PMID: 16528778
Grünwald D, Hoekstra A, Dange T, Buschmann V, Kubitscheck U., Chemphyschem 7(4), 2006
PMID: 16528778
Molecular fluorescence, phosphorescence, and chemiluminescence spectrometry.
Fletcher KA, Fakayode SO, Lowry M, Tucker SA, Neal SL, Kimaru IW, McCarroll ME, Patonay G, Oldham PB, Rusin O, Strongin RM, Warner IM., Anal Chem 78(12), 2006
PMID: 16771540
Fletcher KA, Fakayode SO, Lowry M, Tucker SA, Neal SL, Kimaru IW, McCarroll ME, Patonay G, Oldham PB, Rusin O, Strongin RM, Warner IM., Anal Chem 78(12), 2006
PMID: 16771540
Intranuclear binding kinetics and mobility of single native U1 snRNP particles in living cells.
Grünwald D, Spottke B, Buschmann V, Kubitscheck U., Mol Biol Cell 17(12), 2006
PMID: 16987963
Grünwald D, Spottke B, Buschmann V, Kubitscheck U., Mol Biol Cell 17(12), 2006
PMID: 16987963
Accurate and unbiased estimation of power-law exponents from single-emitter blinking data.
Hoogenboom JP, den Otter WK, Offerhaus HL., J Chem Phys 125(20), 2006
PMID: 17144729
Hoogenboom JP, den Otter WK, Offerhaus HL., J Chem Phys 125(20), 2006
PMID: 17144729
Synthesis of a new pair of fluorescence resonance energy transfer donor and acceptor dyes and its use in a protease assay.
Kainmüller EK, Ollé EP, Bannwarth W., Chem Commun (Camb) (43), 2005
PMID: 16261246
Kainmüller EK, Ollé EP, Bannwarth W., Chem Commun (Camb) (43), 2005
PMID: 16261246
343 References
Daten bereitgestellt von Europe PubMed Central.
Binnig, Rev. Mod. Phys. 59(), 1987
Probing the free-energy surface for protein folding with single-molecule fluorescence spectroscopy.
Schuler B, Lipman EA, Eaton WA., Nature 419(6908), 2002
PMID: 12384704
Schuler B, Lipman EA, Eaton WA., Nature 419(6908), 2002
PMID: 12384704
Single-molecule measurement of protein folding kinetics.
Lipman EA, Schuler B, Bakajin O, Eaton WA., Science 301(5637), 2003
PMID: 12947198
Lipman EA, Schuler B, Bakajin O, Eaton WA., Science 301(5637), 2003
PMID: 12947198
Measurement of submicrosecond intramolecular contact formation in peptides at the single-molecule level.
Neuweiler H, Schulz A, Bohmer M, Enderlein J, Sauer M., J. Am. Chem. Soc. 125(18), 2003
PMID: 12720444
Neuweiler H, Schulz A, Bohmer M, Enderlein J, Sauer M., J. Am. Chem. Soc. 125(18), 2003
PMID: 12720444
Zero-mode waveguides for single-molecule analysis at high concentrations.
Levene MJ, Korlach J, Turner SW, Foquet M, Craighead HG, Webb WW., Science 299(5607), 2003
PMID: 12560545
Levene MJ, Korlach J, Turner SW, Foquet M, Craighead HG, Webb WW., Science 299(5607), 2003
PMID: 12560545
Sequence information can be obtained from single DNA molecules.
Braslavsky I, Hebert B, Kartalov E, Quake SR., Proc. Natl. Acad. Sci. U.S.A. 100(7), 2003
PMID: 12651960
Braslavsky I, Hebert B, Kartalov E, Quake SR., Proc. Natl. Acad. Sci. U.S.A. 100(7), 2003
PMID: 12651960
High-speed DNA sequencing: an approach based upon fluorescence detection of single molecules.
Jett JH, Keller RA, Martin JC, Marrone BL, Moyzis RK, Ratliff RL, Seitzinger NK, Shera EB, Stewart CC., J. Biomol. Struct. Dyn. 7(2), 1989
PMID: 2557861
Jett JH, Keller RA, Martin JC, Marrone BL, Moyzis RK, Ratliff RL, Seitzinger NK, Shera EB, Stewart CC., J. Biomol. Struct. Dyn. 7(2), 1989
PMID: 2557861
Single molecule DNA sequencing in submicrometer channels: state of the art and future prospects.
Sauer M, Angerer B, Ankenbauer W, Foldes-Papp Z, Gobel F, Han KT, Rigler R, Schulz A, Wolfrum J, Zander C., J. Biotechnol. 86(3), 2001
PMID: 11257531
Sauer M, Angerer B, Ankenbauer W, Foldes-Papp Z, Gobel F, Han KT, Rigler R, Schulz A, Wolfrum J, Zander C., J. Biotechnol. 86(3), 2001
PMID: 11257531
Dorre, Bioimaging 5(), 1997
Progress towards single-molecule DNA sequencing: a one color demonstration.
Werner JH, Cai H, Jett JH, Reha-Krantz L, Keller RA, Goodwin PM., J. Biotechnol. 102(1), 2003
PMID: 12668309
Werner JH, Cai H, Jett JH, Reha-Krantz L, Keller RA, Goodwin PM., J. Biotechnol. 102(1), 2003
PMID: 12668309
Moerner, Angew. Chem. 105(), 1993
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. Engl. 32(), 1993
Xie, Acc. Chem. Res. 29(), 1996
Optical detection of single molecules.
Nie S, Zare RN., Annu Rev Biophys Biomol Struct 26(), 1997
PMID: 9241430
Nie S, Zare RN., Annu Rev Biophys Biomol Struct 26(), 1997
PMID: 9241430
Optical studies of single molecules at room temperature.
Xie XS, Trautman JK., Annu Rev Phys Chem 49(), 1998
PMID: 15012434
Xie XS, Trautman JK., Annu Rev Phys Chem 49(), 1998
PMID: 15012434
Single molecule fluorescence spectroscopy at ambient temperature.
Ambrose WP, Goodwin PM, Jett JH, Van Orden A, Werner JH, Keller RA., Chem. Rev. 99(10), 1999
PMID: 11749506
Ambrose WP, Goodwin PM, Jett JH, Van Orden A, Werner JH, Keller RA., Chem. Rev. 99(10), 1999
PMID: 11749506
Moerner, Science 283(), 1999
Single-molecular detection in solution: a new tool for analytical chemistry.
Zander C., Fresenius J Anal Chem 366(6-7), 2000
PMID: 11225785
Zander C., Fresenius J Anal Chem 366(6-7), 2000
PMID: 11225785
Ratiometric single-molecule studies of freely diffusing biomolecules.
Deniz AA, Laurence TA, Dahan M, Chemla DS, Schultz PG, Weiss S., Annu Rev Phys Chem 52(), 2001
PMID: 11326065
Deniz AA, Laurence TA, Dahan M, Chemla DS, Schultz PG, Weiss S., Annu Rev Phys Chem 52(), 2001
PMID: 11326065
Moerner, J. Phys. Chem. B 106(), 2002
Jung, J. Chem. Phys. 117(), 2002
Orrit, J. Chem. Phys. 117(), 2002
Kapanidis, J. Chem. Phys. 117(), 2002
Moerner, J. Chem. Phys. 117(), 2002
Sunney, J. Chem. Phys. 117(), 2002
Keller, Anal. Chem. 74(), 2002
Kubitscheck, Single Mol. 3(), 2002
Boehmer, ChemPhysChem 4(), 2003
Moerner, Rev. Sci. Instrum. 74(), 2003
Förster, Ann. Phys. 2(), 1948
Optical detection and spectroscopy of single molecules in a solid.
Moerner WE, Kador L., Phys. Rev. Lett. 62(21), 1989
PMID: 10040013
Moerner WE, Kador L., Phys. Rev. Lett. 62(21), 1989
PMID: 10040013
Shera, Chem. Phys. Lett. 174(), 1990
Zarrin, Anal. Chem. 57(), 1985
Single molecules observed by near-field scanning optical microscopy.
Betzig E, Chichester RJ., Science 262(5138), 1993
PMID: 17736823
Betzig E, Chichester RJ., Science 262(5138), 1993
PMID: 17736823
Alterations of single molecule fluorescence lifetimes in near-field optical microscopy.
Ambrose WP, Goodwin PM, Keller RA, Martin JC., Science 265(5170), 1994
PMID: 17838037
Ambrose WP, Goodwin PM, Keller RA, Martin JC., Science 265(5170), 1994
PMID: 17838037
Near-field fluorescence microscopy of cells.
Enderle T, Ha T, Chemla DS, Weiss S., Ultramicroscopy 71(1-4), 1998
PMID: 9566345
Enderle T, Ha T, Chemla DS, Weiss S., Ultramicroscopy 71(1-4), 1998
PMID: 9566345
De, J. Cell Sci. 114(), 2001
Koopman, Appl. Phys. Lett. 83(), 2003
Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells.
