MERCURIAL ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE PROCOLLAGENASE

BLASER J, KNAUPER V, OSTHUES A, REINKE H, Tschesche H (1991)
EUROPEAN JOURNAL OF BIOCHEMISTRY 202(3): 1223-1230.

Download
Es wurde kein Volltext hochgeladen. Nur Publikationsnachweis!
Zeitschriftenaufsatz | Veröffentlicht | Englisch
Autor
; ; ; ;
Abstract / Bemerkung
The mechanism of human polymorphonuclear leucocyte (PMNL) procollagenase activation by HgCl2 was investigated by kinetic and sequence analysis of the reaction products. HgCl2 activated PMNL procollagenase by intramolecular autoproteolytic cleavage of the Asn53 - Val54 peptide bond to generate a collagenase species of M(r) 65000, which was immediately converted into a second intermediate collagenase form by further autoproteolytic cleavage of the Asp64 - Met65 peptide bond within the propeptide domain. This intermediate form (Met65 N-terminus) reached maximum concentrations after 45 min and displayed only about 40% of the maximum available enzymatic activity. Final activation was obtained after autoproteolytic cleavage of either Phe79 - Met80 or Met80 - Leu81 peptide bonds. Furthermore, activation in the presence of TIMP-1 did not suppress the intramolecular autoproteolytic cleavage of the Asn53 - Val54 peptide bond. Complete inhibition of further autoproteolytic decay of the enzyme or generated peptides was observed, which was obviously due to complex formation between the intermediate collagenase form (Val54 N-terminus) and inhibitor, which was visualized using the Western blot technique. Thus PMNL procollagenase activation by HgCl2 followed a three-step activation mechanism which is entirely different from the known activation mechanisms of the fibroblast matrix metalloproteinases.
Erscheinungsjahr
Zeitschriftentitel
EUROPEAN JOURNAL OF BIOCHEMISTRY
Band
202
Ausgabe
3
Seite(n)
1223-1230
ISSN
eISSN
PUB-ID

Zitieren

BLASER J, KNAUPER V, OSTHUES A, REINKE H, Tschesche H. MERCURIAL ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE PROCOLLAGENASE. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1991;202(3):1223-1230.
BLASER, J., KNAUPER, V., OSTHUES, A., REINKE, H., & Tschesche, H. (1991). MERCURIAL ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE PROCOLLAGENASE. EUROPEAN JOURNAL OF BIOCHEMISTRY, 202(3), 1223-1230. doi:10.1111/j.1432-1033.1991.tb16494.x
BLASER, J., KNAUPER, V., OSTHUES, A., REINKE, H., and Tschesche, H. (1991). MERCURIAL ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE PROCOLLAGENASE. EUROPEAN JOURNAL OF BIOCHEMISTRY 202, 1223-1230.
BLASER, J., et al., 1991. MERCURIAL ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE PROCOLLAGENASE. EUROPEAN JOURNAL OF BIOCHEMISTRY, 202(3), p 1223-1230.
J. BLASER, et al., “MERCURIAL ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE PROCOLLAGENASE”, EUROPEAN JOURNAL OF BIOCHEMISTRY, vol. 202, 1991, pp. 1223-1230.
BLASER, J., KNAUPER, V., OSTHUES, A., REINKE, H., Tschesche, H.: MERCURIAL ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE PROCOLLAGENASE. EUROPEAN JOURNAL OF BIOCHEMISTRY. 202, 1223-1230 (1991).
BLASER, J, KNAUPER, V, OSTHUES, A, REINKE, H, and Tschesche, Harald. “MERCURIAL ACTIVATION OF HUMAN POLYMORPHONUCLEAR LEUKOCYTE PROCOLLAGENASE”. EUROPEAN JOURNAL OF BIOCHEMISTRY 202.3 (1991): 1223-1230.

15 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

New insights in the pathogenesis of atopic disease.
Ionescu JG., J Med Life 2(2), 2009
PMID: 20108533
Nitric oxide regulation of MMP-9 activation and its relationship to modifications of the cysteine switch.
McCarthy SM, Bove PF, Matthews DE, Akaike T, van der Vliet A., Biochemistry 47(21), 2008
PMID: 18452312
The human neutrophil lipocalin supports the allosteric activation of matrix metalloproteinases.
Tschesche H, Zölzer V, Triebel S, Bartsch S., Eur J Biochem 268(7), 2001
PMID: 11277914
Activation of neutrophil collagenase in periodontitis.
Romanelli R, Mancini S, Laschinger C, Overall CM, Sodek J, McCulloch CA., Infect Immun 67(5), 1999
PMID: 10225890
Activation of human neutrophil procollagenase by stromelysin 2.
Knäuper V, Murphy G, Tschesche H., Eur J Biochem 235(1-2), 1996
PMID: 8631328
Structural implications for the role of the N terminus in the 'superactivation' of collagenases. A crystallographic study.
Reinemer P, Grams F, Huber R, Kleine T, Schnierer S, Piper M, Tschesche H, Bode W., FEBS Lett 338(2), 1994
PMID: 8307185
Neutrophil procollagenase can be activated by stromelysin-2.
Knäuper V, Murphy G, Tschesche H., Ann N Y Acad Sci 732(), 1994
PMID: 7978810
Fragmentation of human polymorphonuclear-leucocyte collagenase.
Knäuper V, Osthues A, DeClerck YA, Langley KE, Bläser J, Tschesche H., Biochem J 291 ( Pt 3)(), 1993
PMID: 8489511
Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.
Fosang AJ, Last K, Knäuper V, Neame PJ, Murphy G, Hardingham TE, Tschesche H, Hamilton JA., Biochem J 295 ( Pt 1)(), 1993
PMID: 8216228
Direct activation of human neutrophil procollagenase by recombinant stromelysin.
Knäuper V, Wilhelm SM, Seperack PK, DeClerck YA, Langley KE, Osthues A, Tschesche H., Biochem J 295 ( Pt 2)(), 1993
PMID: 8240261

