Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements

Kolben M, Lopens A, Blaser J, Huber A, Frank M, Wilhelm O, Wilhelm S, Schneider KTM, Ulm K, Tschesche H, Schmitt M, et al. (1995)
In: Gynäkologisch-geburtshilfliche Rundschau. GYNÄKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU, 35(1). KARGER: 126-131.

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Autor*in
Kolben, M; Lopens, A; Blaser, J; Huber, A; Frank, M; Wilhelm, O; Wilhelm, S; Schneider, KTM; Ulm, K; Tschesche, HaraldUniBi; Schmitt, M; Graeff, H
Alle
Abstract / Bemerkung
Objective: Impaired trophoblast invasion plays a major role in the development of preeclampsia. Therefore various factors that are involved in invasion were investigated in gestational disease. Methods: In pregnant women with HELLP-syndrome (n = 18), pre-/eclampsia (n = 21) and highly pathological Doppler flow measurements (hpD) (n = 13), plasma and placental tissue extract concentrations of uPA, uPA-receptor, tPA, PAI-1, MMP-8, MMP-9, TIMP-1, thrombomodulin, and angiogenin were measured using ELISA. Results: In all three collectives, PAI-1 plasma concentrations were significantly higher (p < 0,05) than in normal pregnancies, in patients with HELLP-syndrome, tPA and TIMP-1 plasma levels were also elevated. MMP-9 concentrations in placental tissue extracts were lower in pre-/eclampsia than in normal pregnancies. Conclusions: Impaired placental implantation and remodelling in gestational disease is reflected by changes in plasma and placental tissue extract concentrations of various factors that are involved in these processes.
Stichworte
HELLP syndrome; invasion; Doppler flow; pre-eclampsia; trophoblast; proteases
Erscheinungsjahr
1995
Titel des Konferenzbandes
Gynäkologisch-geburtshilfliche Rundschau
Band
35
Ausgabe
1
Seite(n)
126-131
ISSN
1018-8843
Page URI
https://pub.uni-bielefeld.de/record/1639623

Zitieren

Kolben M, Lopens A, Blaser J, et al. Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements. In: Gynäkologisch-geburtshilfliche Rundschau. GYNÄKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. Vol 35. KARGER; 1995: 126-131.
Kolben, M., Lopens, A., Blaser, J., Huber, A., Frank, M., Wilhelm, O., Wilhelm, S., et al. (1995). Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements. Gynäkologisch-geburtshilfliche Rundschau, GYNÄKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU, 35, 126-131. KARGER. doi:10.1159/000272583
Kolben, M., Lopens, A., Blaser, J., Huber, A., Frank, M., Wilhelm, O., Wilhelm, S., Schneider, K. T. M., Ulm, K., Tschesche, H., et al. (1995). “Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements” in Gynäkologisch-geburtshilfliche Rundschau GYNÄKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU, vol. 35, (KARGER), 126-131.
Kolben, M., et al., 1995. Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements. In Gynäkologisch-geburtshilfliche Rundschau. GYNÄKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. no.35 KARGER, pp. 126-131.
M. Kolben, et al., “Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements”, Gynäkologisch-geburtshilfliche Rundschau, GYNÄKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU, vol. 35, KARGER, 1995, pp.126-131.
Kolben, M., Lopens, A., Blaser, J., Huber, A., Frank, M., Wilhelm, O., Wilhelm, S., Schneider, K.T.M., Ulm, K., Tschesche, H., Schmitt, M., Graeff, H.: Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements. Gynäkologisch-geburtshilfliche Rundschau. GYNÄKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. 35, p. 126-131. KARGER (1995).
Kolben, M, Lopens, A, Blaser, J, Huber, A, Frank, M, Wilhelm, O, Wilhelm, S, Schneider, KTM, Ulm, K, Tschesche, Harald, Schmitt, M, and Graeff, H. “Concentration of different proteolytic and angiogenic factors in plasma and placenta extract of patients with HELLP syndrome, pre-/eclampsia, and highly pathological Doppler flow measurements”. Gynäkologisch-geburtshilfliche Rundschau. KARGER, 1995.Vol. 35. GYNÄKOLOGISCH-GEBURTSHILFLICHE RUNDSCHAU. 126-131.

5 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Protein profiling of preeclampsia placental tissues.
Shu C, Liu Z, Cui L, Wei C, Wang S, Tang JJ, Cui M, Lian G, Li W, Liu X, Xu H, Jiang J, Lee P, Zhang DY, He J, Ye F., PLoS One 9(11), 2014
PMID: 25392996
Aetiology and physiopathology of preeclampsia and related forms.
Lorquet S, Pequeux C, Munaut C, Foidart JM., Acta Clin Belg 65(4), 2010
PMID: 20954461
Dysregulation of anti-angiogenic agents (sFlt-1, PLGF, and sEndoglin) in preeclampsia--a step forward but not the definitive answer.
Foidart JM, Schaaps JP, Chantraine F, Munaut C, Lorquet S., J Reprod Immunol 82(2), 2009
PMID: 19853925
Molecular mechanisms of preeclampsia.
Mutter WP, Karumanchi SA., Microvasc Res 75(1), 2008
PMID: 17553534

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