Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies

Sedehizade F, Klocke R, Jockusch H (1997)
Muscle & Nerve 20(2): 186-194.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
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DOI
Autor*in
Sedehizade, F; Klocke, R; Jockusch, HaraldUniBi
Einrichtung
Fakultät für Biologie
Abstract / Bemerkung
The expression of the genes for the alpha-subunit of AChR (AChR alpha), for the myogenic factors myogenin and MyoD, for the calcium-binding protein parvalbumin (PV), and for the muscular chloride channel CIC-1 was studied in the three mouse spinal muscular atrophies (SMAs). These were the mutants ''wobbler'' (WR), ''muscle deficient'' (MDF) and ''progressive motor neuronopathy'' (PMN). Murine myopathies ''muscular dystrophy with myositis'' (MDM) and ''X-linked muscular dystrophy'' (MDX) were used as controls. AChR alpha and myogenin mRNA levels were strongly elevated in muscles affected by SMAs (reflecting denervation), whereas only myogenin mRNA was moderately elevated in MDX and MDM muscles, probably due to fiber regeneration, As in denervated muscle, CIC-1 and PV mRNA levels were lowered in SMAs, No changes were seen in muscles of up to 222-day-old symptomless ciliary neurotrophic factor (CNTF) knockout mice. The patterns of gene expression were characteristic for the type of muscle disease, indicating their possible usefulness for clinical diagnosis. (C) 1997 John Wiley & Sons, Inc.
Stichworte
neuromuscular diseases; mouse models; myogenic factors; acetylcholine; receptor; AChR alpha; chloride channel 1; parvalbumin; denervation; effects
Erscheinungsjahr
1997
Zeitschriftentitel
Muscle & Nerve
Band
20
Ausgabe
2
Seite(n)
186-194
ISSN
0148-639X
eISSN
1097-4598
Page URI
https://pub.uni-bielefeld.de/record/1638016

Zitieren

Sedehizade F, Klocke R, Jockusch H. Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies. Muscle & Nerve. 1997;20(2):186-194.
Sedehizade, F., Klocke, R., & Jockusch, H. (1997). Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies. Muscle & Nerve, 20(2), 186-194. https://doi.org/10.1002/(SICI)1097-4598(199702)20:2<186::AID-MUS8>3.0.CO;2-8
Sedehizade, F, Klocke, R, and Jockusch, Harald. 1997. “Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies”. Muscle & Nerve 20 (2): 186-194.
Sedehizade, F., Klocke, R., and Jockusch, H. (1997). Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies. Muscle & Nerve 20, 186-194.
Sedehizade, F., Klocke, R., & Jockusch, H., 1997. Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies. Muscle & Nerve, 20(2), p 186-194.
F. Sedehizade, R. Klocke, and H. Jockusch, “Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies”, Muscle & Nerve, vol. 20, 1997, pp. 186-194.
Sedehizade, F., Klocke, R., Jockusch, H.: Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies. Muscle & Nerve. 20, 186-194 (1997).
Sedehizade, F, Klocke, R, and Jockusch, Harald. “Expression of nerve-regulated genes in muscles of mouse mutants affected by spinal muscular atrophies and muscular dystrophies”. Muscle & Nerve 20.2 (1997): 186-194.

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