NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN

FOSANG AJ, LAST K, NEAME PJ, MURPHY G, KNAUPER V, Tschesche H, HUGHES CE, CATERSON B, HARDINGHAM TE (1994)
BIOCHEMICAL JOURNAL 304: 347-351.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
FOSANG, AJ; LAST, K; NEAME, PJ; MURPHY, G; KNAUPER, V; Tschesche, HaraldUniBi; HUGHES, CE; CATERSON, B; HARDINGHAM, TE
Einrichtung
Fakultät für Chemie > Biochemie I
Abstract / Bemerkung
Native and recombinant neutrophil collagenase (MMP-8) was shown to cleave at the E(373)-A(374) 'aggrecanase'' site in the interglobular domain of aggrecan. The time course of digestion in vitro showed that MMP-8 cleaved initially at N-341-F-342, the predominant metalloproteinase site, before cleaving at the E(373)-A(374) site. A synthetic peptide, IPENFFG, inhibited cleavage at E(373)-A(374) but not N-341-F-342 in vitro, indicating that the E(373)-A(374) sequence was a less preferred site for MMP-8 cleavage than N-341-F-342. IPENFFG also inhibited release of A(374) RGSVI fragments from cartilage in explant culture, suggesting that a metalloproteinase cleaved at the aggrecanase site in situ. The possibility remains that 'aggrecanase' may be a metalloproteinase in cartilage.
Erscheinungsjahr
1994
Zeitschriftentitel
BIOCHEMICAL JOURNAL
Band
304
Seite(n)
347-351
ISSN
0264-6021
Page URI
https://pub.uni-bielefeld.de/record/1642014

Zitieren

FOSANG AJ, LAST K, NEAME PJ, et al. NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN. BIOCHEMICAL JOURNAL. 1994;304:347-351.
FOSANG, A. J., LAST, K., NEAME, P. J., MURPHY, G., KNAUPER, V., Tschesche, H., HUGHES, C. E., et al. (1994). NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN. BIOCHEMICAL JOURNAL, 304, 347-351. https://doi.org/10.1042/bj3040347
FOSANG, AJ, LAST, K, NEAME, PJ, MURPHY, G, KNAUPER, V, Tschesche, Harald, HUGHES, CE, CATERSON, B, and HARDINGHAM, TE. 1994. “NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN”. BIOCHEMICAL JOURNAL 304: 347-351.
FOSANG, A. J., LAST, K., NEAME, P. J., MURPHY, G., KNAUPER, V., Tschesche, H., HUGHES, C. E., CATERSON, B., and HARDINGHAM, T. E. (1994). NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN. BIOCHEMICAL JOURNAL 304, 347-351.
FOSANG, A.J., et al., 1994. NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN. BIOCHEMICAL JOURNAL, 304, p 347-351.
A.J. FOSANG, et al., “NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN”, BIOCHEMICAL JOURNAL, vol. 304, 1994, pp. 347-351.
FOSANG, A.J., LAST, K., NEAME, P.J., MURPHY, G., KNAUPER, V., Tschesche, H., HUGHES, C.E., CATERSON, B., HARDINGHAM, T.E.: NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN. BIOCHEMICAL JOURNAL. 304, 347-351 (1994).
FOSANG, AJ, LAST, K, NEAME, PJ, MURPHY, G, KNAUPER, V, Tschesche, Harald, HUGHES, CE, CATERSON, B, and HARDINGHAM, TE. “NEUTROPHIL COLLAGENASE (MMP-8) CLEAVES AT THE AGGRECANASE SITE E(373)-A(374) IN THE INTERGLOBULAR DOMAIN OF CARTILAGE AGGRECAN”. BIOCHEMICAL JOURNAL 304 (1994): 347-351.

62 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

IL-1β Damages Fibrocartilage and Upregulates MMP-13 Expression in Fibrochondrocytes in the Condyle of the Temporomandibular Joint.
Tabeian H, Betti BF, Dos Santos Cirqueira C, de Vries TJ, Lobbezoo F, Ter Linde AV, Zandieh-Doulabi B, Koenders MI, Everts V, Bakker AD., Int J Mol Sci 20(9), 2019
PMID: 31067826
Inflammatory biomarkers in saliva and serum of patients with rheumatoid arthritis with respect to periodontal status.
