NF-kappaB in the nervous system

Kaltschmidt B, Kaltschmidt C (2009)
Cold Spring Harbour Perspectives in Biology 1(3): a001271.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Abstract / Bemerkung
The transcription factor NF-kappaB has diverse functions in the nervous system, depending on the cellular context. NF-kappaB is constitutively activated in glutamatergic neurons. Knockout of p65 or inhibition of neuronal NF-kappaB by super-repressor IkappaB resulted in the loss of neuroprotection and defects in learning and memory. Similarly, p50-/- mice have a lower learning ability and are sensitive to neurotoxins. Activated NF-kappaB can be transported retrogradely from activated synapses to the nucleus to translate short-term processes to long-term changes such as axon growth, which is important for long-term memory. In glia, NF-kappaB is inducible and regulates inflammatory processes that exacerbate diseases such as autoimmune encephalomyelitis, ischemia, and Alzheimer's disease. In summary, inhibition of NF-kappaB in glia might ameliorate disease, whereas activation in neurons might enhance memory. This review focuses on results produced by the analysis of genetic models.
Cold Spring Harbour Perspectives in Biology
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Kaltschmidt B, Kaltschmidt C. NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology. 2009;1(3):a001271.
Kaltschmidt, B., & Kaltschmidt, C. (2009). NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology, 1(3), a001271.
Kaltschmidt, Barbara, and Kaltschmidt, Christian. 2009. “NF-kappaB in the nervous system”. Cold Spring Harbour Perspectives in Biology 1 (3): a001271.
Kaltschmidt, B., and Kaltschmidt, C. (2009). NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology 1, a001271.
Kaltschmidt, B., & Kaltschmidt, C., 2009. NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology, 1(3), p a001271.
B. Kaltschmidt and C. Kaltschmidt, “NF-kappaB in the nervous system”, Cold Spring Harbour Perspectives in Biology, vol. 1, 2009, pp. a001271.
Kaltschmidt, B., Kaltschmidt, C.: NF-kappaB in the nervous system. Cold Spring Harbour Perspectives in Biology. 1, a001271 (2009).
Kaltschmidt, Barbara, and Kaltschmidt, Christian. “NF-kappaB in the nervous system”. Cold Spring Harbour Perspectives in Biology 1.3 (2009): a001271.

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