Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse

Schleef M, Zühlke C, Schöffl F, Jockusch H (1994)
Neuromuscular Disorders 4(3): 205-217.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Schleef, M.; Zühlke, C.; Schöffl, F.; Jockusch, HaraldUniBi
Einrichtung
Fakultät für Biologie
Abstract / Bemerkung
In myotonic ADR mice that are homozygous for a defect in the muscular chloride channel gene adr/Clc-1, the hyperexcitability of fast muscles is associated with secondary changes in gene expression and fibre type composition, cDNA clones derived from a set of genes down regulated in fast muscles of the myotonic ADR mouse were isolated by a subtractive cloning procedure. A total of 1200 clones were analysed for high expression in fast muscle of wild type and low expression in mutant mouse. Differential transcript levels were verified by northern blot hybridizations. The identities of the corresponding transcripts were determined by sequencing as myosin heavy chain IIB, alpha-tropomyosin, troponin C, a Ca2+ ATPase and parvalbumin mRNAs. Of these, mRNAs for parvalbumin and myosin heavy chain IIB were drastically downregulated in myotonic muscle (to < 10% of control). A full length cDNA clone for skeletal muscle alpha-tropomyosin was homologous to the mouse fibroblast tropomyosin isoform 2, except for the portion encoding the alpha-tropomyosin specific amino acids 258-284. A cDNA derived from the 1100 nucleotide parvalbumin transcript was cloned and the sequence for the as yet unknown 3' extended trailer, generated by alternative polyadenylation, was determined.
Stichworte
MUSCLE FIBER; MUSCLE GENE EXPRESSION; CONTRACTILE; PROTEINS; PROTEINS; CALCIUM BINDING; ALTERNATIVE SPLICING; ALTERNATIVE POLYADENYLATION; MYOTONIA; SUBTRACTIVE CDNA CLONING
Erscheinungsjahr
1994
Zeitschriftentitel
Neuromuscular Disorders
Band
4
Ausgabe
3
Seite(n)
205-217
ISSN
0960-8966
Page URI
https://pub.uni-bielefeld.de/record/1643617

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Schleef M, Zühlke C, Schöffl F, Jockusch H. Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse. Neuromuscular Disorders. 1994;4(3):205-217.
Schleef, M., Zühlke, C., Schöffl, F., & Jockusch, H. (1994). Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse. Neuromuscular Disorders, 4(3), 205-217. https://doi.org/10.1016/0960-8966(94)90021-3
Schleef, M., Zühlke, C., Schöffl, F., and Jockusch, Harald. 1994. “Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse”. Neuromuscular Disorders 4 (3): 205-217.
Schleef, M., Zühlke, C., Schöffl, F., and Jockusch, H. (1994). Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse. Neuromuscular Disorders 4, 205-217.
Schleef, M., et al., 1994. Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse. Neuromuscular Disorders, 4(3), p 205-217.
M. Schleef, et al., “Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse”, Neuromuscular Disorders, vol. 4, 1994, pp. 205-217.
Schleef, M., Zühlke, C., Schöffl, F., Jockusch, H.: Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse. Neuromuscular Disorders. 4, 205-217 (1994).
Schleef, M., Zühlke, C., Schöffl, F., and Jockusch, Harald. “Subtractive cDNA cloning as a tool to analyse secondary effects of a muscle disease. Characterization of affected genes in the myotonic ADR mouse”. Neuromuscular Disorders 4.3 (1994): 205-217.

6 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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