Cambi A, de Lange F, van Maarseveen NM, Nijhuis M, Joosten B, van Dijk EM, de Bakker BI, Fransen JA, Bovee-Geurts PH, van Leeuwen FN, Van Hulst NF, Figdor CG., J. Cell Biol. 164(1), 2004
PMID: 14709546
Cambi A, de Lange F, van Maarseveen NM, Nijhuis M, Joosten B, van Dijk EM, de Bakker BI, Fransen JA, Bovee-Geurts PH, van Leeuwen FN, Van Hulst NF, Figdor CG., J. Cell Biol. 164(1), 2004
PMID: 14709546
Pawley, 1995
Rigler, Proc. SPIE-Int. Soc. Opt. Eng. Proc. SPIE (), 1992
Rigler, Eur. Biophys. J. Biophys. Lett. 22(), 1993
Xu, Proc. Natl. Acad. Sci. USA 93(), 1996
Single-molecule detection by two-photon-excited fluorescence.
Mertz J, Xu C, Webb WW., Opt Lett 20(24), 1995
PMID: 19865276
Mertz J, Xu C, Webb WW., Opt Lett 20(24), 1995
PMID: 19865276
Brand, J. Phys. Chem. A 101(), 1997
Two-photon laser scanning fluorescence microscopy.
Denk W, Strickler JH, Webb WW., Science 248(4951), 1990
PMID: 2321027
Denk W, Strickler JH, Webb WW., Science 248(4951), 1990
PMID: 2321027
Fluorescence of coumarins and xanthenes after two-photon absorption with a pulsed titanium-sapphire laser.
Fischer A, Cremer C, Stelzer EH., Appl Opt 34(12), 1995
PMID: 21037746
Fischer A, Cremer C, Stelzer EH., Appl Opt 34(12), 1995
PMID: 21037746
Xu, J. Opt. Soc. Am. B 13(), 1996
Two-photon fluorescence coincidence analysis: rapid measurements of enzyme kinetics.
Heinze KG, Rarbach M, Jahnz M, Schwille P., Biophys. J. 83(3), 2002
PMID: 12202390
Heinze KG, Rarbach M, Jahnz M, Schwille P., Biophys. J. 83(3), 2002
PMID: 12202390
Sorting single molecules: application to diagnostics and evolutionary biotechnology.
Eigen M, Rigler R., Proc. Natl. Acad. Sci. U.S.A. 91(13), 1994
PMID: 7517036
Eigen M, Rigler R., Proc. Natl. Acad. Sci. U.S.A. 91(13), 1994
PMID: 7517036
Maiti, Proc. Natl. Acad. Sci. USA 94(), 1997
The photon counting histogram in fluorescence fluctuation spectroscopy.
Chen Y, Muller JD, So PT, Gratton E., Biophys. J. 77(1), 1999
PMID: 10388780
Chen Y, Muller JD, So PT, Gratton E., Biophys. J. 77(1), 1999
PMID: 10388780
Kask, Proc. Natl. Acad. Sci. USA 96(), 1999
Two-dimensional fluorescence intensity distribution analysis: theory and applications.
Kask P, Palo K, Fay N, Brand L, Mets U, Ullmann D, Jungmann J, Pschorr J, Gall K., Biophys. J. 78(4), 2000
PMID: 10733953
Kask P, Palo K, Fay N, Brand L, Mets U, Ullmann D, Jungmann J, Pschorr J, Gall K., Biophys. J. 78(4), 2000
PMID: 10733953
Fluorescence intensity multiple distributions analysis: concurrent determination of diffusion times and molecular brightness.
Palo K, Mets U, Jager S, Kask P, Gall K., Biophys. J. 79(6), 2000
PMID: 11106594
Palo K, Mets U, Jager S, Kask P, Gall K., Biophys. J. 79(6), 2000
PMID: 11106594
Laurence, J. Phys. Chem. B 108(), 2004
High-throughput single molecule screening of DNA and proteins.
Yeung ES., Chem Rec 1(2), 2001
PMID: 11893062
Yeung ES., Chem Rec 1(2), 2001
PMID: 11893062
Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase.
Ha T, Rasnik I, Cheng W, Babcock HP, Gauss GH, Lohman TM, Chu S., Nature 419(6907), 2002
PMID: 12374984
Ha T, Rasnik I, Cheng W, Babcock HP, Gauss GH, Lohman TM, Chu S., Nature 419(6907), 2002
PMID: 12374984
Total internal reflection fluorescence microscopy.
Axelrod D., Methods Cell Biol. 30(), 1989
PMID: 2648112
Axelrod D., Methods Cell Biol. 30(), 1989
PMID: 2648112
Single-molecule detection with total internal reflection excitation: comparing signal-to-background and total signals in different geometries.
Ambrose WP, Goodwin PM, Nolan JP., Cytometry 36(3), 1999
PMID: 10404972
Ambrose WP, Goodwin PM, Nolan JP., Cytometry 36(3), 1999
PMID: 10404972
Imaging of single fluorescent molecules and individual ATP turnovers by single myosin molecules in aqueous solution.
Funatsu T, Harada Y, Tokunaga M, Saito K, Yanagida T., Nature 374(6522), 1995
PMID: 7700383
Funatsu T, Harada Y, Tokunaga M, Saito K, Yanagida T., Nature 374(6522), 1995
PMID: 7700383
Single molecule imaging of fluorophores and enzymatic reactions achieved by objective-type total internal reflection fluorescence microscopy.
Tokunaga M, Kitamura K, Saito K, Iwane AH, Yanagida T., Biochem. Biophys. Res. Commun. 235(1), 1997
PMID: 9196033
Tokunaga M, Kitamura K, Saito K, Iwane AH, Yanagida T., Biochem. Biophys. Res. Commun. 235(1), 1997
PMID: 9196033
Kinesin walks hand-over-hand.
Yildiz A, Tomishige M, Vale RD, Selvin PR., Science 303(5658), 2003
PMID: 14684828
Yildiz A, Tomishige M, Vale RD, Selvin PR., Science 303(5658), 2003
PMID: 14684828
Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization.
Yildiz A, Forkey JN, McKinney SA, Ha T, Goldman YE, Selvin PR., Science 300(5628), 2003
PMID: 12791999
Yildiz A, Forkey JN, McKinney SA, Ha T, Goldman YE, Selvin PR., Science 300(5628), 2003
PMID: 12791999
Direct observation of single kinesin molecules moving along microtubules.
Vale RD, Funatsu T, Pierce DW, Romberg L, Harada Y, Yanagida T., Nature 380(6573), 1996
PMID: 8602245
Vale RD, Funatsu T, Pierce DW, Romberg L, Harada Y, Yanagida T., Nature 380(6573), 1996
PMID: 8602245
Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization.
Forkey JN, Quinlan ME, Shaw MA, Corrie JE, Goldman YE., Nature 422(6930), 2003
PMID: 12660775
Forkey JN, Quinlan ME, Shaw MA, Corrie JE, Goldman YE., Nature 422(6930), 2003
PMID: 12660775
Wilkerson, Appl. Phys. Lett. 62(), 1993
Sauer, Bioimaging 6(), 1998
Soper, J. Opt. Soc. Am. B 9(), 1992
Fluorescence correlation spectroscopy for rapid multicomponent analysis in a capillary electrophoresis system.
Van Orden A, Keller RA., Anal. Chem. 70(21), 1998
PMID: 21644691
Van Orden A, Keller RA., Anal. Chem. 70(21), 1998
PMID: 21644691
Schaffer, J. Phys. Chem. A 103(), 1999
Stracke, Chem. Phys. Lett. 325(), 2000
Meixner, J. Lumin. 86(), 2000
Weston, J. Phys. Chem. A 102(), 1998
Lu, Nature 385(), 1997
Weston, J. Phys. Chem. B 105(), 2001
Tinnefeld, Single Mol. 1(), 2000
Tinnefeld, J. Phys. Chem. A 105(), 2001
Single Molecule Dynamics Studied by Polarization Modulation.
Ha T, Enderle T, Chemla S, Selvin R, Weiss S., Phys. Rev. Lett. 77(19), 1996
PMID: 10062357
Ha T, Enderle T, Chemla S, Selvin R, Weiss S., Phys. Rev. Lett. 77(19), 1996
PMID: 10062357
Single-molecule identification by spectrally and time-resolved fluorescence detection
Prummer M, Hubner CG, Sick B, Hecht B, Renn A, Wild UP., Anal. Chem. 72(3), 2000
PMID: 10695126
Prummer M, Hubner CG, Sick B, Hecht B, Renn A, Wild UP., Anal. Chem. 72(3), 2000
PMID: 10695126
Multiparameter microscopy and spectroscopy for single-molecule analytics.
Prummer M, Sick B, Renn A, Wild UP., Anal. Chem. 76(6), 2004
PMID: 15018561
Prummer M, Sick B, Renn A, Wild UP., Anal. Chem. 76(6), 2004
PMID: 15018561
Herten, Appl. Phys. B 71(), 2000
Detection and identification of single molecules in living cells using spectrally resolved fluorescence lifetime imaging microscopy.
Knemeyer JP, Herten DP, Sauer M., Anal. Chem. 75(9), 2003
PMID: 12720354
Knemeyer JP, Herten DP, Sauer M., Anal. Chem. 75(9), 2003
PMID: 12720354
English, J. Chem. Phys. 114(), 2001
Self-terminating, oxidative radical cyclizations: a novel reaction of acyloxyl radicals.
Wille U., J. Am. Chem. Soc. 124(1), 2002
PMID: 11772050
Wille U., J. Am. Chem. Soc. 124(1), 2002
PMID: 11772050
Data registration and selective single-molecule analysis using multi-parameter fluorescence detection.