Äyräväinen L, Heikkinen AM, Kuuliala A, Ahola K, Koivuniemi R, Laasonen L, Moilanen E, Hämäläinen M, Tervahartiala T, Meurman JH, Leirisalo-Repo M, Sorsa T., Ann Med 50(4), 2018
PMID: 29683364
MMP-8 single-nucleotide polymorphisms are related to ankylosing spondylitis in Chinese Han population.
Meng C, Bai R, Zhao Z, Huang G, Jin T, Feng W, Liu W., Medicine (Baltimore) 97(35), 2018
PMID: 30170451
In vitro response of human chondrocytes to a combination of growth factors and a proteinase inhibitor.
Pifer MA, Kibuule LK, Maerz T, Studzinski DM, Baker KC, Herkowitz HN., Orthopedics 35(1), 2012
PMID: 22229919
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.
Durigova M, Nagase H, Mort JS, Roughley PJ., Matrix Biol 30(2), 2011
PMID: 21055468
The role of matrix metalloproteinases in cystic fibrosis lung disease.
Gaggar A, Hector A, Bratcher PE, Mall MA, Griese M, Hartl D., Eur Respir J 38(3), 2011
PMID: 21233269
Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression.
Cox JH, Starr AE, Kappelhoff R, Yan R, Roberts CR, Overall CM., Arthritis Rheum 62(12), 2010
PMID: 21120997
A quantitative evaluation of inflammatory cells in human temporomandibular joint tissues from patients with and without implants.
Alonso A, Kaimal S, Look J, Swift J, Fricton J, Myers S, Kehl L., J Oral Maxillofac Surg 67(4), 2009
PMID: 19304036
Characterization of an ADAMTS-5-mediated cleavage site in aggrecan in OSM-stimulated bovine cartilage.
Durigova M, Soucy P, Fushimi K, Nagase H, Mort JS, Roughley PJ., Osteoarthritis Cartilage 16(10), 2008
PMID: 18372197
Proteolytic activities of human ADAMTS-5: comparative studies with ADAMTS-4.
Gendron C, Kashiwagi M, Lim NH, Enghild JJ, Thøgersen IB, Hughes C, Caterson B, Nagase H., J Biol Chem 282(25), 2007
PMID: 17430884
Blocking aggrecanase cleavage in the aggrecan interglobular domain abrogates cartilage erosion and promotes cartilage repair.
Little CB, Meeker CT, Golub SB, Lawlor KE, Farmer PJ, Smith SM, Fosang AJ., J Clin Invest 117(6), 2007
PMID: 17510707
In situ localization of gelatinolytic activity during development and resorption of Meckel's cartilage in mice.
Sakakura Y, Hosokawa Y, Tsuruga E, Irie K, Yajima T., Eur J Oral Sci 115(3), 2007
PMID: 17587297
Fibrin glue mixed with gelatin/hyaluronic acid/chondroitin-6-sulfate tri-copolymer for articular cartilage tissue engineering: the results of real-time polymerase chain reaction.
Chou CH, Cheng WT, Kuo TF, Sun JS, Lin FH, Tsai JC., J Biomed Mater Res A 82(3), 2007
PMID: 17326136
Physiological and behavioral evidence for focal nociception induced by epidural glutamate infusion in rats.
Harrington JF, Messier AA, Hoffman L, Yu E, Dykhuizen M, Barker K., Spine (Phila Pa 1976) 30(6), 2005
PMID: 15770173
Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and fluid synovial fibroblasts.
Fuchs S, Skwara A, Bloch M, Dankbar B., Osteoarthritis Cartilage 12(5), 2004
PMID: 15094140
Mature bovine articular cartilage contains abundant aggrecan that is C-terminally truncated at Ala719-Ala720, a site which is readily cleaved by m-calpain.
Oshita H, Sandy JD, Suzuki K, Akaike A, Bai Y, Sasaki T, Shimizu K., Biochem J 382(pt 1), 2004
PMID: 15175011
Expression of matrix metalloproteinase 8 (MMP-8) and tyrosinase-related protein-1 (TYRP-1) correlates with the absence of metastasis in an isogenic human breast cancer model.
Agarwal D, Goodison S, Nicholson B, Tarin D, Urquidi V., Differentiation 71(2), 2003
PMID: 12641565
A microplate assay specific for the enzyme aggrecanase.
