Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, Mitchell P, Hambor J, Diekmann O, Tschesche H, Chen J, et al. (1997)

Zeitschriftenaufsatz | Veröffentlicht | Englisch
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Billinghurst, RC; Dahlberg, L; Ionescu, M; Reiner, A; Bourne, R; Rorabeck, C; Mitchell, P; Hambor, J; Diekmann, O; Tschesche, HaraldUniBi; Chen, J; VanWart, H
Abstract / Bemerkung
We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) and amino-terminal (COL2-1/4N1) neoepitopes general ed by cleavage of native human type II collagen by collagenase matrix metalloproteinase (MMP)-1 (collagenase-1), MMP-8 (collagenase-2), and MMP-13 (collagenase-3). A secondary cleavage followed the initial cleavage produced by these recombinant collagenases. This generated neoepitope COL2-1/4N2. There was significantly more COL2-3/4C(short) neoepitope in osteoarthritis (OA) compared to adult nonarthritic cartilages as determined by immunoassay of cartilage extracts. A synthetic preferential inhibitor of MMP-13 significantly reduced the unstimulated release in culture of neoepitope COL2-3/4C(short) from human osteoarthritic cartilage explants. These data suggest that collagenase(s) produced by chondrocytes is (are) involved in the cleavage and denaturation of type II collagen in articular cartilage, that this is increased in OA, and that MMP-13 may play a significant role in this process.
matrix metalloproteinases; chondrocytes; antibodies; arthritis
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Billinghurst RC, Dahlberg L, Ionescu M, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION. 1997;99(7):1534-1545.
Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., et al. (1997). Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION, 99(7), 1534-1545. https://doi.org/10.1172/JCI119316
Billinghurst, RC, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C, Mitchell, P, et al. 1997. “Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage”. JOURNAL OF CLINICAL INVESTIGATION 99 (7): 1534-1545.
Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., Hambor, J., Diekmann, O., Tschesche, H., et al. (1997). Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION 99, 1534-1545.
Billinghurst, R.C., et al., 1997. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION, 99(7), p 1534-1545.
R.C. Billinghurst, et al., “Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage”, JOURNAL OF CLINICAL INVESTIGATION, vol. 99, 1997, pp. 1534-1545.
Billinghurst, R.C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., Hambor, J., Diekmann, O., Tschesche, H., Chen, J., VanWart, H., Poole, A.R.: Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION. 99, 1534-1545 (1997).
Billinghurst, RC, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C, Mitchell, P, Hambor, J, Diekmann, O, Tschesche, Harald, Chen, J, VanWart, H, and Poole, AR. “Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage”. JOURNAL OF CLINICAL INVESTIGATION 99.7 (1997): 1534-1545.

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Upadhyay J, Baker SJ, Rajagovindan R, Hart M, Chandran P, Hooker BA, Cassar S, Mikusa JP, Tovcimak A, Wald MJ, Joshi SK, Bannon A, Medema JK, Beaver J, Honore P, Kamath RV, Fox GB, Day M., Neuroimage 64(), 2013
PMID: 22982372
A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose.
Pretzel D, Linss S, Ahrem H, Endres M, Kaps C, Klemm D, Kinne RW., Arthritis Res Ther 15(3), 2013
PMID: 23673274
Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis.
Chen J, Crawford R, Xiao Y., J Cell Biochem 114(2), 2013
PMID: 22930581
Potential of Raloxifene in reversing osteoarthritis-like alterations in rat chondrocytes: an in vitro model study.
Kavas A, Cagatay ST, Banerjee S, Keskin D, Tezcaner A., J Biosci 38(1), 2013
PMID: 23385821
Effects of strontium on collagen content and expression of related genes in rat chondrocytes cultured in vitro.
Wang J, Zhu X, Liu L, Shi X, Yin L, Zhang Y, Li X, Wang Z, Liu G., Biol Trace Elem Res 153(1-3), 2013
PMID: 23475370
The emerging roles of HTRA1 in musculoskeletal disease.
Tiaden AN, Richards PJ., Am J Pathol 182(5), 2013
PMID: 23499460
T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor κB signaling.
Ma B, Zhong L, van Blitterswijk CA, Post JN, Karperien M., J Biol Chem 288(24), 2013
PMID: 23603903
Acute Myocardial Infarction and Pulmonary Diseases Result in Two Different Degradation Profiles of Elastin as Quantified by Two Novel ELISAs.
Skjøt-Arkil H, Clausen RE, Rasmussen LM, Wang W, Wang Y, Zheng Q, Mickley H, Saaby L, Diederichsen AC, Lambrechtsen J, Martinez FJ, Hogaboam CM, Han M, Larsen MR, Nawrocki A, Vainer B, Krustrup D, Bjørling-Poulsen M, Karsdal MA, Leeming DJ., PLoS One 8(6), 2013
PMID: 23805173
Expression of gelatinases (MMP-2, MMP-9) in human articular cartilage.
Lipari L, Gerbino A., Int J Immunopathol Pharmacol 26(3), 2013
PMID: 24067484
Potent inhibitors precise to S1' loop of MMP-13, a crucial target for osteoarthritis.
Kalva S, Saranyah K, Suganya PR, Nisha M, Saleena LM., J Mol Graph Model 44(), 2013
PMID: 23938376
Changes in serum biomarkers of cartilage turnover after anterior cruciate ligament injury.
Svoboda SJ, Harvey TM, Owens BD, Brechue WF, Tarwater PM, Cameron KL., Am J Sports Med 41(9), 2013
PMID: 23831890
Biomimetic aggrecan reduces cartilage extracellular matrix from degradation and lowers catabolic activity in ex vivo and in vivo models.
Sharma S, Lee A, Choi K, Kim K, Youn I, Trippel SB, Panitch A., Macromol Biosci 13(9), 2013
PMID: 23836445
Autologous solution protects bovine cartilage explants from IL-1α- and TNFα-induced cartilage degradation.
Matuska A, O'shaughnessey K, King W, Woodell-May J., J Orthop Res 31(12), 2013
PMID: 23966313
Transcriptomic signatures in cartilage ageing.
Peffers M, Liu X, Clegg P., Arthritis Res Ther 15(4), 2013
PMID: 23971731
Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury.
Haslauer CM, Elsaid KA, Fleming BC, Proffen BL, Johnson VM, Murray MM., Osteoarthritis Cartilage 21(12), 2013
PMID: 24036379
Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.
Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D., Arthritis Rheum 65(12), 2013
PMID: 23982761
MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays.
Sand JM, Larsen L, Hogaboam C, Martinez F, Han M, Røssel Larsen M, Nawrocki A, Zheng Q, Karsdal MA, Leeming DJ., PLoS One 8(12), 2013
PMID: 24376856
Age-dependent alteration of TGF-β signalling in osteoarthritis.
van der Kraan PM, Goumans MJ, Blaney Davidson E, ten Dijke P., Cell Tissue Res 347(1), 2012
PMID: 21638205
Proteases involved in cartilage matrix degradation in osteoarthritis.
Troeberg L, Nagase H., Biochim Biophys Acta 1824(1), 2012
PMID: 21777704
Early effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: An open-label observational prospective study.
Conrozier T, Balblanc JC, Richette P, Mulleman D, Maillet B, Henrotin Y, Rannou F, Piroth C, Hilliquin P, Mathieu P, Walliser-Lohse A, Rousselot I, Plattner V, Maillefert JF, Vignon E, Chevalier X, Osteoarthritis Group of the French Society of Rheumatology., J Orthop Res 30(5), 2012
PMID: 22025307
Serum xylosyltransferase 1 level increases during early posttraumatic osteoarthritis in mice with high bone forming potential.
McCoy SY, Falgowski KA, Srinivasan PP, Thompson WR, Selva EM, Kirn-Safran CB., Bone 51(2), 2012
PMID: 22146554
E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress.
Otero M, Plumb DA, Tsuchimochi K, Dragomir CL, Hashimoto K, Peng H, Olivotto E, Bevilacqua M, Tan L, Yang Z, Zhan Y, Oettgen P, Li Y, Marcu KB, Goldring MB., J Biol Chem 287(5), 2012
PMID: 22158614
Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis.
Usmani SE, Appleton CT, Beier F., J Orthop Res 30(9), 2012
PMID: 22407503
Development of a novel immunoassay for the measurement of type II collagen neoepitope generated by collagenase cleavage.
Takahashi T, Naito S, Onoda J, Yamauchi A, Nakamura E, Kishino J, Kawai T, Matsukawa S, Toyosaki-Maeda T, Tanimura M, Fukui N, Numata Y, Yamane S., Clin Chim Acta 413(19-20), 2012
PMID: 22507082
The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage.