Eggeling C, Berger S, Brand L, Fries JR, Schaffer J, Volkmer A, Seidel CA., J. Biotechnol. 86(3), 2001
PMID: 11257530
Eggeling C, Berger S, Brand L, Fries JR, Schaffer J, Volkmer A, Seidel CA., J. Biotechnol. 86(3), 2001
PMID: 11257530
Kühnemuth, Single Mol. 2(), 2001
Chemical physics. Single-molecule spectroscopy comes of age.
Kelley AM, Michalet X, Weiss S., Science 292(5522), 2001
PMID: 11387465
Kelley AM, Michalet X, Weiss S., Science 292(5522), 2001
PMID: 11387465
Tinnefeld, Chem. Phys. Lett. 345(), 2001
Measuring the number of independent emitters in single-molecule fluorescence images and trajectories using coincident photons.
Weston KD, Dyck M, Tinnefeld P, Muller C, Herten DP, Sauer M., Anal. Chem. 74(20), 2002
PMID: 12403591
Weston KD, Dyck M, Tinnefeld P, Muller C, Herten DP, Sauer M., Anal. Chem. 74(20), 2002
PMID: 12403591
Vosch, J. Phys. Chem. A 107(), 2003
Monitoring conformational dynamics of a single molecule by selective fluorescence spectroscopy.
Eggeling C, Fries JR, Brand L, Gunther R, Seidel CA., Proc. Natl. Acad. Sci. U.S.A. 95(4), 1998
PMID: 9465054
Eggeling C, Fries JR, Brand L, Gunther R, Seidel CA., Proc. Natl. Acad. Sci. U.S.A. 95(4), 1998
PMID: 9465054
Fries, J. Phys. Chem. A 102(), 1998
Tellinghuisen, Anal. Chem. 65(), 1993
Enderlein, J. Phys. Chem. A 105(), 2001
Enderlein, Chem. Phys. Lett. 270(), 1997
An experimental comparison of the maximum likelihood estimation and nonlinear least-squares fluorescence lifetime analysis of single molecules.
Maus M, Cotlet M, Hofkens J, Gensch T, De Schryver FC, Schaffer J, Seidel CA., Anal. Chem. 73(9), 2001
PMID: 11354494
Maus M, Cotlet M, Hofkens J, Gensch T, De Schryver FC, Schaffer J, Seidel CA., Anal. Chem. 73(9), 2001
PMID: 11354494
Ha, Chem. Phys. Lett. 271(), 1997
Hanbury, Nature 178(), 1956
Photon antibunching in the fluorescence of a single dye molecule trapped in a solid.
Basche T, Moerner WE, Orrit M, Talon H., Phys. Rev. Lett. 69(10), 1992
PMID: 10046242
Basche T, Moerner WE, Orrit M, Talon H., Phys. Rev. Lett. 69(10), 1992
PMID: 10046242
Nonclassical photon statistics in single-molecule fluorescence at room temperature
Fleury L, Segura J, Zumofen G, Hecht B, Wild UP., Phys. Rev. Lett. 84(6), 2000
PMID: 11017465
Fleury L, Segura J, Zumofen G, Hecht B, Wild UP., Phys. Rev. Lett. 84(6), 2000
PMID: 11017465
Ambrose, Chem. Phys. Lett. 269(), 1997
Wu, J. Phys. Chem. 100(), 1996
Hofkens, J. Am. Chem. Soc. 122(), 2000
Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes.
Rothwell PJ, Berger S, Kensch O, Felekyan S, Antonik M, Wohrl BM, Restle T, Goody RS, Seidel CA., Proc. Natl. Acad. Sci. U.S.A. 100(4), 2003
PMID: 12578980
Rothwell PJ, Berger S, Kensch O, Felekyan S, Antonik M, Wohrl BM, Restle T, Goody RS, Seidel CA., Proc. Natl. Acad. Sci. U.S.A. 100(4), 2003
PMID: 12578980
Dual-view microscopy with a single camera: real-time imaging of molecular orientations and calcium.
Kinosita K Jr, Itoh H, Ishiwata S, Hirano K, Nishizaka T, Hayakawa T., J. Cell Biol. 115(1), 1991
PMID: 1918140
Kinosita K Jr, Itoh H, Ishiwata S, Hirano K, Nishizaka T, Hayakawa T., J. Cell Biol. 115(1), 1991
PMID: 1918140
Cognet, Appl. Phys. Lett. 77(), 2000
Energy transfer: a spectroscopic ruler.
Stryer L, Haugland RP., Proc. Natl. Acad. Sci. U.S.A. 58(2), 1967
PMID: 5233469
Stryer L, Haugland RP., Proc. Natl. Acad. Sci. U.S.A. 58(2), 1967
PMID: 5233469
Fluorescence energy transfer as a spectroscopic ruler.
Stryer L., Annu. Rev. Biochem. 47(), 1978
PMID: 354506
Stryer L., Annu. Rev. Biochem. 47(), 1978
PMID: 354506
The dimeric nature of the gramicidin A transmembrane channel: conductance and fluorescence energy transfer studies of hybrid channels.
Veatch W, Stryer L., J. Mol. Biol. 113(1), 1977
PMID: 69713
Veatch W, Stryer L., J. Mol. Biol. 113(1), 1977
PMID: 69713
Application of fluorescence resonance energy transfer in the clinical laboratory: routine and research.
Szollosi J, Damjanovich S, Matyus L., Cytometry 34(4), 1998
PMID: 9725457
Szollosi J, Damjanovich S, Matyus L., Cytometry 34(4), 1998
PMID: 9725457
Stühmeier, Biochemistry 36(), 1997
Simultaneous binding and bending of promoter DNA by the TATA binding protein: real time kinetic measurements.
Parkhurst KM, Brenowitz M, Parkhurst LJ., Biochemistry 35(23), 1996
PMID: 8652523
Parkhurst KM, Brenowitz M, Parkhurst LJ., Biochemistry 35(23), 1996
PMID: 8652523
A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements.
Tuschl T, Gohlke C, Jovin TM, Westhof E, Eckstein F., Science 266(5186), 1994
PMID: 7973630
Tuschl T, Gohlke C, Jovin TM, Westhof E, Eckstein F., Science 266(5186), 1994
PMID: 7973630
Measuring conformational dynamics of biomolecules by single molecule fluorescence spectroscopy.
Weiss S., Nat. Struct. Biol. 7(9), 2000
PMID: 10966638
Weiss S., Nat. Struct. Biol. 7(9), 2000
PMID: 10966638
Single-molecule protein folding: diffusion fluorescence resonance energy transfer studies of the denaturation of chymotrypsin inhibitor 2.
Deniz AA, Laurence TA, Beligere GS, Dahan M, Martin AB, Chemla DS, Dawson PE, Schultz PG, Weiss S., Proc. Natl. Acad. Sci. U.S.A. 97(10), 2000
PMID: 10792044
Deniz AA, Laurence TA, Beligere GS, Dahan M, Martin AB, Chemla DS, Dawson PE, Schultz PG, Weiss S., Proc. Natl. Acad. Sci. U.S.A. 97(10), 2000
PMID: 10792044
Ha, Single Mol. 2(), 2001
Mg2+-dependent conformational change of RNA studied by fluorescence correlation and FRET on immobilized single molecules.
Kim HD, Nienhaus GU, Ha T, Orr JW, Williamson JR, Chu S., Proc. Natl. Acad. Sci. U.S.A. 99(7), 2002
PMID: 11929999
Kim HD, Nienhaus GU, Ha T, Orr JW, Williamson JR, Chu S., Proc. Natl. Acad. Sci. U.S.A. 99(7), 2002
PMID: 11929999
Ligand-induced conformational changes observed in single RNA molecules.
Ha T, Zhuang X, Kim HD, Orr JW, Williamson JR, Chu S., Proc. Natl. Acad. Sci. U.S.A. 96(16), 1999
PMID: 10430898
Ha T, Zhuang X, Kim HD, Orr JW, Williamson JR, Chu S., Proc. Natl. Acad. Sci. U.S.A. 96(16), 1999
PMID: 10430898
A single-molecule study of RNA catalysis and folding.
Zhuang X, Bartley LE, Babcock HP, Russell R, Ha T, Herschlag D, Chu S., Science 288(5473), 2000
PMID: 10856219
Zhuang X, Bartley LE, Babcock HP, Russell R, Ha T, Herschlag D, Chu S., Science 288(5473), 2000
PMID: 10856219
A four-way junction accelerates hairpin ribozyme folding via a discrete intermediate.
Tan E, Wilson TJ, Nahas MK, Clegg RM, Lilley DM, Ha T., Proc. Natl. Acad. Sci. U.S.A. 100(16), 2003
PMID: 12883002
Tan E, Wilson TJ, Nahas MK, Clegg RM, Lilley DM, Ha T., Proc. Natl. Acad. Sci. U.S.A. 100(16), 2003
PMID: 12883002
Stepwise rotation of the gamma-subunit of EF(0)F(1)-ATP synthase observed by intramolecular single-molecule fluorescence resonance energy transfer.
Borsch M, Diez M, Zimmermann B, Reuter R, Graber P., FEBS Lett. 527(1-3), 2002
PMID: 12220651
Borsch M, Diez M, Zimmermann B, Reuter R, Graber P., FEBS Lett. 527(1-3), 2002
PMID: 12220651
Watching proteins fold one molecule at a time.
