Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR)
Heimann P, LAAGE S, Jockusch H (1991)
Differentiation 47(2): 77-83.
Zeitschriftenaufsatz
| Veröffentlicht | Englisch
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
Autor*in
Heimann, PeterUniBi;
LAAGE, S;
Jockusch, HaraldUniBi
Einrichtung
Abstract / Bemerkung
In the wobbler (WR) mouse, a neuromuscular mutant characterized by a motoneuron degeneration and male infertility, the cellular basis of the defect in spermiogenesis was studied by light and electron microscopy as well as by lectin binding. Spermatozoa of the wobbler mutant had rounded heads, and their motility was reduced. In histological sections of WR testes, spermatogenesis appeared normal up to the stage of round spermatids, but the elongation and flattening of the nucleus during late spermiogenesis did not occur. Numbers of spermatid nuclei in WR testes were reduced to 70%-80% of controls. The acrosomal marker glycoprotein, peanut agglutinin receptor, was synthesized, but the acrosomal membrane did not attach to the nucleus. The disturbance in spermiogenesis of the wobbler mouse is not due to impaired descent of the testis, nor to a lack of testosterone, and is distinct from that observed in other mouse mutants (quaking, QK; Purkinje cell degeneration, PCD) with combined neurological and spermiogenesis defects.
Erscheinungsjahr
1991
Zeitschriftentitel
Differentiation
Band
47
Ausgabe
2
Seite(n)
77-83
ISSN
0301-4681
eISSN
1432-0436
Page URI
https://pub.uni-bielefeld.de/record/1649614
Zitieren
Heimann P, LAAGE S, Jockusch H. Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation. 1991;47(2):77-83.
Heimann, P., LAAGE, S., & Jockusch, H. (1991). Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation, 47(2), 77-83. https://doi.org/10.1111/j.1432-0436.1991.tb00225.x
Heimann, Peter, LAAGE, S, and Jockusch, Harald. 1991. “Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR)”. Differentiation 47 (2): 77-83.
Heimann, P., LAAGE, S., and Jockusch, H. (1991). Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation 47, 77-83.
Heimann, P., LAAGE, S., & Jockusch, H., 1991. Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation, 47(2), p 77-83.
P. Heimann, S. LAAGE, and H. Jockusch, “Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR)”, Differentiation, vol. 47, 1991, pp. 77-83.
Heimann, P., LAAGE, S., Jockusch, H.: Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR). Differentiation. 47, 77-83 (1991).
Heimann, Peter, LAAGE, S, and Jockusch, Harald. “Defect of sperm assembly in a neurological mutant of the mouse, wobbler (WR)”. Differentiation 47.2 (1991): 77-83.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
OMIM
1 Eintrag gefunden, die diesen Artikel zitieren
UNIPROT
5 Einträge gefunden, die diesen Artikel zitieren
Vacuolar protein sorting-associated protein 54 (UNIPROT: Q5SRW8)
Organism: Mus musculus
Download in FASTA format
Organism: Mus musculus
Download in FASTA format
Vacuolar protein sorting-associated protein 54 (UNIPROT: Q5SPW0)
Organism: Mus musculus
Download in FASTA format
Organism: Mus musculus
Download in FASTA format
36 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Dynamic of contribution of UBPy-sorted cargo to acrosome biogenesis: effects of its derailment in a mouse model of globozoospermia, the infertile Vps54 (L967Q) mutant.
Gioria M, Pasini ME, Berruti G., Cell Tissue Res. (), 2017
PMID: 28299521
Gioria M, Pasini ME, Berruti G., Cell Tissue Res. (), 2017
PMID: 28299521
Towards defining an 'origin'-The case for the mammalian acrosome.
Berruti G., Semin. Cell Dev. Biol. 59(), 2016
PMID: 26775129
Berruti G., Semin. Cell Dev. Biol. 59(), 2016
PMID: 26775129
Accumulation of glucosylceramide in the absence of the beta-glucosidase GBA2 alters cytoskeletal dynamics.
