The structure of the mouse parvalbumin gene

Schleef M, Zühlke C, Jockusch H, Schöffl F (1992)
Mammalian Genome 3(4): 217-225.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Schleef, M.; Zühlke, C.; Jockusch, HaraldUniBi; Schöffl, F.
Abstract / Bemerkung
Parvalbumin (PV) is a calcium-binding protein of the EF-hand family, expressed mainly in fast contracting/relaxing muscles of vertebrates. We have isolated five overlapping genomic PV clones which overall span 28 kilobase pairs (kb) around the Pva locus on mouse Chromosome (Chr) 15. The positions of four introns were determined by DNA sequencing. They interrupt the coding sequences at positions corresponding to those in rat and human PV genes. The transcription start site, 25 bp downstream from the TATA-box, was mapped by oligonucleotide primer extension on poly(A)+-RNA. The analysis of 0.4 kb promoter sequence of the mouse PV gene revealed CCAAT- and TATA-box sequences and a 59 bp GC-rich stretch between positions -59 and -118. Similar motifs have been found in the parvalbumin genes of rat and human. A perfect 11-bp repeat upstream to positions -149 and -163 respectively is homologous only to the rat promoter. These results will be related to tissue and species differences in PV expression.
Mammalian Genome
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Schleef M, Zühlke C, Jockusch H, Schöffl F. The structure of the mouse parvalbumin gene. Mammalian Genome. 1992;3(4):217-225.
Schleef, M., Zühlke, C., Jockusch, H., & Schöffl, F. (1992). The structure of the mouse parvalbumin gene. Mammalian Genome, 3(4), 217-225.
Schleef, M., Zühlke, C., Jockusch, Harald, and Schöffl, F. 1992. “The structure of the mouse parvalbumin gene”. Mammalian Genome 3 (4): 217-225.
Schleef, M., Zühlke, C., Jockusch, H., and Schöffl, F. (1992). The structure of the mouse parvalbumin gene. Mammalian Genome 3, 217-225.
Schleef, M., et al., 1992. The structure of the mouse parvalbumin gene. Mammalian Genome, 3(4), p 217-225.
M. Schleef, et al., “The structure of the mouse parvalbumin gene”, Mammalian Genome, vol. 3, 1992, pp. 217-225.
Schleef, M., Zühlke, C., Jockusch, H., Schöffl, F.: The structure of the mouse parvalbumin gene. Mammalian Genome. 3, 217-225 (1992).
Schleef, M., Zühlke, C., Jockusch, Harald, and Schöffl, F. “The structure of the mouse parvalbumin gene”. Mammalian Genome 3.4 (1992): 217-225.

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Characterization of two parvalbumin genes and their association with growth traits in Asian seabass (Lates calcarifer).
Xu YX, Zhu ZY, Lo LC, Wang CM, Lin G, Feng F, Yue GH., Anim Genet 37(3), 2006
PMID: 16734689
Identification of estrogen-responsive genes in the GH3 cell line by cDNA microarray analysis.
Fujimoto N, Igarashi K, Kanno J, Inoue T., J Steroid Biochem Mol Biol 91(3), 2004
PMID: 15276619
Different regulatory sequences are required for parvalbumin gene expression in skeletal muscles and neuronal cells of transgenic mice.
Hazama M, Watanabe D, Suzuki M, Mizoguchi A, Pastan I, Nakanishi S., Brain Res Mol Brain Res 100(1-2), 2002
PMID: 12008021
Myocyte-specific enhancer binding factor 2C expression in gerbil brain following global cerebral ischemia.
Speliotes EK, Kowall NW, Shanti BF, Kosofsky B, Finklestein SP, Leifer D., Neuroscience 70(1), 1996
PMID: 8848137
Structure and chromosomal localization of the mouse oncomodulin gene.
Staubli F, Klein A, Rentsch JM, Hameister H, Berchtold MW., Mamm Genome 6(11), 1995
PMID: 8597631
Human alpha and beta parvalbumins. Structure and tissue-specific expression.
Föhr UG, Weber BR, Müntener M, Staudenmann W, Hughes GJ, Frutiger S, Banville D, Schäfer BW, Heizmann CW., Eur J Biochem 215(3), 1993
PMID: 8354278
New nucleotide sequence data on the EMBL File Server.
, Nucleic Acids Res 20(17), 1992
PMID: 1408781

48 References

Daten bereitgestellt von Europe PubMed Central.