Rhoades E, Gussakovsky E, Haran G., Proc. Natl. Acad. Sci. U.S.A. 100(6), 2003
PMID: 12612345
Rhoades E, Gussakovsky E, Haran G., Proc. Natl. Acad. Sci. U.S.A. 100(6), 2003
PMID: 12612345
Single-pair fluorescence resonance energy transfer on freely diffusing molecules: observation of Forster distance dependence and subpopulations.
Deniz AA, Dahan M, Grunwell JR, Ha T, Faulhaber AE, Chemla DS, Weiss S, Schultz PG., Proc. Natl. Acad. Sci. U.S.A. 96(7), 1999
PMID: 10097095
Deniz AA, Dahan M, Grunwell JR, Ha T, Faulhaber AE, Chemla DS, Weiss S, Schultz PG., Proc. Natl. Acad. Sci. U.S.A. 96(7), 1999
PMID: 10097095
Sauer, Chem. Phys. Lett. 284(), 1998
Kinetics of conformational fluctuations in DNA hairpin-loops.
Bonnet G, Krichevsky O, Libchaber A., Proc. Natl. Acad. Sci. U.S.A. 95(15), 1998
PMID: 9671724
Bonnet G, Krichevsky O, Libchaber A., Proc. Natl. Acad. Sci. U.S.A. 95(15), 1998
PMID: 9671724
Sequence dependent rigidity of single stranded DNA.
Goddard NL, Bonnet G, Krichevsky O, Libchaber A., Phys. Rev. Lett. 85(11), 2000
PMID: 10978020
Goddard NL, Bonnet G, Krichevsky O, Libchaber A., Phys. Rev. Lett. 85(11), 2000
PMID: 10978020
Non-Arrhenius kinetics for the loop closure of a DNA hairpin.
Wallace MI, Ying L, Balasubramanian S, Klenerman D., Proc. Natl. Acad. Sci. U.S.A. 98(10), 2001
PMID: 11320222
Wallace MI, Ying L, Balasubramanian S, Klenerman D., Proc. Natl. Acad. Sci. U.S.A. 98(10), 2001
PMID: 11320222
Piestert, Nano Lett. 3(), 2003
Osborne, J. Phys. Chem. B 105(), 2001
Talaga, Proc. Natl. Acad. Sci. USA 97(), 2000
Margittai, Proc. Natl. Acad. Sci. USA 100(), 2003
Proton-powered subunit rotation in single membrane-bound F0F1-ATP synthase.
Diez M, Zimmermann B, Borsch M, Konig M, Schweinberger E, Steigmiller S, Reuter R, Felekyan S, Kudryavtsev V, Seidel CA, Graber P., Nat. Struct. Mol. Biol. 11(2), 2004
PMID: 14730350
Diez M, Zimmermann B, Borsch M, Konig M, Schweinberger E, Steigmiller S, Reuter R, Felekyan S, Kudryavtsev V, Seidel CA, Graber P., Nat. Struct. Mol. Biol. 11(2), 2004
PMID: 14730350
Rehm, Isr. J. Chem. 8(), 1970
Marcus, Biochim. Biophys. Acta 811(), 1985
Chattopadhyay, Proc. Natl. Acad. Sci. USA 99(), 2002
Mechanism of quenching of fluorescein by anti-fluorescein IgG antibodies.
Watt RM, Voss EW Jr., Immunochemistry 14(7), 1977
PMID: 303233
Watt RM, Voss EW Jr., Immunochemistry 14(7), 1977
PMID: 303233
Inter- and intramolecular fluorescence quenching of organic dyes by tryptophan.
Marme N, Knemeyer JP, Sauer M, Wolfrum J., Bioconjug. Chem. 14(6), 2003
PMID: 14624626
Marme N, Knemeyer JP, Sauer M, Wolfrum J., Bioconjug. Chem. 14(6), 2003
PMID: 14624626
Protein conformational dynamics probed by single-molecule electron transfer.
Yang H, Luo G, Karnchanaphanurach P, Louie TM, Rech I, Cova S, Xun L, Xie XS., Science 302(5643), 2003
PMID: 14551431
Yang H, Luo G, Karnchanaphanurach P, Louie TM, Rech I, Cova S, Xun L, Xie XS., Science 302(5643), 2003
PMID: 14551431
Using photoinduced charge transfer reactions to study conformational dynamics of biopolymers at the single-molecule level.
Neuweiler H, Sauer M., Curr Pharm Biotechnol 5(3), 2004
PMID: 15180550
Neuweiler H, Sauer M., Curr Pharm Biotechnol 5(3), 2004
PMID: 15180550
New fluorescent dyes in the red region for biodiagnostics.
Sauer M, Han KT, Muller R, Nord S, Schulz A, Seeger S, Wolfrum J, Arden-Jacob J, Deltau G, Marx NJ, Zander C, Drexhage KH., J Fluoresc 5(3), 1995
PMID: 24226792
Sauer M, Han KT, Muller R, Nord S, Schulz A, Seeger S, Wolfrum J, Arden-Jacob J, Deltau G, Marx NJ, Zander C, Drexhage KH., J Fluoresc 5(3), 1995
PMID: 24226792
Probes for detection of specific DNA sequences at the single-molecule level.
Knemeyer JP, Marme N, Sauer M., Anal. Chem. 72(16), 2000
PMID: 10959954
Knemeyer JP, Marme N, Sauer M., Anal. Chem. 72(16), 2000
PMID: 10959954
Heinlein, J. Phys. Chem. B 107(), 2003
Virus-ligand interactions: identification and characterization of ligand binding by NMR spectroscopy.
Benie AJ, Moser R, Bauml E, Blaas D, Peters T., J. Am. Chem. Soc. 125(1), 2003
PMID: 12515488
Benie AJ, Moser R, Bauml E, Blaas D, Peters T., J. Am. Chem. Soc. 125(1), 2003
PMID: 12515488
Neuweiler, Angew. Chem. 114(), 2002
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 41(), 2002
Measuring the rate of intramolecular contact formation in polypeptides.
Lapidus LJ, Eaton WA, Hofrichter J., Proc. Natl. Acad. Sci. U.S.A. 97(13), 2000
PMID: 10860987
Lapidus LJ, Eaton WA, Hofrichter J., Proc. Natl. Acad. Sci. U.S.A. 97(13), 2000
PMID: 10860987
The humoral response to the tumor-suppressor gene-product p53 in human cancer: implications for diagnosis and therapy.
Soussi T., Immunol. Today 17(8), 1996
PMID: 8783493
Soussi T., Immunol. Today 17(8), 1996
PMID: 8783493
Sauer, Angew. Chem. 115(), 2003
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 42(), 2003
Van, Science 277(), 1997
Yip, J. Phys. Chem. A 102(), 1998
Huser, Proc. Natl. Acad. Sci. USA 97(), 2000
White, J. Chem. Phys. 114(), 2001
Bopp, Proc. Natl. Acad. Sci. USA 94(), 1997
Bopp, Proc. Natl. Acad. Sci. USA 96(), 1999
Hofkens, Spectrochim. Acta Part A 57(), 2001
Ying, J. Phys. Chem. B 102(), 1998
Lounis, J. Phys. Chem. B 105(), 2001
Cotlet, Proc. Natl. Acad. Sci. USA 98(), 2001
Garcia-Parajo, Proc. Natl. Acad. Sci. USA 98(), 2001
Christ, J. Lumin. 98(), 2002
Hernando, J. Phys. Chem. A 107(), 2003
Tinnefeld, J. Phys. Chem. A 107(), 2003
Unmasking electronic energy transfer of conjugated polymers by suppression of O(2) quenching
Yu J, Hu D, Barbara PF., Science 289(5483), 2000
PMID: 10958774
Yu J, Hu D, Barbara PF., Science 289(5483), 2000
PMID: 10958774
Gensch, Angew. Chem. 111(), 1999
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 38(), 1999
Intramolecular Forster energy transfer in a dendritic system at the single molecule level.
Gronheid R, Hofkens J, Kohn F, Weil T, Reuther E, Mullen K, De Schryver FC., J. Am. Chem. Soc. 124(11), 2002
PMID: 11890773
Gronheid R, Hofkens J, Kohn F, Weil T, Reuther E, Mullen K, De Schryver FC., J. Am. Chem. Soc. 124(11), 2002
PMID: 11890773
Basche, Nature 373(), 1995
Bernard, J. Chem. Phys. 98(), 1993
English, J. Phys. Chem. A 104(), 2000
Photon antibunching and collective effects in the fluorescence of single bichromophoric molecules.
Hubner CG, Zumofen G, Renn A, Herrmann A, Mullen K, Basche T., Phys. Rev. Lett. 91(9), 2003
PMID: 14525184
Hubner CG, Zumofen G, Renn A, Herrmann A, Mullen K, Basche T., Phys. Rev. Lett. 91(9), 2003
PMID: 14525184
Hofkens, Proc. Natl. Acad. Sci. USA 100(), 2003
Coherent electronic coupling versus localization in individual molecular dimers.
Lippitz M, Hubner CG, Christ T, Eichner H, Bordat P, Herrmann A, Mullen K, Basche T., Phys. Rev. Lett. 92(10), 2004
PMID: 15089202
Lippitz M, Hubner CG, Christ T, Eichner H, Bordat P, Herrmann A, Mullen K, Basche T., Phys. Rev. Lett. 92(10), 2004
PMID: 15089202
Wagner, J. Am. Chem. Soc. 116(), 1994
Heilemann, Proc. SPIE-Int. Soc. Opt. Eng. 4962(), 2003
Multistep energy transfer in single molecular photonic wires.
