Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder.

Starcke K, Tuschen-Caffier B, Markowitsch HJ, Brand M (2009)
Cogn Neuropsychiatry 14(3): 199-216.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Starcke, Katrin; Tuschen-Caffier, Brunna; Markowitsch, Hans J.UniBi; Brand, Matthias
Abstract / Bemerkung
INTRODUCTION: Patients with obsessive-compulsive disorder (OCD) often have difficulties in everyday decision making. In addition, recent research suggests that patients have reduced performance on the Iowa Gambling Task, a laboratory decision-making task with implicit rules that taps emotional feedback processing. Disadvantageous decision making is accompanied by reduced skin conductance responses (SCRs) generated during task performance. METHODS: The current study investigates behavioural and SCR data during the Iowa Gambling Task (IGT) and additionally the Game of Dice Task (GDT), a decision-making task with explicit and stable rules. We examined 14 patients with OCD and 15 comparison subjects performing the two decision-making tasks while recording accompanying SCR. RESULTS: Patients showed difficulties on the Iowa Gambling Task but not the Game of Dice Task. This was also confirmed by the SCR results. In the Iowa Gambling Task differences in SCR patterns for patients and comparison subjects were observed, whereas SCRs during the Game of Dice Task did not differ between groups. CONCLUSIONS: Behavioural and SCR data indicate that patients with OCD have difficulties in decisions under implicit but not under explicit risk conditions.
Cogn Neuropsychiatry
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Starcke K, Tuschen-Caffier B, Markowitsch HJ, Brand M. Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder. Cogn Neuropsychiatry. 2009;14(3):199-216.
Starcke, K., Tuschen-Caffier, B., Markowitsch, H. J., & Brand, M. (2009). Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder. Cogn Neuropsychiatry, 14(3), 199-216.
Starcke, K., Tuschen-Caffier, B., Markowitsch, H. J., and Brand, M. (2009). Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder. Cogn Neuropsychiatry 14, 199-216.
Starcke, K., et al., 2009. Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder. Cogn Neuropsychiatry, 14(3), p 199-216.
K. Starcke, et al., “Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder.”, Cogn Neuropsychiatry, vol. 14, 2009, pp. 199-216.
Starcke, K., Tuschen-Caffier, B., Markowitsch, H.J., Brand, M.: Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder. Cogn Neuropsychiatry. 14, 199-216 (2009).
Starcke, Katrin, Tuschen-Caffier, Brunna, Markowitsch, Hans J., and Brand, Matthias. “Skin conductance responses during decisions in ambiguous and risky situations in obsessive-compulsive disorder.”. Cogn Neuropsychiatry 14.3 (2009): 199-216.

22 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Selective impairment of decision making under ambiguity in alexithymia.
Zhang L, Wang X, Zhu Y, Li H, Zhu C, Yu F, Wang K., BMC Psychiatry 17(1), 2017
PMID: 29179707
Dissociation of decision making under ambiguity and decision making under risk: a neurocognitive endophenotype candidate for obsessive-compulsive disorder.
Zhang L, Dong Y, Ji Y, Zhu C, Yu F, Ma H, Chen X, Wang K., Prog Neuropsychopharmacol Biol Psychiatry 57(), 2015
PMID: 25315855
Trait Anxiety Has Effect on Decision Making under Ambiguity but Not Decision Making under Risk.
Zhang L, Wang K, Zhu C, Yu F, Chen X., PLoS One 10(5), 2015
PMID: 26000629
Think twice: Impulsivity and decision making in obsessive-compulsive disorder.
Grassi G, Pallanti S, Righi L, Figee M, Mantione M, Denys D, Piccagliani D, Rossi A, Stratta P., J Behav Addict 4(4), 2015
PMID: 26690621
Decision-making under risk is improved by both dopaminergic medication and subthalamic stimulation in Parkinson's disease.
Boller JK, Barbe MT, Pauls KA, Reck C, Brand M, Maier F, Fink GR, Timmermann L, Kalbe E., Exp Neurol 254(), 2014
PMID: 24444545
The cost of fear: avoidant decision making in a spider gambling task.
Pittig A, Brand M, Pawlikowski M, Alpers GW., J Anxiety Disord 28(3), 2014
PMID: 24682086
Review of cognitive performance in hoarding disorder.
Woody SR, Kellman-McFarlane K, Welsted A., Clin Psychol Rev 34(4), 2014
PMID: 24794835
Avoidant decision making in social anxiety: the interaction of angry faces and emotional responses.
Pittig A, Pawlikowski M, Craske MG, Alpers GW., Front Psychol 5(), 2014
PMID: 25324792
Iowa gambling task performance in currently depressed suicide attempters.
Gorlyn M, Keilp JG, Oquendo MA, Burke AK, John Mann J., Psychiatry Res 207(3), 2013
PMID: 23489594
The somatic marker affecting decisional processes in obsessive-compulsive disorder.
Cavedini P, Zorzi C, Baraldi C, Patrini S, Salomoni G, Bellodi L, Freire RC, Perna G., Cogn Neuropsychiatry 17(2), 2012
PMID: 21991936
Brain functional connectivity during induced sadness in patients with obsessive-compulsive disorder.
Fontenelle LF, Harrison BJ, Pujol J, Davey CG, Fornito A, Bora E, Pantelis C, Yücel M., J Psychiatry Neurosci 37(4), 2012
PMID: 22452963
Poor performance on the Iowa gambling task in children with obsessive-compulsive disorder.
Kodaira M, Iwadare Y, Ushijima H, Oiji A, Kato M, Sugiyama N, Sasayama D, Usami M, Watanabe K, Saito K., Ann Gen Psychiatry 11(1), 2012
PMID: 23062199
Place your bets: psychophysiological correlates of decision-making under risk.
Studer B, Clark L., Cogn Affect Behav Neurosci 11(2), 2011
PMID: 21380769
Decision-making impairment in obsessive-compulsive disorder as measured by the Iowa Gambling Task.
da Rocha FF, Alvarenga NB, Malloy-Diniz L, Corrêa H., Arq Neuropsiquiatr 69(4), 2011
PMID: 21877034
Relationships between affective states and decision-making.
Werner NS, Duschek S, Schandry R., Int J Psychophysiol 74(3), 2009
PMID: 19808059

