REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS

LAUHIO A, KONTTINEN YT, Tschesche H, NORDSTROM D, SALO T, LAHDEVIRTA J, GOLUB LM, SORSA T (1994)
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38(2): 400-402.

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DOI
Autor*in
LAUHIO, A; KONTTINEN, YT; Tschesche, HaraldUniBi; NORDSTROM, D; SALO, T; LAHDEVIRTA, J; GOLUB, LM; SORSA, T
Einrichtung
Fakultät für Chemie > Biochemie I
Abstract / Bemerkung
The aim of this work was to determine whether human polymorphonuclear neutrophilic interstitial collagenase (matrix metalloproteinase 8 [MMP-8]) levels are reduced during long-term doxycycline treatment in humans with reactive arthritis. Serum MMP-8 levels were reduced (mean +/- standard error of the mean, 678.9 +/- 185.6 versus 491.2 +/- 144.8 ng of MMP-8 per ml), but not statistically significantly. However, the reduction of salivary MMP-8 levels was statistically significant (3,729 +/- 1,905.3 versus 1,866 +/- 780.0 ng of MMP-8 per ml, P < 0.05). This study demonstrated that a 2-month regimen of doxycycline can reduce MMP-8 levels in serum and especially in body fluids (i.e., saliva) containing inflammatory exudates and thus may contribute to reduced tissue destruction.
Erscheinungsjahr
1994
Zeitschriftentitel
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Band
38
Ausgabe
2
Seite(n)
400-402
ISSN
0066-4804
eISSN
1098-6596
Page URI
https://pub.uni-bielefeld.de/record/1644370

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LAUHIO A, KONTTINEN YT, Tschesche H, et al. REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 1994;38(2):400-402.
LAUHIO, A., KONTTINEN, Y. T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L. M., et al. (1994). REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 38(2), 400-402. https://doi.org/10.1128/AAC.38.2.400
LAUHIO, A, KONTTINEN, YT, Tschesche, Harald, NORDSTROM, D, SALO, T, LAHDEVIRTA, J, GOLUB, LM, and SORSA, T. 1994. “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38 (2): 400-402.
LAUHIO, A., KONTTINEN, Y. T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L. M., and SORSA, T. (1994). REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38, 400-402.
LAUHIO, A., et al., 1994. REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 38(2), p 400-402.
A. LAUHIO, et al., “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”, ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, vol. 38, 1994, pp. 400-402.
LAUHIO, A., KONTTINEN, Y.T., Tschesche, H., NORDSTROM, D., SALO, T., LAHDEVIRTA, J., GOLUB, L.M., SORSA, T.: REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 38, 400-402 (1994).
LAUHIO, A, KONTTINEN, YT, Tschesche, Harald, NORDSTROM, D, SALO, T, LAHDEVIRTA, J, GOLUB, LM, and SORSA, T. “REDUCTION OF MATRIX METALLOPROTEINASE 8-NEUTROPHIL COLLAGENASE LEVELS DURING LONG-TERM DOXYCYCLINE TREATMENT OF REACTIVE ARTHRITIS”. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 38.2 (1994): 400-402.

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