Heilemann M, Tinnefeld P, Sanchez Mosteiro G, Garcia Parajo M, Van Hulst NF, Sauer M., J. Am. Chem. Soc. 126(21), 2004
PMID: 15161254
Heilemann M, Tinnefeld P, Sanchez Mosteiro G, Garcia Parajo M, Van Hulst NF, Sauer M., J. Am. Chem. Soc. 126(21), 2004
PMID: 15161254
Vyawahare, Nano Lett. 4(), 2004
Entropic elasticity of lambda-phage DNA.
Bustamante C, Marko JF, Siggia ED, Smith S., Science 265(5178), 1994
PMID: 8079175
Bustamante C, Marko JF, Siggia ED, Smith S., Science 265(5178), 1994
PMID: 8079175
Calzaferri, Angew. Chem. 115(), 2003
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 42(), 2003
Organic chemistry: a digital fluorescent molecular photoswitch.
Irie M, Fukaminato T, Sasaki T, Tamai N, Kawai T., Nature 420(6917), 2002
PMID: 12490936
Irie M, Fukaminato T, Sasaki T, Tamai N, Kawai T., Nature 420(6917), 2002
PMID: 12490936
Macromolecular domains within the cell nucleus.
Spector DL., Annu. Rev. Cell Biol. 9(), 1993
PMID: 8280462
Spector DL., Annu. Rev. Cell Biol. 9(), 1993
PMID: 8280462
Structure and function in the nucleus.
Lamond AI, Earnshaw WC., Science 280(5363), 1998
PMID: 9554838
Lamond AI, Earnshaw WC., Science 280(5363), 1998
PMID: 9554838
Chromosome territories, nuclear architecture and gene regulation in mammalian cells.
Cremer T, Cremer C., Nat. Rev. Genet. 2(4), 2001
PMID: 11283701
Cremer T, Cremer C., Nat. Rev. Genet. 2(4), 2001
PMID: 11283701
Wansink, J. Cell Biol. 62(), 1996
Regional specialization in human nuclei: visualization of discrete sites of transcription by RNA polymerase III.
Pombo A, Jackson DA, Hollinshead M, Wang Z, Roeder RG, Cook PR., EMBO J. 18(8), 1999
PMID: 10205177
Pombo A, Jackson DA, Hollinshead M, Wang Z, Roeder RG, Cook PR., EMBO J. 18(8), 1999
PMID: 10205177
Visualization of single RNA transcripts in situ.
Femino AM, Fay FS, Fogarty K, Singer RH., Science 280(5363), 1998
PMID: 9554849
Femino AM, Fay FS, Fogarty K, Singer RH., Science 280(5363), 1998
PMID: 9554849
Single-cell gene expression profiling.
Levsky JM, Shenoy SM, Pezo RC, Singer RH., Science 297(5582), 2002
PMID: 12161654
Levsky JM, Shenoy SM, Pezo RC, Singer RH., Science 297(5582), 2002
PMID: 12161654
Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization.
Lawrence JB, Singer RH, Marselle LM., Cell 57(3), 1989
PMID: 2541917
Lawrence JB, Singer RH, Marselle LM., Cell 57(3), 1989
PMID: 2541917
RNA molecules lighting up under the microscope.
Dirks RW., Histochem. Cell Biol. 106(2), 1996
PMID: 8877377
Dirks RW., Histochem. Cell Biol. 106(2), 1996
PMID: 8877377
Methods for visualizing RNA processing and transport pathways in living cells.
Dirks RW, Molenaar C, Tanke HJ., Histochem. Cell Biol. 115(1), 2001
PMID: 11219605
Dirks RW, Molenaar C, Tanke HJ., Histochem. Cell Biol. 115(1), 2001
PMID: 11219605
Creating new fluorescent probes for cell biology.
Zhang J, Campbell RE, Ting AY, Tsien RY., Nat. Rev. Mol. Cell Biol. 3(12), 2002
PMID: 12461557
Zhang J, Campbell RE, Ting AY, Tsien RY., Nat. Rev. Mol. Cell Biol. 3(12), 2002
PMID: 12461557
Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity.
Thierry AR, Dritschilo A., Nucleic Acids Res. 20(21), 1992
PMID: 1454532
Thierry AR, Dritschilo A., Nucleic Acids Res. 20(21), 1992
PMID: 1454532
Zander, Chem. Phys. Lett. 286(), 1998
Becker, Rev. Sci. Instrum. 70(), 1999
TAT peptide on the surface of liposomes affords their efficient intracellular delivery even at low temperature and in the presence of metabolic inhibitors.
Torchilin VP, Rammohan R, Weissig V, Levchenko TS., Proc. Natl. Acad. Sci. U.S.A. 98(15), 2001
PMID: 11438707
Torchilin VP, Rammohan R, Weissig V, Levchenko TS., Proc. Natl. Acad. Sci. U.S.A. 98(15), 2001
PMID: 11438707
In vivo protein transduction: delivery of a biologically active protein into the mouse.
Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF., Science 285(5433), 1999
PMID: 10477521
Schwarze SR, Ho A, Vocero-Akbani A, Dowdy SF., Science 285(5433), 1999
PMID: 10477521
Vives, J. Biol. Chem. 272(), 1997
Cellular uptake studies with beta-peptides.
Rueping M, Mahajan Y, Sauer M, Seebach D., Chembiochem 3(2-3), 2002
PMID: 11921409
Rueping M, Mahajan Y, Sauer M, Seebach D., Chembiochem 3(2-3), 2002
PMID: 11921409
Seebach, Chem. Biodiversity 1(), 2004
Schütz, Single Mol. 1(), 2000
Marme, Angew. Chem. 116(), 2004
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 43(), 2004
Baird, Proc. Natl. Acad. Sci. USA 97(), 2000
Myosin dynamics in live Dictyostelium cells.
Moores SL, Sabry JH, Spudich JA., Proc. Natl. Acad. Sci. U.S.A. 93(1), 1996
PMID: 8552657
Moores SL, Sabry JH, Spudich JA., Proc. Natl. Acad. Sci. U.S.A. 93(1), 1996
PMID: 8552657
Analysis of MAP 4 function in living cells using green fluorescent protein (GFP) chimeras.
Olson KR, McIntosh JR, Olmsted JB., J. Cell Biol. 130(3), 1995
PMID: 7622564
Olson KR, McIntosh JR, Olmsted JB., J. Cell Biol. 130(3), 1995
PMID: 7622564
Autofluorescent proteins in single-molecule research: applications to live cell imaging microscopy.
Harms GS, Cognet L, Lommerse PH, Blab GA, Schmidt T., Biophys. J. 80(5), 2001
PMID: 11325739
Harms GS, Cognet L, Lommerse PH, Blab GA, Schmidt T., Biophys. J. 80(5), 2001
PMID: 11325739
Single-molecule imaging of l-type Ca(2+) channels in live cells.
Harms GS, Cognet L, Lommerse PH, Blab GA, Kahr H, Gamsjager R, Spaink HP, Soldatov NM, Romanin C, Schmidt T., Biophys. J. 81(5), 2001
PMID: 11606277
Harms GS, Cognet L, Lommerse PH, Blab GA, Kahr H, Gamsjager R, Spaink HP, Soldatov NM, Romanin C, Schmidt T., Biophys. J. 81(5), 2001
PMID: 11606277
Iino, J. Fluoresc. 11(), 2001
Single molecule imaging of green fluorescent proteins in living cells: E-cadherin forms oligomers on the free cell surface.
Iino R, Koyama I, Kusumi A., Biophys. J. 80(6), 2001
PMID: 11371443
Iino R, Koyama I, Kusumi A., Biophys. J. 80(6), 2001
PMID: 11371443
Widengren, Chem. Phys. 249(), 1999
Zumbusch, Single Mol. 1(), 2000
Cotlet, J. Phys. Chem. B 105(), 2001
Fluorescent proteins from nonbioluminescent Anthozoa species.
Matz MV, Fradkov AF, Labas YA, Savitsky AP, Zaraisky AG, Markelov ML, Lukyanov SA., Nat. Biotechnol. 17(10), 1999
PMID: 10504696
Matz MV, Fradkov AF, Labas YA, Savitsky AP, Zaraisky AG, Markelov ML, Lukyanov SA., Nat. Biotechnol. 17(10), 1999
PMID: 10504696
Bevis, Nat. Biotechnol. 20(), 2002
Wiedenmann, Proc. Natl. Acad. Sci. USA 99(), 2002
GFP-like chromoproteins as a source of far-red fluorescent proteins.
Gurskaya NG, Fradkov AF, Terskikh A, Matz MV, Labas YA, Martynov VI, Yanushevich YG, Lukyanov KA, Lukyanov SA., FEBS Lett. 507(1), 2001
PMID: 11682051
Gurskaya NG, Fradkov AF, Terskikh A, Matz MV, Labas YA, Martynov VI, Yanushevich YG, Lukyanov KA, Lukyanov SA., FEBS Lett. 507(1), 2001
PMID: 11682051
A monomeric red fluorescent protein.