Raju D, Schonauer S, Hamzeh H, Flynn KC, Bradke F, Vom Dorp K, Dormann P, Yildiz Y, Trotschel C, Poetsch A, Breiden B, Sandhoff K, Korschen HG, Wachten D., PLoS Genet. 11(3), 2015
PMID: 25803043
Raju D, Schonauer S, Hamzeh H, Flynn KC, Bradke F, Vom Dorp K, Dormann P, Yildiz Y, Trotschel C, Poetsch A, Breiden B, Sandhoff K, Korschen HG, Wachten D., PLoS Genet. 11(3), 2015
PMID: 25803043
Comparative profiling of the sperm proteome.
Holland A, Ohlendieck K., Proteomics 15(4), 2015
PMID: 24909132
Holland A, Ohlendieck K., Proteomics 15(4), 2015
PMID: 24909132
Molecular chaperones, cochaperones, and ubiquitination/deubiquitination system: involvement in the production of high quality spermatozoa.
Meccariello R, Chianese R, Ciaramella V, Fasano S, Pierantoni R., Biomed Res Int 2014(), 2014
PMID: 25045686
Meccariello R, Chianese R, Ciaramella V, Fasano S, Pierantoni R., Biomed Res Int 2014(), 2014
PMID: 25045686
Ubiquitination regulates the morphogenesis and function of sperm organelles.
Nakamura N., Cells 2(4), 2013
PMID: 24709878
Nakamura N., Cells 2(4), 2013
PMID: 24709878
UBPy/MSJ-1 system during male germ cell progression in the frog, Rana esculenta.
Meccariello R, Chianese R, Scarpa D, Berruti G, Cobellis G, Pierantoni R, Fasano S., Gen. Comp. Endocrinol. 153(1-3), 2007
PMID: 17187787
Meccariello R, Chianese R, Scarpa D, Berruti G, Cobellis G, Pierantoni R, Fasano S., Gen. Comp. Endocrinol. 153(1-3), 2007
PMID: 17187787
Structure of msj-1 gene: a comparative analysis.
Meccariello R, Tedeschi G, Monsurro MR, Chianese R, Cobellis G, Pierantoni R, Fasano S., Ann. N. Y. Acad. Sci. 1040(), 2005
PMID: 15891074
Meccariello R, Tedeschi G, Monsurro MR, Chianese R, Cobellis G, Pierantoni R, Fasano S., Ann. N. Y. Acad. Sci. 1040(), 2005
PMID: 15891074
Spinal muscular atrophy gene wobbler of the mouse: evidence from chimeric spinal cord and testis for cell-autonomous function.
Augustin M, Heimann P, Rathke S, Jockusch H., Dev. Dyn. 209(3), 1997
PMID: 9215643
Augustin M, Heimann P, Rathke S, Jockusch H., Dev. Dyn. 209(3), 1997
PMID: 9215643
Identification of thyrotropin-releasing hormone receptor mRNA in the Leydig cells of the mouse testis by in situ hybridization.
Zhang SH, Zhang YQ, Vacca-Galloway LL., Neuropeptides 29(6), 1995
PMID: 8837956
Zhang SH, Zhang YQ, Vacca-Galloway LL., Neuropeptides 29(6), 1995
PMID: 8837956
Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler spinal muscular atrophy gene on proximal mouse chromosome 11.
Lengeling A, Zimmer WE, Goodman SR, Ma Y, Bloom ML, Bruneau G, Krieger M, Thibault J, Kaupmann K, Jockusch H., Mamm. Genome 5(3), 1994
PMID: 8199405
Lengeling A, Zimmer WE, Goodman SR, Ma Y, Bloom ML, Bruneau G, Krieger M, Thibault J, Kaupmann K, Jockusch H., Mamm. Genome 5(3), 1994
PMID: 8199405
26 References
Daten bereitgestellt von Europe PubMed Central.
Astrocyte overgrowth in the brain stem and spinal cord of mice affected by spinal atrophy, wobbler.
Laage S, Zobel G, Jockusch H., Dev. Neurosci. 10(3), 1988
PMID: 3142758
Laage S, Zobel G, Jockusch H., Dev. Neurosci. 10(3), 1988
PMID: 3142758
Export
Markieren/ Markierung löschen
Markierte Publikationen
Web of Science
Dieser Datensatz im Web of Science®Quellen
PMID: 1955109
PubMed | Europe PMC
Suchen in