Lu M, Cao J, Liu F, Li S, Chen J, Fu Q, Zhang Z, Liu J, Luo M, Wang J, Li J, Caterson B., Cells Tissues Organs 196(3), 2012
PMID: 22538829
Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage.
Dejica VM, Mort JS, Laverty S, Antoniou J, Zukor DJ, Tanzer M, Poole AR., Arthritis Res Ther 14(3), 2012
PMID: 22584047
Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.
Burleigh A, Chanalaris A, Gardiner MD, Driscoll C, Boruc O, Saklatvala J, Vincent TL., Arthritis Rheum 64(7), 2012
PMID: 22307759
Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.
Manka SW, Carafoli F, Visse R, Bihan D, Raynal N, Farndale RW, Murphy G, Enghild JJ, Hohenester E, Nagase H., Proc Natl Acad Sci U S A 109(31), 2012
PMID: 22761315
Regulation of inflammatory response in human chondrocytes by lentiviral mediated RNA interference against S100A10.
Song C, Zhou X, Dong Q, Fan R, Wu G, Ji B, Meng Q, Zheng M., Inflamm Res 61(11), 2012
PMID: 22797859
A review of translational animal models for knee osteoarthritis.
Gregory MH, Capito N, Kuroki K, Stoker AM, Cook JL, Sherman SL., Arthritis 2012(), 2012
PMID: 23326663
Selective MMP13 inhibitors.
Li JJ, Johnson AR., Med Res Rev 31(6), 2011
PMID: 20196103
Emerging MRI methods in rheumatoid arthritis.
Borrero CG, Mountz JM, Mountz JD., Nat Rev Rheumatol 7(2), 2011
PMID: 21045791
Glycoconjugate markers of joint diseases.
Popko J, Olszewski S, Guszczyn T, Zwierz K, Pancewicz S., Biochem Soc Trans 39(1), 2011
PMID: 21265798
Impact of sex hormones, insulin, growth factors and peptides on cartilage health and disease.
Claassen H, Schicht M, Paulsen F., Prog Histochem Cytochem 45(4), 2011
PMID: 21251699
Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening.
Mazzini F, Nuti E, Petri A, Rossello A., J Chromatogr B Analyt Technol Biomed Life Sci 879(11-12), 2011
PMID: 21397574
Effects of diallyl sulphide in chondrocyte and cartilage in experimental osteoarthritis in rabbit.
Chen WP, Tang JL, Bao JP, Hu PF, Yu C, Shi ZL, Wu LD., Phytother Res 25(3), 2011
PMID: 20683842
Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis.
Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, Gardiner J, Garnero P, Hardin J, Henrotin Y, Heinegård D, Ko A, Lohmander LS, Matthews G, Menetski J, Moskowitz R, Persiani S, Poole AR, Rousseau JC, Todman M, OARSI FDA Osteoarthritis Biomarkers Working Group., Osteoarthritis Cartilage 19(5), 2011
PMID: 21396468
Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
Sengupta K, Kolla JN, Krishnaraju AV, Yalamanchili N, Rao CV, Golakoti T, Raychaudhuri S, Raychaudhuri SP., Mol Cell Biochem 354(1-2), 2011
PMID: 21479939
Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities.
Karsdal MA, Woodworth T, Henriksen K, Maksymowych WP, Genant H, Vergnaud P, Christiansen C, Schubert T, Qvist P, Schett G, Platt A, Bay-Jensen AC., Arthritis Res Ther 13(2), 2011
PMID: 21539724
The relation between cartilage biomarkers (C2C, C1,2C, CS846, and CPII) and the long-term outcome of rheumatoid arthritis patients within the CAMERA trial.
Bakker MF, Verstappen SM, Welsing PM, Jacobs JW, Jahangier ZN, van der Veen MJ, Bijlsma JW, Lafeber FP, Utrecht Arthritis Cohort study group., Arthritis Res Ther 13(3), 2011
PMID: 21539729
The constitutive expression of type x collagen in mesenchymal stem cells from osteoarthritis patients is reproduced in a rabbit model of osteoarthritis.
Mwale F, Rampersad S, Richard H, Guoying Y, Al Rowas S, Madiraju P, Antoniou J, Laverty S., J Tissue Eng 2011(), 2011
PMID: 21808721
Urinary biomarkers and occupational musculoskeletal disorders in the lower limbs.
Mason HJ, Evans G, Moore A., Occup Med (Lond) 61(5), 2011
PMID: 21831821
Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability.
Mitsui H, Aoyama T, Furu M, Ito K, Jin Y, Maruyama T, Kanaji T, Fujimura S, Sugihara H, Nishiura A, Otsuka T, Nakamura T, Toguchida J., Arthritis Res Ther 13(5), 2011
PMID: 21914215
Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.
Li H, Liang C, Chen Q, Yang Z., Med Hypotheses 77(6), 2011
PMID: 21962453
Effect of low-intensity pulsed ultrasound on MMP-13 and MAPKs signaling pathway in rabbit knee osteoarthritis.
Li X, Li J, Cheng K, Lin Q, Wang D, Zhang H, An H, Gao M, Chen A., Cell Biochem Biophys 61(2), 2011
PMID: 21567132
Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.
Higashiyama R, Miyaki S, Yamashita S, Yoshitaka T, Lindman G, Ito Y, Sasho T, Takahashi K, Lotz M, Asahara H., Mod Rheumatol 20(1), 2010
PMID: 19784544
Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants.
Piecha D, Weik J, Kheil H, Becher G, Timmermann A, Jaworski A, Burger M, Hofmann MW., Inflamm Res 59(5), 2010
PMID: 19902332
Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Schnute ME, O'Brien PM, Nahra J, Morris M, Howard Roark W, Hanau CE, Ruminski PG, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Patt WC, Shieh HS, Collins B, Pavlovsky AG, Palmquist KE, Aston KW, Hitchcock J, Rogers MD, McDonald J, Johnson AR, Munie GE, Wittwer AJ, Man CF, Settle SL, Nemirovskiy O, Vickery LE, Agawal A, Dyer RD, Sunyer T., Bioorg Med Chem Lett 20(2), 2010
PMID: 20005097
Haem oxygenase-1 down-regulates high mobility group box 1 and matrix metalloproteinases in osteoarthritic synoviocytes.
García-Arnandis I, Guillén MI, Castejón MA, Gomar F, Alcaraz MJ., Rheumatology (Oxford) 49(5), 2010
PMID: 20110250
Biochemical markers of joint tissue turnover.
Bay-Jensen AC, Sondergaard BC, Christiansen C, Karsdal MA, Madsen SH, Qvist P., Assay Drug Dev Technol 8(1), 2010
PMID: 19715454
Application of biochemical markers in development of drugs for treatment of osteoarthritis.
Qvist P, Christiansen C, Karsdal MA, Madsen SH, Sondergaard BC, Bay-Jensen AC., Biomarkers 15(1), 2010
PMID: 20085489
MMP-mediated collagen breakdown induced by activated protein C in equine cartilage is reduced by corticosteroids.
Garvican ER, Vaughan-Thomas A, Redmond C, Gabriel N, Clegg PD., J Orthop Res 28(3), 2010
PMID: 19777546
Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.
Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI., J Bone Miner Metab 28(6), 2010
PMID: 20376510
Protein geranylgeranylation controls collagenase expression in osteoarthritic cartilage.
Sverdrup FM, Yates MP, Vickery LE, Klover JA, Song LR, Anglin CP, Misko TP., Osteoarthritis Cartilage 18(7), 2010
PMID: 20417291
Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs.
Chowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A, Homandberg GA., Arthritis Res Ther 12(3), 2010
PMID: 20462435
Effects of increased chronic loading on articular cartilage material properties in the lapine tibio-femoral joint.
Roemhildt ML, Coughlin KM, Peura GD, Badger GJ, Churchill D, Fleming BC, Beynnon BD., J Biomech 43(12), 2010
PMID: 20488444
Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model.
Wei L, Fleming BC, Sun X, Teeple E, Wu W, Jay GD, Elsaid KA, Luo J, Machan JT, Chen Q., J Orthop Res 28(7), 2010
PMID: 20108346
Cartilage biology, pathology, and repair.
Umlauf D, Frank S, Pap T, Bertrand J., Cell Mol Life Sci 67(24), 2010
PMID: 20734104
High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes.
García-Arnandis I, Guillén MI, Gomar F, Pelletier JP, Martel-Pelletier J, Alcaraz MJ., Arthritis Res Ther 12(4), 2010
PMID: 20799933
Serum biomarker levels for musculoskeletal disease in two- and three-year-old racing Thoroughbred horses: A prospective study of 130 horses.
Frisbie DD, Mc Ilwraith CW, Arthur RM, Blea J, Baker VA, Billinghurst RC., Equine Vet J 42(7), 2010
PMID: 20840580
17β-estradiol reduces expression of MMP-1, -3, and -13 in human primary articular chondrocytes from female patients cultured in a three dimensional alginate system.