Cloning of the rat parvalbumin gene.
Berchtold MW., Meth. Enzymol. 139(), 1987
PMID: 3587027

Berchtold, 1988
Primary structure of parvalbumin from rat skeletal muscle.
Berchtold MW, Heizmann CW, Wilson KJ., Eur. J. Biochem. 127(2), 1982
PMID: 6754379
Parvalbumin in non-muscle tissues of the rat. Quantitation and immunohistochemical localization.
Berchtold MW, Celio MR, Heizmann CW., J. Biol. Chem. 259(8), 1984
PMID: 6715341
Structural organization and chromosomal assignment of the parvalbumin gene.
Berchtold MW, Epstein P, Beaudet AL, Payne ME, Heizmann CW, Means AR., J. Biol. Chem. 262(18), 1987
PMID: 3036821
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter WJ., Biochemistry 18(24), 1979
PMID: 518835
Promoter sequences of eukaryotic protein-coding genes.
Corden J, Wasylyk B, Buchwalder A, Sassone-Corsi P, Kedinger C, Chambon P., Science 209(4463), 1980
PMID: 6251548
Isolation of a rat parvalbumin gene and full length cDNA.
Epstein P, Means AR, Berchtold MW., J. Biol. Chem. 261(13), 1986
PMID: 3009434
Lambda replacement vectors carrying polylinker sequences.
Frischauf AM, Lehrach H, Poustka A, Murray N., J. Mol. Biol. 170(4), 1983
PMID: 6315951
Direct correlation of parvalbumin levels with myosin isoforms and succinate dehydrogenase activity on frozen sections of rodent muscle.
Fuchtbauer EM, Rowlerson AM, Gotz K, Friedrich G, Mabuchi K, Gergely J, Jockusch H., J. Histochem. Cytochem. 39(3), 1991
PMID: 1825216

Heizmann, 1988
Correlation of parvalbumin concentration with relaxation speed in mammalian muscles.
Heizmann CW, Berchtold MW, Rowlerson AM., Proc. Natl. Acad. Sci. U.S.A. 79(23), 1982
PMID: 6961404
Packaging recombinant DNA molecules into bacteriophage particles in vitro.
Hohn B, Murray K., Proc. Natl. Acad. Sci. U.S.A. 74(8), 1977
PMID: 333431
Rapid and efficient cosmid cloning.
Ish-Horowicz D, Burke JF., Nucleic Acids Res. 9(13), 1981
PMID: 6269067

Jockusch, 1990
Reduction of myosin-light-chain phosphorylation and of parvalbumin content in myotonic mouse muscle and its reversal by tocainide.
Jockusch H, Reininghaus J, Stuhlfauth I, Zippel M., Eur. J. Biochem. 171(1-2), 1988
PMID: 3123225
Intron splicing: a conserved internal signal in introns of animal pre-mRNAs.
Keller EB, Noon WA., Proc. Natl. Acad. Sci. U.S.A. 81(23), 1984
PMID: 6209716
Opposite regulation of the mRNAs for parvalbumin and p19/6.8 in myotonic mouse muscle.
Kluxen FW, Schoffl F, Berchtold MW, Jockusch H., Eur. J. Biochem. 176(1), 1988
PMID: 3138114
Complex regulation of the muscle-specific contractile protein (troponin I) gene.
Konieczny SF, Emerson CP Jr., Mol. Cell. Biol. 7(9), 1987
PMID: 3670306
Structure and evolution of calcium-modulated proteins.
Kretsinger RH., CRC Crit. Rev. Biochem. 8(2), 1980
PMID: 6105043
Neural regulation of parvalbumin expression in mammalian skeletal muscle.
Leberer E, Pette D., Biochem. J. 235(1), 1986
PMID: 3741391

