Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

Billinghurst, RC; Dahlberg, L; Ionescu, M; Reiner, A; Bourne, R; Rorabeck, C; Mitchell, P; Hambor, J; Diekmann, O; Tschesche, Harald; Chen, J; VanWart, H; Poole, AR

Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage

Billinghurst RC, Dahlberg L, Ionescu M, Reiner A, Bourne R, Rorabeck C, Mitchell P, Hambor J, Diekmann O, Tschesche H, Chen J, et al. (1997)
JOURNAL OF CLINICAL INVESTIGATION 99(7): 1534-1545.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.1172/JCI119316

Autor*in

Billinghurst, RC; Dahlberg, L; Ionescu, M; Reiner, A; Bourne, R; Rorabeck, C; Mitchell, P; Hambor, J; Diekmann, O; Tschesche, Harald^UniBi; Chen, J; VanWart, H
Alle

Einrichtung

Fakultät für Chemie > Biochemie I

Abstract / Bemerkung

We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic human femoral condylar cartilage by developing and using antibodies reactive to carboxy-terminal (COL2-3/4C(short)) and amino-terminal (COL2-1/4N1) neoepitopes general ed by cleavage of native human type II collagen by collagenase matrix metalloproteinase (MMP)-1 (collagenase-1), MMP-8 (collagenase-2), and MMP-13 (collagenase-3). A secondary cleavage followed the initial cleavage produced by these recombinant collagenases. This generated neoepitope COL2-1/4N2. There was significantly more COL2-3/4C(short) neoepitope in osteoarthritis (OA) compared to adult nonarthritic cartilages as determined by immunoassay of cartilage extracts. A synthetic preferential inhibitor of MMP-13 significantly reduced the unstimulated release in culture of neoepitope COL2-3/4C(short) from human osteoarthritic cartilage explants. These data suggest that collagenase(s) produced by chondrocytes is (are) involved in the cleavage and denaturation of type II collagen in articular cartilage, that this is increased in OA, and that MMP-13 may play a significant role in this process.

Stichworte

matrix metalloproteinases; chondrocytes; antibodies; arthritis

Erscheinungsjahr

1997

Zeitschriftentitel

JOURNAL OF CLINICAL INVESTIGATION

Band

Ausgabe

Seite(n)

1534-1545

ISSN

0021-9738

Page URI

https://pub.uni-bielefeld.de/record/1637425

Zitieren

Billinghurst RC, Dahlberg L, Ionescu M, et al. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION. 1997;99(7):1534-1545.

Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., et al. (1997). Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION, 99(7), 1534-1545. https://doi.org/10.1172/JCI119316

Billinghurst, RC, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C, Mitchell, P, et al. 1997. “Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage”. JOURNAL OF CLINICAL INVESTIGATION 99 (7): 1534-1545.

Billinghurst, R. C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., Hambor, J., Diekmann, O., Tschesche, H., et al. (1997). Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION 99, 1534-1545.

Billinghurst, R.C., et al., 1997. Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION, 99(7), p 1534-1545.

R.C. Billinghurst, et al., “Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage”, JOURNAL OF CLINICAL INVESTIGATION, vol. 99, 1997, pp. 1534-1545.

Billinghurst, R.C., Dahlberg, L., Ionescu, M., Reiner, A., Bourne, R., Rorabeck, C., Mitchell, P., Hambor, J., Diekmann, O., Tschesche, H., Chen, J., VanWart, H., Poole, A.R.: Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage. JOURNAL OF CLINICAL INVESTIGATION. 99, 1534-1545 (1997).

Billinghurst, RC, Dahlberg, L, Ionescu, M, Reiner, A, Bourne, R, Rorabeck, C, Mitchell, P, Hambor, J, Diekmann, O, Tschesche, Harald, Chen, J, VanWart, H, and Poole, AR. “Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage”. JOURNAL OF CLINICAL INVESTIGATION 99.7 (1997): 1534-1545.

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Daten bereitgestellt von Europe PubMed Central.

Phenotypic instability of chondrocytes in osteoarthritis: on a path to hypertrophy.
Singh P, Marcu KB, Goldring MB, Otero M., Ann N Y Acad Sci 1442(1), 2019
PMID: 30008181

Recent advances in understanding the regulation of metalloproteinases
Young DA, Barter MJ, Wilkinson DJ., 2019
PMID: PPR70701

Recent advances in understanding the regulation of metalloproteinases.
Young DA, Barter MJ, Wilkinson DJ., F1000Res 8(), 2019
PMID: 30828429

Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.
Chahal J, Gómez-Aristizábal A, Shestopaloff K, Bhatt S, Chaboureau A, Fazio A, Chisholm J, Weston A, Chiovitti J, Keating A, Kapoor M, Ogilvie-Harris DJ, Syed KA, Gandhi R, Mahomed NN, Marshall KW, Sussman MS, Naraghi AM, Viswanathan S., Stem Cells Transl Med 8(8), 2019
PMID: 30964245

Oral shea nut oil triterpene concentrate supplement ameliorates pain and histological assessment of articular cartilage deterioration in an ACLT injured rat knee osteoarthritis model.
Chen IJ, Lin SH, Wong CS., PLoS One 14(4), 2019
PMID: 31002699

Chondroprotective Effects of Genistein against Osteoarthritis Induced Joint Inflammation.
Liu FC, Wang CC, Lu JW, Lee CH, Chen SC, Ho YJ, Peng YJ., Nutrients 11(5), 2019
PMID: 31137797

Inducible knockout of CHUK/IKKα in adult chondrocytes reduces progression of cartilage degradation in a surgical model of osteoarthritis.
Culley KL, Lessard SG, Green JD, Quinn J, Chang J, Khilnani T, Wondimu EB, Dragomir CL, Marcu KB, Goldring MB, Otero M., Sci Rep 9(1), 2019
PMID: 31222033

PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes.
Ma CH, Wu CH, Jou IM, Tu YK, Hung CH, Hsieh PL, Tsai KL., Redox Biol 14(), 2018
PMID: 28869834

Biomarkers of hand osteoarthritis.
Lennerová T, Pavelka K, Šenolt L., Rheumatol Int 38(5), 2018
PMID: 29098370

Calcium-phosphate complex increased during subchondral bone remodeling affects earlystage osteoarthritis.
Jung YK, Han MS, Park HR, Lee EJ, Jang JA, Kim GW, Lee SY, Moon D, Han S., Sci Rep 8(1), 2018
PMID: 29323204

Impact of Arginine to Cysteine Mutations in Collagen II on Protein Secretion and Cell Survival.
Chakkalakal SA, Heilig J, Baumann U, Paulsson M, Zaucke F., Int J Mol Sci 19(2), 2018
PMID: 29439465

Isoliquiritigenin Inhibits IL-1β-Induced Production of Matrix Metalloproteinase in Articular Chondrocytes.
Zhang L, Ma S, Su H, Cheng J., Mol Ther Methods Clin Dev 9(), 2018
PMID: 29766025

Chondroprotective Effects and Mechanisms of Dextromethorphan: Repurposing Antitussive Medication for Osteoarthritis Treatment.
Chen LW, Liu FC, Hung LF, Huang CY, Lien SB, Lin LC, Lai JH, Ho LJ., Int J Mol Sci 19(3), 2018
PMID: 29534535

The Effects of Well-Rounded Exercise Program on Systemic Biomarkers Related to Cartilage Metabolism.
Azukizawa M, Ito H, Hamamoto Y, Fujii T, Morita Y, Okahata A, Tomizawa T, Furu M, Nishitani K, Kuriyama S, Nakamura S, Yoshitomi H, Nakatani T, Tsuboyama T, Hamaguchi M, Matsuda S, Yasuda T., Cartilage (), 2018
PMID: 29644876

Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes.
Löfvall H, Newbould H, Karsdal MA, Dziegiel MH, Richter J, Henriksen K, Thudium CS., Arthritis Res Ther 20(1), 2018
PMID: 29636095

Arthroprotective Effects of Cf-02 Sharing Structural Similarity with Quercetin.
Liu FC, Lu JW, Chien CY, Huang HS, Lee CC, Lien SB, Lin LC, Chen LW, Ho YJ, Shen MC, Ho LJ, Lai JH., Int J Mol Sci 19(5), 2018
PMID: 29757957

Platelet-Rich Plasma, Hydroxyapatite, and Chitosan in the Bone and Cartilaginous Regeneration of Femoral Trochlea in Rabbits: Clinical, Radiographic, and Histomorphometric Evaluations.
Segundo FAS, Costa EIS, de Azevedo AS, de Araújo AL, Silva ACF, de Lima GG, de Sá MJC., J Healthc Eng 2018(), 2018
PMID: 30034675

Intra-Articular Injection of Alginate-Microencapsulated Adipose Tissue-Derived Mesenchymal Stem Cells for the Treatment of Osteoarthritis in Rabbits.
Choi S, Kim JH, Ha J, Jeong BI, Jung YC, Lee GS, Woo HM, Kang BJ., Stem Cells Int 2018(), 2018
PMID: 30046312

Effects of insulin-like growth factor-induced Wharton jelly mesenchymal stem cells toward chondrogenesis in an osteoarthritis model.
Widowati W, Afifah E, Mozef T, Sandra F, Rizal R, Amalia A, Arinta Y, Bachtiar I, Murti H., Iran J Basic Med Sci 21(7), 2018
PMID: 30140415

Proprotein convertase furin inhibits matrix metalloproteinase 13 in a TGFβ-dependent manner and limits osteoarthritis in mice.
Lin H, Hay E, Latourte A, Funck-Brentano T, Bouaziz W, Ea HK, Khatib AM, Richette P, Cohen-Solal M., Sci Rep 8(1), 2018
PMID: 29992982

Intra-articular administration of EP2 enhances the articular cartilage repair in a rabbit model.
Tani Y, Sato M, Yokoyama M, Yokoyama M, Takahashi T, Toyoda E, Okada E, Fujimura S, Maruki H, Kato Y, Yamato M, Okano T, Mochida J., J Tissue Eng Regen Med 12(11), 2018
PMID: 30075064

Intra-Articular Injection of Fructus Ligustri Lucidi Extract Attenuates Pain Behavior and Cartilage Degeneration in Mono-Iodoacetate Induced Osteoarthritic Rats.
Yan B, Zhou L, Wang C, Wang R, Yan L, Yu L, Liu F, Du W, Yu G, Yuan Q, Tong P, Shan L, Efferth T., Front Pharmacol 9(), 2018
PMID: 30532708

Intra-articular injection of N-acetylglucosamine and hyaluronic acid combined with PLGA scaffolds for osteochondral repair in rabbits.
Wang HC, Lin YT, Lin TH, Chang NJ, Lin CC, Hsu HC, Yeh ML., PLoS One 13(12), 2018
PMID: 30596714

Current strategies for integrative cartilage repair.
Boushell MK, Hung CT, Hunziker EB, Strauss EJ, Lu HH., Connect Tissue Res 58(5), 2017
PMID: 27599801

Pulsed electromagnetic field ameliorates cartilage degeneration by inhibiting mitogen-activated protein kinases in a rat model of osteoarthritis.
Zhou J, Liao Y, Xie H, Liao Y, Liu H, Zeng Y, Li N., Phys Ther Sport 24(), 2017
PMID: 27856169

Matrix metalloproteinase activity and prostaglandin E2 are elevated in the synovial fluid of meniscus tear patients.
Liu B, Goode AP, Carter TE, Utturkar GM, Huebner JL, Taylor DC, Moorman CT, Garrett WE, Kraus VB, Guilak F, DeFrate LE, McNulty AL., Connect Tissue Res 58(3-4), 2017
PMID: 27813662

Adipokines induce catabolism of newly synthesized matrix in cartilage and meniscus tissues.
Nishimuta JF, Levenston ME., Connect Tissue Res 58(3-4), 2017
PMID: 28095064

Biomarker Changes in Anterior Cruciate Ligament-Deficient Knees Compared With Healthy Controls.
Kaplan DJ, Cuellar VG, Jazrawi LM, Strauss EJ., Arthroscopy 33(5), 2017
PMID: 28130030

Attenuation of subchondral bone abnormal changes in osteoarthritis by inhibition of SDF-1 signaling.
Chen Y, Lin S, Sun Y, Guo J, Lu Y, Suen CW, Zhang J, Zha Z, Ho KW, Pan X, Li G., Osteoarthritis Cartilage 25(6), 2017
PMID: 28131784

Cellular senescence in osteoarthritis pathology.
McCulloch K, Litherland GJ, Rai TS., Aging Cell 16(2), 2017
PMID: 28124466

Vascular Canals in Permanent Hyaline Cartilage: Development, Corrosion of Nonmineralized Cartilage Matrix, and Removal of Matrix Degradation Products.
Gabner S, Häusler G, Böck P., Anat Rec (Hoboken) 300(6), 2017
PMID: 27997075

Differences in type II collagen turnover of osteoarthritic human knee and ankle joints.
Aurich M, Hofmann GO, Rolauffs B., Int Orthop 41(5), 2017
PMID: 28168551

Culture-expanded allogenic adipose tissue-derived stem cells attenuate cartilage degeneration in an experimental rat osteoarthritis model.
Mei L, Shen B, Ling P, Ling P, Liu S, Xue J, Liu F, Shao H, Chen J, Ma A, Liu X., PLoS One 12(4), 2017
PMID: 28419155

Evaluation of the effect of salmon nasal proteoglycan on biomarkers for cartilage metabolism in individuals with knee joint discomfort: A randomized double-blind placebo-controlled clinical study.
Tomonaga A, Takahashi T, Tanaka YT, Tsuboi M, Ito K, Nagaoka I., Exp Ther Med 14(1), 2017
PMID: 28672901

Physiological concentrations of soluble uric acid are chondroprotective and anti-inflammatory.
Lai JH, Luo SF, Hung LF, Huang CY, Lien SB, Lin LC, Liu FC, Yen BL, Ho LJ., Sci Rep 7(1), 2017
PMID: 28539647

Reduction of the Serum Levels of a Specific Biomarker of Cartilage Degradation (Coll2-1) by Hyaluronic Acid (KARTILAGE® CROSS) Compared to Placebo in Painful Knee Osteoarthritis Patients: the EPIKART Study, a Pilot Prospective Comparative Randomized Double Blind Trial.
Henrotin Y, Berenbaum F, Chevalier X, Marty M, Richette P, Rannou F., BMC Musculoskelet Disord 18(1), 2017
PMID: 28549430

Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes.
Huang G, Chubinskaya S, Liao W, Loeser RF., Osteoarthritis Cartilage 25(9), 2017
PMID: 28587781

Oleanolic acid prevents cartilage degeneration in diabetic mice via PPARγ associated mitochondrial stabilization.
Kang X, Yang Z, Sheng J, Liu JB, Xie QY, Zheng W, Chen K., Biochem Biophys Res Commun 490(3), 2017
PMID: 28647370

Plasma level of Osteopontin does not respond to total replacement Surgery in patients with severe Primary knee/Hip Osteoarthritis.
Abdelnaby R, El Deeb S, Khachab A, Bläsius K, Tingart M, Rath B., J Orthop 14(3), 2017
PMID: 28706379

Synovial tissue research: a state-of-the-art review.
Orr C, Vieira-Sousa E, Boyle DL, Buch MH, Buckley CD, Cañete JD, Catrina AI, Choy EHS, Emery P, Fearon U, Filer A, Gerlag D, Humby F, Isaacs JD, Just SA, Lauwerys BR, Le Goff B, Manzo A, McGarry T, McInnes IB, Najm A, Pitzalis C, Pratt A, Smith M, Tak PP, Thurlings R, Fonseca JE, Veale DJ, Tas SW., Nat Rev Rheumatol 13(8), 2017
PMID: 28701760

Expression of matrix metalloproteinases and components of the endocannabinoid system in the knee joint are associated with biphasic pain progression in a rat model of osteoarthritis.
Pajak A, Kostrzewa M, Malek N, Korostynski M, Starowicz K., J Pain Res 10(), 2017
PMID: 28860852

Cartilage matrix remodelling differs by disease state and joint type.
Hsueh MF, Kraus VB, Önnerfjord P., Eur Cell Mater 34(), 2017
PMID: 28836259

In Situ Imaging of Tissue Remodeling with Collagen Hybridizing Peptides.
Hwang J, Huang Y, Burwell TJ, Peterson NC, Connor J, Weiss SJ, Yu SM, Li Y., ACS Nano 11(10), 2017
PMID: 28877431

An improved collagen zymography approach for evaluating the collagenases MMP-1, MMP-8, and MMP-13.
Inanc S, Keles D, Oktay G., Biotechniques 63(4), 2017
PMID: 29048269

TGF-β Family Signaling in Connective Tissue and Skeletal Diseases.
MacFarlane EG, Haupt J, Dietz HC, Shore EM., Cold Spring Harb Perspect Biol 9(11), 2017
PMID: 28246187

New insights on the MMP-13 regulatory network in the pathogenesis of early osteoarthritis.
Li H, Wang D, Yuan Y, Min J., Arthritis Res Ther 19(1), 2017
PMID: 29126436

Progranulin derived engineered protein Atsttrin suppresses TNF-α-mediated inflammation in intervertebral disc degenerative disease.
Ding H, Wei J, Zhao Y, Liu Y, Liu L, Cheng L., Oncotarget 8(65), 2017
PMID: 29312639

Prediction of progression of damage to articular cartilage 2 years after anterior cruciate ligament reconstruction: use of aggrecan and type II collagen biomarkers in a retrospective observational study.
Sobue Y, Kojima T, Kurokouchi K, Takahashi S, Yoshida H, Poole R, Ishiguro N., Arthritis Res Ther 19(1), 2017
PMID: 29208010