Claassen H, Steffen R, Hassenpflug J, Varoga D, Wruck CJ, Brandenburg LO, Pufe T., Cell Tissue Res 342(2), 2010
PMID: 20941509
Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture.
Coughlan TC, Crawford A, Goldring MB, Hatton PV, Barker MD., J Tissue Eng Regen Med 4(8), 2010
PMID: 20568084
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
Lauer-Fields JL, Minond D, Chase PS, Baillargeon PE, Saldanha SA, Stawikowska R, Hodder P, Fields GB., Bioorg Med Chem 17(3), 2009
PMID: 18358729
IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways.
Zhang M, Zhou Q, Liang QQ, Li CG, Holz JD, Tang D, Sheu TJ, Li TF, Shi Q, Wang YJ., Osteoarthritis Cartilage 17(1), 2009
PMID: 18595745
Mapping proteolytic cancer cell-extracellular matrix interfaces.
Wolf K, Friedl P., Clin Exp Metastasis 26(4), 2009
PMID: 18600304
Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus.
McNulty AL, Weinberg JB, Guilak F., Clin Orthop Relat Res 467(6), 2009
PMID: 18975039
Inhibition of glycosaminoglycan incorporation influences collagen network formation during cartilage matrix production.
Bastiaansen-Jenniskens YM, Koevoet W, Jansen KM, Verhaar JA, DeGroot J, VanOsch GJ., Biochem Biophys Res Commun 379(2), 2009
PMID: 19101519
Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.
Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D., J Bone Miner Res 24(1), 2009
PMID: 18767925
Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial.
Brown JP, Prince RL, Deal C, Recker RR, Kiel DP, de Gregorio LH, Hadji P, Hofbauer LC, Alvaro-Gracia JM, Wang H, Austin M, Wagman RB, Newmark R, Libanati C, San Martin J, Bone HG., J Bone Miner Res 24(1), 2009
PMID: 18767928
Over-expression of c-maf by chondrocytes in osteoarthritis.
Li T, Xiao J, Wu Z, Qiu G., J Int Med Res 37(1), 2009
PMID: 19215682
Proteoglycan production is required in initial stages of new cartilage matrix formation but inhibits integrative cartilage repair.
Bastiaansen-Jenniskens YM, Koevoet W, Feijt C, Bos PK, Verhaar JA, Van Osch GJ, DeGroot J., J Tissue Eng Regen Med 3(2), 2009
PMID: 19160351
Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage.
Blaise R, Mahjoub M, Salvat C, Barbe U, Brou C, Corvol MT, Savouret JF, Rannou F, Berenbaum F, Bausero P., Arthritis Rheum 60(2), 2009
PMID: 19180482
Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.
Chabane N, Zayed N, Benderdour M, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H., Arthritis Res Ther 11(2), 2009
PMID: 19296842
Relationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallions.
Verwilghen D, Busoni V, Gangl M, Franck T, Lejeune JP, Vanderheyden L, Detilleux J, Grulke S, Deberg M, Henrotin Y, Serteyn D., Res Vet Sci 87(2), 2009
PMID: 19298987
Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis.
Sakao K, Takahashi KA, Arai Y, Saito M, Honjo K, Hiraoka N, Asada H, Shin-Ya M, Imanishi J, Mazda O, Kubo T., J Bone Miner Metab 27(4), 2009
PMID: 19333684
Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study.
Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM., Arthritis Rheum 60(5), 2009
PMID: 19404937
Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis.
Su J, Yu J, Ren T, Zhang W, Zhang Y, Liu X, Sun T, Lu H, Miyazawa K, Yao L., Mol Cell Biochem 330(1-2), 2009
PMID: 19415460
Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression.
Kisiday JD, Lee JH, Siparsky PN, Frisbie DD, Flannery CR, Sandy JD, Grodzinsky AJ., Ann Biomed Eng 37(7), 2009
PMID: 19415495
Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.
Wu Q, Huang JH, Sampson ER, Kim KO, Zuscik MJ, O'Keefe RJ, Chen D, Rosier RN., Exp Cell Res 315(14), 2009
PMID: 19481076
Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1.
Nugent AE, Speicher DM, Gradisar I, McBurney DL, Baraga A, Doane KJ, Horton WE., J Histochem Cytochem 57(10), 2009
PMID: 19546472
A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Baragi VM, Becher G, Bendele AM, Biesinger R, Bluhm H, Boer J, Deng H, Dodd R, Essers M, Feuerstein T, Gallagher BM, Gege C, Hochgürtel M, Hofmann M, Jaworski A, Jin L, Kiely A, Korniski B, Kroth H, Nix D, Nolte B, Piecha D, Powers TS, Richter F, Schneider M, Steeneck C, Sucholeiki I, Taveras A, Timmermann A, Van Veldhuizen J, Weik J, Wu X, Xia B., Arthritis Rheum 60(7), 2009
PMID: 19565489
Measures of molecular composition and structure in osteoarthritis.
Burstein D, Gray M, Mosher T, Dardzinski B., Radiol Clin North Am 47(4), 2009
PMID: 19631075
Fourier transform-second-harmonic generation imaging of biological tissues.
Rao RA, Mehta MR, Toussaint KC., Opt Express 17(17), 2009
PMID: 19687932
Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.
Heim-Riether A, Taylor SJ, Liang S, Gao DA, Xiong Z, Michael August E, Collins BK, Farmer BT, Haverty K, Hill-Drzewi M, Junker HD, Mariana Margarit S, Moss N, Neumann T, Proudfoot JR, Keenan LS, Sekul R, Zhang Q, Li J, Farrow NA., Bioorg Med Chem Lett 19(18), 2009
PMID: 19692239
Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes.
Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lavigne M, Martel-Pelletier J., Arthritis Res Ther 11(4), 2009
PMID: 19664212
The effect of early hyaluronic acid delivery on the development of an acute articular cartilage lesion in a sheep model.
Kaplan LD, Lu Y, Snitzer J, Nemke B, Hao Z, Biro S, Albiero W, Stampfli HF, Markel M, Popkin C, Baum SZ., Am J Sports Med 37(12), 2009
PMID: 19723621
Influence of extracellular matrix on the expression of inflammatory cytokines, proteases, and apoptosis-related genes induced by hydrostatic pressure in three-dimensionally cultured chondrocytes.
Kunitomo T, Takahashi KA, Arai Y, Sakao K, Honjo K, Saito M, Inoue A, Tonomura H, Morihara T, Mazda O, Imanishi J, Kubo T., J Orthop Sci 14(6), 2009
PMID: 19997826
Modulating hedgehog signaling can attenuate the severity of osteoarthritis.
Lin AC, Seeto BL, Bartoszko JM, Khoury MA, Whetstone H, Ho L, Hsu C, Ali SA, Alman BA., Nat Med 15(12), 2009
PMID: 19915594
Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes.
Tardif G, Hum D, Pelletier JP, Duval N, Martel-Pelletier J., BMC Musculoskelet Disord 10(), 2009
PMID: 19948051
Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.
Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M, Thompson EW., Arthritis Rheum 60(12), 2009
PMID: 19950295
Contribution of collagen network features to functional properties of engineered cartilage.
Bastiaansen-Jenniskens YM, Koevoet W, de Bart AC, van der Linden JC, Zuurmond AM, Weinans H, Verhaar JA, van Osch GJ, Degroot J., Osteoarthritis Cartilage 16(3), 2008
PMID: 17714957
Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage.
Bay-Jensen AC, Andersen TL, Charni-Ben Tabassi N, Kristensen PW, Kjaersgaard-Andersen P, Sandell L, Garnero P, Delaissé JM., Osteoarthritis Cartilage 16(5), 2008
PMID: 17950629
Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.
Olivotto E, Borzi RM, Vitellozzi R, Pagani S, Facchini A, Battistelli M, Penzo M, Li X, Flamigni F, Li J, Falcieri E, Facchini A, Marcu KB., Arthritis Rheum 58(1), 2008
PMID: 18163512
Modification of the composition of articular cartilage collagen fibrils with increasing age.
Vaughan-Thomas A, Dudhia J, Bayliss MT, Kadler KE, Duance VC., Connect Tissue Res 49(5), 2008
PMID: 18991091
Haem oxygenase-1 regulates catabolic and anabolic processes in osteoarthritic chondrocytes.
Guillén M, Megías J, Gomar F, Alcaraz M., J Pathol 214(4), 2008
PMID: 18200630
A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Gaggar A, Jackson PL, Noerager BD, O'Reilly PJ, McQuaid DB, Rowe SM, Clancy JP, Blalock JE., J Immunol 180(8), 2008
PMID: 18390751
The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation.