Miller JA, Liu RQ, Davis GL, Pratta MA, Trzaskos JM, Copeland RA., Anal Biochem 314(2), 2003
PMID: 12654313
ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the matrix metalloproteinase site (Asn341-Phe342) in the aggrecan interglobular domain.
Westling J, Fosang AJ, Last K, Thompson VP, Tomkinson KN, Hebert T, McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD., J Biol Chem 277(18), 2002
PMID: 11854269
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.
Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B., Matrix Biol 21(3), 2002
PMID: 12009333
Human knee and ankle cartilage explants: catabolic differences.
Eger W, Schumacher BL, Mollenhauer J, Kuettner KE, Cole AA., J Orthop Res 20(3), 2002
PMID: 12038627
Phenotypic characterization of inflammatory cells from osteoarthritic synovium and synovial fluids.
Haynes MK, Hume EL, Smith JB., Clin Immunol 105(3), 2002
PMID: 12498813
Biochemical basis of the pharmacologic action of chondroitin sulfates on the osteoarticular system.
Bali JP, Cousse H, Neuzil E., Semin Arthritis Rheum 31(1), 2001
PMID: 11503140
The role of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) in a model of cartilage degradation.
Tortorella MD, Malfait AM, Deccico C, Arner E., Osteoarthritis Cartilage 9(6), 2001
PMID: 11520168
Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: the role of advanced glycation end products.
DeGroot J, Verzijl N, Wenting-Van Wijk MJ, Bank RA, Lafeber FP, Bijlsma JW, TeKoppele JM., Arthritis Rheum 44(11), 2001
PMID: 11710713
Herniated lumbar disc material as a source of free glutamate available to affect pain signals through the dorsal root ganglion.
Harrington JF, Messier AA, Bereiter D, Barnes B, Epstein MH., Spine (Phila Pa 1976) 25(8), 2000
PMID: 10767804
Mutations in the interglobular domain of aggrecan alter matrix metalloproteinase and aggrecanase cleavage patterns. Evidence that matrix metalloproteinase cleavage interferes with aggrecanase activity.
Mercuri FA, Maciewicz RA, Tart J, Last K, Fosang AJ., J Biol Chem 275(42), 2000
PMID: 11032846
Truncation of the amino-terminus of the recombinant aggrecan rAgg1mut leads to reduced cleavage at the aggrecanase site. Efficient aggrecanase catabolism may depend on multiple substrate interactions.
Hörber C, Büttner FH, Kern C, Schmiedeknecht G, Bartnik E., Matrix Biol 19(6), 2000
PMID: 11068207
Chondrocyte apoptosis induced by aggrecan G1 domain as a result of decreased cell adhesion.
Cao L, Yang BB., Exp Cell Res 246(2), 1999
PMID: 9925769
The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment.
Ghosh P., Semin Arthritis Rheum 28(4), 1999
PMID: 10073500
Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.
van Meurs JB, van Lent PL, Holthuysen AE, Singer II, Bayne EK, van den Berg WB., Arthritis Rheum 42(6), 1999
PMID: 10366105
Immunochemical and tissue analysis of protease generated neoepitopes of BM-40 (osteonectin, SPARC) which are correlated to a higher affinity binding to collagens.
Sasaki T, Miosge N, Timpl R., Matrix Biol 18(5), 1999
PMID: 10601737
Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro.
Little CB, Flannery CR, Hughes CE, Mort JS, Roughley PJ, Dent C, Caterson B., Biochem J 344 Pt 1(), 1999
PMID: 10548534
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T., Bone 22(1), 1998
PMID: 9437511
Membrane type 1 matrix metalloproteinase (MT1-MMP) cleaves the recombinant aggrecan substrate rAgg1mut at the 'aggrecanase' and the MMP sites. Characterization of MT1-MMP catabolic activities on the interglobular domain of aggrecan.
Büttner FH, Hughes CE, Margerie D, Lichte A, Tschesche H, Caterson B, Bartnik E., Biochem J 333 ( Pt 1)(), 1998
PMID: 9639575
Matrix metalloproteinases: the clue to intervertebral disc degeneration?
Goupille P, Jayson MI, Valat JP, Freemont AJ., Spine (Phila Pa 1976) 23(14), 1998
PMID: 9682320
Membrane-type 1 MMP (MMP-14) cleaves at three sites in the aggrecan interglobular domain.
