MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE

KOLTGEN D, BRINKMEIER H, Jockusch H (1991)
MUSCLE & NERVE 14(8): 775-780.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Autor/in
; ;
Abstract / Bemerkung
The role of neuromuscular transmission and acetylcholine receptors in the phenotypic expression of hereditary myotonia was reinvestigated in two mutants of the mouse, ADR (adr/adr) and MTO (adr(mto)/adr(mto). Three neuromuscular blockers, curare, flaxedil, and alpha-bungarotoxin, did not prevent mechanical myotonia of EDL and soleus muscles from the two mutants. Furthermore, electrical myotonia was demonstrated in isolated ADR muscle fibers devoid of nerve endings. We conclude that neither release nor reception of acetylcholine are important for the mechanism of myotonia in mouse mutants. The previously described suppression of myotonic aftercontractions by high concentrations of curare (Muscle & Nerve 1987; 10:293-298) could not be reproduced; rather, a prolongation of aftercontractions was found. The other drugs had no significant effect on myotonic aftercontractions. Because neuromuscular transmission is not involved in human myotonias, this result supports the use of myotonic mice as a model, at least for recessive generalized myotonia (Becker).
Stichworte
INTRACELLULAR RECORDINGS; NEUROMUSCULAR BLOCKING AGENTS; CONTRACTION MEASUREMENTS; DISSOCIATED; MUSCLE FIBERS
Erscheinungsjahr
1991
Zeitschriftentitel
MUSCLE & NERVE
Band
14
Ausgabe
8
Seite(n)
775-780
ISSN
0148-639X
eISSN
1097-4598
Page URI
https://pub.uni-bielefeld.de/record/1649637

Zitieren

KOLTGEN D, BRINKMEIER H, Jockusch H. MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE. 1991;14(8):775-780.
KOLTGEN, D., BRINKMEIER, H., & Jockusch, H. (1991). MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE, 14(8), 775-780. doi:10.1002/mus.880140813
KOLTGEN, D., BRINKMEIER, H., and Jockusch, H. (1991). MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE 14, 775-780.
KOLTGEN, D., BRINKMEIER, H., & Jockusch, H., 1991. MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE, 14(8), p 775-780.
D. KOLTGEN, H. BRINKMEIER, and H. Jockusch, “MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE”, MUSCLE & NERVE, vol. 14, 1991, pp. 775-780.
KOLTGEN, D., BRINKMEIER, H., Jockusch, H.: MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE. 14, 775-780 (1991).
KOLTGEN, D, BRINKMEIER, H, and Jockusch, Harald. “MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE”. MUSCLE & NERVE 14.8 (1991): 775-780.

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 1653899
PubMed | Europe PMC

Suchen in

Google Scholar