Charni-Ben Tabassi N, Desmarais S, Bay-Jensen AC, Delaissé JM, Percival MD, Garnero P., Osteoarthritis Cartilage 16(10), 2008
PMID: 18403221
Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses.
Frisbie DD, Al-Sobayil F, Billinghurst RC, Kawcak CE, McIlwraith CW., Osteoarthritis Cartilage 16(10), 2008
PMID: 18442931
Early changes in biomarkers of skeletal metabolism and their association to the occurrence of osteochondrosis (OC) in the horse.
Donabédian M, van Weeren PR, Perona G, Fleurance G, Robert C, Léger S, Bergero D, Lepage O, Martin-Rosset W., Equine Vet J 40(3), 2008
PMID: 18267892
Long-lasting tissue inflammatory processes trigger autoimmune responses to extracellular matrix molecules.
Bei R, Masuelli L, Palumbo C, Tresoldi I, Scardino A, Modesti A., Int Rev Immunol 27(3), 2008
PMID: 18437603
Methods in studying ECM degradation.
Everts V, Buttle DJ., Methods 45(1), 2008
PMID: 18442708
Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-kappaB ligand in cells derived from osteoarthritic subchondral bone.
Sakao K, Takahashi KA, Mazda O, Arai Y, Tonomura H, Inoue A, Saito M, Fujioka M, Takamiya H, Imanishi J, Kubo T., J Orthop Sci 13(3), 2008
PMID: 18528653
Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference.
Saadat E, Jobke B, Chu B, Lu Y, Cheng J, Li X, Ries MD, Majumdar S, Link TM., Eur Radiol 18(10), 2008
PMID: 18491096
Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage.
Dejica VM, Mort JS, Laverty S, Percival MD, Antoniou J, Zukor DJ, Poole AR., Am J Pathol 173(1), 2008
PMID: 18511517
Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity.
Karsdal MA, Madsen SH, Christiansen C, Henriksen K, Fosang AJ, Sondergaard BC., Arthritis Res Ther 10(3), 2008
PMID: 18513402
A double epitope tag for quantification of recombinant protein using fluorescence resonance energy transfer.
Enomoto K, Uwabe K, Naito S, Onoda J, Yamauchi A, Numata Y, Takemoto H., Anal Biochem 380(2), 2008
PMID: 18570884
Discovery and development of the N-terminal procollagen type II (NPII) biomarker: a tool for measuring collagen type II synthesis.
Nemirovskiy OV, Sunyer T, Aggarwal P, Abrams M, Hellio Le Graverand MP, Mathews WR., Osteoarthritis Cartilage 16(12), 2008
PMID: 18556223
Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13.
Sakurai A, Okahashi N, Maruyama F, Ooshima T, Hamada S, Nakagawa I., Biochem Biophys Res Commun 373(3), 2008
PMID: 18586009
Characterization of metalloprotease cleavage products of human articular cartilage.
Zhen EY, Brittain IJ, Laska DA, Mitchell PG, Sumer EU, Karsdal MA, Duffin KL., Arthritis Rheum 58(8), 2008
PMID: 18668564
Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies.
Conrozier T, Ferrand F, Poole AR, Verret C, Mathieu P, Ionescu M, Vincent F, Piperno M, Spiegel A, Vignon E., Osteoarthritis Cartilage 15(4), 2007
PMID: 17055306
Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.
Wilson CG, Palmer AW, Zuo F, Eugui E, Wilson S, Mackenzie R, Sandy JD, Levenston ME., Matrix Biol 26(4), 2007
PMID: 17174540
Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: from in vitro to in vivo.
Nemirovskiy OV, Dufield DR, Sunyer T, Aggarwal P, Welsch DJ, Mathews WR., Anal Biochem 361(1), 2007
PMID: 17187753
Diffusion tensor imaging of native and degenerated human articular cartilage.
Deng X, Farley M, Nieminen MT, Gray M, Burstein D., Magn Reson Imaging 25(2), 2007
PMID: 17275610
Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study.
Hunter DJ, Li J, LaValley M, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D, Felson DT., Arthritis Res Ther 9(5), 2007
PMID: 17958892
Collagen biomarkers for arthritis applications.
Birmingham JD, Vilim V, Kraus VB., Biomark Insights 1(), 2007
PMID: 19690637
In search of partners: linking extracellular proteases to substrates.
Overall CM, Blobel CP., Nat Rev Mol Cell Biol 8(3), 2007
PMID: 17299501
Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice.
Sahebjam S, Khokha R, Mort JS., Arthritis Rheum 56(3), 2007
PMID: 17328064
The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis.
Cahue S, Sharma L, Dunlop D, Ionescu M, Song J, Lobanok T, King L, Poole AR., Osteoarthritis Cartilage 15(7), 2007
PMID: 17344068
Genistein reduces the production of proinflammatory molecules in human chondrocytes.
Hooshmand S, Soung do Y, Lucas EA, Madihally SV, Levenson CW, Arjmandi BH., J Nutr Biochem 18(9), 2007
PMID: 17368882
Monitoring cartilage turnover.
Charni-Ben Tabassi N, Garnero P., Curr Rheumatol Rep 9(1), 2007
PMID: 17437662
Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle.
Temple MM, Bae WC, Chen MQ, Lotz M, Amiel D, Coutts RD, Sah RL., Osteoarthritis Cartilage 15(9), 2007
PMID: 17468016
Global analyses of gene expression in early experimental osteoarthritis.
Appleton CT, Pitelka V, Henry J, Beier F., Arthritis Rheum 56(6), 2007
PMID: 17530714
Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence.
Aigner T, Söder S, Gebhard PM, McAlinden A, Haag J., Nat Clin Pract Rheumatol 3(7), 2007
PMID: 17599073
Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.
Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P., Nat Cell Biol 9(8), 2007
PMID: 17618273
Type II collagen markers in osteoarthritis: what do they indicate?
Henrotin Y, Addison S, Kraus V, Deberg M., Curr Opin Rheumatol 19(5), 2007
PMID: 17762609
Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy.
Mullan RH, Matthews C, Bresnihan B, FitzGerald O, King L, Poole AR, Fearon U, Veale DJ., Arthritis Rheum 56(9), 2007
PMID: 17763421
Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Freeman-Cook KD, Reiter LA, Noe MC, Antipas AS, Danley DE, Datta K, Downs JT, Eisenbeis S, Eskra JD, Garmene DJ, Greer EM, Griffiths RJ, Guzman R, Hardink JR, Janat F, Jones CS, Martinelli GJ, Mitchell PG, Laird ER, Liras JL, Lopresti-Morrow LL, Pandit J, Reilly UD, Robertson D, Vaughn-Bowser ML, Wolf-Gouviea LA, Yocum SA., Bioorg Med Chem Lett 17(23), 2007
PMID: 17935984
The chemical biomarkers C2C, Coll2-1, and Coll2-1NO2 provide complementary information on type II collagen catabolism in healthy and osteoarthritic mice.
Ameye LG, Deberg M, Oliveira M, Labasse A, Aeschlimann JM, Henrotin Y., Arthritis Rheum 56(10), 2007
PMID: 17907187
Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage.
Naito S, Shiomi T, Okada A, Kimura T, Chijiiwa M, Fujita Y, Yatabe T, Komiya K, Enomoto H, Fujikawa K, Okada Y., Pathol Int 57(11), 2007
PMID: 17922681
Maturational differences in superficial and deep zone articular chondrocytes.
Hidaka C, Cheng C, Alexandre D, Bhargava M, Torzilli PA., Cell Tissue Res 323(1), 2006
PMID: 16133144
Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament.
Nelson F, Billinghurst RC, Pidoux I, Reiner A, Langworthy M, McDermott M, Malogne T, Sitler DF, Kilambi NR, Lenczner E, Poole AR., Osteoarthritis Cartilage 14(2), 2006
PMID: 16242972
Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells.
Kim SJ, Shin HH, Park SY, Lee DS, Lee EA, Cho SD, Cho HR, Miyazawa K, Choi HS., Osteoarthritis Cartilage 14(2), 2006
PMID: 16242974
Review: Collagen markers in early arthritic diseases.
Elsaid KA, Chichester CO., Clin Chim Acta 365(1-2), 2006
PMID: 16257399
A hypothesis for the origin and pathogenesis of rheumatoid diseases.
Lorenz W, Sigrist G, Shakibaei M, Mobasheri A, Trautmann C., Rheumatol Int 26(7), 2006
PMID: 16362367
Production of lipid peroxidation products in osteoarthritic tissues: new evidence linking 4-hydroxynonenal to cartilage degradation.
Morquette B, Shi Q, Lavigne P, Ranger P, Fernandes JC, Benderdour M., Arthritis Rheum 54(1), 2006
PMID: 16385544
Collagen and proteoglycan turnover in focally damaged human ankle cartilage: evidence for a generalized response and active matrix remodeling across the entire joint surface.