The effects of different molecular weight chondroitin-4-sulfates in chondrocyte pellet culture.
Yang SR, Peng S, Ko CY, Chu IM., Cytotechnology 68(3), 2016
PMID: 25283267

Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.
Hui W, Young DA, Rowan AD, Xu X, Cawston TE, Proctor CJ., Ann Rheum Dis 75(2), 2016
PMID: 25475114

Matrix metalloproteinases and risk stratification in patients undergoing surgical revascularisation for critical limb ischaemia.
De Caridi G, Massara M, Spinelli F, David A, Gangemi S, Fugetto F, Grande R, Butrico L, Stefanelli R, Colosimo M, de Franciscis S, Serra R., Int Wound J 13(4), 2016
PMID: 26012891

Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues.
Kozawa E, Cheng XW, Urakawa H, Arai E, Yamada Y, Kitamura S, Sato K, Kuzuya M, Ishiguro N, Nishida Y., J Orthop Res 34(1), 2016
PMID: 26241216

Advanced glycation end-products induced VEGF production and inflammatory responses in human synoviocytes via RAGE-NF-κB pathway activation.
Chen YJ, Chan DC, Chiang CK, Wang CC, Yang TH, Lan KC, Chao SC, Tsai KS, Yang RS, Liu SH., J Orthop Res 34(5), 2016
PMID: 26497299

Association study of MMP8 gene in osteoarthritis.
Näkki A, Rodriguez-Fontenla C, Gonzalez A, Harilainen A, Leino-Arjas P, Heliövaara M, Eriksson JG, Tallroth K, Videman T, Kaprio J, Saarela J, Kujala UM., Connect Tissue Res 57(1), 2016
PMID: 26577236

RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes.
McDermott BT, Ellis S, Bou-Gharios G, Clegg PD, Tew SR., Osteoarthritis Cartilage 24(7), 2016
PMID: 26853752

Early reversal cells in adult human bone remodeling: osteoblastic nature, catabolic functions and interactions with osteoclasts.
Abdelgawad ME, Delaisse JM, Hinge M, Jensen PR, Alnaimi RW, Rolighed L, Engelholm LH, Marcussen N, Andersen TL., Histochem Cell Biol 145(6), 2016
PMID: 26860863

Role of Thyroid Hormones in Skeletal Development and Bone Maintenance.
Bassett JH, Williams GR., Endocr Rev 37(2), 2016
PMID: 26862888

MMP-13 is involved in oral cancer cell metastasis.
Huang SH, Law CH, Kuo PH, Hu RY, Yang CC, Chung TW, Li JM, Lin LH, Liu YC, Liao EC, Tsai YT, Wei YS, Lin CC, Chang CW, Chou HC, Wang WC, Chang MD, Wang LH, Kung HJ, Chan HL, Lyu PC., Oncotarget 7(13), 2016
PMID: 26958809

Roles of microRNA and signaling pathway in osteoarthritis pathogenesis.
Xu B, Li YY, Ma J, Pei FX., J Zhejiang Univ Sci B 17(3), 2016
PMID: 26984840

Translational potential of ginsenoside Rb1 in managing progression of osteoarthritis.
Chen Y, Lin S, Sun Y, Pan X, Xiao L, Zou L, Ho KW, Li G., J Orthop Translat 6(), 2016
PMID: 30035080

The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis.
Benabdoune H, Rondon EP, Shi Q, Fernandes J, Ranger P, Fahmi H, Benderdour M., Inflamm Res 65(8), 2016
PMID: 27056390

The Association Between Serum Biomarkers of Collagen Turnover and Subsequent Anterior Cruciate Ligament Rupture.
Svoboda SJ, Owens BD, Harvey TM, Tarwater PM, Brechue WF, Cameron KL., Am J Sports Med 44(7), 2016
PMID: 27159304

Mesenchymal stem cell therapy in the treatment of osteoarthritis: reparative pathways, safety and efficacy - a review.
Freitag J, Bates D, Boyd R, Shah K, Barnard A, Huguenin L, Tenen A., BMC Musculoskelet Disord 17(), 2016
PMID: 27229856

Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1β and MMP-13.
Li P, Deng J, Wei X, Jayasuriya CT, Zhou J, Chen Q, Zhang J, Wei L, Wei F., Mol Med Rep 14(2), 2016
PMID: 27356492

Context-specific protection of TGFα null mice from osteoarthritis.
Usmani SE, Ulici V, Pest MA, Hill TL, Welch ID, Beier F., Sci Rep 6(), 2016
PMID: 27457421

Ataxia-telangiectasia mutated activation mediates tumor necrosis factor-alpha induced MMP-13 up-regulation and metastasis in lung cancer cells.
Yan HQ, Zhang D, Shi YY, You X, Shi L, Li Q, Gao FG., Oncotarget 7(38), 2016
PMID: 27556690

Association between genetic polymorphisms of MMP8 and the risk of steroid-induced osteonecrosis of the femoral head in the population of northern China.
Du J, Jin T, Cao Y, Chen J, Guo Y, Sun M, Li J, Zhang X, Wang G, Wang J., Medicine (Baltimore) 95(37), 2016
PMID: 27631232

[Degenerative DNA alterations in osteoarthritis].
Söder S., Pathologe 37(suppl 2), 2016
PMID: 27638529

Osteopontin Bridging Innate and Adaptive Immunity in Autoimmune Diseases.
Clemente N, Raineri D, Cappellano G, Boggio E, Favero F, Soluri MF, Dianzani C, Comi C, Dianzani U, Chiocchetti A., J Immunol Res 2016(), 2016
PMID: 28097158

Current serological possibilities for the diagnosis of arthritis with special focus on proteins and proteoglycans from the extracellular matrix.
Lord MS, Farrugia BL, Rnjak-Kovacina J, Whitelock JM., Expert Rev Mol Diagn 15(1), 2015
PMID: 25382274

PPARγ is involved in the hyperglycemia-induced inflammatory responses and collagen degradation in human chondrocytes and diabetic mouse cartilages.
Chen YJ, Chan DC, Lan KC, Wang CC, Chen CM, Chao SC, Tsai KS, Yang RS, Liu SH., J Orthop Res 33(3), 2015
PMID: 25410618

Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid.
Sakata S, Hayashi S, Fujishiro T, Kawakita K, Kanzaki N, Hashimoto S, Iwasa K, Chinzei N, Kihara S, Haneda M, Ueha T, Nishiyama T, Kuroda R, Kurosaka M., J Orthop Res 33(3), 2015
PMID: 25469820

Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation.
Thorpe CT, Chaudhry S, Lei II, Varone A, Riley GP, Birch HL, Clegg PD, Screen HR., Scand J Med Sci Sports 25(4), 2015
PMID: 25639911

Sirtuin 1 is a negative regulator of parathyroid hormone stimulation of matrix metalloproteinase 13 expression in osteoblastic cells: role of sirtuin 1 in the action of PTH on osteoblasts.
Fei Y, Shimizu E, McBurney MW, Partridge NC., J Biol Chem 290(13), 2015
PMID: 25631045

Peroxisome proliferator-activated receptor δ promotes the progression of posttraumatic osteoarthritis in a mouse model.
Ratneswaran A, LeBlanc EA, Walser E, Welch I, Mort JS, Borradaile N, Beier F., Arthritis Rheumatol 67(2), 2015
PMID: 25331977

Adult mice lacking the type 2 iodothyronine deiodinase have increased subchondral bone but normal articular cartilage.
Waung JA, Bassett JH, Williams GR., Thyroid 25(3), 2015
PMID: 25549200

Cytokine networking of chondrocyte dedifferentiation in vitro and its implications for cell-based cartilage therapy.
Duan L, Ma B, Liang Y, Chen J, Zhu W, Li M, Wang D., Am J Transl Res 7(2), 2015
PMID: 25901191

Injury of primary afferent neurons may contribute to osteoarthritis induced pain: an experimental study using the collagenase model in rats.
Adães S, Ferreira-Gomes J, Mendonça M, Almeida L, Castro-Lopes JM, Neto FL., Osteoarthritis Cartilage 23(6), 2015
PMID: 25701166

Analysis of a collagen II degradation protein C2C and a collagen II formation protein CP II in serum of Asian elephants (Elephas maximus).
Kilgallon CP, Larsen S, Wong A, Yellowley C., J Zoo Wildl Med 46(1), 2015
PMID: 25831589

Articular cartilage zonal differentiation via 3D Second-Harmonic Generation imaging microscopy.
Chaudhary R, Campbell KR, Tilbury KB, Vanderby R, Block WF, Kijowski R, Campagnola PJ., Connect Tissue Res 56(2), 2015
PMID: 25738523

In vivo cartilage strain increases following medial meniscal tear and correlates with synovial fluid matrix metalloproteinase activity.
Carter TE, Taylor KA, Spritzer CE, Utturkar GM, Taylor DC, Moorman CT, Garrett WE, Guilak F, McNulty AL, DeFrate LE., J Biomech 48(8), 2015
PMID: 25801424

Correlating high-resolution magic angle spinning NMR spectroscopy and gene analysis in osteoarthritic cartilage.
Tufts L, Shet Vishnudas K, Fu E, Kurhanewicz J, Ries M, Alliston T, Li X., NMR Biomed 28(5), 2015
PMID: 25761416

New self-assembling multifunctional templates for the biofabrication and controlled self-release of cultured tissue.
Gouveia RM, Castelletto V, Hamley IW, Connon CJ., Tissue Eng Part A 21(11-12), 2015
PMID: 25712617

Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes.
Nagai K, Matsushita T, Matsuzaki T, Takayama K, Matsumoto T, Kuroda R, Kurosaka M., Osteoarthritis Cartilage 23(8), 2015
PMID: 25819580

Self-assembly of a dual functional bioactive peptide amphiphile incorporating both matrix metalloprotease substrate and cell adhesion motifs.
Dehsorkhi A, Gouveia RM, Smith AM, Hamley IW, Castelletto V, Connon CJ, Reza M, Ruokolainen J., Soft Matter 11(16), 2015
PMID: 25779650

Repeated exposure to high-frequency low-amplitude vibration induces degeneration of murine intervertebral discs and knee joints.
McCann MR, Patel P, Pest MA, Ratneswaran A, Lalli G, Beaucage KL, Backler GB, Kamphuis MP, Esmail Z, Lee J, Barbalinardo M, Mort JS, Holdsworth DW, Beier F, Dixon SJ, Séguin CA., Arthritis Rheumatol 67(8), 2015
PMID: 25891852

Activating enhancer binding protein 2 epsilon (AP-2ε)-deficient mice exhibit increased matrix metalloproteinase 13 expression and progressive osteoarthritis development.
Niebler S, Schubert T, Hunziker EB, Bosserhoff AK., Arthritis Res Ther 17(), 2015
PMID: 25964075

Articular Cartilage of the Human Knee Joint: In Vivo Multicomponent T2 Analysis at 3.0 T.
Liu F, Choi KW, Samsonov A, Spencer RG, Wilson JJ, Block WF, Kijowski R., Radiology 277(2), 2015
PMID: 26024307

Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise.
Spiesz EM, Thorpe CT, Chaudhry S, Riley GP, Birch HL, Clegg PD, Screen HR., J Orthop Res 33(6), 2015
PMID: 25721513

Chondropenia: current concept review.
Speziali A, Delcogliano M, Tei M, Placella G, Chillemi M, Tiribuzi R, Cerulli G., Musculoskelet Surg 99(3), 2015
PMID: 26068954

Deletion of Panx3 Prevents the Development of Surgically Induced Osteoarthritis.
Moon PM, Penuela S, Barr K, Khan S, Pin CL, Welch I, Attur M, Abramson SB, Laird DW, Beier F., J Mol Med (Berl) 93(8), 2015
PMID: 26138248

Intraarticular Matrix Metalloproteinases and Aggrecan Degradation Are Elevated After Articular Fracture.
Haller JM, Swearingen CA, Partridge D, McFadden M, Thirunavukkarasu K, Higgins TF., Clin Orthop Relat Res 473(10), 2015
PMID: 26162411

Novel Insights into Osteoarthritis Joint Pathology from Studies in Mice.
Moon PM, Beier F., Curr Rheumatol Rep 17(8), 2015
PMID: 26113010

Molecular targets in arthritis and recent trends in nanotherapy.
Roy K, Kanwar RK, Kanwar JR., Int J Nanomedicine 10(), 2015
PMID: 26345140

Effects of dendritic polyglycerol sulfate on articular chondrocytes.
Schneider T, Welker P, Haag R, Dernedde J, Hug T, Licha K, Kohl B, Arens S, Ertel W, Schulze-Tanzil G., Inflamm Res 64(11), 2015
PMID: 26350038

Reduction in disease progression by inhibition of transforming growth factor α-CCL2 signaling in experimental posttraumatic osteoarthritis.
Appleton CT, Usmani SE, Pest MA, Pitelka V, Mort JS, Beier F., Arthritis Rheumatol 67(10), 2015
PMID: 26138996

Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis.
Pest MA, Pest CA, Bellini MR, Feng Q, Beier F., PLoS One 10(11), 2015
PMID: 26562438

Cartilage degradation in temporomandibular joint induced by unilateral anterior crossbite prosthesis.
Wang YL, Zhang J, Zhang M, Lu L, Wang X, Guo M, Zhang X, Wang MQ., Oral Dis 20(3), 2014
PMID: 23614573

Influence of the molecular weight of poly(lactide-co-glycolide) on the in vivo cartilage repair by a construct of poly(lactide-co-glycolide)/fibrin gel/mesenchymal stem cells/transforming growth factor-β1.
Li B, Yang J, Ma L, Li F, Tu Z, Gao C., Tissue Eng Part A 20(1-2), 2014
PMID: 23924293

The anti-inflammatory and matrix restorative mechanisms of platelet-rich plasma in osteoarthritis.
Sundman EA, Cole BJ, Karas V, Della Valle C, Tetreault MW, Mohammed HO, Fortier LA., Am J Sports Med 42(1), 2014
PMID: 24192391

An in vitro model for the pathological degradation of articular cartilage in osteoarthritis.
Grenier S, Bhargava MM, Torzilli PA., J Biomech 47(3), 2014
PMID: 24360770

Biomarkers of cartilage and surrounding joint tissue.
Siebuhr AS, He Y, Gudmann NS, Gram A, Kjelgaard-Petersen CF, Qvist P, Karsdal MA, Bay-Jensen AC., Biomark Med 8(5), 2014
PMID: 25123039

Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis.
Adães S, Mendonça M, Santos TN, Castro-Lopes JM, Ferreira-Gomes J, Neto FL., Arthritis Res Ther 16(1), 2014
PMID: 24423138

Osteoarthritic cartilage lesions in the bovine patellar groove: a macroscopic, histological and immunohistological analysis.
Heinola T, Sukura A, Virkki LM, Sillat T, Lekszycki T, Konttinen YT., Vet J 200(1), 2014
PMID: 24581814

Molecular adhesion between cartilage extracellular matrix macromolecules.
Rojas FP, Batista MA, Lindburg CA, Dean D, Grodzinsky AJ, Ortiz C, Han L., Biomacromolecules 15(3), 2014
PMID: 24491174

Evaluation of biomarkers for osteoarthritis caused by fragmented medial coronoid process in dogs.
Hurlbeck C, Einspanier R, Pfeil I, Bondzio A., Res Vet Sci 96(3), 2014
PMID: 24684895

TGFβ signaling in cartilage development and maintenance.
Wang W, Rigueur D, Lyons KM., Birth Defects Res C Embryo Today 102(1), 2014
PMID: 24677722

Chondroprotective effects of zoledronic acid on articular cartilage in dogs with experimentally induced osteoarthritis.
Dearmin MG, Trumble TN, García A, Chambers JN, Budsberg SC., Am J Vet Res 75(4), 2014
PMID: 24669915

The effect of recombinant human fibroblast growth factor-18 on articular cartilage following single impact load.
Barr L, Getgood A, Guehring H, Rushton N, Henson FM., J Orthop Res 32(7), 2014
PMID: 24719286

Experimental chondrocyte hypertrophy is promoted by the activation of discoidin domain receptor 2.
Zhang S, Zhong Y, Li R, Wang W, Zeng L, Wang Z, Jia P, Wu R., Mol Med Rep 10(3), 2014
PMID: 24938620

Targeting MMP-2 to treat ischemic heart injury.
Hughes BG, Schulz R., Basic Res Cardiol 109(4), 2014
PMID: 24986221

Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin.
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F, Perretti M., Biochem Pharmacol 91(3), 2014
PMID: 25117448

SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes.
Choi CH, Kim TH, Sung YK, Choi CB, Na YI, Yoo H, Jun JB., Korean J Intern Med 29(5), 2014
PMID: 25228841

In silico study combining docking and QSAR methods on a series of matrix metalloproteinase 13 inhibitors.
Xi L, Li S, Yao X, Wei Y, Li J, Liu H, Wu X., Arch Pharm (Weinheim) 347(11), 2014
PMID: 25363411

Cordycepin modulates inflammatory and catabolic gene expression in interleukin-1beta-induced human chondrocytes from advanced-stage osteoarthritis: an in vitro study.
Hu P, Chen W, Bao J, Jiang L, Wu L., Int J Clin Exp Pathol 7(10), 2014
PMID: 25400736

Cross-relaxation imaging of human patellar cartilage in vivo at 3.0T.
Sritanyaratana N, Samsonov A, Mossahebi P, Wilson JJ, Block WF, Kijowski R., Osteoarthritis Cartilage 22(10), 2014
PMID: 25278066

Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degeneration.
Cao K, Wei L, Zhang Z, Guo L, Zhang C, Li Y, Sun C, Sun X, Wang S, Li P, Wei X., Arthritis Res Ther 16(6), 2014
PMID: 25424126

Pharmacological modulation of brain activity in a preclinical model of osteoarthritis.
Upadhyay J, Baker SJ, Rajagovindan R, Hart M, Chandran P, Hooker BA, Cassar S, Mikusa JP, Tovcimak A, Wald MJ, Joshi SK, Bannon A, Medema JK, Beaver J, Honore P, Kamath RV, Fox GB, Day M., Neuroimage 64(), 2013
PMID: 22982372

Yeast hydrolysate protects cartilage via stimulation of type II collagen synthesis and suppression of MMP-13 production.
Lee HS, Park SY, Park Y, Bae SH, Suh HJ., Phytother Res 27(9), 2013
PMID: 23070893

A novel in vitro bovine cartilage punch model for assessing the regeneration of focal cartilage defects with biocompatible bacterial nanocellulose.
Pretzel D, Linss S, Ahrem H, Endres M, Kaps C, Klemm D, Kinne RW., Arthritis Res Ther 15(3), 2013
PMID: 23673274

Cartilage collagen damage in hip osteoarthritis similar to that seen in knee osteoarthritis; a case-control study of relationship between collagen, glycosaminoglycan and cartilage swelling.
Hosseininia S, Lindberg LR, Dahlberg LE., BMC Musculoskelet Disord 14(), 2013
PMID: 23302451

Vertical inhibition of the PI3K/Akt/mTOR pathway for the treatment of osteoarthritis.
Chen J, Crawford R, Xiao Y., J Cell Biochem 114(2), 2013
PMID: 22930581

UV-mediated downregulation of the endocytic collagen receptor, Endo180, contributes to accumulation of extracellular collagen fragments in photoaged skin.
Tang S, Lucius R, Wenck H, Gallinat S, Weise JM., J Dermatol Sci 70(1), 2013
PMID: 23433549

Potential of Raloxifene in reversing osteoarthritis-like alterations in rat chondrocytes: an in vitro model study.
Kavas A, Cagatay ST, Banerjee S, Keskin D, Tezcaner A., J Biosci 38(1), 2013
PMID: 23385821

Effects of strontium on collagen content and expression of related genes in rat chondrocytes cultured in vitro.
Wang J, Zhu X, Liu L, Shi X, Yin L, Zhang Y, Li X, Wang Z, Liu G., Biol Trace Elem Res 153(1-3), 2013
PMID: 23475370

The emerging roles of HTRA1 in musculoskeletal disease.
Tiaden AN, Richards PJ., Am J Pathol 182(5), 2013
PMID: 23499460

New selective inhibitors of MMP-13 for inflammatory diseases: a patent evaluation (W02012151158).
Li NG, Tang YP, Duan JA., Expert Opin Ther Pat 23(5), 2013
PMID: 23506002

T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor κB signaling.
Ma B, Zhong L, van Blitterswijk CA, Post JN, Karperien M., J Biol Chem 288(24), 2013
PMID: 23603903

Advanced glycation end products induce peroxisome proliferator-activated receptor γ down-regulation-related inflammatory signals in human chondrocytes via Toll-like receptor-4 and receptor for advanced glycation end products.
Chen YJ, Sheu ML, Tsai KS, Yang RS, Liu SH., PLoS One 8(6), 2013
PMID: 23776688

Acute Myocardial Infarction and Pulmonary Diseases Result in Two Different Degradation Profiles of Elastin as Quantified by Two Novel ELISAs.
Skjøt-Arkil H, Clausen RE, Rasmussen LM, Wang W, Wang Y, Zheng Q, Mickley H, Saaby L, Diederichsen AC, Lambrechtsen J, Martinez FJ, Hogaboam CM, Han M, Larsen MR, Nawrocki A, Vainer B, Krustrup D, Bjørling-Poulsen M, Karsdal MA, Leeming DJ., PLoS One 8(6), 2013
PMID: 23805173

Expression of gelatinases (MMP-2, MMP-9) in human articular cartilage.
Lipari L, Gerbino A., Int J Immunopathol Pharmacol 26(3), 2013
PMID: 24067484

Potent inhibitors precise to S1' loop of MMP-13, a crucial target for osteoarthritis.
Kalva S, Saranyah K, Suganya PR, Nisha M, Saleena LM., J Mol Graph Model 44(), 2013
PMID: 23938376

Changes in serum biomarkers of cartilage turnover after anterior cruciate ligament injury.
Svoboda SJ, Harvey TM, Owens BD, Brechue WF, Tarwater PM, Cameron KL., Am J Sports Med 41(9), 2013
PMID: 23831890

Biomimetic aggrecan reduces cartilage extracellular matrix from degradation and lowers catabolic activity in ex vivo and in vivo models.
Sharma S, Lee A, Choi K, Kim K, Youn I, Trippel SB, Panitch A., Macromol Biosci 13(9), 2013
PMID: 23836445

Molecular mechanisms of the cartilage-specific microRNA-140 in osteoarthritis.
Zhang R, Ma J, Yao J., Inflamm Res 62(10), 2013
PMID: 23942573

Autologous solution protects bovine cartilage explants from IL-1α- and TNFα-induced cartilage degradation.
Matuska A, O'shaughnessey K, King W, Woodell-May J., J Orthop Res 31(12), 2013
PMID: 23966313

Transcriptomic signatures in cartilage ageing.
Peffers M, Liu X, Clegg P., Arthritis Res Ther 15(4), 2013
PMID: 23971731

Effects of Payena dasyphylla (Miq.) on hyaluronidase enzyme activity and metalloproteinases protein expressions in interleukin-1β stimulated human chondrocytes cells.
Citalingam K, Zareen S, Shaari K, Ahmad S., BMC Complement Altern Med 13(), 2013
PMID: 23971790

The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis.
Maldonado M, Nam J., Biomed Res Int 2013(), 2013
PMID: 24069595

Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury.
Haslauer CM, Elsaid KA, Fleming BC, Proffen BL, Johnson VM, Murray MM., Osteoarthritis Cartilage 21(12), 2013
PMID: 24036379

Deletion of the transforming growth factor β receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice.
Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D., Arthritis Rheum 65(12), 2013
PMID: 23982761

Conditioned media from adipose-tissue-derived mesenchymal stem cells downregulate degradative mediators induced by interleukin-1β in osteoarthritic chondrocytes.
Platas J, Guillén MI, del Caz MD, Gomar F, Mirabet V, Alcaraz MJ., Mediators Inflamm 2013(), 2013
PMID: 24363499

MMP mediated degradation of type IV collagen alpha 1 and alpha 3 chains reflects basement membrane remodeling in experimental and clinical fibrosis--validation of two novel biomarker assays.
Sand JM, Larsen L, Hogaboam C, Martinez F, Han M, Røssel Larsen M, Nawrocki A, Zheng Q, Karsdal MA, Leeming DJ., PLoS One 8(12), 2013
PMID: 24376856

Age-dependent alteration of TGF-β signalling in osteoarthritis.
van der Kraan PM, Goumans MJ, Blaney Davidson E, ten Dijke P., Cell Tissue Res 347(1), 2012
PMID: 21638205

Proteases involved in cartilage matrix degradation in osteoarthritis.
Troeberg L, Nagase H., Biochim Biophys Acta 1824(1), 2012
PMID: 21777704

Early effect of hyaluronic acid intra-articular injections on serum and urine biomarkers in patients with knee osteoarthritis: An open-label observational prospective study.
Conrozier T, Balblanc JC, Richette P, Mulleman D, Maillet B, Henrotin Y, Rannou F, Piroth C, Hilliquin P, Mathieu P, Walliser-Lohse A, Rousselot I, Plattner V, Maillefert JF, Vignon E, Chevalier X, Osteoarthritis Group of the French Society of Rheumatology., J Orthop Res 30(5), 2012
PMID: 22025307

Regulation of human chondrocyte function through direct inhibition of cartilage master regulator SOX9 by microRNA-145 (miRNA-145).
Martinez-Sanchez A, Dudek KA, Murphy CL., J Biol Chem 287(2), 2012
PMID: 22102413

Serum xylosyltransferase 1 level increases during early posttraumatic osteoarthritis in mice with high bone forming potential.
McCoy SY, Falgowski KA, Srinivasan PP, Thompson WR, Selva EM, Kirn-Safran CB., Bone 51(2), 2012
PMID: 22146554

E74-like factor 3 (ELF3) impacts on matrix metalloproteinase 13 (MMP13) transcriptional control in articular chondrocytes under proinflammatory stress.
Otero M, Plumb DA, Tsuchimochi K, Dragomir CL, Hashimoto K, Peng H, Olivotto E, Bevilacqua M, Tan L, Yang Z, Zhan Y, Oettgen P, Li Y, Marcu KB, Goldring MB., J Biol Chem 287(5), 2012
PMID: 22158614

New insights into cartilage repair - the role of migratory progenitor cells in osteoarthritis.
Gerter R, Kruegel J, Miosge N., Matrix Biol 31(3), 2012
PMID: 22266025

Molecular analysis of age and sex-related gene expression in meniscal tears with and without a concomitant anterior cruciate ligament tear.
Brophy RH, Rai MF, Zhang Z, Torgomyan A, Sandell LJ., J Bone Joint Surg Am 94(5), 2012
PMID: 22362494

Transforming growth factor-alpha induces endothelin receptor A expression in osteoarthritis.
Usmani SE, Appleton CT, Beier F., J Orthop Res 30(9), 2012
PMID: 22407503

Development of a novel immunoassay for the measurement of type II collagen neoepitope generated by collagenase cleavage.
Takahashi T, Naito S, Onoda J, Yamauchi A, Nakamura E, Kishino J, Kawai T, Matsukawa S, Toyosaki-Maeda T, Tanimura M, Fukui N, Numata Y, Yamane S., Clin Chim Acta 413(19-20), 2012
PMID: 22507082

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis.
Bui C, Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA., FASEB J 26(7), 2012
PMID: 22505473

The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage.
Lu M, Cao J, Liu F, Li S, Chen J, Fu Q, Zhang Z, Liu J, Luo M, Wang J, Li J, Caterson B., Cells Tissues Organs 196(3), 2012
PMID: 22538829

Carrageenan-induced transient inflammation in a rabbit knee model: molecular changes consistent with an early osteoarthritis phenotype.
Achari Y, Reno CR, Frank CB, Hart DA., Inflamm Res 61(8), 2012
PMID: 22581309

Increased type II collagen cleavage by cathepsin K and collagenase activities with aging and osteoarthritis in human articular cartilage.
Dejica VM, Mort JS, Laverty S, Antoniou J, Zukor DJ, Tanzer M, Poole AR., Arthritis Res Ther 14(3), 2012
PMID: 22584047

Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.
Burleigh A, Chanalaris A, Gardiner MD, Driscoll C, Boruc O, Saklatvala J, Vincent TL., Arthritis Rheum 64(7), 2012
PMID: 22307759

Structural insights into triple-helical collagen cleavage by matrix metalloproteinase 1.
Manka SW, Carafoli F, Visse R, Bihan D, Raynal N, Farndale RW, Murphy G, Enghild JJ, Hohenester E, Nagase H., Proc Natl Acad Sci U S A 109(31), 2012
PMID: 22761315

Regulation of inflammatory response in human chondrocytes by lentiviral mediated RNA interference against S100A10.
Song C, Zhou X, Dong Q, Fan R, Wu G, Ji B, Meng Q, Zheng M., Inflamm Res 61(11), 2012
PMID: 22797859

Fibroblast growth factor-2 promotes catabolism via FGFR1-Ras-Raf-MEK1/2-ERK1/2 axis that coordinates with the PKCδ pathway in human articular chondrocytes.
Yan D, Chen D, Im HJ., J Cell Biochem 113(9), 2012
PMID: 22488450

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis.
Chen CG, Thuillier D, Chin EN, Alliston T., Arthritis Rheum 64(10), 2012
PMID: 22674505

A review of translational animal models for knee osteoarthritis.
Gregory MH, Capito N, Kuroki K, Stoker AM, Cook JL, Sherman SL., Arthritis 2012(), 2012
PMID: 23326663

Selective MMP13 inhibitors.
Li JJ, Johnson AR., Med Res Rev 31(6), 2011
PMID: 20196103

Emerging MRI methods in rheumatoid arthritis.
Borrero CG, Mountz JM, Mountz JD., Nat Rev Rheumatol 7(2), 2011
PMID: 21045791

Developmental mechanisms in articular cartilage degradation in osteoarthritis.
Tchetina EV., Arthritis 2011(), 2011
PMID: 22046522

Glycoconjugate markers of joint diseases.
Popko J, Olszewski S, Guszczyn T, Zwierz K, Pancewicz S., Biochem Soc Trans 39(1), 2011
PMID: 21265798

Impact of sex hormones, insulin, growth factors and peptides on cartilage health and disease.
Claassen H, Schicht M, Paulsen F., Prog Histochem Cytochem 45(4), 2011
PMID: 21251699

Immobilization of matrix metalloproteinase 8 (MMP-8) for online drug screening.
Mazzini F, Nuti E, Petri A, Rossello A., J Chromatogr B Analyt Technol Biomed Life Sci 879(11-12), 2011
PMID: 21397574

Effects of diallyl sulphide in chondrocyte and cartilage in experimental osteoarthritis in rabbit.
Chen WP, Tang JL, Bao JP, Hu PF, Yu C, Shi ZL, Wu LD., Phytother Res 25(3), 2011
PMID: 20683842

Collagen fragments inhibit hyaluronan synthesis in skin fibroblasts in response to ultraviolet B (UVB): new insights into mechanisms of matrix remodeling.
Röck K, Grandoch M, Majora M, Krutmann J, Fischer JW., J Biol Chem 286(20), 2011
PMID: 21454612

Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis.
Kraus VB, Burnett B, Coindreau J, Cottrell S, Eyre D, Gendreau M, Gardiner J, Garnero P, Hardin J, Henrotin Y, Heinegård D, Ko A, Lohmander LS, Matthews G, Menetski J, Moskowitz R, Persiani S, Poole AR, Rousseau JC, Todman M, OARSI FDA Osteoarthritis Biomarkers Working Group., Osteoarthritis Cartilage 19(5), 2011
PMID: 21396468

Advanced glycation end products cause collagen II reduction by activating Janus kinase/signal transducer and activator of transcription 3 pathway in porcine chondrocytes.
Huang CY, Lai KY, Hung LF, Wu WL, Liu FC, Ho LJ., Rheumatology (Oxford) 50(8), 2011
PMID: 21482542

Cellular and molecular mechanisms of anti-inflammatory effect of Aflapin: a novel Boswellia serrata extract.
Sengupta K, Kolla JN, Krishnaraju AV, Yalamanchili N, Rao CV, Golakoti T, Raychaudhuri S, Raychaudhuri SP., Mol Cell Biochem 354(1-2), 2011
PMID: 21479939

Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities.
Karsdal MA, Woodworth T, Henriksen K, Maksymowych WP, Genant H, Vergnaud P, Christiansen C, Schubert T, Qvist P, Schett G, Platt A, Bay-Jensen AC., Arthritis Res Ther 13(2), 2011
PMID: 21539724

The relation between cartilage biomarkers (C2C, C1,2C, CS846, and CPII) and the long-term outcome of rheumatoid arthritis patients within the CAMERA trial.
Bakker MF, Verstappen SM, Welsing PM, Jacobs JW, Jahangier ZN, van der Veen MJ, Bijlsma JW, Lafeber FP, Utrecht Arthritis Cohort study group., Arthritis Res Ther 13(3), 2011
PMID: 21539729

The constitutive expression of type x collagen in mesenchymal stem cells from osteoarthritis patients is reproduced in a rabbit model of osteoarthritis.
Mwale F, Rampersad S, Richard H, Guoying Y, Al Rowas S, Madiraju P, Antoniou J, Laverty S., J Tissue Eng 2011(), 2011
PMID: 21808721

Urinary biomarkers and occupational musculoskeletal disorders in the lower limbs.
Mason HJ, Evans G, Moore A., Occup Med (Lond) 61(5), 2011
PMID: 21831821

A benzamide-linked small molecule HS-Cf inhibits TNF-α-induced interferon regulatory factor-1 in porcine chondrocytes: a potential disease-modifying drug for osteoarthritis therapeutics.
Liu FC, Huang HS, Huang CY, Yang R, Chang DM, Lai JH, Ho LJ., J Clin Immunol 31(6), 2011
PMID: 21858617

Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.
Pickarski M, Hayami T, Zhuo Y, Duong LT., BMC Musculoskelet Disord 12(), 2011
PMID: 21864409

Prostaglandin E2 receptor type 2-selective agonist prevents the degeneration of articular cartilage in rabbit knees with traumatic instability.
Mitsui H, Aoyama T, Furu M, Ito K, Jin Y, Maruyama T, Kanaji T, Fujimura S, Sugihara H, Nishiura A, Otsuka T, Nakamura T, Toguchida J., Arthritis Res Ther 13(5), 2011
PMID: 21914215

Rhein: a potential biological therapeutic drug for intervertebral disc degeneration.
Li H, Liang C, Chen Q, Yang Z., Med Hypotheses 77(6), 2011
PMID: 21962453

Effect of low-intensity pulsed ultrasound on MMP-13 and MAPKs signaling pathway in rabbit knee osteoarthritis.
Li X, Li J, Cheng K, Lin Q, Wang D, Zhang H, An H, Gao M, Chen A., Cell Biochem Biophys 61(2), 2011
PMID: 21567132