Campbell RE, Tour O, Palmer AE, Steinbach PA, Baird GS, Zacharias DA, Tsien RY., Proc. Natl. Acad. Sci. U.S.A. 99(12), 2002
PMID: 12060735
Campbell RE, Tour O, Palmer AE, Steinbach PA, Baird GS, Zacharias DA, Tsien RY., Proc. Natl. Acad. Sci. U.S.A. 99(12), 2002
PMID: 12060735
Visualization of interactions among bZIP and Rel family proteins in living cells using bimolecular fluorescence complementation.
Hu CD, Chinenov Y, Kerppola TK., Mol. Cell 9(4), 2002
PMID: 11983170
Hu CD, Chinenov Y, Kerppola TK., Mol. Cell 9(4), 2002
PMID: 11983170
Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells.
Politz JC, Browne ES, Wolf DE, Pederson T., Proc. Natl. Acad. Sci. U.S.A. 95(11), 1998
PMID: 9600914
Politz JC, Browne ES, Wolf DE, Pederson T., Proc. Natl. Acad. Sci. U.S.A. 95(11), 1998
PMID: 9600914
Dual-color fluorescence cross-correlation spectroscopy for multicomponent diffusional analysis in solution.
Schwille P, Meyer-Almes FJ, Rigler R., Biophys. J. 72(4), 1997
PMID: 9083691
Schwille P, Meyer-Almes FJ, Rigler R., Biophys. J. 72(4), 1997
PMID: 9083691
Brock, Proc. Natl. Acad. Sci. USA 96(), 1999
Probing single molecules in single living cells.
Byassee TA, Chan WC, Nie S., Anal. Chem. 72(22), 2000
PMID: 11101238
Byassee TA, Chan WC, Nie S., Anal. Chem. 72(22), 2000
PMID: 11101238
Kues, Proc. Natl. Acad. Sci. USA 98(), 2001
Visualization and tracking of single protein molecules in the cell nucleus.
Kues T, Peters R, Kubitscheck U., Biophys. J. 80(6), 2001
PMID: 11371468
Kues T, Peters R, Kubitscheck U., Biophys. J. 80(6), 2001
PMID: 11371468
Real-time single-molecule imaging of the infection pathway of an adeno-associated virus.
Seisenberger G, Ried MU, Endress T, Buning H, Hallek M, Brauchle C., Science 294(5548), 2001
PMID: 11729319
Seisenberger G, Ried MU, Endress T, Buning H, Hallek M, Brauchle C., Science 294(5548), 2001
PMID: 11729319
Correlating structural dynamics and function in single ribozyme molecules.
Zhuang X, Kim H, Pereira MJ, Babcock HP, Walter NG, Chu S., Science 296(5572), 2002
PMID: 12029135
Zhuang X, Kim H, Pereira MJ, Babcock HP, Walter NG, Chu S., Science 296(5572), 2002
PMID: 12029135
Semiconductor nanocrystals as fluorescent biological labels.
Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP., Science 281(5385), 1998
PMID: 9748157
Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP., Science 281(5385), 1998
PMID: 9748157
Time-gated biological imaging by use of colloidal quantum dots.
Dahan M, Laurence T, Pinaud F, Chemla DS, Alivisatos AP, Sauer M, Weiss S., Opt Lett 26(11), 2001
PMID: 18040463
Dahan M, Laurence T, Pinaud F, Chemla DS, Alivisatos AP, Sauer M, Weiss S., Opt Lett 26(11), 2001
PMID: 18040463
Quantum dot bioconjugates for ultrasensitive nonisotopic detection.
Chan WC, Nie S., Science 281(5385), 1998
PMID: 9748158
Chan WC, Nie S., Science 281(5385), 1998
PMID: 9748158
In vivo imaging of quantum dots encapsulated in phospholipid micelles.
Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A., Science 298(5599), 2002
PMID: 12459582
Dubertret B, Skourides P, Norris DJ, Noireaux V, Brivanlou AH, Libchaber A., Science 298(5599), 2002
PMID: 12459582
Long-term multiple color imaging of live cells using quantum dot bioconjugates.
Jaiswal JK, Mattoussi H, Mauro JM, Simon SM., Nat. Biotechnol. 21(1), 2002
PMID: 12459736
Jaiswal JK, Mattoussi H, Mauro JM, Simon SM., Nat. Biotechnol. 21(1), 2002
PMID: 12459736
Preparation of quantum dot-biotin conjugates and their use in immunochromatography assays.
Lingerfelt BM, Mattoussi H, Goldman ER, Mauro JM, Anderson GP., Anal. Chem. 75(16), 2003
PMID: 14632116
Lingerfelt BM, Mattoussi H, Goldman ER, Mauro JM, Anderson GP., Anal. Chem. 75(16), 2003
PMID: 14632116
Avidin: a natural bridge for quantum dot-antibody conjugates.
Goldman ER, Balighian ED, Mattoussi H, Kuno MK, Mauro JM, Tran PT, Anderson GP., J. Am. Chem. Soc. 124(22), 2002
PMID: 12033868
Goldman ER, Balighian ED, Mattoussi H, Kuno MK, Mauro JM, Tran PT, Anderson GP., J. Am. Chem. Soc. 124(22), 2002
PMID: 12033868
Mattoussi, J. Am. Chem. Soc. 122(), 2000
Immunofluorescent labeling of cancer marker Her2 and other cellular targets with semiconductor quantum dots.
Wu X, Liu H, Liu J, Haley KN, Treadway JA, Larson JP, Ge N, Peale F, Bruchez MP., Nat. Biotechnol. 21(1), 2002
PMID: 12459735
Wu X, Liu H, Liu J, Haley KN, Treadway JA, Larson JP, Ge N, Peale F, Bruchez MP., Nat. Biotechnol. 21(1), 2002
PMID: 12459735
Water-soluble quantum dots for multiphoton fluorescence imaging in vivo.
Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, Webb WW., Science 300(5624), 2003
PMID: 12775841
Larson DR, Zipfel WR, Williams RM, Clark SW, Bruchez MP, Wise FW, Webb WW., Science 300(5624), 2003
PMID: 12775841
Pinaud, Eur. Biophys. J. 32(), 2003
Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking.
Dahan M, Levi S, Luccardini C, Rostaing P, Riveau B, Triller A., Science 302(5644), 2003
PMID: 14564008
Dahan M, Levi S, Luccardini C, Rostaing P, Riveau B, Triller A., Science 302(5644), 2003
PMID: 14564008
Nirmal, Nature 383(), 1996
Kuno, J. Chem. Phys. 112(), 2000
Kuno, J. Chem. Phys. 115(), 2001
Near-complete suppression of quantum dot blinking in ambient conditions.
Hohng S, Ha T., J. Am. Chem. Soc. 126(5), 2004
PMID: 14759174
Hohng S, Ha T., J. Am. Chem. Soc. 126(5), 2004
PMID: 14759174
Cordero, J. Phys. Chem. B 104(), 2000
Parak, Adv. Mater. 14(), 2002
Real time imaging of single fluorophores on moving actin with an epifluorescence microscope.
Sase I, Miyata H, Corrie JE, Craik JS, Kinosita K Jr., Biophys. J. 69(2), 1995
PMID: 8527645
Sase I, Miyata H, Corrie JE, Craik JS, Kinosita K Jr., Biophys. J. 69(2), 1995
PMID: 8527645
Schmidt, J. Phys. Chem. 99(), 1995
Imaging of single molecule diffusion.
Schmidt T, Schutz GJ, Baumgartner W, Gruber HJ, Schindler H., Proc. Natl. Acad. Sci. U.S.A. 93(7), 1996
PMID: 8610144
Schmidt T, Schutz GJ, Baumgartner W, Gruber HJ, Schindler H., Proc. Natl. Acad. Sci. U.S.A. 93(7), 1996
PMID: 8610144
Three-dimensional imaging of single molecules solvated in pores of poly(acrylamide) gels.
Dickson RM, Norris DJ, Tzeng YL, Moerner WE., Science 274(5289), 1996
PMID: 8875935
Dickson RM, Norris DJ, Tzeng YL, Moerner WE., Science 274(5289), 1996
PMID: 8875935
Single-molecule high-resolution imaging with photobleaching.
Gordon MP, Ha T, Selvin PR., Proc. Natl. Acad. Sci. U.S.A. 101(17), 2004
PMID: 15096603
Gordon MP, Ha T, Selvin PR., Proc. Natl. Acad. Sci. U.S.A. 101(17), 2004
PMID: 15096603
Patwardhan, Bioimaging 4(), 1996
Three-dimensional spectral precision distance microscopy of chromatin nanostructures after triple-colour DNA labelling: a study of the BCR region on chromosome 22 and the Philadelphia chromosome.
Esa A, Edelmann P, Kreth G, Trakhtenbrot L, Amariglio N, Rechavi G, Hausmann M, Cremer C., J Microsc 199(Pt 2), 2000
PMID: 10947902
Esa A, Edelmann P, Kreth G, Trakhtenbrot L, Amariglio N, Rechavi G, Hausmann M, Cremer C., J Microsc 199(Pt 2), 2000
PMID: 10947902
van, Chem. Phys. Lett. 292(), 1998
Ultrahigh-resolution multicolor colocalization of single fluorescent probes.