Aurich M, Mwale F, Reiner A, Mollenhauer JA, Anders JO, Fuhrmann RA, Kuettner KE, Poole AR, Cole AA., Arthritis Rheum 54(1), 2006
PMID: 16388531
Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes.
Fichter M, Körner U, Schömburg J, Jennings L, Cole AA, Mollenhauer J., J Orthop Res 24(1), 2006
PMID: 16419970
Cartilage destruction by matrix degradation products.
Yasuda T., Mod Rheumatol 16(4), 2006
PMID: 16906368
Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation.
Monfort J, Garcia-Giralt N, López-Armada MJ, Monllau JC, Bonilla A, Benito P, Blanco FJ., Arthritis Res Ther 8(5), 2006
PMID: 16972994
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site.
Monfort J, Tardif G, Reboul P, Mineau F, Roughley P, Pelletier JP, Martel-Pelletier J., Arthritis Res Ther 8(1), 2006
PMID: 16507124
Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis.
Verstappen SM, Poole AR, Ionescu M, King LE, Abrahamowicz M, Hofman DM, Bijlsma JW, Lafeber FP, Utrecht Rheumatoid Arthritis Cohort Study group (SRU)., Arthritis Res Ther 8(1), 2006
PMID: 16507130
Causes of mechanically induced collagen damage in articular cartilage.
Wilson W, van Burken C, van Donkelaar C, Buma P, van Rietbergen B, Huiskes R., J Orthop Res 24(2), 2006
PMID: 16435355
Enhanced production of MMP-1, MMP-3, MMP-13, and RANTES by interaction of chondrocytes with autologous T cells.
Nakamura H, Tanaka M, Masuko-Hongo K, Yudoh K, Kato T, Beppu M, Nishioka K., Rheumatol Int 26(11), 2006
PMID: 16468043
Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes.
Raggatt LJ, Jefcoat SC, Choudhury I, Williams S, Tiku M, Partridge NC., Osteoarthritis Cartilage 14(7), 2006
PMID: 16516501
Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M.
Catterall JB, Rowan AD, Sarsfield S, Saklatvala J, Wait R, Cawston TE., Rheumatology (Oxford) 45(9), 2006
PMID: 16567360
Biochemical and functional modulation of the cartilage collagen network by IGF1, TGFbeta2 and FGF2.
Jenniskens YM, Koevoet W, de Bart AC, Weinans H, Jahr H, Verhaar JA, DeGroot J, van Osch GJ., Osteoarthritis Cartilage 14(11), 2006
PMID: 16730198
Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.
Yasuda T, Tchetina E, Ohsawa K, Roughley PJ, Wu W, Mousa A, Ionescu M, Pidoux I, Poole AR., Matrix Biol 25(7), 2006
PMID: 16919430
Biomarkers in spondyloarthritis.
Na KS, Kim TH, Inman RD., Curr Rheumatol Rep 8(4), 2006
PMID: 16839507
Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.
Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung UI, Kawaguchi H., Arthritis Rheum 54(8), 2006
PMID: 16868966
Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter.
Fan Z, Tardif G, Boileau C, Bidwell JP, Geng C, Hum D, Watson A, Pelletier JP, Lavigne M, Martel-Pelletier J., Arthritis Rheum 54(8), 2006
PMID: 16868967
Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Reiter LA, Freeman-Cook KD, Jones CS, Martinelli GJ, Antipas AS, Berliner MA, Datta K, Downs JT, Eskra JD, Forman MD, Greer EM, Guzman R, Hardink JR, Janat F, Keene NF, Laird ER, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robertson D, Sperger D, Vaughn-Bowser ML, Waller DM, Yocum SA., Bioorg Med Chem Lett 16(22), 2006
PMID: 16942871
A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis.
Lee H, Overall CM, McCulloch CA, Sodek J., Mol Biol Cell 17(11), 2006
PMID: 16971509
Development of partial thickness articular cartilage injury in an ovine model.
Lu Y, Markel MD, Swain C, Kaplan LD., J Orthop Res 24(10), 2006
PMID: 16894593
Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs.
Stoker AM, Cook JL, Kuroki K, Fox DB., J Orthop Surg Res 1(), 2006
PMID: 17150128
MMP-3 and -8 expression is found in the condylar surface of temporomandibular joints with internal derangement.
Tiilikainen P, Pirttiniemi P, Kainulainen T, Pernu H, Raustia A., J Oral Pathol Med 34(1), 2005
PMID: 15610405
Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints.
Aurich M, Squires GR, Reiner A, Mollenhauer JA, Kuettner KE, Poole AR, Cole AA., Arthritis Rheum 52(1), 2005
PMID: 15641059
Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.
Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR., Arthritis Rheum 52(1), 2005
PMID: 15641080
Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis.
Sabatini M, Lesur C, Thomas M, Chomel A, Anract P, de Nanteuil G, Pastoureau P., Arthritis Rheum 52(1), 2005
PMID: 15641085
Fourier transform infrared imaging spectroscopy analysis of collagenase-induced cartilage degradation.
West PA, Torzilli PA, Chen C, Lin P, Camacho NP., J Biomed Opt 10(1), 2005
PMID: 15847596
Anatomical localization of cartilage degradation markers in a surgically induced rat osteoarthritis model.
Wancket LM, Baragi V, Bove S, Kilgore K, Korytko PJ, Guzman RE., Toxicol Pathol 33(4), 2005
PMID: 16036866
Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage.
Gebauer M, Saas J, Haag J, Dietz U, Takigawa M, Bartnik E, Aigner T., Arthritis Res Ther 7(2), 2005
PMID: 15743474
Increase in degraded collagen type II in synovial fluid early in the rabbit meniscectomy model of osteoarthritis.
Lindhorst E, Wachsmuth L, Kimmig N, Raiss R, Aigner T, Atley L, Eyre D., Osteoarthritis Cartilage 13(2), 2005
PMID: 15694575
Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs.
Kobayashi T, Notoya K, Naito T, Unno S, Nakamura A, Martel-Pelletier J, Pelletier JP., Arthritis Rheum 52(2), 2005
PMID: 15692987
Histologic evaluation of temporomandibular arthritis induced by mild mechanical loading in rabbits.
Fujimura K, Kobayashi S, Suzuki T, Segami N., J Oral Pathol Med 34(3), 2005
PMID: 15689229
New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis.
Deberg M, Labasse A, Christgau S, Cloos P, Bang Henriksen D, Chapelle JP, Zegels B, Reginster JY, Henrotin Y., Osteoarthritis Cartilage 13(3), 2005
PMID: 15727893
Rehabilitation after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind comparison of programs administered over 2 different time intervals.
Beynnon BD, Uh BS, Johnson RJ, Abate JA, Nichols CE, Fleming BC, Poole AR, Roos H., Am J Sports Med 33(3), 2005
PMID: 15716250
Cartilage biomarkers in ankylosing spondylitis: relationship to clinical variables and treatment response.
Kim TH, Stone M, Payne U, Zhang X, Ionescu M, Lobanok T, King L, Poole AR, Inman RD., Arthritis Rheum 52(3), 2005
PMID: 15751093
Reduction of arthritis severity in protease-activated receptor-deficient mice.
Yang YH, Hall P, Little CB, Fosang AJ, Milenkovski G, Santos L, Xue J, Tipping P, Morand EF., Arthritis Rheum 52(4), 2005
PMID: 15818676
Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis.
Tiraloche G, Girard C, Chouinard L, Sampalis J, Moquin L, Ionescu M, Reiner A, Poole AR, Laverty S., Arthritis Rheum 52(4), 2005
PMID: 15818693
Effect of tissue maturity on cell viability in load-injured articular cartilage explants.
Levin AS, Chen CT, Torzilli PA., Osteoarthritis Cartilage 13(6), 2005
PMID: 15922183
Osteoarthritis development in novel experimental mouse models induced by knee joint instability.
Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, Uchida M, Ogata N, Seichi A, Nakamura K, Kawaguchi H., Osteoarthritis Cartilage 13(7), 2005
PMID: 15896985
Osteoarthritis: an overview of the disease and its treatment strategies.
Sarzi-Puttini P, Cimmino MA, Scarpa R, Caporali R, Parazzini F, Zaninelli A, Atzeni F, Canesi B., Semin Arthritis Rheum 35(1 suppl 1), 2005
PMID: 16084227
Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.
Forsyth CB, Cole A, Murphy G, Bienias JL, Im HJ, Loeser RF., J Gerontol A Biol Sci Med Sci 60(9), 2005
PMID: 16183949
One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression.
Deberg MA, Labasse AH, Collette J, Seidel L, Reginster JY, Henrotin YE., Osteoarthritis Cartilage 13(12), 2005
PMID: 16154771
Collagen biosynthesis of mechanically loaded articular cartilage explants.
