Overshooting production of satellite cells in murine skeletal muscle affected by the mutation ''muscular dystrophy with myositis'' (mdm, Chr 2)

Heimann P, Menke A, Rothkegel B, Jockusch H (1996)
Cell & tissue research 283(3): 435-441.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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Autor/in
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Abstract / Bemerkung
The hereditary degenerative muscle disease ''muscular dystrophy with myositis'' of the mouse (MDM, genotype mdm/mdm) is caused by a spontaneous recessive mutation on chromosome 2. Skeletal muscles of MDM mice degenerate during the first few postnatal weeks and subsequently regenerate. The cellular and molecular mechanisms of this muscle disease are not yet understood. An inflammatory component as implied by its name seems unlikely. By applying quantitative electron microscopy, we demonstrate a transient increase of up to 4-fold in the satellite cell frequency in both fast and slow muscles of affected animals. This difference from wildtype controls (+/+ or +/mdm) is also reflected in the yield of mononucleate myogenic cells upon dissociation of skeletal muscle and subsequent cell culture. Unlike the increase in satellite cell density in the myotonic ADR mouse, this phenomenon is not accompanied with a shift to more oxidative fibre types. It may however be related to the more profuse micro-vascularization of MDM muscle.
Stichworte
muscle cell culture; neuromuscular disease; muscular dystrophy with myositis; mouse; chromosome 2; titin; (C57BL/6J mdm); mouse; satellite cells
Erscheinungsjahr
1996
Zeitschriftentitel
Cell & tissue research
Band
283
Ausgabe
3
Seite(n)
435-441
ISSN
0302-766X
eISSN
1432-0878
Page URI
https://pub.uni-bielefeld.de/record/1639765

Zitieren

Heimann P, Menke A, Rothkegel B, Jockusch H. Overshooting production of satellite cells in murine skeletal muscle affected by the mutation ''muscular dystrophy with myositis'' (mdm, Chr 2). Cell & tissue research. 1996;283(3):435-441.
Heimann, P., Menke, A., Rothkegel, B., & Jockusch, H. (1996). Overshooting production of satellite cells in murine skeletal muscle affected by the mutation ''muscular dystrophy with myositis'' (mdm, Chr 2). Cell & tissue research, 283(3), 435-441. doi:10.1007/s004410050554
Heimann, P., Menke, A., Rothkegel, B., and Jockusch, H. (1996). Overshooting production of satellite cells in murine skeletal muscle affected by the mutation ''muscular dystrophy with myositis'' (mdm, Chr 2). Cell & tissue research 283, 435-441.
Heimann, P., et al., 1996. Overshooting production of satellite cells in murine skeletal muscle affected by the mutation ''muscular dystrophy with myositis'' (mdm, Chr 2). Cell & tissue research, 283(3), p 435-441.
P. Heimann, et al., “Overshooting production of satellite cells in murine skeletal muscle affected by the mutation ''muscular dystrophy with myositis'' (mdm, Chr 2)”, Cell & tissue research, vol. 283, 1996, pp. 435-441.
Heimann, P., Menke, A., Rothkegel, B., Jockusch, H.: Overshooting production of satellite cells in murine skeletal muscle affected by the mutation ''muscular dystrophy with myositis'' (mdm, Chr 2). Cell & tissue research. 283, 435-441 (1996).
Heimann, Peter, Menke, A, Rothkegel, B, and Jockusch, Harald. “Overshooting production of satellite cells in murine skeletal muscle affected by the mutation ''muscular dystrophy with myositis'' (mdm, Chr 2)”. Cell & tissue research 283.3 (1996): 435-441.

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