OSMERS RGW, BLASER J, KUHN W, Tschesche H (1995)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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OSMERS, RGW; BLASER, J; KUHN, W; Tschesche, HaraldUniBi
Abstract / Bemerkung
Objective: To examine the role of cytokines in cervical dilation. Methods: In 55 patients undergoing cesarean delivery, we took samples from the lower uterine segment, the decidua, and the membranes. We determined the concentrations of interleukin (IL)-2, IL-8, tumor necrosis factor-alpha, matrix metalloproteinase (MMP)-8, and MMP-9 in the different tissues. Results: Depending on the state of labor, we observed a significant increase (P < .001) in IL-8 concentrations in the lower uterine segment. The leukocyte enzymes MMP-8 and MMP-9 were highly significantly correlated with the IL-8 concentrations. Conclusion: Interleukin-8 is critically involved in the process of parturition in humans. Interleukin-6 concentrations in the myometrium, decidua, and membranes correlated strongly with the observed MMP-8 and MMP-9 concentrations.
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113 Zitationen in Europe PMC

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