Fosang AJ, Last K, Fujii Y, Seiki M, Okada Y., FEBS Lett 430(3), 1998
PMID: 9688535
Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown.
Kozaci LD, Brown CJ, Adcocks C, Galloway A, Hollander AP, Buttle DJ., Mol Pathol 51(5), 1998
PMID: 10193524
An aggrecan-degrading activity associated with chondrocyte membranes.
Billington CJ, Clark IM, Cawston TE., Biochem J 336 ( Pt 1)(), 1998
PMID: 9806902
Matrix metalloproteinases, tumor necrosis factor and multiple sclerosis: an overview.
Chandler S, Miller KM, Clements JM, Lury J, Corkill D, Anthony DC, Adams SE, Gearing AJ., J Neuroimmunol 72(2), 1997
PMID: 9042108
Osteoarthritis in ankle and knee joints.
Huch K, Kuettner KE, Dieppe P., Semin Arthritis Rheum 26(4), 1997
PMID: 9062947
Inhibition of bovine nasal cartilage degradation by selective matrix metalloproteinase inhibitors.
Bottomley KM, Borkakoti N, Bradshaw D, Brown PA, Broadhurst MJ, Budd JM, Elliott L, Eyers P, Hallam TJ, Handa BK, Hill CH, James M, Lahm HW, Lawton G, Merritt JE, Nixon JS, Röthlisberger U, Whittle A, Johnson WH., Biochem J 323 ( Pt 2)(), 1997
PMID: 9163342
Aggrecan degradation in human cartilage. Evidence for both matrix metalloproteinase and aggrecanase activity in normal, osteoarthritic, and rheumatoid joints.
Lark MW, Bayne EK, Flanagan J, Harper CF, Hoerrner LA, Hutchinson NI, Singer II, Donatelli SA, Weidner JR, Williams HR, Mumford RA, Lohmander LS., J Clin Invest 100(1), 1997
PMID: 9202061
Utilization of a recombinant substrate rAgg1 to study the biochemical properties of aggrecanase in cell culture systems.
Hughes CE, Büttner FH, Eidenmüller B, Caterson B, Bartnik E., J Biol Chem 272(32), 1997
PMID: 9242707
Aggrecan degradation in human intervertebral disc and articular cartilage.
Sztrolovics R, Alini M, Roughley PJ, Mort JS., Biochem J 326 ( Pt 1)(), 1997
PMID: 9337874
Human neutrophil collagenase MMP-8 in peri-implant sulcus fluid and its inhibition by clodronate.
Teronen O, Konttinen YT, Lindqvist C, Salo T, Ingman T, Lauhio A, Ding Y, Santavirta S, Sorsa T., J Dent Res 76(9), 1997
PMID: 9294486
Aggrecanase and metalloproteinase-specific aggrecan neo-epitopes are induced in the articular cartilage of mice with collagen II-induced arthritis.
Singer II, Scott S, Kawka DW, Bayne EK, Weidner JR, Williams HR, Mumford RA, Lark MW, McDonnell J, Christen AJ, Moore VL, Mudgett JS, Visco DM., Osteoarthritis Cartilage 5(6), 1997
PMID: 9536289
Osteoarthritic lesions: involvement of three different collagenases.
Shlopov BV, Lie WR, Mainardi CL, Cole AA, Chubinskaya S, Hasty KA., Arthritis Rheum 40(11), 1997
PMID: 9365097
Activation of human neutrophil procollagenase by stromelysin 2.
Knäuper V, Murphy G, Tschesche H., Eur J Biochem 235(1-2), 1996
PMID: 8631328
Human matrix metalloproteinase specificity studies using collagen sequence-based synthetic peptides.
Nagase H, Fields GB., Biopolymers 40(4), 1996
PMID: 8765610
Collagenase: a key enzyme in collagen turnover.
Shingleton WD, Hodges DJ, Brick P, Cawston TE., Biochem Cell Biol 74(6), 1996
PMID: 9164646
Aggrecan: A Target Molecule of Autoimmune Reactions.
Buzás EI, Mikecz K, Glant TT., Pathol Oncol Res 2(4), 1996
PMID: 11173607
Degradation of cartilage aggrecan by collagenase-3 (MMP-13).
