CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS
GROEGER C, Wenzel H, Tschesche H (1991)
JOURNAL OF PROTEIN CHEMISTRY 10(5): 527-533.
Zeitschriftenaufsatz
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Autor*in
GROEGER, C;
Wenzel, HerbertUniBi;
Tschesche, HaraldUniBi
Einrichtung
Abstract / Bemerkung
An extended concept for the replacement of amino acids in the P' region of aprotinin by chemical semisynthesis is presented. Either fragment condensation with dipeptides protected as tert-butyl ester or stepwise introduction of two single amino acid-tert-butyl esters into a partially esterified aprotinin derivative (with free Lys15-carboxyl group) lacking the amino acids Ala16 and Arg17 leads to aprotinin homologues and derivatives mutated in the P1' and P2' position. This method may complement the recently reported enzymatic synthesis by enabling access to aprotinin homologues and derivatives, which cannot be prepared enzymatically. The synthesis of [Ala17]BPTI and [seco-17/18]BPTI is described in detail.
Stichworte
APROTININ;
INHIBITORY SPECIFICITY;
BOVINE PANCREATIC TRYPSIN INHIBITOR;
SEMISYNTHESIS;
KALLIKREIN INHIBITION
Erscheinungsjahr
1991
Zeitschriftentitel
JOURNAL OF PROTEIN CHEMISTRY
Band
10
Ausgabe
5
Seite(n)
527-533
ISSN
0277-8033
eISSN
1573-4943
Page URI
https://pub.uni-bielefeld.de/record/1649242
Zitieren
GROEGER C, Wenzel H, Tschesche H. CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS. JOURNAL OF PROTEIN CHEMISTRY. 1991;10(5):527-533.
GROEGER, C., Wenzel, H., & Tschesche, H. (1991). CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS. JOURNAL OF PROTEIN CHEMISTRY, 10(5), 527-533. https://doi.org/10.1007/BF01025481
GROEGER, C, Wenzel, Herbert, and Tschesche, Harald. 1991. “CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS”. JOURNAL OF PROTEIN CHEMISTRY 10 (5): 527-533.
GROEGER, C., Wenzel, H., and Tschesche, H. (1991). CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS. JOURNAL OF PROTEIN CHEMISTRY 10, 527-533.
GROEGER, C., Wenzel, H., & Tschesche, H., 1991. CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS. JOURNAL OF PROTEIN CHEMISTRY, 10(5), p 527-533.
C. GROEGER, H. Wenzel, and H. Tschesche, “CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS”, JOURNAL OF PROTEIN CHEMISTRY, vol. 10, 1991, pp. 527-533.
GROEGER, C., Wenzel, H., Tschesche, H.: CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS. JOURNAL OF PROTEIN CHEMISTRY. 10, 527-533 (1991).
GROEGER, C, Wenzel, Herbert, and Tschesche, Harald. “CHEMICAL SEMISYNTHESIS OF APROTININ HOMOLOGS AND DERIVATIVES MUTATED IN P' POSITIONS”. JOURNAL OF PROTEIN CHEMISTRY 10.5 (1991): 527-533.
Daten bereitgestellt von European Bioinformatics Institute (EBI)
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