Maniatis, 1982
Regulation of inducible and tissue-specific gene expression.
Maniatis T, Goodbourn S, Fischer JA., Science 236(4806), 1987
PMID: 3296191
The myotonic mouse mutant ADR: electrophysiology of the muscle fiber.
Mehrke G, Brinkmeier H, Jockusch H., Muscle Nerve 11(5), 1988
PMID: 2453798
A catalogue of splice junction sequences.
Mount SM., Nucleic Acids Res. 10(2), 1982
PMID: 7063411
Lambdoid phages that simplify the recovery of in vitro recombinants.
Murray NE, Brammar WJ, Murray K., Mol. Gen. Genet. 150(1), 1977
PMID: 319344
Alternative transcription and two modes of splicing results in two myosin light chains from one gene.
Nabeshima Y, Fujii-Kuriyama Y, Muramatsu M, Ogata K., Nature 308(5957), 1984
PMID: 6709041
Sequence signals in eukaryotic upstream regions.
Nussinov R., Crit. Rev. Biochem. Mol. Biol. 25(3), 1990
PMID: 2196161
Improved tools for biological sequence comparison.
Pearson WR, Lipman DJ., Proc. Natl. Acad. Sci. U.S.A. 85(8), 1988
PMID: 3162770
The myotonic mouse mutant ADR: physiological and histochemical properties of muscle.
Reininghaus J, Fuchtbauer EM, Bertram K, Jockusch H., Muscle Nerve 11(5), 1988
PMID: 2967431
Excision of an intact intron as a novel lariat structure during pre-mRNA splicing in vitro.
Ruskin B, Krainer AR, Maniatis T, Green MR., Cell 38(1), 1984
PMID: 6088074
DNA sequencing with chain-terminating inhibitors.
Sanger F, Nicklen S, Coulson AR., Proc. Natl. Acad. Sci. U.S.A. 74(12), 1977
PMID: 271968
Genetic mapping and physical characterization of parvalbumin genes.
Schoffl F, Jockusch H., Int. J. Biochem. 22(11), 1990
PMID: 2257946
Localization of parvalbumin mRNA in rat brain by in situ hybridization histochemistry.
Seto-Ohshima A, Emson PC, Berchtold MW, Heizmann CW., Exp Brain Res 75(3), 1989
PMID: 2744122
Structural analysis of a maize gene coding for glutathione-S-transferase involved in herbicide detoxification.
Shah DM, Hironaka CM, Wiegand RC, Harding EI, Krivi GG, Tiemeier DC., Plant Mol. Biol. 6(4), 1986
PMID: IND86033490
Inactivation of muscle chloride channel by transposon insertion in myotonic mice.
Steinmeyer K, Klocke R, Ortland C, Gronemeier M, Jockusch H, Grunder S, Jentsch TJ., Nature 354(6351), 1991
PMID: 1659665
Calcium-binding protein, parvalbumin, is reduced in mutant mammalian muscle with abnormal contractile properties.
Stuhlfauth I, Reininghaus J, Jockusch H, Heizmann CW., Proc. Natl. Acad. Sci. U.S.A. 81(15), 1984
PMID: 6589628
Myosin isoenzymes as molecular markers for muscle physiology.
Whalen RG., J. Exp. Biol. 115(), 1985
PMID: 3897445
cDNA sequence and chromosomal localization of the mouse parvalbumin gene, Pva.
Zuhlke C, Schoffl F, Jockusch H, Simon D, Guenet JL., Genet. Res. 54(1), 1989
PMID: 2572511

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