Fosang AJ, Last K, Knäuper V, Murphy G, Neame PJ., FEBS Lett 380(1-2), 1996
PMID: 8603731
Computational sequence analysis of matrix metalloproteinases.
Sang QA, Douglas DA., J Protein Chem 15(2), 1996
PMID: 8924199
Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase.
Cole AA, Chubinskaya S, Schumacher B, Huch K, Szabo G, Yao J, Mikecz K, Hasty KA, Kuettner KE., J Biol Chem 271(18), 1996
PMID: 8631924
Aggrecan is degraded by matrix metalloproteinases in human arthritis. Evidence that matrix metalloproteinase and aggrecanase activities can be independent.
Fosang AJ, Last K, Maciewicz RA., J Clin Invest 98(10), 1996
PMID: 8941646
Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chondrocytes.
Verschure PJ, Van Noorden CJ, Van Marle J, Van den Berg WB., Histochem J 28(12), 1996
PMID: 9015706
Inhibitors of collagenase but not of gelatinase reduce cartilage explant proteoglycan breakdown despite only low levels of matrix metalloproteinase activity.
Brown CJ, Rahman S, Morton AC, Beauchamp CL, Bramwell H, Buttle DJ., Clin Mol Pathol 49(6), 1996
PMID: 16696099
Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
Hughes CE, Caterson B, Fosang AJ, Roughley PJ, Mort JS., Biochem J 305 ( Pt 3)(), 1995
PMID: 7531436
Cell-mediated catabolism of aggrecan. Evidence that cleavage at the "aggrecanase" site (Glu373-Ala374) is a primary event in proteolysis of the interglobular domain.
Lark MW, Gordy JT, Weidner JR, Ayala J, Kimura JH, Williams HR, Mumford RA, Flannery CR, Carlson SS, Iwata M., J Biol Chem 270(6), 1995
PMID: 7852317
Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.
Fosang AJ, Last K, Gardiner P, Jackson DC, Brown L., Biochem J 310 ( Pt 1)(), 1995
PMID: 7544117
Proteolytic mechanisms of cartilage breakdown: a target for arthritis therapy?
Buttle DJ, Bramwell H, Hollander AP., Clin Mol Pathol 48(4), 1995
PMID: 16696000

26 References

Daten bereitgestellt von Europe PubMed Central.

A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures.
Farndale RW, Sayers CA, Barrett AJ., Connect. Tissue Res. 9(4), 1982
PMID: 6215207
The recovery of articular cartilage in explant culture from interleukin-1 alpha: effects on proteoglycan synthesis and degradation.
Rayan V, Hardingham T., Matrix Biol. 14(3), 1994
PMID: 7921543
Electrophoresis of 35S-labeled proteoglycans on polyacrylamide-agarose composite gels and their visualization by fluorography.
Carney SL, Bayliss MT, Collier JM, Muir H., Anal. Biochem. 156(1), 1986
PMID: 3740416
Isolation of the N-terminal globular protein domains from cartilage proteoglycans. Identification of G2 domain and its lack of interaction with hyaluronate and link protein.
Fosang AJ, Hardingham TE., Biochem. J. 261(3), 1989
PMID: 2803245
Characterization and activation of procollagenase from human polymorphonuclear leucocytes. N-terminal sequence determination of the proenzyme and various proteolytically activated forms.
Knauper V, Kramer S, Reinke H, Tschesche H., Eur. J. Biochem. 189(2), 1990
PMID: 2159879
The tissue metalloproteinase family and the inhibitor TIMP: a study using cDNAs and recombinant proteins.
Docherty AJ, Murphy G., Ann. Rheum. Dis. 49 Suppl 1(), 1990
PMID: 2197998
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
Doege KJ, Sasaki M, Kimura T, Yamada Y., J. Biol. Chem. 266(2), 1991
PMID: 1985970
Catabolism of aggrecan in cartilage explants. Identification of a major cleavage site within the interglobular domain.
Sandy JD, Neame PJ, Boynton RE, Flannery CR., J. Biol. Chem. 266(14), 1991
PMID: 2026585
Purification of recombinant human prostromelysin. Studies on heat activation to give high-Mr and low-Mr active forms, and a comparison of recombinant with natural stromelysin activities.