Lacoste TD, Michalet X, Pinaud F, Chemla DS, Alivisatos AP, Weiss S., Proc. Natl. Acad. Sci. U.S.A. 97(17), 2000
PMID: 10931959
Lacoste TD, Michalet X, Pinaud F, Chemla DS, Alivisatos AP, Weiss S., Proc. Natl. Acad. Sci. U.S.A. 97(17), 2000
PMID: 10931959
Ultrahigh-resolution colocalization of spectrally separable point-like fluorescent probes.
Michalet X, Lacoste TD, Weiss S., Methods 25(1), 2001
PMID: 11559000
Michalet X, Lacoste TD, Weiss S., Methods 25(1), 2001
PMID: 11559000
Zander, Appl. Phys. B 63(), 1996
High-resolution colocalization of single dye molecules by fluorescence lifetime imaging microscopy.
Heilemann M, Herten DP, Heintzmann R, Cremer C, Muller C, Tinnefeld P, Weston KD, Wolfrum J, Sauer M., Anal. Chem. 74(14), 2002
PMID: 12139062
Heilemann M, Herten DP, Heintzmann R, Cremer C, Muller C, Tinnefeld P, Weston KD, Wolfrum J, Sauer M., Anal. Chem. 74(14), 2002
PMID: 12139062
Hell, J. Opt. Soc. Am. 9(), 1992
Fast 100-nm resolution three-dimensional microscope reveals structural plasticity of mitochondria in live yeast.
Egner A, Jakobs S, Hell SW., Proc. Natl. Acad. Sci. U.S.A. 99(6), 2002
PMID: 11904401
Egner A, Jakobs S, Hell SW., Proc. Natl. Acad. Sci. U.S.A. 99(6), 2002
PMID: 11904401
Membrane specific mapping and colocalization of malarial and host skeletal proteins in the Plasmodium falciparum infected erythrocyte by dual-color near-field scanning optical microscopy.
Enderle T, Ha T, Ogletree DF, Chemla DS, Magowan C, Weiss S., Proc. Natl. Acad. Sci. U.S.A. 94(2), 1997
PMID: 9012816
Enderle T, Ha T, Ogletree DF, Chemla DS, Magowan C, Weiss S., Proc. Natl. Acad. Sci. U.S.A. 94(2), 1997
PMID: 9012816
Influencing the angular emission of a single molecule.
Gersen H, Garcia-Parajo MF, Novotny L, Veerman JA, Kuipers L, van Hulst NF ., Phys. Rev. Lett. 85(25), 2000
PMID: 11135984
Gersen H, Garcia-Parajo MF, Novotny L, Veerman JA, Kuipers L, van Hulst NF ., Phys. Rev. Lett. 85(25), 2000
PMID: 11135984
Resolution enhancement in standing-wave total internal reflection microscopy: a point-spread-function engineering approach.
So PT, Kwon HS, Dong CY., J Opt Soc Am A Opt Image Sci Vis 18(11), 2001
PMID: 11688874
So PT, Kwon HS, Dong CY., J Opt Soc Am A Opt Image Sci Vis 18(11), 2001
PMID: 11688874
Spatially modulated illumination microscopy: online visualization of intensity distribution and prediction of nanometer precision of axial distance measurements by computer simulations.
Albrecht B, Failla AV, Heintzmann R, Cremer C., J Biomed Opt 6(3), 2001
PMID: 11516319
Albrecht B, Failla AV, Heintzmann R, Cremer C., J Biomed Opt 6(3), 2001
PMID: 11516319
Nanosizing of fluorescent objects by spatially modulated illumination microscopy.
Failla AV, Spoeri U, Albrecht B, Kroll A, Cremer C., Appl Opt 41(34), 2002
PMID: 12477118
Failla AV, Spoeri U, Albrecht B, Kroll A, Cremer C., Appl Opt 41(34), 2002
PMID: 12477118
Nanometer resolution and coherent optical dipole coupling of two individual molecules.
Hettich C, Schmitt C, Zitzmann J, Kuhn S, Gerhardt I, Sandoghdar V., Science 298(5592), 2002
PMID: 12215651
Hettich C, Schmitt C, Zitzmann J, Kuhn S, Gerhardt I, Sandoghdar V., Science 298(5592), 2002
PMID: 12215651
Fluorescence microscopy with diffraction resolution barrier broken by stimulated emission.
Klar TA, Jakobs S, Dyba M, Egner A, Hell SW., Proc. Natl. Acad. Sci. U.S.A. 97(15), 2000
PMID: 10899992
Klar TA, Jakobs S, Dyba M, Egner A, Hell SW., Proc. Natl. Acad. Sci. U.S.A. 97(15), 2000
PMID: 10899992
Westphal, Appl. Phys. Lett. 82(), 2003
Immunofluorescence stimulated emission depletion microscopy.
Dyba M, Jakobs S, Hell SW., Nat. Biotechnol. 21(11), 2003
PMID: 14566345
Dyba M, Jakobs S, Hell SW., Nat. Biotechnol. 21(11), 2003
PMID: 14566345
Westphal, Appl. Phys. B 77(), 2003
Directly labeled DNA probes using fluorescent nucleotides with different length linkers.
Zhu Z, Chao J, Yu H, Waggoner AS., Nucleic Acids Res. 22(16), 1994
PMID: 8078779
Zhu Z, Chao J, Yu H, Waggoner AS., Nucleic Acids Res. 22(16), 1994
PMID: 8078779
Cyanine dye dUTP analogs for enzymatic labeling of DNA probes.
Yu H, Chao J, Patek D, Mujumdar R, Mujumdar S, Waggoner AS., Nucleic Acids Res. 22(15), 1994
PMID: 8065939
Yu H, Chao J, Patek D, Mujumdar R, Mujumdar S, Waggoner AS., Nucleic Acids Res. 22(15), 1994
PMID: 8065939
The large fragment of Escherichia coli DNA polymerase I can synthesize DNA exclusively from fluorescently labeled nucleotides.
Brakmann S, Nieckchen P., Chembiochem 2(10), 2001
PMID: 11948861
Brakmann S, Nieckchen P., Chembiochem 2(10), 2001
PMID: 11948861
Brakmann, Angew. Chem. 2002, 114 (), 0
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 41(), 2002
Brakmann, Angew. Chem. 113(), 2001
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 40(), 2001
Absolute comparison of simulated and experimental protein-folding dynamics.
Snow CD, Nguyen H, Pande VS, Gruebele M., Nature 420(6911), 2002
PMID: 12422224
Snow CD, Nguyen H, Pande VS, Gruebele M., Nature 420(6911), 2002
PMID: 12422224
Edman, Chem. Phys. 247(), 1999
Memory landscapes of single-enzyme molecules.
Edman L, Rigler R., Proc. Natl. Acad. Sci. U.S.A. 97(15), 2000
PMID: 10880561
Edman L, Rigler R., Proc. Natl. Acad. Sci. U.S.A. 97(15), 2000
PMID: 10880561
Fluorescence-aided molecule sorting: analysis of structure and interactions by alternating-laser excitation of single molecules.
Kapanidis AN, Lee NK, Laurence TA, Doose S, Margeat E, Weiss S., Proc. Natl. Acad. Sci. U.S.A. 101(24), 2004
PMID: 15175430
Kapanidis AN, Lee NK, Laurence TA, Doose S, Margeat E, Weiss S., Proc. Natl. Acad. Sci. U.S.A. 101(24), 2004
PMID: 15175430
The scanning ion-conductance microscope.
Hansma PK, Drake B, Marti O, Gould SA, Prater CB., Science 243(4891), 1989
PMID: 2464851
Hansma PK, Drake B, Marti O, Gould SA, Prater CB., Science 243(4891), 1989
PMID: 2464851
Scanning ion conductance microscopy of living cells.
Korchev YE, Bashford CL, Milovanovic M, Vodyanoy I, Lab MJ., Biophys. J. 73(2), 1997
PMID: 9251784
Korchev YE, Bashford CL, Milovanovic M, Vodyanoy I, Lab MJ., Biophys. J. 73(2), 1997
PMID: 9251784
Hybrid scanning ion conductance and scanning near-field optical microscopy for the study of living cells.
Korchev YE, Raval M, Lab MJ, Gorelik J, Edwards CR, Rayment T, Klenerman D., Biophys. J. 78(5), 2000
PMID: 10777763
Korchev YE, Raval M, Lab MJ, Gorelik J, Edwards CR, Rayment T, Klenerman D., Biophys. J. 78(5), 2000
PMID: 10777763
Single-molecule analysis of chemotactic signaling in Dictyostelium cells.
Ueda M, Sako Y, Tanaka T, Devreotes P, Yanagida T., Science 294(5543), 2001
PMID: 11679673
Ueda M, Sako Y, Tanaka T, Devreotes P, Yanagida T., Science 294(5543), 2001
PMID: 11679673
Functional localization of single active ion channels on the surface of a living cell.
Korchev YE, Negulyaev YA, Edwards CR, Vodyanoy I, Lab MJ., Nat. Cell Biol. 2(9), 2000
PMID: 10980702
Korchev YE, Negulyaev YA, Edwards CR, Vodyanoy I, Lab MJ., Nat. Cell Biol. 2(9), 2000
PMID: 10980702
Sonnleitner, Proc. Natl. Acad. Sci. USA 99(), 2002
Probing conformational changes of gramicidin ion channels by single-molecule patch-clamp fluorescence microscopy.