15-deoxy-Δ(12,14) -prostaglandin-J2 and ciglitazone inhibit TNF-α-induced matrix metalloproteinase 13 production via the antagonism of NF-κB activation in human synovial fibroblasts.
Lin TH, Tang CH, Wu K, Fong YC, Yang RS, Fu WM., J Cell Physiol 226(12), 2011
PMID: 21344384

Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis.
Higashiyama R, Miyaki S, Yamashita S, Yoshitaka T, Lindman G, Ito Y, Sasho T, Takahashi K, Lotz M, Asahara H., Mod Rheumatol 20(1), 2010
PMID: 19784544

Pleiotropic roles of matrix metalloproteinases in tumor angiogenesis: contrasting, overlapping and compensatory functions.
Deryugina EI, Quigley JP., Biochim Biophys Acta 1803(1), 2010
PMID: 19800930

Rho/ROCK and MEK/ERK activation by transforming growth factor-alpha induces articular cartilage degradation.
Appleton CT, Usmani SE, Mort JS, Beier F., Lab Invest 90(1), 2010
PMID: 19823173

Novel selective MMP-13 inhibitors reduce collagen degradation in bovine articular and human osteoarthritis cartilage explants.
Piecha D, Weik J, Kheil H, Becher G, Timmermann A, Jaworski A, Burger M, Hofmann MW., Inflamm Res 59(5), 2010
PMID: 19902332

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation.
Sondergaard BC, Schultz N, Madsen SH, Bay-Jensen AC, Kassem M, Karsdal MA., Osteoarthritis Cartilage 18(3), 2010
PMID: 19932675

Mechanical loading of in situ chondrocytes in lapine retropatellar cartilage after anterior cruciate ligament transection.
Han SK, Seerattan R, Herzog W., J R Soc Interface 7(47), 2010
PMID: 19933220

Discovery of (pyridin-4-yl)-2H-tetrazole as a novel scaffold to identify highly selective matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis.
Schnute ME, O'Brien PM, Nahra J, Morris M, Howard Roark W, Hanau CE, Ruminski PG, Scholten JA, Fletcher TR, Hamper BC, Carroll JN, Patt WC, Shieh HS, Collins B, Pavlovsky AG, Palmquist KE, Aston KW, Hitchcock J, Rogers MD, McDonald J, Johnson AR, Munie GE, Wittwer AJ, Man CF, Settle SL, Nemirovskiy O, Vickery LE, Agawal A, Dyer RD, Sunyer T., Bioorg Med Chem Lett 20(2), 2010
PMID: 20005097

Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis.
Mapp PI, Walsh DA, Bowyer J, Maciewicz RA., Osteoarthritis Cartilage 18(4), 2010
PMID: 20067755

Haem oxygenase-1 down-regulates high mobility group box 1 and matrix metalloproteinases in osteoarthritic synoviocytes.
García-Arnandis I, Guillén MI, Castejón MA, Gomar F, Alcaraz MJ., Rheumatology (Oxford) 49(5), 2010
PMID: 20110250

Biochemical markers of joint tissue turnover.
Bay-Jensen AC, Sondergaard BC, Christiansen C, Karsdal MA, Madsen SH, Qvist P., Assay Drug Dev Technol 8(1), 2010
PMID: 19715454

Application of biochemical markers in development of drugs for treatment of osteoarthritis.
Qvist P, Christiansen C, Karsdal MA, Madsen SH, Sondergaard BC, Bay-Jensen AC., Biomarkers 15(1), 2010
PMID: 20085489

Type II and VI collagen in nasal and articular cartilage and the effect of IL-1alpha on the distribution of these collagens.
Jansen ID, Hollander AP, Buttle DJ, Everts V., J Mol Histol 41(1), 2010
PMID: 20213143

Complementary interplay between matrix metalloproteinase-9, vascular endothelial growth factor and osteoclast function drives endochondral bone formation.
Ortega N, Wang K, Ferrara N, Werb Z, Vu TH., Dis Model Mech 3(3-4), 2010
PMID: 20142327

MMP-mediated collagen breakdown induced by activated protein C in equine cartilage is reduced by corticosteroids.
Garvican ER, Vaughan-Thomas A, Redmond C, Gabriel N, Clegg PD., J Orthop Res 28(3), 2010
PMID: 19777546

Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system.
Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI., J Bone Miner Metab 28(6), 2010
PMID: 20376510

Protein geranylgeranylation controls collagenase expression in osteoarthritic cartilage.
Sverdrup FM, Yates MP, Vickery LE, Klover JA, Song LR, Anglin CP, Misko TP., Osteoarthritis Cartilage 18(7), 2010
PMID: 20417291

Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs.
Chowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A, Homandberg GA., Arthritis Res Ther 12(3), 2010
PMID: 20462435

Effects of increased chronic loading on articular cartilage material properties in the lapine tibio-femoral joint.
Roemhildt ML, Coughlin KM, Peura GD, Badger GJ, Churchill D, Fleming BC, Beynnon BD., J Biomech 43(12), 2010
PMID: 20488444

Comparison of differential biomarkers of osteoarthritis with and without posttraumatic injury in the Hartley guinea pig model.
Wei L, Fleming BC, Sun X, Teeple E, Wu W, Jay GD, Elsaid KA, Luo J, Machan JT, Chen Q., J Orthop Res 28(7), 2010
PMID: 20108346

Cartilage biology, pathology, and repair.
Umlauf D, Frank S, Pap T, Bertrand J., Cell Mol Life Sci 67(24), 2010
PMID: 20734104

High mobility group box 1 potentiates the pro-inflammatory effects of interleukin-1β in osteoarthritic synoviocytes.
García-Arnandis I, Guillén MI, Gomar F, Pelletier JP, Martel-Pelletier J, Alcaraz MJ., Arthritis Res Ther 12(4), 2010
PMID: 20799933

Cheminformatics-based drug design approach for identification of inhibitors targeting the characteristic residues of MMP-13 hemopexin domain.
Kothapalli R, Khan AM, Basappa, Gopalsamy A, Chong YS, Annamalai L., PLoS One 5(8), 2010
PMID: 20824169

Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-dependent acetylation of PCAF.
Lee M, Partridge NC., J Biol Chem 285(49), 2010
PMID: 20870727

Cartilage degradation biomarkers predict efficacy of a novel, highly selective matrix metalloproteinase 13 inhibitor in a dog model of osteoarthritis: confirmation by multivariate analysis that modulation of type II collagen and aggrecan degradation peptides parallels pathologic changes.
Settle S, Vickery L, Nemirovskiy O, Vidmar T, Bendele A, Messing D, Ruminski P, Schnute M, Sunyer T., Arthritis Rheum 62(10), 2010
PMID: 20533541

Serum biomarker levels for musculoskeletal disease in two- and three-year-old racing Thoroughbred horses: A prospective study of 130 horses.
Frisbie DD, Mc Ilwraith CW, Arthur RM, Blea J, Baker VA, Billinghurst RC., Equine Vet J 42(7), 2010
PMID: 20840580

17β-estradiol reduces expression of MMP-1, -3, and -13 in human primary articular chondrocytes from female patients cultured in a three dimensional alginate system.
Claassen H, Steffen R, Hassenpflug J, Varoga D, Wruck CJ, Brandenburg LO, Pufe T., Cell Tissue Res 342(2), 2010
PMID: 20941509

Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture.
Coughlan TC, Crawford A, Goldring MB, Hatton PV, Barker MD., J Tissue Eng Regen Med 4(8), 2010
PMID: 20568084

Matrix metalloproteinase 8 deficiency in mice exacerbates inflammatory arthritis through delayed neutrophil apoptosis and reduced caspase 11 expression.
Cox JH, Starr AE, Kappelhoff R, Yan R, Roberts CR, Overall CM., Arthritis Rheum 62(12), 2010
PMID: 21120997

High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate.
Lauer-Fields JL, Minond D, Chase PS, Baillargeon PE, Saldanha SA, Stawikowska R, Hodder P, Fields GB., Bioorg Med Chem 17(3), 2009
PMID: 18358729

IGF-1 regulation of type II collagen and MMP-13 expression in rat endplate chondrocytes via distinct signaling pathways.
Zhang M, Zhou Q, Liang QQ, Li CG, Holz JD, Tang D, Sheu TJ, Li TF, Shi Q, Wang YJ., Osteoarthritis Cartilage 17(1), 2009
PMID: 18595745

Mapping proteolytic cancer cell-extracellular matrix interfaces.
Wolf K, Friedl P., Clin Exp Metastasis 26(4), 2009
PMID: 18600304

Osteochondral injury increases type II collagen degradation products (C2C) in synovial fluid of Thoroughbred racehorses.
Trumble TN, Scarbrough AB, Brown MP., Osteoarthritis Cartilage 17(3), 2009
PMID: 18799328

Skeletal unloading induces a full-thickness patellar cartilage defect with increase of urinary collagen II CTx degradation marker in growing rats.
Tomiya M, Fujikawa K, Ichimura S, Kikuchi T, Yoshihara Y, Nemoto K., Bone 44(2), 2009
PMID: 19000792

Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus.
McNulty AL, Weinberg JB, Guilak F., Clin Orthop Relat Res 467(6), 2009
PMID: 18975039

Inhibition of glycosaminoglycan incorporation influences collagen network formation during cartilage matrix production.
Bastiaansen-Jenniskens YM, Koevoet W, Jansen KM, Verhaar JA, DeGroot J, VanOsch GJ., Biochem Biophys Res Commun 379(2), 2009
PMID: 19101519

Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice.
Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D., J Bone Miner Res 24(1), 2009
PMID: 18767925

Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial.
Brown JP, Prince RL, Deal C, Recker RR, Kiel DP, de Gregorio LH, Hadji P, Hofbauer LC, Alvaro-Gracia JM, Wang H, Austin M, Wagman RB, Newmark R, Libanati C, San Martin J, Bone HG., J Bone Miner Res 24(1), 2009
PMID: 18767928

The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy.
Jansen NW, Roosendaal G, Lundin B, Heijnen L, Mauser-Bunschoten E, Bijlsma JW, Theobald M, Lafeber FP., Arthritis Rheum 60(1), 2009
PMID: 19116938

Over-expression of c-maf by chondrocytes in osteoarthritis.
Li T, Xiao J, Wu Z, Qiu G., J Int Med Res 37(1), 2009
PMID: 19215682

Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes.
Wang X, Song Y, Jacobi JL, Tuan RS., Growth Factors 27(1), 2009
PMID: 19107653

Proteoglycan production is required in initial stages of new cartilage matrix formation but inhibits integrative cartilage repair.
Bastiaansen-Jenniskens YM, Koevoet W, Feijt C, Bos PK, Verhaar JA, Van Osch GJ, DeGroot J., J Tissue Eng Regen Med 3(2), 2009
PMID: 19160351

Involvement of the Notch pathway in the regulation of matrix metalloproteinase 13 and the dedifferentiation of articular chondrocytes in murine cartilage.
Blaise R, Mahjoub M, Salvat C, Barbe U, Brou C, Corvol MT, Savouret JF, Rannou F, Berenbaum F, Bausero P., Arthritis Rheum 60(2), 2009
PMID: 19180482

Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix.
Loeser RF., Osteoarthritis Cartilage 17(8), 2009
PMID: 19303469

Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis.
Chabane N, Zayed N, Benderdour M, Martel-Pelletier J, Pelletier JP, Duval N, Fahmi H., Arthritis Res Ther 11(2), 2009
PMID: 19296842

Relationship between biochemical markers and radiographic scores in the evaluation of the osteoarticular status of Warmblood stallions.
Verwilghen D, Busoni V, Gangl M, Franck T, Lejeune JP, Vanderheyden L, Detilleux J, Grulke S, Deberg M, Henrotin Y, Serteyn D., Res Vet Sci 87(2), 2009
PMID: 19298987

Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritis.
Sakao K, Takahashi KA, Arai Y, Saito M, Honjo K, Hiraoka N, Asada H, Shin-Ya M, Imanishi J, Mazda O, Kubo T., J Bone Miner Metab 27(4), 2009
PMID: 19333684

Evaluation of a magnetic resonance biomarker of osteoarthritis disease progression: doxycycline slows tibial cartilage loss in the Dunkin Hartley guinea pig.
Bowyer J, Heapy CG, Flannelly JK, Waterton JC, Maciewicz RA., Int J Exp Pathol 90(2), 2009
PMID: 19335556

Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study.
Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM., Arthritis Rheum 60(5), 2009
PMID: 19404937

Discoidin domain receptor 2 is associated with the increased expression of matrix metalloproteinase-13 in synovial fibroblasts of rheumatoid arthritis.
Su J, Yu J, Ren T, Zhang W, Zhang Y, Liu X, Sun T, Lu H, Miyazawa K, Yao L., Mol Cell Biochem 330(1-2), 2009
PMID: 19415460

Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression.
Kisiday JD, Lee JH, Siparsky PN, Frisbie DD, Flannery CR, Sandy JD, Grodzinsky AJ., Ann Biomed Eng 37(7), 2009
PMID: 19415495

Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene.
Boumah CE, Lee M, Selvamurugan N, Shimizu E, Partridge NC., Mol Endocrinol 23(8), 2009
PMID: 19423655

Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage.
Wu Q, Huang JH, Sampson ER, Kim KO, Zuscik MJ, O'Keefe RJ, Chen D, Rosier RN., Exp Cell Res 315(14), 2009
PMID: 19481076

Neoepitopes reveal the features of type II collagen cleavage and the identity of a collagenase involved in the transformation of the epiphyses anlagen in development.
Lee ER, Lamplugh L, Kluczyk B, Leblond CP, Mort JS., Dev Dyn 238(6), 2009
PMID: 19441084

Advanced osteoarthritis in humans is associated with altered collagen VI expression and upregulation of ER-stress markers Grp78 and bag-1.
Nugent AE, Speicher DM, Gradisar I, McBurney DL, Baraga A, Doane KJ, Horton WE., J Histochem Cytochem 57(10), 2009
PMID: 19546472

A new class of potent matrix metalloproteinase 13 inhibitors for potential treatment of osteoarthritis: Evidence of histologic and clinical efficacy without musculoskeletal toxicity in rat models.
Baragi VM, Becher G, Bendele AM, Biesinger R, Bluhm H, Boer J, Deng H, Dodd R, Essers M, Feuerstein T, Gallagher BM, Gege C, Hochgürtel M, Hofmann M, Jaworski A, Jin L, Kiely A, Korniski B, Kroth H, Nix D, Nolte B, Piecha D, Powers TS, Richter F, Schneider M, Steeneck C, Sucholeiki I, Taveras A, Timmermann A, Van Veldhuizen J, Weik J, Wu X, Xia B., Arthritis Rheum 60(7), 2009
PMID: 19565489

Measures of molecular composition and structure in osteoarthritis.
Burstein D, Gray M, Mosher T, Dardzinski B., Radiol Clin North Am 47(4), 2009
PMID: 19631075

Up-regulation of alveolar macrophage matrix metalloproteinases in HIV1(+) smokers with early emphysema.
Kaner RJ, Santiago F, Crystal RG., J Leukoc Biol 86(4), 2009
PMID: 19605697

Fourier transform-second-harmonic generation imaging of biological tissues.
Rao RA, Mehta MR, Toussaint KC., Opt Express 17(17), 2009
PMID: 19687932

Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation.
Clutterbuck AL, Mobasheri A, Shakibaei M, Allaway D, Harris P., Ann N Y Acad Sci 1171(), 2009
PMID: 19723086

Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors.
Heim-Riether A, Taylor SJ, Liang S, Gao DA, Xiong Z, Michael August E, Collins BK, Farmer BT, Haverty K, Hill-Drzewi M, Junker HD, Mariana Margarit S, Moss N, Neumann T, Proudfoot JR, Keenan LS, Sekul R, Zhang Q, Li J, Farrow NA., Bioorg Med Chem Lett 19(18), 2009
PMID: 19692239

Treatment with ephrin B2 positively impacts the abnormal metabolism of human osteoarthritic chondrocytes.
Kwan Tat S, Pelletier JP, Amiable N, Boileau C, Lavigne M, Martel-Pelletier J., Arthritis Res Ther 11(4), 2009
PMID: 19664212

The effect of early hyaluronic acid delivery on the development of an acute articular cartilage lesion in a sheep model.
Kaplan LD, Lu Y, Snitzer J, Nemke B, Hao Z, Biro S, Albiero W, Stampfli HF, Markel M, Popkin C, Baum SZ., Am J Sports Med 37(12), 2009
PMID: 19723621

Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro.
Voigt H, Lemke AK, Mentlein R, Schünke M, Kurz B., Arthritis Res Ther 11(5), 2009
PMID: 19778432

Analysing the role of endogenous matrix molecules in the development of osteoarthritis.
Sofat N., Int J Exp Pathol 90(5), 2009
PMID: 19765101

Influence of extracellular matrix on the expression of inflammatory cytokines, proteases, and apoptosis-related genes induced by hydrostatic pressure in three-dimensionally cultured chondrocytes.
Kunitomo T, Takahashi KA, Arai Y, Sakao K, Honjo K, Saito M, Inoue A, Tonomura H, Morihara T, Mazda O, Imanishi J, Kubo T., J Orthop Sci 14(6), 2009
PMID: 19997826

Modulating hedgehog signaling can attenuate the severity of osteoarthritis.
Lin AC, Seeto BL, Bartoszko JM, Khoury MA, Whetstone H, Ho L, Hsu C, Ali SA, Alman BA., Nat Med 15(12), 2009
PMID: 19915594

Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes.
Tardif G, Hum D, Pelletier JP, Duval N, Martel-Pelletier J., BMC Musculoskelet Disord 10(), 2009
PMID: 19948051

Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development.
Little CB, Barai A, Burkhardt D, Smith SM, Fosang AJ, Werb Z, Shah M, Thompson EW., Arthritis Rheum 60(12), 2009
PMID: 19950295

Chondroitin sulfate modulation of matrix and inflammatory gene expression in IL-1beta-stimulated chondrocytes--study in hypoxic alginate bead cultures.
Legendre F, Baugé C, Roche R, Saurel AS, Pujol JP., Osteoarthritis Cartilage 16(1), 2008
PMID: 17625924

Contribution of collagen network features to functional properties of engineered cartilage.
Bastiaansen-Jenniskens YM, Koevoet W, de Bart AC, van der Linden JC, Zuurmond AM, Weinans H, Verhaar JA, van Osch GJ, Degroot J., Osteoarthritis Cartilage 16(3), 2008
PMID: 17714957

Biochemical markers of type II collagen breakdown and synthesis are positioned at specific sites in human osteoarthritic knee cartilage.
Bay-Jensen AC, Andersen TL, Charni-Ben Tabassi N, Kristensen PW, Kjaersgaard-Andersen P, Sandell L, Garnero P, Delaissé JM., Osteoarthritis Cartilage 16(5), 2008
PMID: 17950629

Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.
Olivotto E, Borzi RM, Vitellozzi R, Pagani S, Facchini A, Battistelli M, Penzo M, Li X, Flamigni F, Li J, Falcieri E, Facchini A, Marcu KB., Arthritis Rheum 58(1), 2008
PMID: 18163512

Modification of the composition of articular cartilage collagen fibrils with increasing age.
Vaughan-Thomas A, Dudhia J, Bayliss MT, Kadler KE, Duance VC., Connect Tissue Res 49(5), 2008
PMID: 18991091

Effect of a Type II Collagen Fragment on the Expression of Genes of the Extracellular Matrix in Cells of the Intervertebral Disc.
Mwale F, Wang HT, Zukor DJ, Huk OL, Petit A, Antoniou J., Open Orthop J 2(), 2008
PMID: 19461923

Haem oxygenase-1 regulates catabolic and anabolic processes in osteoarthritic chondrocytes.
Guillén M, Megías J, Gomar F, Alcaraz M., J Pathol 214(4), 2008
PMID: 18200630

A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.
Gaggar A, Jackson PL, Noerager BD, O'Reilly PJ, McQuaid DB, Rowe SM, Clancy JP, Blalock JE., J Immunol 180(8), 2008
PMID: 18390751

The type II collagen fragments Helix-II and CTX-II reveal different enzymatic pathways of human cartilage collagen degradation.
Charni-Ben Tabassi N, Desmarais S, Bay-Jensen AC, Delaissé JM, Percival MD, Garnero P., Osteoarthritis Cartilage 16(10), 2008
PMID: 18403221

Changes in synovial fluid and serum biomarkers with exercise and early osteoarthritis in horses.
Frisbie DD, Al-Sobayil F, Billinghurst RC, Kawcak CE, McIlwraith CW., Osteoarthritis Cartilage 16(10), 2008
PMID: 18442931

Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts.
Lu HT, Liang YC, Sheu MT, Ho HO, Lin YT, Hsieh MS, Chen CH., J Cell Biochem 104(1), 2008
PMID: 18080321

Early changes in biomarkers of skeletal metabolism and their association to the occurrence of osteochondrosis (OC) in the horse.
Donabédian M, van Weeren PR, Perona G, Fleurance G, Robert C, Léger S, Bergero D, Lepage O, Martin-Rosset W., Equine Vet J 40(3), 2008
PMID: 18267892

Long-lasting tissue inflammatory processes trigger autoimmune responses to extracellular matrix molecules.
Bei R, Masuelli L, Palumbo C, Tresoldi I, Scardino A, Modesti A., Int Rev Immunol 27(3), 2008
PMID: 18437603

Methods in studying ECM degradation.
Everts V, Buttle DJ., Methods 45(1), 2008
PMID: 18442708

Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-kappaB ligand in cells derived from osteoarthritic subchondral bone.
Sakao K, Takahashi KA, Mazda O, Arai Y, Tonomura H, Inoue A, Saito M, Fujioka M, Takamiya H, Imanishi J, Kubo T., J Orthop Sci 13(3), 2008
PMID: 18528653

Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis.
Ellman MB, An HS, Muddasani P, Im HJ., Gene 420(1), 2008
PMID: 18565695

Diagnostic performance of in vivo 3-T MRI for articular cartilage abnormalities in human osteoarthritic knees using histology as standard of reference.
Saadat E, Jobke B, Chu B, Lu Y, Cheng J, Li X, Ries MD, Majumdar S, Link TM., Eur Radiol 18(10), 2008
PMID: 18491096

Cleavage of type II collagen by cathepsin K in human osteoarthritic cartilage.
Dejica VM, Mort JS, Laverty S, Percival MD, Antoniou J, Zukor DJ, Poole AR., Am J Pathol 173(1), 2008
PMID: 18511517

Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity.
Karsdal MA, Madsen SH, Christiansen C, Henriksen K, Fosang AJ, Sondergaard BC., Arthritis Res Ther 10(3), 2008
PMID: 18513402

A double epitope tag for quantification of recombinant protein using fluorescence resonance energy transfer.
Enomoto K, Uwabe K, Naito S, Onoda J, Yamauchi A, Numata Y, Takemoto H., Anal Biochem 380(2), 2008
PMID: 18570884

Is collagenase-3 (MMP-13) expression in chondrosarcoma of the jaws a true marker for tumor aggressiveness?
Zyada MM, Shamaa AA., Diagn Pathol 3(), 2008
PMID: 18554405

Discovery and development of the N-terminal procollagen type II (NPII) biomarker: a tool for measuring collagen type II synthesis.
Nemirovskiy OV, Sunyer T, Aggarwal P, Abrams M, Hellio Le Graverand MP, Mathews WR., Osteoarthritis Cartilage 16(12), 2008
PMID: 18556223

Streptococcus pyogenes degrades extracellular matrix in chondrocytes via MMP-13.
Sakurai A, Okahashi N, Maruyama F, Ooshima T, Hamada S, Nakagawa I., Biochem Biophys Res Commun 373(3), 2008
PMID: 18586009

Characterization of metalloprotease cleavage products of human articular cartilage.
Zhen EY, Brittain IJ, Laska DA, Mitchell PG, Sumer EU, Karsdal MA, Duffin KL., Arthritis Rheum 58(8), 2008
PMID: 18668564

Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks.
Iliopoulos D, Malizos KN, Oikonomou P, Tsezou A., PLoS One 3(11), 2008
PMID: 19011694

Differences in biomarkers of type II collagen in atrophic and hypertrophic osteoarthritis of the hip: implications for the differing pathobiologies.
Conrozier T, Ferrand F, Poole AR, Verret C, Mathieu P, Ionescu M, Vincent F, Piperno M, Spiegel A, Vignon E., Osteoarthritis Cartilage 15(4), 2007
PMID: 17055306

Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties.
Wilson CG, Palmer AW, Zuo F, Eugui E, Wilson S, Mackenzie R, Sandy JD, Levenston ME., Matrix Biol 26(4), 2007
PMID: 17174540

Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: from in vitro to in vivo.
Nemirovskiy OV, Dufield DR, Sunyer T, Aggarwal P, Welsch DJ, Mathews WR., Anal Biochem 361(1), 2007
PMID: 17187753

Diffusion tensor imaging of native and degenerated human articular cartilage.
Deng X, Farley M, Nieminen MT, Gray M, Burstein D., Magn Reson Imaging 25(2), 2007
PMID: 17275610

Signaling pathways implicated in oncostatin M-induced aggrecanase-1 and matrix metalloproteinase-13 expression in human articular chondrocytes.
El Mabrouk M, Sylvester J, Zafarullah M., Biochim Biophys Acta 1773(3), 2007
PMID: 17208315

Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy.
Tchetina EV, Di Battista JA, Zukor DJ, Antoniou J, Poole AR., Arthritis Res Ther 9(4), 2007
PMID: 17683641

Cartilage markers and their association with cartilage loss on magnetic resonance imaging in knee osteoarthritis: the Boston Osteoarthritis Knee Study.
Hunter DJ, Li J, LaValley M, Bauer DC, Nevitt M, DeGroot J, Poole R, Eyre D, Guermazi A, Gale D, Felson DT., Arthritis Res Ther 9(5), 2007
PMID: 17958892

Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis.
Tchetina EV, Kobayashi M, Yasuda T, Meijers T, Pidoux I, Poole AR., Matrix Biol 26(4), 2007
PMID: 17306969

Collagen biomarkers for arthritis applications.
Birmingham JD, Vilim V, Kraus VB., Biomark Insights 1(), 2007
PMID: 19690637

In search of partners: linking extracellular proteases to substrates.
Overall CM, Blobel CP., Nat Rev Mol Cell Biol 8(3), 2007
PMID: 17299501

Levels of biomarkers correlate with magnetic resonance imaging progression of knee cartilage degeneration: a study on canine.
Qi C, Changlin H., Knee Surg Sports Traumatol Arthrosc 15(7), 2007
PMID: 17641922

Increased collagen and aggrecan degradation with age in the joints of Timp3(-/-) mice.
Sahebjam S, Khokha R, Mort JS., Arthritis Rheum 56(3), 2007
PMID: 17328064

The ratio of type II collagen breakdown to synthesis and its relationship with the progression of knee osteoarthritis.
Cahue S, Sharma L, Dunlop D, Ionescu M, Song J, Lobanok T, King L, Poole AR., Osteoarthritis Cartilage 15(7), 2007
PMID: 17344068

Genistein reduces the production of proinflammatory molecules in human chondrocytes.
Hooshmand S, Soung do Y, Lucas EA, Madihally SV, Levenson CW, Arjmandi BH., J Nutr Biochem 18(9), 2007
PMID: 17368882

Monitoring cartilage turnover.
Charni-Ben Tabassi N, Garnero P., Curr Rheumatol Rep 9(1), 2007
PMID: 17437662

Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle.
Temple MM, Bae WC, Chen MQ, Lotz M, Amiel D, Coutts RD, Sah RL., Osteoarthritis Cartilage 15(9), 2007
PMID: 17468016

Global analyses of gene expression in early experimental osteoarthritis.
Appleton CT, Pitelka V, Henry J, Beier F., Arthritis Rheum 56(6), 2007
PMID: 17530714

Evidence that estrogen receptor beta enhances MMP-13 promoter activity in HIG-82 cells and that this enhancement can be influenced by ligands and involves specific promoter sites.
Lu T, Achari Y, Rattner JB, Hart DA., Biochem Cell Biol 85(3), 2007
PMID: 17612627

Mechanisms of disease: role of chondrocytes in the pathogenesis of osteoarthritis--structure, chaos and senescence.
Aigner T, Söder S, Gebhard PM, McAlinden A, Haag J., Nat Clin Pract Rheumatol 3(7), 2007
PMID: 17599073

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.
Wolf K, Wu YI, Liu Y, Geiger J, Tam E, Overall C, Stack MS, Friedl P., Nat Cell Biol 9(8), 2007
PMID: 17618273

Type II collagen markers in osteoarthritis: what do they indicate?
Henrotin Y, Addison S, Kraus V, Deberg M., Curr Opin Rheumatol 19(5), 2007
PMID: 17762609

Early changes in serum type II collagen biomarkers predict radiographic progression at one year in inflammatory arthritis patients after biologic therapy.
Mullan RH, Matthews C, Bresnihan B, FitzGerald O, King L, Poole AR, Fearon U, Veale DJ., Arthritis Rheum 56(9), 2007
PMID: 17763421

Potent, selective spiropyrrolidine pyrimidinetrione inhibitors of MMP-13.
Freeman-Cook KD, Reiter LA, Noe MC, Antipas AS, Danley DE, Datta K, Downs JT, Eisenbeis S, Eskra JD, Garmene DJ, Greer EM, Griffiths RJ, Guzman R, Hardink JR, Janat F, Jones CS, Martinelli GJ, Mitchell PG, Laird ER, Liras JL, Lopresti-Morrow LL, Pandit J, Reilly UD, Robertson D, Vaughn-Bowser ML, Wolf-Gouviea LA, Yocum SA., Bioorg Med Chem Lett 17(23), 2007
PMID: 17935984

The chemical biomarkers C2C, Coll2-1, and Coll2-1NO2 provide complementary information on type II collagen catabolism in healthy and osteoarthritic mice.
Ameye LG, Deberg M, Oliveira M, Labasse A, Aeschlimann JM, Henrotin Y., Arthritis Rheum 56(10), 2007
PMID: 17907187

Expression of ADAMTS4 (aggrecanase-1) in human osteoarthritic cartilage.
Naito S, Shiomi T, Okada A, Kimura T, Chijiiwa M, Fujita Y, Yatabe T, Komiya K, Enomoto H, Fujikawa K, Okada Y., Pathol Int 57(11), 2007
PMID: 17922681

Urinary TIINE concentrations in a randomized controlled trial of doxycycline in knee osteoarthritis: implications of the lack of association between TIINE levels and joint space narrowing.
Otterness IG, Brandt KD, Le Graverand MP, Mazzuca SA., Arthritis Rheum 56(11), 2007
PMID: 17968918

Human nasal cartilage responds to oncostatin M in combination with interleukin 1 or tumour necrosis factor alpha by the release of collagen fragments via collagenases.
Morgan TG, Rowan AD, Dickinson SC, Jones D, Hollander AP, Deehan D, Cawston TE., Ann Rheum Dis 65(2), 2006
PMID: 15975972

Novel p38 mitogen-activated protein kinase inhibitor R-130823 protects cartilage by down-regulating matrix metalloproteinase-1,-13 and prostaglandin E2 production in human chondrocytes.
Wada Y, Shimada K, Sugimoto K, Kimura T, Ushiyama S., Int Immunopharmacol 6(2), 2006
PMID: 16399619

Maturational differences in superficial and deep zone articular chondrocytes.
Hidaka C, Cheng C, Alexandre D, Bhargava M, Torzilli PA., Cell Tissue Res 323(1), 2006
PMID: 16133144

Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament.
Nelson F, Billinghurst RC, Pidoux I, Reiner A, Langworthy M, McDermott M, Malogne T, Sitler DF, Kilambi NR, Lenczner E, Poole AR., Osteoarthritis Cartilage 14(2), 2006
PMID: 16242972

Induction of MMP-13 expression by soluble human glucocorticoid-induced tumor necrosis factor receptor in fibroblast-like synovial cells.
Kim SJ, Shin HH, Park SY, Lee DS, Lee EA, Cho SD, Cho HR, Miyazawa K, Choi HS., Osteoarthritis Cartilage 14(2), 2006
PMID: 16242974

Review: Collagen markers in early arthritic diseases.
Elsaid KA, Chichester CO., Clin Chim Acta 365(1-2), 2006
PMID: 16257399

Urinary levels of type II collagen C-telopeptide crosslink are unrelated to joint space narrowing in patients with knee osteoarthritis.
Mazzuca SA, Brandt KD, Eyre DR, Katz BP, Askew J, Lane KA., Ann Rheum Dis 65(8), 2006
PMID: 16339292

A hypothesis for the origin and pathogenesis of rheumatoid diseases.
Lorenz W, Sigrist G, Shakibaei M, Mobasheri A, Trautmann C., Rheumatol Int 26(7), 2006
PMID: 16362367

Production of lipid peroxidation products in osteoarthritic tissues: new evidence linking 4-hydroxynonenal to cartilage degradation.
Morquette B, Shi Q, Lavigne P, Ranger P, Fernandes JC, Benderdour M., Arthritis Rheum 54(1), 2006
PMID: 16385544

Collagen and proteoglycan turnover in focally damaged human ankle cartilage: evidence for a generalized response and active matrix remodeling across the entire joint surface.
Aurich M, Mwale F, Reiner A, Mollenhauer JA, Anders JO, Fuhrmann RA, Kuettner KE, Poole AR, Cole AA., Arthritis Rheum 54(1), 2006
PMID: 16388531

Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production.
Tchetina EV, Antoniou J, Tanzer M, Zukor DJ, Poole AR., Am J Pathol 168(1), 2006
PMID: 16400016

Collagen degradation products modulate matrix metalloproteinase expression in cultured articular chondrocytes.
Fichter M, Körner U, Schömburg J, Jennings L, Cole AA, Mollenhauer J., J Orthop Res 24(1), 2006
PMID: 16419970

A novel approach to measure the contribution of matrix metalloproteinase in the overall net proteolytic activity present in synovial fluids of patients with arthritis.
Simard N, Boire G, de Brum-Fernandes AJ, St-Pierre Y., Arthritis Res Ther 8(4), 2006
PMID: 16859524

Cartilage destruction by matrix degradation products.
Yasuda T., Mod Rheumatol 16(4), 2006
PMID: 16906368

Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation.
Monfort J, Garcia-Giralt N, López-Armada MJ, Monllau JC, Bonilla A, Benito P, Blanco FJ., Arthritis Res Ther 8(5), 2006
PMID: 16972994

Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site.
Monfort J, Tardif G, Reboul P, Mineau F, Roughley P, Pelletier JP, Martel-Pelletier J., Arthritis Res Ther 8(1), 2006
PMID: 16507124

Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis.
Verstappen SM, Poole AR, Ionescu M, King LE, Abrahamowicz M, Hofman DM, Bijlsma JW, Lafeber FP, Utrecht Rheumatoid Arthritis Cohort Study group (SRU)., Arthritis Res Ther 8(1), 2006
PMID: 16507130