34 References

Daten bereitgestellt von Europe PubMed Central.

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL., J. Biol. Chem. 265(20), 1990
PMID: 2164002
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI., J. Biol. Chem. 264(29), 1989
PMID: 2551898

Knauper, Biol. Chem. Hoppe-Seyler 371(), 1990
Human fibroblast collagenase. Complete primary structure and homology to an oncogene transformation-induced rat protein.
Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ., J. Biol. Chem. 261(14), 1986
PMID: 3009463
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
Whitham SE, Murphy G, Angel P, Rahmsdorf HJ, Smith BJ, Lyons A, Harris TJ, Reynolds JJ, Herrlich P, Docherty AJ., Biochem. J. 240(3), 1986
PMID: 3030290
Molecular cloning of human synovial cell collagenase and selection of a single gene from genomic DNA.
Brinckerhoff CE, Ruby PL, Austin SD, Fini ME, White HD., J. Clin. Invest. 79(2), 1987
PMID: 3027129
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI., J. Biol. Chem. 263(14), 1988
PMID: 2834383
The structure of the human skin fibroblast collagenase gene.
Collier IE, Smith J, Kronberger A, Bauer EA, Wilhelm SM, Eisen AZ, Goldberg GI., J. Biol. Chem. 263(22), 1988
PMID: 2839503

Matrisain, Trends, Genet. 6(), 1990
Activation of human leukocyte collagenase by compounds reacting with sulfhydryl groups.
Uitto VJ, Turto H, Huttunen A, Lindy S, Uitto J., Biochim. Biophys. Acta 613(1), 1980
PMID: 6246953

Sorsa, Proc. Finn, Dent. Soc. 83(), 1987
Oxidative autoactivation of latent collagenase by human neutrophils.
Weiss SJ, Peppin G, Ortiz X, Ragsdale C, Test ST., Science 227(4688), 1985
PMID: 2982211
Synthetic substrates for vertebrate collagenase.
Masui Y, Takemoto T, Sakakibara S, Hori H, Nagai Y., Biochem Med 17(2), 1977
PMID: 193489

Heukeshoven, Electrophoresis 6(), 1985

Hunkapiller, Applied Biosystems User Bulletin 14(), 1985
The activation of human skin fibroblast procollagenase. Sequence identification of the major conversion products.
Grant GA, Eisen AZ, Marmer BL, Roswit WT, Goldberg GI., J. Biol. Chem. 262(12), 1987
PMID: 3032947
Mechanisms of activation of tissue procollagenase by matrix metalloproteinase 3 (stromelysin).
Suzuki K, Enghild JJ, Morodomi T, Salvesen G, Nagase H., Biochemistry 29(44), 1990
PMID: 2176865
The activation of human type IV collagenase proenzyme. Sequence identification of the major conversion product following organomercurial activation.
Stetler-Stevenson WG, Krutzsch HC, Wacher MP, Margulies IM, Liotta LA., J. Biol. Chem. 264(3), 1989
PMID: 2536363
Human skin fibroblast procollagenase: mechanisms of activation by organomercurials and trypsin.
Stricklin GP, Jeffrey JJ, Roswit WT, Eisen AZ., Biochemistry 22(1), 1983
PMID: 6299336
Characterization of 58-kilodalton human neutrophil collagenase: comparison with human fibroblast collagenase.
Mallya SK, Mookhtiar KA, Gao Y, Brew K, Dioszegi M, Birkedal-Hansen H, Van Wart HE., Biochemistry 29(47), 1990
PMID: 2176876
Structure-function relationships in the collagenase family member transin.
Sanchez-Lopez R, Nicholson R, Gesnel MC, Matrisian LM, Breathnach R., J. Biol. Chem. 263(24), 1988
PMID: 2841336
An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase.
Windsor LJ, Birkedal-Hansen H, Birkedal-Hansen B, Engler JA., Biochemistry 30(3), 1991
PMID: 1703020

Tschesche, 1990

Wart, Proc. Natl Acad. Sci. USA 87(), 1990

Welgus, Collagen Rel. Res. 5(), 1985

Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®

Quellen

PMID: 1662606
PubMed | Europe PMC

Suchen in

Google Scholar