REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS
LAUHIO A, KONTTINEN YT, Tschesche H, NORDSTROM D, SALO T, LAHDEVIRTA J, GOLUB LM, SORSA T (1994)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38(2): 400-402.
Zeitschriftenaufsatz
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Autor*in
LAUHIO, A;
KONTTINEN, YT;
Tschesche, HaraldUniBi;
NORDSTROM, D;
SALO, T;
LAHDEVIRTA, J;
GOLUB, LM;
SORSA, T
Einrichtung
Abstract / Bemerkung
The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction.
Erscheinungsjahr
1994
Zeitschriftentitel
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Band
38
Ausgabe
2
Seite(n)
400-402
ISSN
0066-4804
eISSN
1098-6596
Page URI
https://pub.uni-bielefeld.de/record/1644370
Zitieren
LAUHIO A, KONTTINEN YT, Tschesche H, et al. REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 1994;38(2):400-402.
LAUHIO, A., KONTTINEN, Y. T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L. M., et al. (1994). REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 38(2), 400-402. https://doi.org/10.1128/AAC.38.2.400
LAUHIO, A, KONTTINEN, YT, Tschesche, Harald, NORDSTROM, D, SALO, T, LAHDEVIRTA, J, GOLUB, LM, and SORSA, T. 1994. “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38 (2): 400-402.
LAUHIO, A., KONTTINEN, Y. T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L. M., and SORSA, T. (1994). REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38, 400-402.
LAUHIO, A., et al., 1994. REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 38(2), p 400-402.
A. LAUHIO, et al., “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 38, 1994, pp. 400-402.
LAUHIO, A., KONTTINEN, Y.T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L.M., SORSA, T.: REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 38, 400-402 (1994).
LAUHIO, A, KONTTINEN, YT, Tschesche, Harald, NORDSTROM, D, SALO, T, LAHDEVIRTA, J, GOLUB, LM, and SORSA, T. “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38.2 (1994): 400-402.
26 Zitationen in Europe PMC
Daten bereitgestellt von Europe PubMed Central.
Enhanced Systemic Response of Matrix Metalloproteinases and Their Regulators in Campylobacter and Salmonella Patients.
Nilsson A, Tervahartiala T, Lennebratt D, Lannergård A, Sorsa T, Rautelin H., Diagnostics (Basel) 8(4), 2018
PMID: 30551610
Nilsson A, Tervahartiala T, Lennebratt D, Lannergård A, Sorsa T, Rautelin H., Diagnostics (Basel) 8(4), 2018
PMID: 30551610
Subclinical inflammation associated with prolonged TIMP-1 upregulation and arterial stiffness after gestational diabetes mellitus: a hospital-based cohort study.
Vilmi-Kerälä T, Lauhio A, Tervahartiala T, Palomäki O, Uotila J, Sorsa T, Palomäki A., Cardiovasc Diabetol 16(1), 2017
PMID: 28407807
Vilmi-Kerälä T, Lauhio A, Tervahartiala T, Palomäki O, Uotila J, Sorsa T, Palomäki A., Cardiovasc Diabetol 16(1), 2017
PMID: 28407807
Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease.
Alfakry H, Malle E, Koyani CN, Pussinen PJ, Sorsa T., Innate Immun 22(1), 2016
PMID: 26608308
Alfakry H, Malle E, Koyani CN, Pussinen PJ, Sorsa T., Innate Immun 22(1), 2016
PMID: 26608308
Current and emerging therapies in the management of diabetic foot ulcers.
Karri VV, Kuppusamy G, Talluri SV, Yamjala K, Mannemala SS, Malayandi R., Curr Med Res Opin 32(3), 2016
PMID: 26643047
Karri VV, Kuppusamy G, Talluri SV, Yamjala K, Mannemala SS, Malayandi R., Curr Med Res Opin 32(3), 2016
PMID: 26643047
Association of MMP-8 with obesity, smoking and insulin resistance.