Causes of mechanically induced collagen damage in articular cartilage.
Wilson W, van Burken C, van Donkelaar C, Buma P, van Rietbergen B, Huiskes R., J Orthop Res 24(2), 2006
PMID: 16435355

Retinoic acid and oncostatin M combine to promote cartilage degradation via matrix metalloproteinase-13 expression in bovine but not human chondrocytes.
Shingleton WD, Jones D, Xu X, Cawston TE, Rowan AD., Rheumatology (Oxford) 45(8), 2006
PMID: 16467367

Enhanced production of MMP-1, MMP-3, MMP-13, and RANTES by interaction of chondrocytes with autologous T cells.
Nakamura H, Tanaka M, Masuko-Hongo K, Yudoh K, Kato T, Beppu M, Nishioka K., Rheumatol Int 26(11), 2006
PMID: 16468043

Matrix metalloproteinase-13 influences ERK signalling in articular rabbit chondrocytes.
Raggatt LJ, Jefcoat SC, Choudhury I, Williams S, Tiku M, Partridge NC., Osteoarthritis Cartilage 14(7), 2006
PMID: 16516501

Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M.
Catterall JB, Rowan AD, Sarsfield S, Saklatvala J, Wait R, Cawston TE., Rheumatology (Oxford) 45(9), 2006
PMID: 16567360

Biochemical and functional modulation of the cartilage collagen network by IGF1, TGFbeta2 and FGF2.
Jenniskens YM, Koevoet W, de Bart AC, Weinans H, Jahr H, Verhaar JA, DeGroot J, van Osch GJ., Osteoarthritis Cartilage 14(11), 2006
PMID: 16730198

The expression of collagenase 3 (MMP-13) mRNA in the synovial tissue is associated with histopathologic type II synovitis in rheumatoid arthritis.
Wernicke D, Seyfert C, Gromnica-Ihle E, Stiehl P., Autoimmunity 39(4), 2006
PMID: 16891219

Peptides of type II collagen can induce the cleavage of type II collagen and aggrecan in articular cartilage.
Yasuda T, Tchetina E, Ohsawa K, Roughley PJ, Wu W, Mousa A, Ionescu M, Pidoux I, Poole AR., Matrix Biol 25(7), 2006
PMID: 16919430

Biomarkers in spondyloarthritis.
Na KS, Kim TH, Inman RD., Curr Rheumatol Rep 8(4), 2006
PMID: 16839507

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.
Kamekura S, Kawasaki Y, Hoshi K, Shimoaka T, Chikuda H, Maruyama Z, Komori T, Sato S, Takeda S, Karsenty G, Nakamura K, Chung UI, Kawaguchi H., Arthritis Rheum 54(8), 2006
PMID: 16868966

Identification in human osteoarthritic chondrocytes of proteins binding to the novel regulatory site AGRE in the human matrix metalloprotease 13 proximal promoter.
Fan Z, Tardif G, Boileau C, Bidwell JP, Geng C, Hum D, Watson A, Pelletier JP, Lavigne M, Martel-Pelletier J., Arthritis Rheum 54(8), 2006
PMID: 16868967

Effects of moving training on histology and biomarkers levels of articular cartilage.
Qi C, Changlin H., J Surg Res 135(2), 2006
PMID: 16904690

Biochemistry of amino acid racemization and clinical application to musculoskeletal disease.
McCudden CR, Kraus VB., Clin Biochem 39(12), 2006
PMID: 17046734

Potent, selective pyrimidinetrione-based inhibitors of MMP-13.
Reiter LA, Freeman-Cook KD, Jones CS, Martinelli GJ, Antipas AS, Berliner MA, Datta K, Downs JT, Eskra JD, Forman MD, Greer EM, Guzman R, Hardink JR, Janat F, Keene NF, Laird ER, Liras JL, Lopresti-Morrow LL, Mitchell PG, Pandit J, Robertson D, Sperger D, Vaughn-Bowser ML, Waller DM, Yocum SA., Bioorg Med Chem Lett 16(22), 2006
PMID: 16942871

A critical role for the membrane-type 1 matrix metalloproteinase in collagen phagocytosis.
Lee H, Overall CM, McCulloch CA, Sodek J., Mol Biol Cell 17(11), 2006
PMID: 16971509

Development of partial thickness articular cartilage injury in an ovine model.
Lu Y, Markel MD, Swain C, Kaplan LD., J Orthop Res 24(10), 2006
PMID: 16894593

Interleukin-1alpha induction of tensile weakening associated with collagen degradation in bovine articular cartilage.
Temple MM, Xue Y, Chen MQ, Sah RL., Arthritis Rheum 54(10), 2006
PMID: 17009261

Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs.
Stoker AM, Cook JL, Kuroki K, Fox DB., J Orthop Surg Res 1(), 2006
PMID: 17150128

Application of biomarkers in the clinical development of new drugs for chondroprotection in destructive joint diseases: a review.
Sumer EU, Schaller S, Sondergaard BC, Tankó LB, Qvist P., Biomarkers 11(6), 2006
PMID: 17056470

Repeated intraarticular injections of triamcinolone acetonide alter cartilage matrix metabolism measured by biomarkers in synovial fluid.
Céleste C, Ionescu M, Robin Poole A, Laverty S., J Orthop Res 23(3), 2005
PMID: 15885481

MMP-3 and -8 expression is found in the condylar surface of temporomandibular joints with internal derangement.
Tiilikainen P, Pirttiniemi P, Kainulainen T, Pernu H, Raustia A., J Oral Pathol Med 34(1), 2005
PMID: 15610405

Differential matrix degradation and turnover in early cartilage lesions of human knee and ankle joints.
Aurich M, Squires GR, Reiner A, Mollenhauer JA, Kuettner KE, Poole AR, Cole AA., Arthritis Rheum 52(1), 2005
PMID: 15641059

Role of interleukin-1 and tumor necrosis factor alpha in matrix degradation of human osteoarthritic cartilage.
Kobayashi M, Squires GR, Mousa A, Tanzer M, Zukor DJ, Antoniou J, Feige U, Poole AR., Arthritis Rheum 52(1), 2005
PMID: 15641080

Effect of inhibition of matrix metalloproteinases on cartilage loss in vitro and in a guinea pig model of osteoarthritis.
Sabatini M, Lesur C, Thomas M, Chomel A, Anract P, de Nanteuil G, Pastoureau P., Arthritis Rheum 52(1), 2005
PMID: 15641085

Fourier transform infrared imaging spectroscopy analysis of collagenase-induced cartilage degradation.
West PA, Torzilli PA, Chen C, Lin P, Camacho NP., J Biomed Opt 10(1), 2005
PMID: 15847596

Anatomical localization of cartilage degradation markers in a surgically induced rat osteoarthritis model.
Wancket LM, Baragi V, Bove S, Kilgore K, Korytko PJ, Guzman RE., Toxicol Pathol 33(4), 2005
PMID: 16036866

Analysis for the major contributor of collagenase to the primary cleavage of type II collagens in cartilage degradation.
Yoshida M, Tsuji M, Funasaki H, Kan I, Fujii K., Mod Rheumatol 15(3), 2005
PMID: 17029059

Repression of anti-proliferative factor Tob1 in osteoarthritic cartilage.
Gebauer M, Saas J, Haag J, Dietz U, Takigawa M, Bartnik E, Aigner T., Arthritis Res Ther 7(2), 2005
PMID: 15743474

Increase in degraded collagen type II in synovial fluid early in the rabbit meniscectomy model of osteoarthritis.
Lindhorst E, Wachsmuth L, Kimmig N, Raiss R, Aigner T, Atley L, Eyre D., Osteoarthritis Cartilage 13(2), 2005
PMID: 15694575

Pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, reduces the progression of experimental osteoarthritis in guinea pigs.
Kobayashi T, Notoya K, Naito T, Unno S, Nakamura A, Martel-Pelletier J, Pelletier JP., Arthritis Rheum 52(2), 2005
PMID: 15692987

Histologic evaluation of temporomandibular arthritis induced by mild mechanical loading in rabbits.
Fujimura K, Kobayashi S, Suzuki T, Segami N., J Oral Pathol Med 34(3), 2005
PMID: 15689229

New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis.
Deberg M, Labasse A, Christgau S, Cloos P, Bang Henriksen D, Chapelle JP, Zegels B, Reginster JY, Henrotin Y., Osteoarthritis Cartilage 13(3), 2005
PMID: 15727893

Rehabilitation after anterior cruciate ligament reconstruction: a prospective, randomized, double-blind comparison of programs administered over 2 different time intervals.
Beynnon BD, Uh BS, Johnson RJ, Abate JA, Nichols CE, Fleming BC, Poole AR, Roos H., Am J Sports Med 33(3), 2005
PMID: 15716250

Cartilage biomarkers in ankylosing spondylitis: relationship to clinical variables and treatment response.
Kim TH, Stone M, Payne U, Zhang X, Ionescu M, Lobanok T, King L, Poole AR, Inman RD., Arthritis Rheum 52(3), 2005
PMID: 15751093

Functional imaging of pericellular proteolysis in cancer cell invasion.
Wolf K, Friedl P., Biochimie 87(3-4), 2005
PMID: 15781318

The role of glucosamine and chondroitin sulfate in treatment for and prevention of osteoarthritis in animals.
Neil KM, Caron JP, Orth MW., J Am Vet Med Assoc 226(7), 2005
PMID: 15825732

Reduction of arthritis severity in protease-activated receptor-deficient mice.
Yang YH, Hall P, Little CB, Fosang AJ, Milenkovski G, Santos L, Xue J, Tipping P, Morand EF., Arthritis Rheum 52(4), 2005
PMID: 15818676

Effect of oral glucosamine on cartilage degradation in a rabbit model of osteoarthritis.
Tiraloche G, Girard C, Chouinard L, Sampalis J, Moquin L, Ionescu M, Reiner A, Poole AR, Laverty S., Arthritis Rheum 52(4), 2005
PMID: 15818693

Urinary type II collagen helical peptide (HELIX-II) as a new biochemical marker of cartilage degradation in patients with osteoarthritis and rheumatoid arthritis.
Charni N, Juillet F, Garnero P., Arthritis Rheum 52(4), 2005
PMID: 15818703

Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes.
Liacini A, Sylvester J, Li WQ, Zafarullah M., Arthritis Res Ther 7(4), 2005
PMID: 15987479

Localization of matrix metalloproteinases, (MMPs) their tissue inhibitors, and vascular endothelial growth factor (VEGF) in growth plates of children and adolescents indicates a role for MMPs in human postnatal growth and skeletal maturation.
Haeusler G, Walter I, Helmreich M, Egerbacher M., Calcif Tissue Int 76(5), 2005
PMID: 15868281

Effect of tissue maturity on cell viability in load-injured articular cartilage explants.
Levin AS, Chen CT, Torzilli PA., Osteoarthritis Cartilage 13(6), 2005
PMID: 15922183

Osteoarthritis development in novel experimental mouse models induced by knee joint instability.
Kamekura S, Hoshi K, Shimoaka T, Chung U, Chikuda H, Yamada T, Uchida M, Ogata N, Seichi A, Nakamura K, Kawaguchi H., Osteoarthritis Cartilage 13(7), 2005
PMID: 15896985

Levels of matrix metalloproteinase (MMP)-1 in paired sera and synovial fluids of juvenile idiopathic arthritis patients: relationship to inflammatory activity, MMP-3 and tissue inhibitor of metalloproteinases-1 in a longitudinal study.
Peake NJ, Khawaja K, Myers A, Jones D, Cawston TE, Rowan AD, Foster HE., Rheumatology (Oxford) 44(11), 2005
PMID: 16049050

Gene expression profiling of serum- and interleukin-1 beta-stimulated primary human adult articular chondrocytes--a molecular analysis based on chondrocytes isolated from one donor.
Aigner T, McKenna L, Zien A, Fan Z, Gebhard PM, Zimmer R., Cytokine 31(3), 2005
PMID: 15955710

Osteoarthritis: an overview of the disease and its treatment strategies.
Sarzi-Puttini P, Cimmino MA, Scarpa R, Caporali R, Parazzini F, Zaninelli A, Atzeni F, Canesi B., Semin Arthritis Rheum 35(1 suppl 1), 2005
PMID: 16084227

The presence of molecular markers of in vivo lipid peroxidation in osteoarthritic cartilage: a pathogenic role in osteoarthritis.
Shah R, Raska K, Tiku ML., Arthritis Rheum 52(9), 2005
PMID: 16145669

Increased matrix metalloproteinase-13 production with aging by human articular chondrocytes in response to catabolic stimuli.
Forsyth CB, Cole A, Murphy G, Bienias JL, Im HJ, Loeser RF., J Gerontol A Biol Sci Med Sci 60(9), 2005
PMID: 16183949

One-year increase of Coll 2-1, a new marker of type II collagen degradation, in urine is highly predictive of radiological OA progression.
Deberg MA, Labasse AH, Collette J, Seidel L, Reginster JY, Henrotin YE., Osteoarthritis Cartilage 13(12), 2005
PMID: 16154771

Collagen biosynthesis of mechanically loaded articular cartilage explants.
Ackermann B, Steinmeyer J., Osteoarthritis Cartilage 13(10), 2005
PMID: 16129631

Squaric acid-based peptidic inhibitors of matrix metalloprotease-1.
Onaran MB, Comeau AB, Seto CT., J Org Chem 70(26), 2005
PMID: 16356002

Characterization of cells from pannus-like tissue over articular cartilage of advanced osteoarthritis.
Yuan GH, Tanaka M, Masuko-Hongo K, Shibakawa A, Kato T, Nishioka K, Nakamura H., Osteoarthritis Cartilage 12(1), 2004
PMID: 14697681

Requirement of mitogen-activated protein kinase for collagenase production by the fibronectin fragment in human articular chondrocytes in culture.
Yasuda T, Julovi SM, Hiramitsu T, Yoshida M, Nakamura T., Mod Rheumatol 14(1), 2004
PMID: 17028806

Ten years in the life of an enzyme: the story of the human MMP-13 (collagenase-3).
Tardif G, Reboul P, Pelletier JP, Martel-Pelletier J., Mod Rheumatol 14(3), 2004
PMID: 17143675

Inhibition of interleukin-1beta-stimulated production of matrix metalloproteinases by hyaluronan via CD44 in human articular cartilage.
Julovi SM, Yasuda T, Shimizu M, Hiramitsu T, Nakamura T., Arthritis Rheum 50(2), 2004
PMID: 14872494

Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis.
Matyas JR, Atley L, Ionescu M, Eyre DR, Poole AR., Arthritis Rheum 50(2), 2004
PMID: 14872497

Evaluation of serum concentrations of biomarkers of skeletal metabolism and results of radiography as indicators of severity of osteochondrosis in foals.
Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, McIlwraith CW., Am J Vet Res 65(2), 2004
PMID: 14974569

Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury.
DiMicco MA, Patwari P, Siparsky PN, Kumar S, Pratta MA, Lark MW, Kim YJ, Grodzinsky AJ., Arthritis Rheum 50(3), 2004
PMID: 15022326

A type XI collagen mutation leads to increased degradation of type II collagen in articular cartilage.
Rodriguez RR, Seegmiller RE, Stark MR, Bridgewater LC., Osteoarthritis Cartilage 12(4), 2004
PMID: 15023383

Fourier transform infrared spectral analysis of degenerative cartilage: an infrared fiber optic probe and imaging study.
West PA, Bostrom MP, Torzilli PA, Camacho NP., Appl Spectrosc 58(4), 2004
PMID: 15104805

Differential induction and regulation of matrix metalloproteinases in osteoarthritic tissue and fluid synovial fibroblasts.
Fuchs S, Skwara A, Bloch M, Dankbar B., Osteoarthritis Cartilage 12(5), 2004
PMID: 15094140

Assessment of cellular, biochemical, and histologic effects of bipolar radiofrequency treatment of canine articular cartilage.
Cook JL, Marberry KM, Kuroki K, Kenter K., Am J Vet Res 65(5), 2004
PMID: 15141880

Adenovirus mediated intra-articular expression of collagenase-3 (MMP-13) induces inflammatory arthritis in mice.
Joronen K, Ala-aho R, Majuri ML, Alenius H, Kähäri VM, Vuorio E., Ann Rheum Dis 63(6), 2004
PMID: 15140772

Protease degradomics: mass spectrometry discovery of protease substrates and the CLIP-CHIP, a dedicated DNA microarray of all human proteases and inhibitors.
Overall CM, Tam EM, Kappelhoff R, Connor A, Ewart T, Morrison CJ, Puente X, López-Otín C, Seth A., Biol Chem 385(6), 2004
PMID: 15255181

Pro-MMP-9 is a specific macrophage product and is activated by osteoarthritic chondrocytes via MMP-3 or a MT1-MMP/MMP-13 cascade.
Dreier R, Grässel S, Fuchs S, Schaumburger J, Bruckner P., Exp Cell Res 297(2), 2004
PMID: 15212936

Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Reiter LA, Robinson RP, McClure KF, Jones CS, Reese MR, Mitchell PG, Otterness IG, Bliven ML, Liras J, Cortina SR, Donahue KM, Eskra JD, Griffiths RJ, Lame ME, Lopez-Anaya A, Martinelli GJ, McGahee SM, Yocum SA, Lopresti-Morrow LL, Tobiassen LM, Vaughn-Bowser ML., Bioorg Med Chem Lett 14(13), 2004
PMID: 15177439

Matrix metalloproteinases as modulators of inflammation and innate immunity.
Parks WC, Wilson CL, López-Boado YS., Nat Rev Immunol 4(8), 2004
PMID: 15286728

