MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE

KOLTGEN D, BRINKMEIER H, Jockusch H (1991)
MUSCLE & NERVE 14(8): 775-780.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
KOLTGEN, D; BRINKMEIER, H; Jockusch, HaraldUniBi
Einrichtung
Fakultät für Biologie
Abstract / Bemerkung
The role of neuromuscular transmission and acetylcholine receptors in the phenotypic expression of hereditary myotonia was reinvestigated in two mutants of the mouse, ADR (adr/adr) and MTO (adr(mto)/adr(mto). Three neuromuscular blockers, curare, flaxedil, and alpha-bungarotoxin, did not prevent mechanical myotonia of EDL and soleus muscles from the two mutants. Furthermore, electrical myotonia was demonstrated in isolated ADR muscle fibers devoid of nerve endings. We conclude that neither release nor reception of acetylcholine are important for the mechanism of myotonia in mouse mutants. The previously described suppression of myotonic aftercontractions by high concentrations of curare (Muscle & Nerve 1987; 10:293-298) could not be reproduced; rather, a prolongation of aftercontractions was found. The other drugs had no significant effect on myotonic aftercontractions. Because neuromuscular transmission is not involved in human myotonias, this result supports the use of myotonic mice as a model, at least for recessive generalized myotonia (Becker).
Stichworte
INTRACELLULAR RECORDINGS; NEUROMUSCULAR BLOCKING AGENTS; CONTRACTION MEASUREMENTS; DISSOCIATED; MUSCLE FIBERS
Erscheinungsjahr
1991
Zeitschriftentitel
MUSCLE & NERVE
Band
14
Ausgabe
8
Seite(n)
775-780
ISSN
0148-639X
eISSN
1097-4598
Page URI
https://pub.uni-bielefeld.de/record/1649637

Zitieren

KOLTGEN D, BRINKMEIER H, Jockusch H. MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE. 1991;14(8):775-780.
KOLTGEN, D., BRINKMEIER, H., & Jockusch, H. (1991). MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE, 14(8), 775-780. https://doi.org/10.1002/mus.880140813
KOLTGEN, D, BRINKMEIER, H, and Jockusch, Harald. 1991. “MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE”. MUSCLE & NERVE 14 (8): 775-780.
KOLTGEN, D., BRINKMEIER, H., and Jockusch, H. (1991). MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE 14, 775-780.
KOLTGEN, D., BRINKMEIER, H., & Jockusch, H., 1991. MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE, 14(8), p 775-780.
D. KOLTGEN, H. BRINKMEIER, and H. Jockusch, “MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE”, MUSCLE & NERVE, vol. 14, 1991, pp. 775-780.
KOLTGEN, D., BRINKMEIER, H., Jockusch, H.: MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE. MUSCLE & NERVE. 14, 775-780 (1991).
KOLTGEN, D, BRINKMEIER, H, and Jockusch, Harald. “MYOTONIA AND NEUROMUSCULAR-TRANSMISSION IN THE MOUSE”. MUSCLE & NERVE 14.8 (1991): 775-780.

3 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Acetylcholine contractures of skeletal muscles: inhibition by chlorpromazine and diltiazem.
Lorkovic H., Neuropharmacology 34(7), 1995
PMID: 8532136
Immunohistological analyses of neutral glycosphingolipids and gangliosides in normal mouse skeletal muscle and in mice with neuromuscular diseases.
Cacic M, Sostaric K, Weber-Schurholz S, Muthing J., Glycoconj. J. 12(5), 1995
PMID: 8595265
Botulinum toxin converts muscle acetylcholine receptors from adult to embryonic type.
Koltgen D, Ceballos-Baumann AO, Franke C., Muscle Nerve 17(7), 1994
PMID: 8008006

25 References

Daten bereitgestellt von Europe PubMed Central.


Brinkmeier, 1988

Becker, 1983
Synthetic interstitial fluid for isolated mammalian tissue.
Bretag AH., Life Sci. 8(5), 1969
PMID: 5781321

Brown, Brain 62(), 1939

Bryant, 1973
Contractile and EMG studies of murine myotonia (mto) and muscular dystrophy (dy/dy).
Entrikin RK, Abresch RT, Sharman RB, Larson DB, Levine NA., Muscle Nerve 10(4), 1987
PMID: 3587263
Myotonic mice: effects of tubocurarine on muscle contractility.
Entrikin RK, Abresch RT., Muscle Nerve 12(2), 1989
PMID: 2710152
Developmental control of the excitability of muscle: transplantation experiments on a myotonic mouse mutant.
Fuchtbauer EM, Reininghaus J, Jockusch H., Proc. Natl. Acad. Sci. U.S.A. 85(11), 1988
PMID: 3375245
Myotonia, a new inherited muscle disease in mice.
Heller AH, Eicher EM, Hallett M, Sidman RL., J. Neurosci. 2(7), 1982
PMID: 7097320

Jockusch, 1990

Jockusch, Genet Res Cambr 52(), 1988
Dolichos biflorus agglutinin receptors in mouse muscle. I. Developmental expression in relation to synaptic acetylcholinesterase and to neuromuscular disease.
Kaupmann K, Heimann P, Jockusch H., Eur. J. Cell Biol. 46(3), 1988
PMID: 3181163

K�ltgen, Mouse News Lett 83(), 1989
The Mechanism of Myotonic Contraction.
Lanari A., Science 104(2697), 1946
PMID: 17747461
The myotonic mouse mutant ADR: electrophysiology of the muscle fiber.
Mehrke G, Brinkmeier H, Jockusch H., Muscle Nerve 11(5), 1988
PMID: 2453798
Characteristics of the chloride conductance in muscle fibers of the rat diaphragm.
Palade PT, Barchi RL., J. Gen. Physiol. 69(3), 1977
PMID: 15046

Reininghaus, Muscle Nerve 12(), 1989
The myotonic mouse mutant ADR: physiological and histochemical properties of muscle.
Reininghaus J, Fuchtbauer EM, Bertram K, Jockusch H., Muscle Nerve 11(5), 1988
PMID: 2967431
The myotonic mouse--a realistic model for the study of human recessive generalized myotonia.
Rudel R., Trends Neurosci. 13(1), 1990
PMID: 1688667
Membrane changes in cells from myotonia patients.
Rudel R, Lehmann-Horn F., Physiol. Rev. 65(2), 1985
PMID: 2580324
Lectin binding reveals a synapse-specific carbohydrate in skeletal muscle.
Sanes JR, Cheney JM., Nature 300(5893), 1982
PMID: 7144916
Myotonia in a horse.
STEINBERG S, BOTELHO S., Science 137(3534), 1962
PMID: 13916691
Calcium-binding protein, parvalbumin, is reduced in mutant mammalian muscle with abnormal contractile properties.
Stuhlfauth I, Reininghaus J, Jockusch H, Heizmann CW., Proc. Natl. Acad. Sci. U.S.A. 81(15), 1984
PMID: 6589628

Thomsen, Arch Psychiatr Nervenkr 6(), 1876
Biological features of the new A2G--adr mouse mutant with abnormal muscle function.
Watkins WJ, Watts DC., Lab. Anim. 18(1), 1984
PMID: 10628777
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