Lauhio A, Färkkilä E, Pietiläinen KH, Åström P, Winkelmann A, Tervahartiala T, Pirilä E, Rissanen A, Kaprio J, Sorsa TA, Salo T., Eur J Clin Invest 46(9), 2016
PMID: 27296149
Lauhio A, Färkkilä E, Pietiläinen KH, Åström P, Winkelmann A, Tervahartiala T, Pirilä E, Rissanen A, Kaprio J, Sorsa TA, Salo T., Eur J Clin Invest 46(9), 2016
PMID: 27296149
The effect of prolonged systemic doxycycline therapy on serum tissue degrading proteinases in coronary bypass patients: a randomized, double-masked, placebo-controlled clinical trial.
Kormi I, Alfakry H, Tervahartiala T, Pussinen PJ, Sinisalo J, Sorsa T., Inflamm Res 63(5), 2014
PMID: 24378958
Kormi I, Alfakry H, Tervahartiala T, Pussinen PJ, Sinisalo J, Sorsa T., Inflamm Res 63(5), 2014
PMID: 24378958
Performance of multiplex cytokine assays in serum and saliva among community-dwelling postmenopausal women.
Browne RW, Kantarci A, LaMonte MJ, Andrews CA, Hovey KM, Falkner KL, Cekici A, Stephens D, Genco RJ, Scannapieco FA, Van Dyke TE, Wactawski-Wende J., PLoS One 8(4), 2013
PMID: 23577067
Browne RW, Kantarci A, LaMonte MJ, Andrews CA, Hovey KM, Falkner KL, Cekici A, Stephens D, Genco RJ, Scannapieco FA, Van Dyke TE, Wactawski-Wende J., PLoS One 8(4), 2013
PMID: 23577067
Matrix metalloproteinase-8/collagenase-2 in childhood otitis media with effusion.
Lauhio A, Rezes S, Tervahartiala T, Sziklai I, Pitkäranta A, Sorsa T., Ann Med 44(1), 2012
PMID: 21047154
Lauhio A, Rezes S, Tervahartiala T, Sziklai I, Pitkäranta A, Sorsa T., Ann Med 44(1), 2012
PMID: 21047154
Serum MMP-8, -9 and TIMP-1 in sepsis: high serum levels of MMP-8 and TIMP-1 are associated with fatal outcome in a multicentre, prospective cohort study. Hypothetical impact of tetracyclines.
Lauhio A, Hästbacka J, Pettilä V, Tervahartiala T, Karlsson S, Varpula T, Varpula M, Ruokonen E, Sorsa T, Kolho E., Pharmacol Res 64(6), 2011
PMID: 21742038
Lauhio A, Hästbacka J, Pettilä V, Tervahartiala T, Karlsson S, Varpula T, Varpula M, Ruokonen E, Sorsa T, Kolho E., Pharmacol Res 64(6), 2011
PMID: 21742038
Slow release antibiotics for treatment of septic arthritis in large animals.
Haerdi-Landerer MC, Habermacher J, Wenger B, Suter MM, Steiner A., Vet J 184(1), 2010
PMID: 19345594
Haerdi-Landerer MC, Habermacher J, Wenger B, Suter MM, Steiner A., Vet J 184(1), 2010
PMID: 19345594
An update on pharmacological interventions for diabetic foot ulcers.
Scimeca CL, Bharara M, Fisher TK, Kimbriel H, Mills JL, Armstrong DG., Foot Ankle Spec 3(5), 2010
PMID: 20685955
Scimeca CL, Bharara M, Fisher TK, Kimbriel H, Mills JL, Armstrong DG., Foot Ankle Spec 3(5), 2010
PMID: 20685955
Assessment of systemic matrix metalloproteinase and their regulator response in children with Helicobacter pylori gastritis.
Rautelin H, Tervahartiala T, Lauhio A, Sorsa T, Kolho KL., Scand J Clin Lab Invest 70(7), 2010
PMID: 20854182
Rautelin H, Tervahartiala T, Lauhio A, Sorsa T, Kolho KL., Scand J Clin Lab Invest 70(7), 2010
PMID: 20854182
Enhanced systemic matrix metalloproteinase response in Helicobacter pylori gastritis.