Transgenic mice expressing selected insulin-like growth factor-binding protein-5 fragments do not exhibit enhanced bone formation.
Durant D, Pereira R, Stadmeyer L, Canalis E., Growth Horm IGF Res 14(4), 2004
PMID: 15231301

Interaction of aldehydes with collagen: effect on thermal, enzymatic and conformational stability.
Fathima NN, Madhan B, Rao JR, Nair BU, Ramasami T., Int J Biol Macromol 34(4), 2004
PMID: 15374680

Detection of aggrecanase- and MMP-generated catabolic neoepitopes in the rat iodoacetate model of cartilage degeneration.
Janusz MJ, Little CB, King LE, Hookfin EB, Brown KK, Heitmeyer SA, Caterson B, Poole AR, Taiwo YO., Osteoarthritis Cartilage 12(9), 2004
PMID: 15325638

Epidermal growth factor receptor-deficient mice have delayed primary endochondral ossification because of defective osteoclast recruitment.
Wang K, Yamamoto H, Chin JR, Werb Z, Vu TH., J Biol Chem 279(51), 2004
PMID: 15456762

Association between spine disc degeneration and type II collagen degradation in postmenopausal women: the OFELY study.
Garnero P, Sornay-Rendu E, Arlot M, Christiansen C, Delmas PD., Arthritis Rheum 50(10), 2004
PMID: 15476251

A study of the relationship between molecular biomarkers of joint degeneration and the magnetic resonance-measured characteristics of cartilage in 16 symptomatic knees.
King KB, Lindsey CT, Dunn TC, Ries MD, Steinbach LS, Majumdar S., Magn Reson Imaging 22(8), 2004
PMID: 15527998

Testican-1, an inhibitor of pro-MMP-2 activation, is expressed in cartilage.
Hausser HJ, Decking R, Brenner RE., Osteoarthritis Cartilage 12(11), 2004
PMID: 15501402

Lectin-like oxidized low-density lipoprotein receptor 1 mediates matrix metalloproteinase 3 synthesis enhanced by oxidized low-density lipoprotein in rheumatoid arthritis cartilage.
Kakinuma T, Yasuda T, Nakagawa T, Hiramitsu T, Akiyoshi M, Akagi M, Sawamura T, Nakamura T., Arthritis Rheum 50(11), 2004
PMID: 15529384

Osteoarthritis and osteoporosis in postmenopausal women: clinical similarities and differences.
Avci D, Bachmann GA., Menopause 11(6 pt 1), 2004
PMID: 15545789

The assessment of cartilage degradation in vivo: development of an immunoassay for the measurement in body fluids of type II collagen cleaved by collagenases.
Poole AR, Ionescu M, Fitzcharles MA, Billinghurst RC., J Immunol Methods 294(1-2), 2004
PMID: 15637808

Effect of matrix depleting agents on the expression of chondrocyte metabolism by equine chondrocytes.
Iqbal J, Bird JL, Hollander AP, Bayliss MT., Res Vet Sci 77(3), 2004
PMID: 15276777

Altered endochondral bone development in matrix metalloproteinase 13-deficient mice.
Stickens D, Behonick DJ, Ortega N, Heyer B, Hartenstein B, Yu Y, Fosang AJ, Schorpp-Kistner M, Angel P, Werb Z., Development 131(23), 2004
PMID: 15539485

Regulation of MMP-13 expression by RUNX2 and FGF2 in osteoarthritic cartilage.
Wang X, Manner PA, Horner A, Shum L, Tuan RS, Nuckolls GH., Osteoarthritis Cartilage 12(12), 2004
PMID: 15564063

Effects of curcumin (diferuloylmethane) on nuclear factor kappaB signaling in interleukin-1beta-stimulated chondrocytes.
Schulze-Tanzil G, Mobasheri A, Sendzik J, John T, Shakibaei M., Ann N Y Acad Sci 1030(), 2004
PMID: 15659840

Drugs in development: bisphosphonates and metalloproteinase inhibitors.
Catterall JB, Cawston TE., Arthritis Res Ther 5(1), 2003
PMID: 12716443

X-ray diffraction of the molecular substructure of human articular cartilage.
Mollenhauer J, Aurich M, Muehleman C, Khelashvilli G, Irving TC., Connect Tissue Res 44(5), 2003
PMID: 14660090

Rapid regulation of collagen but not metalloproteinase 1, 3, 13, 14 and tissue inhibitor of metalloproteinase 1, 2, 3 expression in response to mechanical loading of cartilage explants in vitro.
Fehrenbacher A, Steck E, Rickert M, Roth W, Richter W., Arch Biochem Biophys 410(1), 2003
PMID: 12559975

Cartilage-like gene expression in differentiated human stem cell spheroids: a comparison of bone marrow-derived and adipose tissue-derived stromal cells.
Winter A, Breit S, Parsch D, Benz K, Steck E, Hauner H, Weber RM, Ewerbeck V, Richter W., Arthritis Rheum 48(2), 2003
PMID: 12571852

Metalloproteinases: their role in arthritis and potential as therapeutic targets.
Clark IM, Parker AE., Expert Opin Ther Targets 7(1), 2003
PMID: 12556200

Malondialdehyde oxidation of cartilage collagen by chondrocytes.
Tiku ML, Allison GT, Naik K, Karry SK., Osteoarthritis Cartilage 11(3), 2003
PMID: 12623287

Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathway.
Loeser RF, Forsyth CB, Samarel AM, Im HJ., J Biol Chem 278(27), 2003
PMID: 12730223

The pathobiology of focal lesion development in aging human articular cartilage and molecular matrix changes characteristic of osteoarthritis.
Squires GR, Okouneff S, Ionescu M, Poole AR., Arthritis Rheum 48(5), 2003
PMID: 12746899

Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture.
Yasuda T, Poole AR, Shimizu M, Nakagawa T, Julovi SM, Tamamura H, Fujii N, Nakamura T., Arthritis Rheum 48(5), 2003
PMID: 12746900

Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes.
Im HJ, Pacione C, Chubinskaya S, Van Wijnen AJ, Sun Y, Loeser RF., J Biol Chem 278(28), 2003
PMID: 12734180

Selective inhibition of ADAMTS-1, -4 and -5 by catechin gallate esters.
Vankemmelbeke MN, Jones GC, Fowles C, Ilic MZ, Handley CJ, Day AJ, Knight CG, Mort JS, Buttle DJ., Eur J Biochem 270(11), 2003
PMID: 12755694

Adenoviral gene transfer of interleukin-1 in combination with oncostatin M induces significant joint damage in a murine model.
Rowan AD, Hui W, Cawston TE, Richards CD., Am J Pathol 162(6), 2003
PMID: 12759253

Blockade of advanced glycation end-product formation restores ischemia-induced angiogenesis in diabetic mice.
Tamarat R, Silvestre JS, Huijberts M, Benessiano J, Ebrahimian TG, Duriez M, Wautier MP, Wautier JL, Lévy BI., Proc Natl Acad Sci U S A 100(14), 2003
PMID: 12805564

Early osteoarthritic changes of human femoral head cartilage subsequent to femoro-acetabular impingement.
Wagner S, Hofstetter W, Chiquet M, Mainil-Varlet P, Stauffer E, Ganz R, Siebenrock KA., Osteoarthritis Cartilage 11(7), 2003
PMID: 12814614

Identification and differential expression of human collagenase-3 mRNA species derived from internal deletion, alternative splicing, and different polyadenylation and transcription initiation sites.
Tardif G, Dupuis M, Reboul P, Geng CS, Pelletier JP, Ranger P, Martel-Pelletier J., Osteoarthritis Cartilage 11(7), 2003
PMID: 12814616

Phosphinic acid-based MMP-13 inhibitors that spare MMP-1 and MMP-3.
Reiter LA, Mitchell PG, Martinelli GJ, Lopresti-Morrow LL, Yocum SA, Eskra JD., Bioorg Med Chem Lett 13(14), 2003
PMID: 12824028

Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage.
Chen CT, Bhargava M, Lin PM, Torzilli PA., J Orthop Res 21(5), 2003
PMID: 12919878

The effects of TIMP-1 and -2 on canine chondrocytes cultured in three-dimensional agarose culture system.
Kuroki K, Cook JL, Kreeger JM, Tomlinson JL., Osteoarthritis Cartilage 11(9), 2003
PMID: 12954233

Detection of collagen type II and proteoglycans in the synovial fluids of patients diagnosed with non-infectious knee joint synovitis indicates early damage to the articular cartilage matrix.
Elsaid KA, Jay GD, Chichester CO., Osteoarthritis Cartilage 11(9), 2003
PMID: 12954238

Analysis of matrix metalloproteinase triple-helical peptidase activity with substrates incorporating fluorogenic L- or D-amino acids.
Lauer-Fields JL, Kele P, Sui G, Nagase H, Leblanc RM, Fields GB., Anal Biochem 321(1), 2003
PMID: 12963061

Urinary type II collagen C-telopeptide levels are increased in patients with rapidly destructive hip osteoarthritis.
Garnero P, Conrozier T, Christgau S, Mathieu P, Delmas PD, Vignon E., Ann Rheum Dis 62(10), 2003
PMID: 12972471

Significant exercise-related changes in the serum levels of two biomarkers of collagen metabolism in young horses.
Billinghurst RC, Brama PA, van Weeren PR, Knowlton MS, McIlwraith CW., Osteoarthritis Cartilage 11(10), 2003
PMID: 13129696

Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction.
Roy-Beaudry M, Martel-Pelletier J, Pelletier JP, M'Barek KN, Christgau S, Shipkolye F, Moldovan F., Arthritis Rheum 48(10), 2003
PMID: 14558091

Biochemical/immunochemical biomarkers of osteoarthritis: utility for prediction of incident or progressive osteoarthritis.
Poole AR., Rheum Dis Clin North Am 29(4), 2003
PMID: 14603584

Turnover of type II collagen and aggrecan in cartilage matrix at the onset of inflammatory arthritis in humans: relationship to mediators of systemic and local inflammation.
Fraser A, Fearon U, Billinghurst RC, Ionescu M, Reece R, Barwick T, Emery P, Poole AR, Veale DJ., Arthritis Rheum 48(11), 2003
PMID: 14613270

The release of crosslinked peptides from type II collagen into human synovial fluid is increased soon after joint injury and in osteoarthritis.
Lohmander LS, Atley LM, Pietka TA, Eyre DR., Arthritis Rheum 48(11), 2003
PMID: 14613275

Impairment of the collagenase-3 endocytotic receptor system in cells from patients with osteoarthritis.
Walling HW, Raggatt LJ, Irvine DW, Barmina OY, Toledano JE, Goldring MB, Hruska KA, Adkisson HD, Burdge RE, Gatt CJ, Harwood DA, Partridge NC., Osteoarthritis Cartilage 11(12), 2003
PMID: 14629961

Oncostatin M in combination with tumor necrosis factor alpha induces cartilage damage and matrix metalloproteinase expression in vitro and in vivo.
Hui W, Rowan AD, Richards CD, Cawston TE., Arthritis Rheum 48(12), 2003
PMID: 14673992

Gene deletion of either interleukin-1beta, interleukin-1beta-converting enzyme, inducible nitric oxide synthase, or stromelysin 1 accelerates the development of knee osteoarthritis in mice after surgical transection of the medial collateral ligament and partial medial meniscectomy.
Clements KM, Price JS, Chambers MG, Visco DM, Poole AR, Mason RM., Arthritis Rheum 48(12), 2003
PMID: 14673996

Cartilage viability after repetitive loading: a preliminary report.
Lucchinetti E, Adams CS, Horton WE, Torzilli PA., Osteoarthritis Cartilage 10(1), 2002
PMID: 11795985

Parathyroid hormone-dependent signaling pathways regulating genes in bone cells.
Swarthout JT, D'Alonzo RC, Selvamurugan N, Partridge NC., Gene 282(1-2), 2002
PMID: 11814673

Matrix metalloproteinases as therapeutic targets in arthritic diseases: bull's-eye or missing the mark?
Mengshol JA, Mix KS, Brinckerhoff CE., Arthritis Rheum 46(1), 2002
PMID: 11817584

Stimulation of collagenase 3 expression in synovial fibroblasts of patients with rheumatoid arthritis by contact with a three-dimensional collagen matrix or with normal cartilage when coimplanted in NOD/SCID mice.
Wernicke D, Schulze-Westhoff C, Bräuer R, Petrow P, Zacher J, Gay S, Gromnica-Ihle E., Arthritis Rheum 46(1), 2002
PMID: 11817610

A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathway.
Yasuda T, Poole AR., Arthritis Rheum 46(1), 2002
PMID: 11817586

Tissue inhibitor of metalloproteinases-4 (TIMP-4) gene expression is increased in human osteoarthritic femoral head cartilage.
Huang W, Li WQ, Dehnade F, Zafarullah M., J Cell Biochem 85(2), 2002
PMID: 11948685

Matrix metalloproteinases and collagen catabolism.
Lauer-Fields JL, Juska D, Fields GB., Biopolymers 66(1), 2002
PMID: 12228918

The assembly and remodeling of the extracellular matrix in the growth plate in relationship to mineral deposition and cellular hypertrophy: an in situ study of collagens II and IX and proteoglycan.
Mwale F, Tchetina E, Wu CW, Poole AR., J Bone Miner Res 17(2), 2002
PMID: 11811558

Encounter with unexpected collagenase-1 selective inhibitor: switchover of inhibitor binding pocket induced by fluorine atom.
Sawa M, Kondo H, Nishimura S., Bioorg Med Chem Lett 12(4), 2002
PMID: 11844676

Comparison of collagenase-cleaved articular cartilage collagen in mice in the naturally occurring STR/ort model of osteoarthritis and in collagen-induced arthritis.
Price JS, Chambers MG, Poole AR, Fradin A, Mason RM., Osteoarthritis Cartilage 10(3), 2002
PMID: 11869077

Lack of plasminogen activator inhibitor-1 promotes growth and abnormal matrix remodeling of advanced atherosclerotic plaques in apolipoprotein E-deficient mice.
Luttun A, Lupu F, Storkebaum E, Hoylaerts MF, Moons L, Crawley J, Bono F, Poole AR, Tipping P, Herbert JM, Collen D, Carmeliet P., Arterioscler Thromb Vasc Biol 22(3), 2002
PMID: 11884297

Proteolysis involving matrix metalloproteinase 13 (collagenase-3) is required for chondrocyte differentiation that is associated with matrix mineralization.
Wu CW, Tchetina EV, Mwale F, Hasty K, Pidoux I, Reiner A, Chen J, Van Wart HE, Poole AR., J Bone Miner Res 17(4), 2002
PMID: 11918221

Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes.
Liacini A, Sylvester J, Li WQ, Zafarullah M., Matrix Biol 21(3), 2002
PMID: 12009331

Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation.
Little CB, Hughes CE, Curtis CL, Janusz MJ, Bohne R, Wang-Weigand S, Taiwo YO, Mitchell PG, Otterness IG, Flannery CR, Caterson B., Matrix Biol 21(3), 2002
PMID: 12009333

The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
Stanton H, Ung L, Fosang AJ., Biochem J 364(pt 1), 2002
PMID: 11988091

The effects of immobilization on the characteristics of articular cartilage: current concepts and future directions.
Vanwanseele B, Lucchinetti E, Stüssi E., Osteoarthritis Cartilage 10(5), 2002
PMID: 12027542

Matrix metalloproteinases in arthritic disease.
Murphy G, Knäuper V, Atkinson S, Butler G, English W, Hutton M, Stracke J, Clark I., Arthritis Res 4 Suppl 3(), 2002
PMID: 12110122

Pathologic indicators of degradation and inflammation in human osteoarthritic cartilage are abrogated by exposure to n-3 fatty acids.
Curtis CL, Rees SG, Little CB, Flannery CR, Hughes CE, Wilson C, Dent CM, Otterness IG, Harwood JL, Caterson B., Arthritis Rheum 46(6), 2002
PMID: 12115185

Differential expression patterns of matrix metalloproteinases and their inhibitors during development of osteoarthritis in a transgenic mouse model.
Salminen HJ, Säämänen AM, Vankemmelbeke MN, Auho PK, Perälä MP, Vuorio EI., Ann Rheum Dis 61(7), 2002
PMID: 12079898

Development of selective tolerance to interleukin-1beta by human chondrocytes in vitro.
Lee GM, Tioran ME, Jansen M, Graff RD, Kelley SS, Lin P., J Cell Physiol 192(1), 2002
PMID: 12115742

Detection and analysis of cartilage degeneration by spatially resolved streaming potentials.
Légaré A, Garon M, Guardo R, Savard P, Poole AR, Buschmann MD., J Orthop Res 20(4), 2002
PMID: 12168673

Triple-helical peptide analysis of collagenolytic protease activity.
Lauer-Fields JL, Fields GB., Biol Chem 383(7-8), 2002
PMID: 12437092

Sites of collagenase cleavage and denaturation of type II collagen in aging and osteoarthritic articular cartilage and their relationship to the distribution of matrix metalloproteinase 1 and matrix metalloproteinase 13.
Wu W, Billinghurst RC, Pidoux I, Antoniou J, Zukor D, Tanzer M, Poole AR., Arthritis Rheum 46(8), 2002
PMID: 12209513

Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog.
Chu Q, Lopez M, Hayashi K, Ionescu M, Billinghurst RC, Johnson KA, Poole AR, Markel MD., Osteoarthritis Cartilage 10(8), 2002
PMID: 12479389

Functional genomics of osteoarthritis.
Aigner T, Bartnik E, Zien A, Zimmer R., Pharmacogenomics 3(5), 2002
PMID: 12223049