Koklitis PA, Murphy G, Sutton C, Angal S., Biochem. J. 276 ( Pt 1)(), 1991
PMID: 2039471
The N-terminal domain of tissue inhibitor of metalloproteinases retains metalloproteinase inhibitory activity.
Murphy G, Houbrechts A, Cockett MI, Williamson RA, O'Shea M, Docherty AJ., Biochemistry 30(33), 1991
PMID: 1868085
Cleavage of cartilage proteoglycan between G1 and G2 domains by stromelysins.
Fosang AJ, Neame PJ, Hardingham TE, Murphy G, Hamilton JA., J. Biol. Chem. 266(24), 1991
PMID: 1874716
The purification of tissue inhibitor of metalloproteinases-2 from its 72 kDa progelatinase complex. Demonstration of the biochemical similarities of tissue inhibitor of metalloproteinases-2 and tissue inhibitor of metalloproteinases-1.
Ward RV, Hembry RM, Reynolds JJ, Murphy G., Biochem. J. 278 ( Pt 1)(), 1991
PMID: 1909113
Identification of a stromelysin cleavage site within the interglobular domain of human aggrecan. Evidence for proteolysis at this site in vivo in human articular cartilage.
Flannery CR, Lark MW, Sandy JD., J. Biol. Chem. 267(2), 1992
PMID: 1730630
Cleavage of proteoglycan aggregate by leucocyte elastase.
Mok MT, Ilic MZ, Handley CJ, Robinson HC., Arch. Biochem. Biophys. 292(2), 1992
PMID: 1731610
Mechanism of catabolism of aggrecan by articular cartilage.
Ilic MZ, Handley CJ, Robinson HC, Mok MT., Arch. Biochem. Biophys. 294(1), 1992
PMID: 1550337
The structure of aggrecan fragments in human synovial fluid. Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-Ala 374 bond of the interglobular domain.
Sandy JD, Flannery CR, Neame PJ, Lohmander LS., J. Clin. Invest. 89(5), 1992
PMID: 1569188
The role of the C-terminal domain in collagenase and stromelysin specificity.
Murphy G, Allan JA, Willenbrock F, Cockett MI, O'Connell JP, Docherty AJ., J. Biol. Chem. 267(14), 1992
PMID: 1315762
N-terminal sequence of proteoglycan fragments isolated from medium of interleukin-1-treated articular-cartilage cultures. Putative site(s) of enzymic cleavage.
Loulakis P, Shrikhande A, Davis G, Maniglia CA., Biochem. J. 284 ( Pt 2)(), 1992
PMID: 1599440
Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin.
Hughes CE, Caterson B, White RJ, Roughley PJ, Mort JS., J. Biol. Chem. 267(23), 1992
PMID: 1379586
The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.
Fosang AJ, Neame PJ, Last K, Hardingham TE, Murphy G, Hamilton JA., J. Biol. Chem. 267(27), 1992
PMID: 1326552
The recombinant catalytic domain of human neutrophil collagenase lacks type I collagen substrate specificity.
Schnierer S, Kleine T, Gote T, Hillemann A, Knauper V, Tschesche H., Biochem. Biophys. Res. Commun. 191(2), 1993
PMID: 8460992
Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage.
Mort JS, Dodge GR, Roughley PJ, Liu J, Finch SJ, DiPasquale G, Poole AR., Matrix 13(2), 1993
PMID: 8492744
Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain.
Fosang AJ, Last K, Knauper V, Neame PJ, Murphy G, Hardingham TE, Tschesche H, Hamilton JA., Biochem. J. 295 ( Pt 1)(), 1993
PMID: 8216228
The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis.
Lohmander LS, Neame PJ, Sandy JD., Arthritis Rheum. 36(9), 1993
PMID: 8216415
Inhibition of cartilage proteoglycan release by a specific inactivator of cathepsin B and an inhibitor of matrix metalloproteinases. Evidence for two converging pathways of chondrocyte-mediated proteoglycan degradation.
Buttle DJ, Handley CJ, Ilic MZ, Saklatvala J, Murata M, Barrett AJ., Arthritis Rheum. 36(12), 1993
PMID: 8250991
Purification and characterization of a rabbit bone metalloproteinase that degrades proteoglycan and other connective-tissue components.
Galloway WA, Murphy G, Sandy JD, Gavrilovic J, Cawston TE, Reynolds JJ., Biochem. J. 209(3), 1983
PMID: 6347180
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