TY - JOUR
AB - Global relations between RNA sequences and secondary structures are understood as mappings from sequence space into shape space. These mappings are investigated by exhaustive folding of all GC and AU sequences with chain lengths up to 30. The computed structural data are evaluated through exhaustive enumeration and used as an exact reference for testing analytical results derived from mathematical models and sampling based on statistical methods. Several new concepts of RNA sequence to secondary structure mappings are investigated, among them that of neutral networks (being sets of sequences folding into the same structure). Exhaustive enumeration allows to test several previously suggested relations: the number of(minimum free energy) secondary structures as a function of the chain length as well as the frequency distribution of structures at constant chain length (commonly resulting in generalized forms of Zipf's law).
AU - Grüner, Walter
AU - Giegerich, Robert
AU - Strothmann, Dirk
AU - Reidys, Christian
AU - Weber, Jacqueline
AU - Hofacker, Ivo L.
AU - Stadler, Peter
AU - Schuster, Peter
ID - 1639477
IS - 4
JF - Monatshefte für Chemie
KW - RNA secondary structures
KW - neutral networks
KW - random graphs
KW - Zipf's law
SN - 0026-9247
TI - Analysis of RNA sequence structure maps by exhaustive enumeration .1. Neutral networks
VL - 127
ER -