Rautelin HI, Oksanen AM, Veijola LI, Sipponen PI, Tervahartiala TI, Sorsa TA, Lauhio A., Ann Med 41(3), 2009
PMID: 18979291
Rautelin HI, Oksanen AM, Veijola LI, Sipponen PI, Tervahartiala TI, Sorsa TA, Lauhio A., Ann Med 41(3), 2009
PMID: 18979291
Urinary matrix metalloproteinase -8, -9, -14 and their regulators (TRY-1, TRY-2, TATI) in patients with diabetic nephropathy.
Lauhio A, Sorsa T, Srinivas R, Stenman M, Tervahartiala T, Stenman UH, Grönhagen-Riska C, Honkanen E., Ann Med 40(4), 2008
PMID: 18428024
Lauhio A, Sorsa T, Srinivas R, Stenman M, Tervahartiala T, Stenman UH, Grönhagen-Riska C, Honkanen E., Ann Med 40(4), 2008
PMID: 18428024
Modification of collagen formation using supplemented mesh materials.
Junge K, Rosch R, Anurov M, Titkova S, Ottinger A, Klinge U, Schumpelick V., Hernia 10(6), 2006
PMID: 17028794
Junge K, Rosch R, Anurov M, Titkova S, Ottinger A, Klinge U, Schumpelick V., Hernia 10(6), 2006
PMID: 17028794
Proteases and the diabetic foot syndrome: mechanisms and therapeutic implications.
Lobmann R, Schultz G, Lehnert H., Diabetes Care 28(2), 2005
PMID: 15677818
Lobmann R, Schultz G, Lehnert H., Diabetes Care 28(2), 2005
PMID: 15677818
MMP inhibition and downregulation by bisphosphonates.
Teronen O, Heikkilä P, Konttinen YT, Laitinen M, Salo T, Hanemaaijer R, Teronen A, Maisi P, Sorsa T., Ann N Y Acad Sci 878(), 1999
PMID: 10415748
Teronen O, Heikkilä P, Konttinen YT, Laitinen M, Salo T, Hanemaaijer R, Teronen A, Maisi P, Sorsa T., Ann N Y Acad Sci 878(), 1999
PMID: 10415748
Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate.
Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Sorsa T., J Dent Res 76(9), 1997
PMID: 9294486
Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Sorsa T., J Dent Res 76(9), 1997
PMID: 9294486
Metalloproteinase inhibitors and the prevention of connective tissue breakdown.
Cawston TE., Pharmacol Ther 70(3), 1996
PMID: 8888065
Cawston TE., Pharmacol Ther 70(3), 1996
PMID: 8888065
Cathepsin G and elastase in synovial fluid and peripheral blood in reactive and rheumatoid arthritis.
Nordstrom D, Lindy O, Konttinen YT, Lauhio A, Sorsa T, Friman C, Pettersson T, Santavirta S., Clin Rheumatol 15(1), 1996
PMID: 8929773
Nordstrom D, Lindy O, Konttinen YT, Lauhio A, Sorsa T, Friman C, Pettersson T, Santavirta S., Clin Rheumatol 15(1), 1996
PMID: 8929773
The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors.
Paemen L, Martens E, Norga K, Masure S, Roets E, Hoogmartens J, Opdenakker G., Biochem Pharmacol 52(1), 1996
PMID: 8678893
Paemen L, Martens E, Norga K, Masure S, Roets E, Hoogmartens J, Opdenakker G., Biochem Pharmacol 52(1), 1996
PMID: 8678893
Wound fluids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fluids.
Yager DR, Zhang LY, Liang HX, Diegelmann RF, Cohen IK., J Invest Dermatol 107(5), 1996
PMID: 8875960
Yager DR, Zhang LY, Liang HX, Diegelmann RF, Cohen IK., J Invest Dermatol 107(5), 1996
PMID: 8875960
Human neutrophil collagenase (MMP-8), identified in bronchiectasis BAL fluid, correlates with severity of disease.