Ackermann B, Steinmeyer J., Osteoarthritis Cartilage 13(10), 2005
PMID: 16129631
Squaric acid-based peptidic inhibitors of matrix metalloprotease-1.
Onaran MB, Comeau AB, Seto CT., J Org Chem 70(26), 2005
PMID: 16356002
Characterization of cells from pannus-like tissue over articular cartilage of advanced osteoarthritis.
Yuan GH, Tanaka M, Masuko-Hongo K, Shibakawa A, Kato T, Nishioka K, Nakamura H., Osteoarthritis Cartilage 12(1), 2004
PMID: 14697681
Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3).
Tardif G, Reboul P, Pelletier JP, Martel-Pelletier J., Mod Rheumatol 14(3), 2004
PMID: 17143675
Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis.
Matyas JR, Atley L, Ionescu M, Eyre DR, Poole AR., Arthritis Rheum 50(2), 2004
PMID: 14872497
Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury.
DiMicco MA, Patwari P, Siparsky PN, Kumar S, Pratta MA, Lark MW, Kim YJ, Grodzinsky AJ., Arthritis Rheum 50(3), 2004
PMID: 15022326
A type XI collagen mutation leads to increased degradation of type II collagen in articular cartilage.
Rodriguez RR, Seegmiller RE, Stark MR, Bridgewater LC., Osteoarthritis Cartilage 12(4), 2004
PMID: 15023383
Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice.
Joronen K, Ala-aho R, Majuri ML, Alenius H, Kähäri VM, Vuorio E., Ann Rheum Dis 63(6), 2004
PMID: 15140772
Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors.
Overall CM, Tam EM, Kappelhoff R, Connor A, Ewart T, Morrison CJ, Puente X, López-Otín C, Seth A., Biol Chem 385(6), 2004
PMID: 15255181
Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade.
Dreier R, Grässel S, Fuchs S, Schaumburger J, Bruckner P., Exp Cell Res 297(2), 2004
PMID: 15212936
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Reiter LA, Robinson RP, McClure KF, Jones CS, Reese MR, Mitchell PG, Otterness IG, Bliven ML, Liras J, Cortina SR, Donahue KM, Eskra JD, Griffiths RJ, Lame ME, Lopez-Anaya A, Martinelli GJ, McGahee SM, Yocum SA, Lopresti-Morrow LL, Tobiassen LM, Vaughn-Bowser ML., Bioorg Med Chem Lett 14(13), 2004
PMID: 15177439
Matrix metalloproteinases as modulators of inflammation and innate immunity.
Parks WC, Wilson CL, López-Boado YS., Nat Rev Immunol 4(8), 2004
PMID: 15286728
Interaction of aldehydes with collagen: effect on thermal, enzymatic and conformational stability.
Fathima NN, Madhan B, Rao JR, Nair BU, Ramasami T., Int J Biol Macromol 34(4), 2004
PMID: 15374680
Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration.
Janusz MJ, Little CB, King LE, Hookfin EB, Brown KK, Heitmeyer SA, Caterson B, Poole AR, Taiwo YO., Osteoarthritis Cartilage 12(9), 2004
PMID: 15325638
Association between spine disc degeneration and type II collagen degradation in postmenopausal women: the OFELY study.
Garnero P, Sornay-Rendu E, Arlot M, Christiansen C, Delmas PD., Arthritis Rheum 50(10), 2004
PMID: 15476251
Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage.
Hausser HJ, Decking R, Brenner RE., Osteoarthritis Cartilage 12(11), 2004
PMID: 15501402
Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage.
Kakinuma T, Yasuda T, Nakagawa T, Hiramitsu T, Akiyoshi M, Akagi M, Sawamura T, Nakamura T., Arthritis Rheum 50(11), 2004
PMID: 15529384
Effect of matrix depleting agents on the expression of chondrocyte metabolism by equine chondrocytes.
Iqbal J, Bird JL, Hollander AP, Bayliss MT., Res Vet Sci 77(3), 2004
PMID: 15276777
Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.
Stickens D, Behonick DJ, Ortega N, Heyer B, Hartenstein B, Yu Y, Fosang AJ, Schorpp-Kistner M, Angel P, Werb Z., Development 131(23), 2004
PMID: 15539485
Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage.
Wang X, Manner PA, Horner A, Shum L, Tuan RS, Nuckolls GH., Osteoarthritis Cartilage 12(12), 2004
PMID: 15564063
Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.
Schulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M., Ann N Y Acad Sci 1030(), 2004
PMID: 15659840
Drugs in development: bisphosphonates and metalloproteinase inhibitors.
Catterall JB, Cawston TE., Arthritis Res Ther 5(1), 2003
PMID: 12716443
X-ray diffraction of the molecular substructure of human articular cartilage.
Mollenhauer J, Aurich M, Muehleman C, Khelashvilli G, Irving TC., Connect Tissue Res 44(5), 2003
PMID: 14660090
Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells.
Winter A, Breit S, Parsch D, Benz K, Steck E, Hauner H, Weber RM, Ewerbeck V, Richter W., Arthritis Rheum 48(2), 2003
PMID: 12571852
Metalloproteinases: their role in arthritis and potential as therapeutic targets.
Clark IM, Parker AE., Expert Opin Ther Targets 7(1), 2003
PMID: 12556200
Malondialdehyde oxidation of cartilage collagen by chondrocytes.
Tiku ML, Allison GT, Naik K, Karry SK., Osteoarthritis Cartilage 11(3), 2003
PMID: 12623287
Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture.
Yasuda T, Poole AR, Shimizu M, Nakagawa T, Julovi SM, Tamamura H, Fujii N, Nakamura T., Arthritis Rheum 48(5), 2003
PMID: 12746900
Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.
Vankemmelbeke MN, Jones GC, Fowles C, Ilic MZ, Handley CJ, Day AJ, Knight CG, Mort JS, Buttle DJ., Eur J Biochem 270(11), 2003
PMID: 12755694
Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice.
Tamarat R, Silvestre JS, Huijberts M, Benessiano J, Ebrahimian TG, Duriez M, Wautier MP, Wautier JL, Lévy BI., Proc Natl Acad Sci U S A 100(14), 2003
PMID: 12805564
Early osteoarthritic changes of human femoral head cartilage subsequent to femoro-acetabular impingement.
Wagner S, Hofstetter W, Chiquet M, Mainil-Varlet P, Stauffer E, Ganz R, Siebenrock KA., Osteoarthritis Cartilage 11(7), 2003
PMID: 12814614
Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3.
Reiter LA, Mitchell PG, Martinelli GJ, Lopresti-Morrow LL, Yocum SA, Eskra JD., Bioorg Med Chem Lett 13(14), 2003
PMID: 12824028
The effects of TIMP-1 and -2 on canine chondrocytes cultured in three-dimensional agarose culture system.
Kuroki K, Cook JL, Kreeger JM, Tomlinson JL., Osteoarthritis Cartilage 11(9), 2003
PMID: 12954233
Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids.
Lauer-Fields JL, Kele P, Sui G, Nagase H, Leblanc RM, Fields GB., Anal Biochem 321(1), 2003
PMID: 12963061
Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis.
Garnero P, Conrozier T, Christgau S, Mathieu P, Delmas PD, Vignon E., Ann Rheum Dis 62(10), 2003
PMID: 12972471
Significant exercise-related changes in the serum levels of two biomarkers of collagen metabolism in young horses.
Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, McIlwraith CW., Osteoarthritis Cartilage 11(10), 2003
PMID: 13129696
Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction.
Roy-Beaudry M, Martel-Pelletier J, Pelletier JP, M'Barek KN, Christgau S, Shipkolye F, Moldovan F., Arthritis Rheum 48(10), 2003
PMID: 14558091
Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.
Fraser A, Fearon U, Billinghurst RC, Ionescu M, Reece R, Barwick T, Emery P, Poole AR, Veale DJ., Arthritis Rheum 48(11), 2003
PMID: 14613270
Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis.
Walling HW, Raggatt LJ, Irvine DW, Barmina OY, Toledano JE, Goldring MB, Hruska KA, Adkisson HD, Burdge RE, Gatt CJ, Harwood DA, Partridge NC., Osteoarthritis Cartilage 11(12), 2003
PMID: 14629961
Cartilage viability after repetitive loading: a preliminary report.
Lucchinetti E, Adams CS, Horton WE, Torzilli PA., Osteoarthritis Cartilage 10(1), 2002
PMID: 11795985
Parathyroid hormone-dependent signaling pathways regulating genes in bone cells.
Swarthout JT, D'Alonzo RC, Selvamurugan N, Partridge NC., Gene 282(1-2), 2002
PMID: 11814673
Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark?
Mengshol JA, Mix KS, Brinckerhoff CE., Arthritis Rheum 46(1), 2002
PMID: 11817584
Matrix metalloproteinases and collagen catabolism.