Harms GS, Orr G, Montal M, Thrall BD, Colson SD, Lu HP., Biophys. J. 85(3), 2003
PMID: 12944296
Harms GS, Orr G, Montal M, Thrall BD, Colson SD, Lu HP., Biophys. J. 85(3), 2003
PMID: 12944296
Ide, Single Mol. 3(), 2002
Brunel, Phys. Rev. Lett. 83(), 1999
A novel method for the N-terminal modification of native proteins.
Lewinska M, Seitz C, Skerra A, Schmidtchen FP., Bioconjug. Chem. 15(2), 2004
PMID: 15025517
Lewinska M, Seitz C, Skerra A, Schmidtchen FP., Bioconjug. Chem. 15(2), 2004
PMID: 15025517
Observation of a single-beam gradient force optical trap for dielectric particles.
Ashkin A, Dziedzic JM, Bjorkholm JE, Chu S., Opt Lett 11(5), 1986
PMID: 19730608
Ashkin A, Dziedzic JM, Bjorkholm JE, Chu S., Opt Lett 11(5), 1986
PMID: 19730608
Kneipp, Appl. Spectrosc. 56(), 2002
Gu, J. Appl. Phys. 91(), 2002
Biological applications of optical forces.
Svoboda K, Block SM., Annu Rev Biophys Biomol Struct 23(), 1994
PMID: 7919782
Svoboda K, Block SM., Annu Rev Biophys Biomol Struct 23(), 1994
PMID: 7919782
Characterization of photodamage to Escherichia coli in optical traps.
Neuman KC, Chadd EH, Liou GF, Bergman K, Block SM., Biophys. J. 77(5), 1999
PMID: 10545383
Neuman KC, Chadd EH, Liou GF, Bergman K, Block SM., Biophys. J. 77(5), 1999
PMID: 10545383
Kuhn, J. Chem. Phys. 53(), 1970
Imahori, J. Phys. Chem. B 104(), 2000
Yokota, Phys. Rev. Lett. 80(), 1998
Soni, Curr. Sci. 83(), 2002
Combined optical trapping and single-molecule fluorescence.
Lang MJ, Fordyce PM, Block SM., J. Biol. 2(1), 2003
PMID: 12733997
Lang MJ, Fordyce PM, Block SM., J. Biol. 2(1), 2003
PMID: 12733997
Rubinsztein-Dunlop, Adv. Quantum Chem. 30(), 1998
Analytical chemistry. How to detect weak pairs.
Laurence TA, Weiss S., Science 299(5607), 2003
PMID: 12560536
Laurence TA, Weiss S., Science 299(5607), 2003
PMID: 12560536
Vesicle encapsulation studies reveal that single molecule ribozyme heterogeneities are intrinsic.
Okumus B, Wilson TJ, Lilley DM, Ha T., Biophys. J. 87(4), 2004
PMID: 15454471
Okumus B, Wilson TJ, Lilley DM, Ha T., Biophys. J. 87(4), 2004
PMID: 15454471
Biofunctionalized, ultrathin coatings of cross-linked star-shaped poly(ethylene oxide) allow reversible folding of immobilized proteins.
Groll J, Amirgoulova EV, Ameringer T, Heyes CD, Rocker C, Nienhaus GU, Moller M., J. Am. Chem. Soc. 126(13), 2004
PMID: 15053612
Groll J, Amirgoulova EV, Ameringer T, Heyes CD, Rocker C, Nienhaus GU, Moller M., J. Am. Chem. Soc. 126(13), 2004
PMID: 15053612
Blanchard, Proc. Natl. Acad. Sci. USA 101(), 2004
tRNA selection and kinetic proofreading in translation.
Blanchard SC, Gonzalez RL, Kim HD, Chu S, Puglisi JD., Nat. Struct. Mol. Biol. 11(10), 2004
PMID: 15448679
Blanchard SC, Gonzalez RL, Kim HD, Chu S, Puglisi JD., Nat. Struct. Mol. Biol. 11(10), 2004
PMID: 15448679
Rueda, Proc. Natl. Acad. Sci. USA 101(), 2004
Design of molecular photonic wires based on multistep electronic excitation transfer.
Tinnefeld P, Heilemann M, Sauer M., Chemphyschem 6(2), 2005
PMID: 15751339
Tinnefeld P, Heilemann M, Sauer M., Chemphyschem 6(2), 2005
PMID: 15751339
Clamme, ChemPhysChem 5(), 2004
Higher-excited-state photophysical pathways in multichromophoric systems revealed by single-molecule fluorescence spectroscopy.
Tinnefeld P, Hofkens J, Herten DP, Masuo S, Vosch T, Cotlet M, Habuchi S, Mullen K, De Schryver FC, Sauer M., Chemphyschem 5(11), 2004
PMID: 15580942
Tinnefeld P, Hofkens J, Herten DP, Masuo S, Vosch T, Cotlet M, Habuchi S, Mullen K, De Schryver FC, Sauer M., Chemphyschem 5(11), 2004
PMID: 15580942
Masuo, J. Phys. Chem. B 108(), 2004
Single molecule photobleaching probes the exciton wave function in a multichromophoric system.
Hernando J, Hoogenboom JP, van Dijk EM, Garcia-Lopez JJ, Crego-Calama M, Reinhoudt DN, van Hulst NF, Garcia-Parajo MF., Phys. Rev. Lett. 93(23), 2004
PMID: 15601183
Hernando J, Hoogenboom JP, van Dijk EM, Garcia-Lopez JJ, Crego-Calama M, Reinhoudt DN, van Hulst NF, Garcia-Parajo MF., Phys. Rev. Lett. 93(23), 2004
PMID: 15601183
Schindler, Proc. Natl. Acad. Sci. USA 101(), 2004
Single-molecule imaging analysis of Ras activation in living cells.
Murakoshi H, Iino R, Kobayashi T, Fujiwara T, Ohshima C, Yoshimura A, Kusumi A., Proc. Natl. Acad. Sci. U.S.A. 101(19), 2004
PMID: 15123831
Murakoshi H, Iino R, Kobayashi T, Fujiwara T, Ohshima C, Yoshimura A, Kusumi A., Proc. Natl. Acad. Sci. U.S.A. 101(19), 2004
PMID: 15123831
Ober, Proc. Natl. Acad. Sci. USA 101(), 2004
Yang, Proc. Natl. Acad. Sci. USA 101(), 2004
Velonia, Angew. Chem. 117(), 2005
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 44(), 2005
Flomenbom, Proc. Natl. Acad. Sci. USA 102(), 2005
Harms, Appl. Phys. Lett. 84(), 2004
Sarkar, Proc. Natl. Acad. Sci. USA 101(), 2004
Probing the Cytotoxicity Of Semiconductor Quantum Dots.
Derfus AM, Chan WCW, Bhatia SN., Nano Lett. 4(1), 2003
PMID: 28890669
Derfus AM, Chan WCW, Bhatia SN., Nano Lett. 4(1), 2003
PMID: 28890669
Cytotoxicity of colloidal CdSe and CdSe/ZnS nanoparticles.
Kirchner C, Liedl T, Kudera S, Pellegrino T, Munoz Javier A, Gaub HE, Stolzle S, Fertig N, Parak WJ., Nano Lett. 5(2), 2005
PMID: 15794621
Kirchner C, Liedl T, Kudera S, Pellegrino T, Munoz Javier A, Gaub HE, Stolzle S, Fertig N, Parak WJ., Nano Lett. 5(2), 2005
PMID: 15794621
Quantum dots for live cells, in vivo imaging, and diagnostics.
Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S., Science 307(5709), 2005
PMID: 15681376
Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S., Science 307(5709), 2005
PMID: 15681376
Lagerholm, Nano Lett. 4(), 2004
Derfus, Adv. Mater. 16(), 2004
Qu, Proc. Natl. Acad. Sci. USA 101(), 2004
AUTHOR UNKNOWN, 0
DNA mapping using microfluidic stretching and single-molecule detection of fluorescent site-specific tags.
Chan EY, Goncalves NM, Haeusler RA, Hatch AJ, Larson JW, Maletta AM, Yantz GR, Carstea ED, Fuchs M, Wong GG, Gullans SR, Gilmanshin R., Genome Res. 14(6), 2004
PMID: 15173119
Chan EY, Goncalves NM, Haeusler RA, Hatch AJ, Larson JW, Maletta AM, Yantz GR, Carstea ED, Fuchs M, Wong GG, Gullans SR, Gilmanshin R., Genome Res. 14(6), 2004
PMID: 15173119
Kastrup, Angew. Chem. 116(), 2004
AUTHOR UNKNOWN, Angew. Chem. Int. Ed. 43(), 2004
Hell, Phys. Lett. A 326(), 2004
Concepts for nanoscale resolution in fluorescence microscopy.
Hell SW, Dyba M, Jakobs S., Curr. Opin. Neurobiol. 14(5), 2004
PMID: 15464894
Hell SW, Dyba M, Jakobs S., Curr. Opin. Neurobiol. 14(5), 2004
PMID: 15464894
Single molecule high-resolution colocalization of Cy3 and Cy5 attached to macromolecules measures intramolecular distances through time.
Churchman LS, Okten Z, Rock RS, Dawson JF, Spudich JA., Proc. Natl. Acad. Sci. U.S.A. 102(5), 2005
PMID: 15668396
Churchman LS, Okten Z, Rock RS, Dawson JF, Spudich JA., Proc. Natl. Acad. Sci. U.S.A. 102(5), 2005
PMID: 15668396
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