Sepper R, Konttinen YT, Ding Y, Takagi M, Sorsa T., Chest 107(6), 1995
PMID: 7781360
Sepper R, Konttinen YT, Ding Y, Takagi M, Sorsa T., Chest 107(6), 1995
PMID: 7781360
Protease inhibitors: role and potential therapeutic use in human cancer.
DeClerck YA, Imren S., Eur J Cancer 30A(14), 1994
PMID: 7857719
DeClerck YA, Imren S., Eur J Cancer 30A(14), 1994
PMID: 7857719
Effects of tetracyclines on neutrophil, gingival, and salivary collagenases. A functional and western-blot assessment with special reference to their cellular sources in periodontal diseases.
Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, Ohtani H, Andoh N, Takeha S, Konttinen YT., Ann N Y Acad Sci 732(), 1994
PMID: 7978785
Sorsa T, Ding Y, Salo T, Lauhio A, Teronen O, Ingman T, Ohtani H, Andoh N, Takeha S, Konttinen YT., Ann N Y Acad Sci 732(), 1994
PMID: 7978785
17 References
Daten bereitgestellt von Europe PubMed Central.
Salivary collagenase, elastase- and trypsin-like proteases as biochemical markers of periodontal tissue destruction in adult and localized juvenile periodontitis.
Ingman T, Sorsa T, Konttinen YT, Liede K, Saari H, Lindy O, Suomalainen K., Oral Microbiol. Immunol. 8(5), 1993
PMID: 8265204
Ingman T, Sorsa T, Konttinen YT, Liede K, Saari H, Lindy O, Suomalainen K., Oral Microbiol. Immunol. 8(5), 1993
PMID: 8265204
Minocycline treatment for rheumatoid arthritis: an open dose finding study.
Breedveld FC, Dijkmans BA, Mattie H., J. Rheumatol. 17(1), 1990
PMID: 2313671
Breedveld FC, Dijkmans BA, Mattie H., J. Rheumatol. 17(1), 1990
PMID: 2313671
Double-blind, placebo-controlled study of three-month treatment with lymecycline in reactive arthritis, with special reference to Chlamydia arthritis.
Lauhio A, Leirisalo-Repo M, Lahdevirta J, Saikku P, Repo H., Arthritis Rheum. 34(1), 1991
PMID: 1670621
Lauhio A, Leirisalo-Repo M, Lahdevirta J, Saikku P, Repo H., Arthritis Rheum. 34(1), 1991
PMID: 1670621
Angiogenesis inhibition by minocycline.
Tamargo RJ, Bok RA, Brem H., Cancer Res. 51(2), 1991
PMID: 1702361
Tamargo RJ, Bok RA, Brem H., Cancer Res. 51(2), 1991
PMID: 1702361
Low-dose doxycycline therapy: effect on gingival and crevicular fluid collagenase activity in humans.
Golub LM, Ciancio S, Ramamamurthy NS, Leung M, McNamara TF., J. Periodont. Res. 25(6), 1990
PMID: 2177499
Golub LM, Ciancio S, Ramamamurthy NS, Leung M, McNamara TF., J. Periodont. Res. 25(6), 1990
PMID: 2177499
Metalloproteinases and tissue damage.
Murphy G, Docherty AJ, Hembry RM, Reynolds JJ., Br. J. Rheumatol. 30 Suppl 1(), 1991
PMID: 1991237
Murphy G, Docherty AJ, Hembry RM, Reynolds JJ., Br. J. Rheumatol. 30 Suppl 1(), 1991
PMID: 1991237
The anticollagenolytic potential of lymecycline in the long-term treatment of reactive arthritis.
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT., Arthritis Rheum. 35(2), 1992
PMID: 1310409
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT., Arthritis Rheum. 35(2), 1992
PMID: 1310409
Specificity of the anticollagenase action of tetracyclines: relevance to their anti-inflammatory potential.
Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee HM, Uitto VJ, Saari H, Konttinen YT., Antimicrob. Agents Chemother. 36(1), 1992
PMID: 1317148
Suomalainen K, Sorsa T, Golub LM, Ramamurthy N, Lee HM, Uitto VJ, Saari H, Konttinen YT., Antimicrob. Agents Chemother. 36(1), 1992
PMID: 1317148
Host modulation with tetracyclines and their chemically modified analogues.
Golub LM, Suomalainen K, Sorsa T., Curr Opin Dent 2(), 1992
PMID: 1325849
Golub LM, Suomalainen K, Sorsa T., Curr Opin Dent 2(), 1992
PMID: 1325849
Tetracyclines suppress matrix metalloproteinase activity in adjuvant arthritis and in combination with flurbiprofen, ameliorate bone damage.
Greenwald RA, Moak SA, Ramamurthy NS, Golub LM., J. Rheumatol. 19(6), 1992
PMID: 1404131
Greenwald RA, Moak SA, Ramamurthy NS, Golub LM., J. Rheumatol. 19(6), 1992
PMID: 1404131
Reduction of the severity of canine osteoarthritis by prophylactic treatment with oral doxycycline.
Yu LP Jr, Smith GN Jr, Brandt KD, Myers SL, O'Connor BL, Brandt DA., Arthritis Rheum. 35(10), 1992
PMID: 1329773
Yu LP Jr, Smith GN Jr, Brandt KD, Myers SL, O'Connor BL, Brandt DA., Arthritis Rheum. 35(10), 1992
PMID: 1329773
Tetracycline inhibition and the cellular source of collagenase in gingival crevicular fluid in different periodontal diseases. A review article.
Ingman T, Sorsa T, Suomalainen K, Halinen S, Lindy O, Lauhio A, Saari H, Konttinen YT, Golub LM., J. Periodontol. 64(2), 1993
PMID: 8433257
Ingman T, Sorsa T, Suomalainen K, Halinen S, Lindy O, Lauhio A, Saari H, Konttinen YT, Golub LM., J. Periodontol. 64(2), 1993
PMID: 8433257
Doxycycline in the protection of serum alpha-1-antitrypsin from human neutrophil collagenase and gelatinase.
Sorsa T, Lindy O, Konttinen YT, Suomalainen K, Ingman T, Saari H, Halinen S, Lee HM, Golub LM, Hall J., Antimicrob. Agents Chemother. 37(3), 1993
PMID: 8384819
Sorsa T, Lindy O, Konttinen YT, Suomalainen K, Ingman T, Saari H, Halinen S, Lee HM, Golub LM, Hall J., Antimicrob. Agents Chemother. 37(3), 1993
PMID: 8384819
The regulatory role of doxycycline/tetracycline in collagenolytic activity and tissue destruction in joint diseases: comment on the article by Yu et al.
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT., Arthritis Rheum. 36(9), 1993
PMID: 8216431
Lauhio A, Sorsa T, Lindy O, Suomalainen K, Saari H, Golub LM, Konttinen YT., Arthritis Rheum. 36(9), 1993
PMID: 8216431
Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase.
Ramamurthy NS, Vernillo AT, Greenwald RA, Lee HM, Sorsa T, Golub LM, Rifkin BR., J. Bone Miner. Res. 8(10), 1993
PMID: 8256662
Ramamurthy NS, Vernillo AT, Greenwald RA, Lee HM, Sorsa T, Golub LM, Rifkin BR., J. Bone Miner. Res. 8(10), 1993
PMID: 8256662
Enzyme linked immunosorbent assays (ELISA) for the quantitative determination of human leukocyte collagenase and gelatinase.
Bergmann U, Michaelis J, Oberhoff R, Knauper V, Beckmann R, Tschesche H., J. Clin. Chem. Clin. Biochem. 27(6), 1989
PMID: 2547014
Bergmann U, Michaelis J, Oberhoff R, Knauper V, Beckmann R, Tschesche H., J. Clin. Chem. Clin. Biochem. 27(6), 1989
PMID: 2547014
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