Lauer-Fields JL, Juska D, Fields GB., Biopolymers 66(1), 2002
PMID: 12228918
Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.
Luttun A, Lupu F, Storkebaum E, Hoylaerts MF, Moons L, Crawley J, Bono F, Poole AR, Tipping P, Herbert JM, Collen D, Carmeliet P., Arterioscler Thromb Vasc Biol 22(3), 2002
PMID: 11884297
Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization.
Wu CW, Tchetina EV, Mwale F, Hasty K, Pidoux I, Reiner A, Chen J, Van Wart HE, Poole AR., J Bone Miner Res 17(4), 2002
PMID: 11918221
Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.
Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B., Matrix Biol 21(3), 2002
PMID: 12009333
The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions.
Vanwanseele B, Lucchinetti E, Stüssi E., Osteoarthritis Cartilage 10(5), 2002
PMID: 12027542
Matrix metalloproteinases in arthritic disease.
Murphy G, Knäuper V, Atkinson S, Butler G, English W, Hutton M, Stracke J, Clark I., Arthritis Res 4 Suppl 3(), 2002
PMID: 12110122
Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.
Curtis CL, Rees SG, Little CB, Flannery CR, Hughes CE, Wilson C, Dent CM, Otterness IG, Harwood JL, Caterson B., Arthritis Rheum 46(6), 2002
PMID: 12115185
Differential expression patterns of matrix metalloproteinases and their inhibitors during development of osteoarthritis in a transgenic mouse model.
Salminen HJ, Säämänen AM, Vankemmelbeke MN, Auho PK, Perälä MP, Vuorio EI., Ann Rheum Dis 61(7), 2002
PMID: 12079898
Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro.
Lee GM, Tioran ME, Jansen M, Graff RD, Kelley SS, Lin P., J Cell Physiol 192(1), 2002
PMID: 12115742
Detection and analysis of cartilage degeneration by spatially resolved streaming potentials.
Légaré A, Garon M, Guardo R, Savard P, Poole AR, Buschmann MD., J Orthop Res 20(4), 2002
PMID: 12168673
Triple-helical peptide analysis of collagenolytic protease activity.
Lauer-Fields JL, Fields GB., Biol Chem 383(7-8), 2002
PMID: 12437092
Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog.
Chu Q, Lopez M, Hayashi K, Ionescu M, Billinghurst RC, Johnson KA, Poole AR, Markel MD., Osteoarthritis Cartilage 10(8), 2002
PMID: 12479389
Functional genomics of osteoarthritis.
Aigner T, Bartnik E, Zien A, Zimmer R., Pharmacogenomics 3(5), 2002
PMID: 12223049
Immunohistochemical analysis of matrix metalloproteinase-1, -3, and -13 in naturally occurring cartilaginous tumors of dogs.
Kuroki K, Kreeger JM, Cook JL, Tomlinson JL, Johnson GC, Pace LW, Turnquist SE, Turk JR, Ramos JA, Miller MA., Am J Vet Res 63(9), 2002
PMID: 12224862
A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis.
Huebner JL, Hanes MA, Beekman B, TeKoppele JM, Kraus VB., Osteoarthritis Cartilage 10(10), 2002
PMID: 12359161
Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor.
Janusz MJ, Bendele AM, Brown KK, Taiwo YO, Hsieh L, Heitmeyer SA., Osteoarthritis Cartilage 10(10), 2002
PMID: 12359164
Bilateral subchondral cysts without arthroscopic evidence of articular cartilage degradation.
Bradley MP, Provencher MT, Nelson FR., Arthroscopy 18(8), 2002
PMID: 12368801
Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis.
Garnero P, Ayral X, Rousseau JC, Christgau S, Sandell LJ, Dougados M, Delmas PD., Arthritis Rheum 46(10), 2002
PMID: 12384919
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro.
Bau B, Gebhard PM, Haag J, Knorr T, Bartnik E, Aigner T., Arthritis Rheum 46(10), 2002
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Type II collagen degradation and its regulation in articular cartilage in osteoarthritis.
Poole AR, Kobayashi M, Yasuda T, Laverty S, Mwale F, Kojima T, Sakai T, Wahl C, El-Maadawy S, Webb G, Tchetina E, Wu W., Ann Rheum Dis 61 Suppl 2(), 2002
PMID: 12379630
Matrix homeostasis in aging normal human ankle cartilage.
Aurich M, Poole AR, Reiner A, Mollenhauer C, Margulis A, Kuettner KE, Cole AA., Arthritis Rheum 46(11), 2002
PMID: 12428230
Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis.
Laverty S, Okouneff S, Ionescu M, Reiner A, Pidoux I, Webber C, Rossier Y, Billinghurst RC, Poole AR., J Orthop Res 20(6), 2002
PMID: 12472241
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.
Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, Turner J, Wu W, Billinghurst C, Meijers T, Poole AR, Babij P, DeGennaro LJ., J Clin Invest 107(1), 2001
PMID: 11134178
Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA.
Downs JT, Lane CL, Nestor NB, McLellan TJ, Kelly MA, Karam GA, Mezes PS, Pelletier JP, Otterness IG., J Immunol Methods 247(1-2), 2001
PMID: 11150534
Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis.
Kojima T, Mwale F, Yasuda T, Girard C, Poole AR, Laverty S., Arthritis Rheum 44(1), 2001
PMID: 11212149
The effects of collagen fragments on the extracellular matrix metabolism of bovine and human chondrocytes.
Jennings L, Wu L, King KB, Hämmerle H, Cs-Szabo G, Mollenhauer J., Connect Tissue Res 42(1), 2001
PMID: 11696990
General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.
Chollet AM, Le Diguarher T, Murray L, Bertrand M, Tucker GC, Sabatini M, Pierré A, Atassi G, Bonnet J, Casara P., Bioorg Med Chem Lett 11(3), 2001
PMID: 11212095
The STR/ort mouse and its use as a model of osteoarthritis.
Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J, Bayliss MT., Osteoarthritis Cartilage 9(2), 2001
PMID: 11237655
A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines.
Mix KS, Mengshol JA, Benbow U, Vincenti MP, Sporn MB, Brinckerhoff CE., Arthritis Rheum 44(5), 2001
PMID: 11352241
Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats.
Stoop R, Buma P, van der Kraan PM, Hollander AP, Billinghurst RC, Meijers TH, Poole AR, van den Berg WB., Osteoarthritis Cartilage 9(4), 2001
PMID: 11399094
Stem cell transplantation: limits and hopes.
Machold KP, Smolen JS., Ann Rheum Dis 60(6), 2001
PMID: 11350839
Markers of joint destruction: principles, problems, and potential.
Young-Min SA, Cawston TE, Griffiths ID., Ann Rheum Dis 60(6), 2001
PMID: 11386253
Accumulation of advanced glycation end products decreases collagen turnover by bovine chondrocytes.
DeGroot J, Verzijl N, Budde M, Bijlsma JW, Lafeber FP, TeKoppele JM., Exp Cell Res 266(2), 2001
PMID: 11399058
Alterations in the sensing and transport of phosphate and calcium by differentiating chondrocytes.
Wang D, Canaff L, Davidson D, Corluka A, Liu H, Hendy GN, Henderson JE., J Biol Chem 276(36), 2001
PMID: 11404353
Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis.
Liu J, Shikhman AR, Lotz MK, Wong CH., Chem Biol 8(7), 2001
PMID: 11451670
Use of an antineoepitope antibody for identification of type-II collagen degradation in equine articular cartilage.
Billinghurst RC, Buxton EM, Edwards MG, McGraw MS, McIlwraith CW., Am J Vet Res 62(7), 2001
PMID: 11453476
Novel proteases for drug discovery.
Moss M., Drug Discov Today 6(15), 2001
PMID: 11470583
Synovial fluid gelatinase concentrations and matrix metalloproteinase and cytokine expression in naturally occurring joint disease in horses.
Trumble TN, Trotter GW, Oxford JR, McIlwraith CW, Cammarata S, Goodnight JL, Billinghurst RC, Frisbie DD., Am J Vet Res 62(9), 2001
PMID: 11560279
Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: the role of advanced glycation end products.
DeGroot J, Verzijl N, Wenting-Van Wijk MJ, Bank RA, Lafeber FP, Bijlsma JW, TeKoppele JM., Arthritis Rheum 44(11), 2001
PMID: 11710713
Matrix turnover in human cartilage repair tissue in autologous chondrocyte implantation.
Roberts S, Hollander AP, Caterson B, Menage J, Richardson JB., Arthritis Rheum 44(11), 2001
PMID: 11710715
Molecular sieving and mass spectroscopy reveal enhanced collagen degradation in rabbit atheroma.