43 References

Daten bereitgestellt von Europe PubMed Central.


Insensitivity to future consequences following damage to human prefrontal cortex.
Bechara A, Damasio AR, Damasio H, Anderson SW., Cognition 50(1-3), 1994
PMID: 8039375

Different contributions of the human amygdala and ventromedial prefrontal cortex to decision-making.
Bechara A, Damasio H, Damasio AR, Lee GP., J. Neurosci. 19(13), 1999
PMID: 10377356
Deciding advantageously before knowing the advantageous strategy.
Bechara A, Damasio H, Tranel D, Damasio AR., Science 275(5304), 1997
PMID: 9036851
Failure to respond autonomically to anticipated future outcomes following damage to prefrontal cortex.
Bechara A, Tranel D, Damasio H, Damasio AR., Cereb. Cortex 6(2), 1996
PMID: 8670652

Boucsein, 1992
Decision-making deficits of korsakoff patients in a new gambling task with explicit rules: associations with executive functions.
Brand M, Fujiwara E, Borsutzky S, Kalbe E, Kessler J, Markowitsch HJ., Neuropsychology 19(3), 2005
PMID: 15910113
Role of the amygdala in decisions under ambiguity and decisions under risk: evidence from patients with Urbach-Wiethe disease.
Brand M, Grabenhorst F, Starcke K, Vandekerckhove MM, Markowitsch HJ., Neuropsychologia 45(6), 2006
PMID: 17070876
Decision-making impairments in patients with pathological gambling.
Brand M, Kalbe E, Labudda K, Fujiwara E, Kessler J, Markowitsch HJ., Psychiatry Res 133(1), 2005
PMID: 15698681
Decision-making impairments in patients with Parkinson's disease.
Brand M, Labudda K, Kalbe E, Hilker R, Emmans D, Fuchs G, Kessler J, Markowitsch HJ., Behav Neurol 15(3-4), 2004
PMID: 15706051
Neuropsychological correlates of decision-making in ambiguous and risky situations.
Brand M, Labudda K, Markowitsch HJ., Neural Netw 19(8), 2006
PMID: 16942857
Functional magnetic resonance imaging of symptom provocation in obsessive-compulsive disorder.
Breiter HC, Rauch SL, Kwong KK, Baker JR, Weisskoff RM, Kennedy DN, Kendrick AD, Davis TL, Jiang A, Cohen MS, Stern CE, Belliveau JW, Baer L, O'Sullivan RL, Savage CR, Jenike MA, Rosen BR., Arch. Gen. Psychiatry 53(7), 1996
PMID: 8660126