Chen J, Kindt E, Hallak H, Peterson JT, Rosebury WS, Hubbel AM, Bocan TM, Rekhter MD., Atherosclerosis 159(2), 2001
PMID: 11730808
Gd-DTPA2)-enhanced MRI of femoral knee cartilage: a dose-response study in healthy volunteers.
Tiderius CJ, Olsson LE, de Verdier H, Leander P, Ekberg O, Dahlberg L., Magn Reson Med 46(6), 2001
PMID: 11746570
Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections.
van Beuningen HM, Glansbeek HL, van der Kraan PM, van den Berg WB., Osteoarthritis Cartilage 8(1), 2000
PMID: 10607496
Cellular responses of embryonic hyaline cartilage to experimental wounding in vitro.
Walker EA, Verner A, Flannery CR, Archer CW., J Orthop Res 18(1), 2000
PMID: 10716275
The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases.
Schumann H, Baetge J, Tasanen K, Wojnarowska F, Schäcke H, Zillikens D, Bruckner-Tuderman L., Am J Pathol 156(2), 2000
PMID: 10666397
An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.
Pendás AM, Uría JA, Jiménez MG, Balbín M, Freije JP, López-Otín C., Clin Chim Acta 291(2), 2000
PMID: 10675720
MMP-13 is induced during chondrocyte hypertrophy.
D'Angelo M, Yan Z, Nooreyazdan M, Pacifici M, Sarment DS, Billings PC, Leboy PS., J Cell Biochem 77(4), 2000
PMID: 10771523
Alterations in cartilage type-II procollagen and aggrecan contents in synovial fluid in equine osteochondrosis.
Laverty S, Ionescu M, Marcoux M, Bouré L, Doizé B, Poole AR., J Orthop Res 18(3), 2000
PMID: 10937626
IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion.
Lubberts E, Joosten LA, Chabaud M, van Den Bersselaar L, Oppers B, Coenen-De Roo CJ, Richards CD, Miossec P, van Den Berg WB., J Clin Invest 105(12), 2000
PMID: 10862785
Selective assembly and remodelling of collagens II and IX associated with expression of the chondrocyte hypertrophic phenotype.
Mwale F, Billinghurst C, Wu W, Alini M, Webber C, Reiner A, Ionescu M, Poole J, Poole AR., Dev Dyn 218(4), 2000
PMID: 10906783
Mechanisms involved in cartilage proteoglycan catabolism.
Caterson B, Flannery CR, Hughes CE, Little CB., Matrix Biol 19(4), 2000
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Cartilage damage after intraarticular exposure to collagenase 3.
Otterness IG, Bliven ML, Eskra JD, te Koppele JM, Stukenbrok HA, Milici AJ., Osteoarthritis Cartilage 8(5), 2000
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The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation.
Bank RA, Soudry M, Maroudas A, Mizrahi J, TeKoppele JM., Arthritis Rheum 43(10), 2000
PMID: 11037879
Extracellular ATP and UTP stimulate cartilage proteoglycan and collagen accumulation in bovine articular chondrocyte pellet cultures.
Croucher LJ, Crawford A, Hatton PV, Russell RG, Buttle DJ., Biochim Biophys Acta 1502(2), 2000
PMID: 11040454
Generation of monoclonal antibodies to cryptic collagen sites by using subtractive immunization.
Xu J, Rodriguez D, Kim JJ, Brooks PC., Hybridoma 19(5), 2000
PMID: 11128027
Observations on fiber-forming collagens in the anulus fibrosus.
Schollmeier G, Lahr-Eigen R, Lewandrowski KU., Spine (Phila Pa 1976) 25(21), 2000
PMID: 11064517
Collagenases in different categories of peri-implant vertical bone loss.
Ma J, Kitti U, Teronen O, Sorsa T, Husa V, Laine P, Rönkä H, Salo T, Lindqvist C, Konttinen YT., J Dent Res 79(11), 2000
PMID: 11145357
Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes.
Jin G, Sah RL, Li YS, Lotz M, Shyy JY, Chien S., J Orthop Res 18(6), 2000
PMID: 11192249
Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc.
Roberts S, Caterson B, Menage J, Evans EH, Jaffray DC, Eisenstein SM., Spine (Phila Pa 1976) 25(23), 2000
PMID: 11145811
The distribution of YKL-40 in osteoarthritic and normal human articular cartilage.
Volck B, Ostergaard K, Johansen JS, Garbarsch C, Price PA., Scand J Rheumatol 28(3), 1999
PMID: 10380840
Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures.
Price JS, Wang-Weigand S, Bohne R, Kozaci LD, Hollander AP., Arthritis Rheum 42(1), 1999
PMID: 9920024
Changes in joint cartilage aggrecan after knee injury and in osteoarthritis.
Lohmander LS, Ionescu M, Jugessur H, Poole AR., Arthritis Rheum 42(3), 1999
PMID: 10088777
Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.
Sztrolovics R, White RJ, Poole AR, Mort JS, Roughley PJ., Biochem J 339 ( Pt 3)(), 1999
PMID: 10215595
Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.
Sukhova GK, Schönbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P., Circulation 99(19), 1999
PMID: 10330380
Potential treatment of osteoarthritis by gene therapy.
Evans CH, Robbins PD., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356421
Serum markers of articular cartilage damage and repair.
Wollheim FA., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356426
Synovial fluid markers in osteoarthritis.
Myers SL., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356427
Type II collagen peptide release from rabbit articular cartilage.
Felice BR, Chichester CO, Barrach HJ., Ann N Y Acad Sci 878(), 1999
PMID: 10415782
Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.
Billinghurst RC, O'Brien K, Poole AR, McIlwraith CW., Ann N Y Acad Sci 878(), 1999
PMID: 10415783
Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Westhoff CS, Freudiger D, Petrow P, Seyfert C, Zacher J, Kriegsmann J, Pap T, Gay S, Stiehl P, Gromnica-Ihle E, Wernicke D., Arthritis Rheum 42(7), 1999
PMID: 10403281
Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis.
Song Xy, Zeng L, Jin W, Thompson J, Mizel DE, Lei K, Billinghurst RC, Poole AR, Wahl SM., J Exp Med 190(4), 1999
PMID: 10449524
Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody.
Otterness IG, Downs JT, Lane C, Bliven ML, Stukenbrok H, Scampoli DN, Milici AJ, Mézes PS., Matrix Biol 18(4), 1999
PMID: 10517180
Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity.
van Meurs J, van Lent P, Stoop R, Holthuysen A, Singer I, Bayne E, Mudgett J, Poole R, Billinghurst C, van der Kraan P, Buma P, van den Berg W., Arthritis Rheum 42(10), 1999
PMID: 10524678
Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice.
Stoop R, van der Kraan PM, Buma P, Hollander AP, Billinghurst RC, Poole AR, van den Berg WB., Arthritis Rheum 42(11), 1999
PMID: 10555034
Degradation of cartilage type II collagen precedes the onset of osteoarthritis following anterior cruciate ligament rupture.
Price JS, Till SH, Bickerstaff DR, Bayliss MT, Hollander AP., Arthritis Rheum 42(11), 1999
PMID: 10555035
Matrix metalloproteinases in repair.
Parks WC., Wound Repair Regen 7(6), 1999
PMID: 10633001
Changes in collagen turnover in early acute respiratory distress syndrome.
Armstrong L, Thickett DR, Mansell JP, Ionescu M, Hoyle E, Billinghurst RC, Poole AR, Millar AB., Am J Respir Crit Care Med 160(6), 1999
PMID: 10588605
In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T., Bone 22(1), 1998
PMID: 9437511
Characterization of helical cleavages in type II collagen generated by matrixins.
Vankemmelbeke M, Dekeyser PM, Hollander AP, Buttle DJ, Demeester J., Biochem J 330 ( Pt 2)(), 1998
PMID: 9480869
Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix.
Kafienah W, Brömme D, Buttle DJ, Croucher LJ, Hollander AP., Biochem J 331 ( Pt 3)(), 1998
PMID: 9560298
Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis.
Huebner JL, Otterness IG, Freund EM, Caterson B, Kraus VB., Arthritis Rheum 41(5), 1998
PMID: 9588741
Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Uría JA, Balbín M, López JM, Alvarez J, Vizoso F, Takigawa M, López-Otín C., Am J Pathol 153(1), 1998
PMID: 9665469
Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown.
Kozaci LD, Brown CJ, Adcocks C, Galloway A, Hollander AP, Buttle DJ., Mol Pathol 51(5), 1998
PMID: 10193524
Evidence for altered synthesis of type II collagen in patients with osteoarthritis.
Nelson F, Dahlberg L, Laverty S, Reiner A, Pidoux I, Ionescu M, Fraser GL, Brooks E, Tanzer M, Rosenberg LC, Dieppe P, Robin Poole A., J Clin Invest 102(12), 1998
PMID: 9854047

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