Basal-corticofrontal circuits in schizophrenia and obsessive-compulsive disorder: a controlled, double dissociation study.
Cavallaro R, Cavedini P, Mistretta P, Bassi T, Angelone SM, Ubbiali A, Bellodi L., Biol. Psychiatry 54(4), 2003
PMID: 12915288
Understanding obsessive-compulsive disorder: focus on decision making.
Cavedini P, Gorini A, Bellodi L., Neuropsychol Rev 16(1), 2006
PMID: 16708289
Decision-making heterogeneity in obsessive-compulsive disorder: ventromedial prefrontal cortex function predicts different treatment outcomes.
Cavedini P, Riboldi G, D'Annucci A, Belotti P, Cisima M, Bellodi L., Neuropsychologia 40(2), 2002
PMID: 11640942

Cavedini, Brain and Cognition 51(), 2003
Heart rate and skin conductance analysis of antecendents and consequences of decision making.
Crone EA, Somsen RJ, Van Beek B, Van Der Molen MW., Psychophysiology 41(4), 2004
PMID: 15189476
The somatic marker hypothesis and the possible functions of the prefrontal cortex.
Damasio AR., Philos. Trans. R. Soc. Lond., B, Biol. Sci. 351(1346), 1996
PMID: 8941953
The somatic marker hypothesis: a critical evaluation.
Dunn BD, Dalgleish T, Lawrence AD., Neurosci Biobehav Rev 30(2), 2005
PMID: 16197997

First, 2002

Neuroimaging studies of obsessive-compulsive disorder in adults and children.
Friedlander L, Desrocher M., Clin Psychol Rev 26(1), 2005
PMID: 16242823
Psychophysiological determinants and concomitants of deficient decision making in pathological gamblers.
Goudriaan AE, Oosterlaan J, de Beurs E, van den Brink W., Drug Alcohol Depend 84(3), 2006
PMID: 16574343
Somatic markers, working memory, and decision making.
Hinson JM, Jameson TL, Whitney P., Cogn Affect Behav Neurosci 2(4), 2002
PMID: 12641178

Horn, 1983
Components of working memory and somatic markers in decision making.
Jameson TL, Hinson JM, Whitney P., Psychon Bull Rev 11(3), 2004
PMID: 15376804
Decision making and set shifting impairments are associated with distinct symptom dimensions in obsessive-compulsive disorder.
Lawrence NS, Wooderson S, Mataix-Cols D, David R, Speckens A, Phillips ML., Neuropsychology 20(4), 2006
PMID: 16846259
Direct measurement of skin conductance: a proposal for standardization.
Lykken DT, Venables PH., Psychophysiology 8(5), 1971
PMID: 5116830
Distinct neural correlates of washing, checking, and hoarding symptom dimensions in obsessive-compulsive disorder.
Mataix-Cols D, Wooderson S, Lawrence N, Brammer MJ, Speckens A, Phillips ML., Arch. Gen. Psychiatry 61(6), 2004
PMID: 15184236
Decision making performance in obsessive compulsive disorder.
Nielen MM, Veltman DJ, de Jong R, Mulder G, den Boer JA., J Affect Disord 69(1-3), 2002
PMID: 12103475
Electrophysiological correlates of reward prediction error recorded in the human prefrontal cortex.
Oya H, Adolphs R, Kawasaki H, Bechara A, Damasio A, Howard MA 3rd., Proc. Natl. Acad. Sci. U.S.A. 102(23), 2005
PMID: 15928095

Starcke, Psychiatry Research (), 0
Application of the somatic marker hypothesis to individual differences in decision making.
Suzuki A, Hirota A, Takasawa N, Shigemasu K., Biol Psychol 65(1), 2003
PMID: 14638290
Amygdala volume reductions in pediatric patients with obsessive-compulsive disorder treated with paroxetine: preliminary findings.
Szeszko PR, MacMillan S, McMeniman M, Lorch E, Madden R, Ivey J, Banerjee SP, Moore GJ, Rosenberg DR., Neuropsychopharmacology 29(4), 2004
PMID: 14970831
Orbital frontal and amygdala volume reductions in obsessive-compulsive disorder.
Szeszko PR, Robinson D, Alvir JM, Bilder RM, Lencz T, Ashtari M, Wu H, Bogerts B., Arch. Gen. Psychiatry 56(10), 1999
PMID: 10530633
Frontal-striatal dysfunction during planning in obsessive-compulsive disorder.
van den Heuvel OA, Veltman DJ, Groenewegen HJ, Cath DC, van Balkom AJ, van Hartskamp J, Barkhof F, van Dyck R., Arch. Gen. Psychiatry 62(3), 2005
PMID: 15753243

Venables, 1980



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