Immunohistochemical analysis of matrix metalloproteinase-1, -3, and -13 in naturally occurring cartilaginous tumors of dogs.
Kuroki K, Kreeger JM, Cook JL, Tomlinson JL, Johnson GC, Pace LW, Turnquist SE, Turk JR, Ramos JA, Miller MA., Am J Vet Res 63(9), 2002
PMID: 12224862

Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes.
Forsyth CB, Pulai J, Loeser RF., Arthritis Rheum 46(9), 2002
PMID: 12355484

A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis.
Huebner JL, Hanes MA, Beekman B, TeKoppele JM, Kraus VB., Osteoarthritis Cartilage 10(10), 2002
PMID: 12359161

Induction of osteoarthritis in the rat by surgical tear of the meniscus: Inhibition of joint damage by a matrix metalloproteinase inhibitor.
Janusz MJ, Bendele AM, Brown KK, Taiwo YO, Hsieh L, Heitmeyer SA., Osteoarthritis Cartilage 10(10), 2002
PMID: 12359164

Bilateral subchondral cysts without arthroscopic evidence of articular cartilage degradation.
Bradley MP, Provencher MT, Nelson FR., Arthroscopy 18(8), 2002
PMID: 12368801

Can serum biomarker assays measure the progression of cartilage degeneration in osteoarthritis?
Poole AR., Arthritis Rheum 46(10), 2002
PMID: 12384909

Uncoupling of type II collagen synthesis and degradation predicts progression of joint damage in patients with knee osteoarthritis.
Garnero P, Ayral X, Rousseau JC, Christgau S, Sandell LJ, Dougados M, Delmas PD., Arthritis Rheum 46(10), 2002
PMID: 12384919

Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitro.
Bau B, Gebhard PM, Haag J, Knorr T, Bartnik E, Aigner T., Arthritis Rheum 46(10), 2002
PMID: 12384923

Type II collagen degradation and its regulation in articular cartilage in osteoarthritis.
Poole AR, Kobayashi M, Yasuda T, Laverty S, Mwale F, Kojima T, Sakai T, Wahl C, El-Maadawy S, Webb G, Tchetina E, Wu W., Ann Rheum Dis 61 Suppl 2(), 2002
PMID: 12379630

Matrix homeostasis in aging normal human ankle cartilage.
Aurich M, Poole AR, Reiner A, Mollenhauer C, Margulis A, Kuettner KE, Cole AA., Arthritis Rheum 46(11), 2002
PMID: 12428230

Cyclic compression of cartilage/bone explants in vitro leads to physical weakening, mechanical breakdown of collagen and release of matrix fragments.
Thibault M, Poole AR, Buschmann MD., J Orthop Res 20(6), 2002
PMID: 12472239

Excessive degradation of type II collagen in articular cartilage in equine osteochondrosis.
Laverty S, Okouneff S, Ionescu M, Reiner A, Pidoux I, Webber C, Rossier Y, Billinghurst RC, Poole AR., J Orthop Res 20(6), 2002
PMID: 12472241

Expression of matrix metalloproteinases in articular cartilage of temporomandibular and knee joints of mice during growth, maturation, and aging.
Gepstein A, Shapiro S, Arbel G, Lahat N, Livne E., Arthritis Rheum 46(12), 2002
PMID: 12483728

Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in mice.
Neuhold LA, Killar L, Zhao W, Sung ML, Warner L, Kulik J, Turner J, Wu W, Billinghurst C, Meijers T, Poole AR, Babij P, DeGennaro LJ., J Clin Invest 107(1), 2001
PMID: 11134178

Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA.
Downs JT, Lane CL, Nestor NB, McLellan TJ, Kelly MA, Karam GA, Mezes PS, Pelletier JP, Otterness IG., J Immunol Methods 247(1-2), 2001
PMID: 11150534

Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis.
Kojima T, Mwale F, Yasuda T, Girard C, Poole AR, Laverty S., Arthritis Rheum 44(1), 2001
PMID: 11212149

Changes in leucine-rich repeat proteoglycans during maturation of the bovine growth plate.
Alini M, Roughley PJ., Matrix Biol 19(8), 2001
PMID: 11223340

The effects of collagen fragments on the extracellular matrix metabolism of bovine and human chondrocytes.
Jennings L, Wu L, King KB, Hämmerle H, Cs-Szabo G, Mollenhauer J., Connect Tissue Res 42(1), 2001
PMID: 11696990

Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis.
Sandell LJ, Aigner T., Arthritis Res 3(2), 2001
PMID: 11178118

General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.
Chollet AM, Le Diguarher T, Murray L, Bertrand M, Tucker GC, Sabatini M, Pierré A, Atassi G, Bonnet J, Casara P., Bioorg Med Chem Lett 11(3), 2001
PMID: 11212095

The STR/ort mouse and its use as a model of osteoarthritis.
Mason RM, Chambers MG, Flannelly J, Gaffen JD, Dudhia J, Bayliss MT., Osteoarthritis Cartilage 9(2), 2001
PMID: 11237655

Insulin-like growth factor 1 blocks collagen release and down regulates matrix metalloproteinase-1, -3, -8, and -13 mRNA expression in bovine nasal cartilage stimulated with oncostatin M in combination with interleukin 1alpha.
Hui W, Rowan AD, Cawston T., Ann Rheum Dis 60(3), 2001
PMID: 11171688

Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changes.
Tetlow LC, Adlam DJ, Woolley DE., Arthritis Rheum 44(3), 2001
PMID: 11263773

Type IIA procollagen: expression in developing chicken limb cartilage and human osteoarthritic articular cartilage.
Nah HD, Swoboda B, Birk DE, Kirsch T., Dev Dyn 220(4), 2001
PMID: 11307165

A synthetic triterpenoid selectively inhibits the induction of matrix metalloproteinases 1 and 13 by inflammatory cytokines.
Mix KS, Mengshol JA, Benbow U, Vincenti MP, Sporn MB, Brinckerhoff CE., Arthritis Rheum 44(5), 2001
PMID: 11352241

Type II collagen degradation in articular cartilage fibrillation after anterior cruciate ligament transection in rats.
Stoop R, Buma P, van der Kraan PM, Hollander AP, Billinghurst RC, Meijers TH, Poole AR, van den Berg WB., Osteoarthritis Cartilage 9(4), 2001
PMID: 11399094

Stem cell transplantation: limits and hopes.
Machold KP, Smolen JS., Ann Rheum Dis 60(6), 2001
PMID: 11350839

Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage.
Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E., Ann Rheum Dis 60(6), 2001
PMID: 11350852

Markers of joint destruction: principles, problems, and potential.
Young-Min SA, Cawston TE, Griffiths ID., Ann Rheum Dis 60(6), 2001
PMID: 11386253

Accumulation of advanced glycation end products decreases collagen turnover by bovine chondrocytes.
DeGroot J, Verzijl N, Budde M, Bijlsma JW, Lafeber FP, TeKoppele JM., Exp Cell Res 266(2), 2001
PMID: 11399058

Alterations in the sensing and transport of phosphate and calcium by differentiating chondrocytes.
Wang D, Canaff L, Davidson D, Corluka A, Liu H, Hendy GN, Henderson JE., J Biol Chem 276(36), 2001
PMID: 11404353

Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis.
Liu J, Shikhman AR, Lotz MK, Wong CH., Chem Biol 8(7), 2001
PMID: 11451670

Use of an antineoepitope antibody for identification of type-II collagen degradation in equine articular cartilage.
Billinghurst RC, Buxton EM, Edwards MG, McGraw MS, McIlwraith CW., Am J Vet Res 62(7), 2001
PMID: 11453476

Novel proteases for drug discovery.
Moss M., Drug Discov Today 6(15), 2001
PMID: 11470583

ADAM-10 protein is present in human articular cartilage primarily in the membrane-bound form and is upregulated in osteoarthritis and in response to IL-1alpha in bovine nasal cartilage.
Chubinskaya S, Mikhail R, Deutsch A, Tindal MH., J Histochem Cytochem 49(9), 2001
PMID: 11511685

Articular chondrocytes from animals with a dermatan sulfate storage disease undergo a high rate of apoptosis and release nitric oxide and inflammatory cytokines: a possible mechanism underlying degenerative joint disease in the mucopolysaccharidoses.
Simonaro CM, Haskins ME, Schuchman EH., Lab Invest 81(9), 2001
PMID: 11555679

Synovial fluid gelatinase concentrations and matrix metalloproteinase and cytokine expression in naturally occurring joint disease in horses.
Trumble TN, Trotter GW, Oxford JR, McIlwraith CW, Cammarata S, Goodnight JL, Billinghurst RC, Frisbie DD., Am J Vet Res 62(9), 2001
PMID: 11560279

Activation of procollagenases is a key control point in cartilage collagen degradation: interaction of serine and metalloproteinase pathways.
Milner JM, Elliott SF, Cawston TE., Arthritis Rheum 44(9), 2001
PMID: 11592371

IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathways.
Mengshol JA, Vincenti MP, Brinckerhoff CE., Nucleic Acids Res 29(21), 2001
PMID: 11691923

Relationships of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover and inflammation as revealed by analyses of synovial fluids from patients with rheumatoid arthritis.
Ishiguro N, Ito T, Oguchi T, Kojima T, Iwata H, Ionescu M, Poole AR., Arthritis Rheum 44(11), 2001
PMID: 11710706

Age-related decrease in susceptibility of human articular cartilage to matrix metalloproteinase-mediated degradation: the role of advanced glycation end products.
DeGroot J, Verzijl N, Wenting-Van Wijk MJ, Bank RA, Lafeber FP, Bijlsma JW, TeKoppele JM., Arthritis Rheum 44(11), 2001
PMID: 11710713

Matrix turnover in human cartilage repair tissue in autologous chondrocyte implantation.
Roberts S, Hollander AP, Caterson B, Menage J, Richardson JB., Arthritis Rheum 44(11), 2001
PMID: 11710715

Molecular sieving and mass spectroscopy reveal enhanced collagen degradation in rabbit atheroma.
Chen J, Kindt E, Hallak H, Peterson JT, Rosebury WS, Hubbel AM, Bocan TM, Rekhter MD., Atherosclerosis 159(2), 2001
PMID: 11730808

Anabolic and catabolic gene expression pattern analysis in normal versus osteoarthritic cartilage using complementary DNA-array technology.
Aigner T, Zien A, Gehrsitz A, Gebhard PM, McKenna L., Arthritis Rheum 44(12), 2001
PMID: 11762938

Gd-DTPA2)-enhanced MRI of femoral knee cartilage: a dose-response study in healthy volunteers.
Tiderius CJ, Olsson LE, de Verdier H, Leander P, Ekberg O, Dahlberg L., Magn Reson Med 46(6), 2001
PMID: 11746570

A degeneration-based hypothesis for interpreting fibrillar changes in the osteoarthritic cartilage matrix.
Broom N, Chen MH, Hardy A., J Anat 199(pt 6), 2001
PMID: 11787822

Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-beta injections.
van Beuningen HM, Glansbeek HL, van der Kraan PM, van den Berg WB., Osteoarthritis Cartilage 8(1), 2000
PMID: 10607496

Cellular responses of embryonic hyaline cartilage to experimental wounding in vitro.
Walker EA, Verner A, Flannery CR, Archer CW., J Orthop Res 18(1), 2000
PMID: 10716275

The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases.
Schumann H, Baetge J, Tasanen K, Wojnarowska F, Schäcke H, Zillikens D, Bruckner-Tuderman L., Am J Pathol 156(2), 2000
PMID: 10666397

An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies.
Pendás AM, Uría JA, Jiménez MG, Balbín M, Freije JP, López-Otín C., Clin Chim Acta 291(2), 2000
PMID: 10675720

MMP-13 is induced during chondrocyte hypertrophy.
D'Angelo M, Yan Z, Nooreyazdan M, Pacifici M, Sarment DS, Billings PC, Leboy PS., J Cell Biochem 77(4), 2000
PMID: 10771523

Alterations in cartilage type-II procollagen and aggrecan contents in synovial fluid in equine osteochondrosis.
Laverty S, Ionescu M, Marcoux M, Bouré L, Doizé B, Poole AR., J Orthop Res 18(3), 2000
PMID: 10937626

Effects of interleukin-1beta and tumor necrosis factor-alpha on expression of matrix-related genes by cultured equine articular chondrocytes.
Richardson DW, Dodge GR., Am J Vet Res 61(6), 2000
PMID: 10850836

IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion.
Lubberts E, Joosten LA, Chabaud M, van Den Bersselaar L, Oppers B, Coenen-De Roo CJ, Richards CD, Miossec P, van Den Berg WB., J Clin Invest 105(12), 2000
PMID: 10862785

Activation of annexin II and V expression, terminal differentiation, mineralization and apoptosis in human osteoarthritic cartilage.
Kirsch T, Swoboda B, Nah H., Osteoarthritis Cartilage 8(4), 2000
PMID: 10903884

Selective assembly and remodelling of collagens II and IX associated with expression of the chondrocyte hypertrophic phenotype.
Mwale F, Billinghurst C, Wu W, Alini M, Webber C, Reiner A, Ionescu M, Poole J, Poole AR., Dev Dyn 218(4), 2000
PMID: 10906783

Solution structure of the catalytic domain of human collagenase-3 (MMP-13) complexed to a potent non-peptidic sulfonamide inhibitor: binding comparison with stromelysin-1 and collagenase-1.
Zhang X, Gonnella NC, Koehn J, Pathak N, Ganu V, Melton R, Parker D, Hu SI, Nam KY., J Mol Biol 301(2), 2000
PMID: 10926524

Mechanisms involved in cartilage proteoglycan catabolism.
Caterson B, Flannery CR, Hughes CE, Little CB., Matrix Biol 19(4), 2000
PMID: 10963994

Cartilage damage after intraarticular exposure to collagenase 3.
Otterness IG, Bliven ML, Eskra JD, te Koppele JM, Stukenbrok HA, Milici AJ., Osteoarthritis Cartilage 8(5), 2000
PMID: 10966843

The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation.
Bank RA, Soudry M, Maroudas A, Mizrahi J, TeKoppele JM., Arthritis Rheum 43(10), 2000
PMID: 11037879

Extracellular ATP and UTP stimulate cartilage proteoglycan and collagen accumulation in bovine articular chondrocyte pellet cultures.
Croucher LJ, Crawford A, Hatton PV, Russell RG, Buttle DJ., Biochim Biophys Acta 1502(2), 2000
PMID: 11040454

Generation of monoclonal antibodies to cryptic collagen sites by using subtractive immunization.
Xu J, Rodriguez D, Kim JJ, Brooks PC., Hybridoma 19(5), 2000
PMID: 11128027

Observations on fiber-forming collagens in the anulus fibrosus.
Schollmeier G, Lahr-Eigen R, Lewandrowski KU., Spine (Phila Pa 1976) 25(21), 2000
PMID: 11064517

Collagenases in different categories of peri-implant vertical bone loss.
Ma J, Kitti U, Teronen O, Sorsa T, Husa V, Laine P, Rönkä H, Salo T, Lindqvist C, Konttinen YT., J Dent Res 79(11), 2000
PMID: 11145357

Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes.
Jin G, Sah RL, Li YS, Lotz M, Shyy JY, Chien S., J Orthop Res 18(6), 2000
PMID: 11192249

Matrix metalloproteinases and aggrecanase: their role in disorders of the human intervertebral disc.
Roberts S, Caterson B, Menage J, Evans EH, Jaffray DC, Eisenstein SM., Spine (Phila Pa 1976) 25(23), 2000
PMID: 11145811

The distribution of YKL-40 in osteoarthritic and normal human articular cartilage.
Volck B, Ostergaard K, Johansen JS, Garbarsch C, Price PA., Scand J Rheumatol 28(3), 1999
PMID: 10380840

Relationship of matrix metalloproteinases and their inhibitors to cartilage proteoglycan and collagen turnover: analyses of synovial fluid from patients with osteoarthritis.
Ishiguro N, Ito T, Ito H, Iwata H, Jugessur H, Ionescu M, Poole AR., Arthritis Rheum 42(1), 1999
PMID: 9920023

Retinoic acid-induced type II collagen degradation does not correlate with matrix metalloproteinase activity in cartilage explant cultures.
Price JS, Wang-Weigand S, Bohne R, Kozaci LD, Hollander AP., Arthritis Rheum 42(1), 1999
PMID: 9920024

The use of cleavage site specific antibodies to delineate protein processing and breakdown pathways.
Mort JS, Buttle DJ., Mol Pathol 52(1), 1999
PMID: 10439833

The pathobiology of osteoarthritis and the rationale for the use of pentosan polysulfate for its treatment.
Ghosh P., Semin Arthritis Rheum 28(4), 1999
PMID: 10073500

Changes in joint cartilage aggrecan after knee injury and in osteoarthritis.
Lohmander LS, Ionescu M, Jugessur H, Poole AR., Arthritis Rheum 42(3), 1999
PMID: 10088777

Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolism.
Sztrolovics R, White RJ, Poole AR, Mort JS, Roughley PJ., Biochem J 339 ( Pt 3)(), 1999
PMID: 10215595

Evidence for increased collagenolysis by interstitial collagenases-1 and -3 in vulnerable human atheromatous plaques.
Sukhova GK, Schönbeck U, Rabkin E, Schoen FJ, Poole AR, Billinghurst RC, Libby P., Circulation 99(19), 1999
PMID: 10330380

Potential treatment of osteoarthritis by gene therapy.
Evans CH, Robbins PD., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356421

Serum markers of articular cartilage damage and repair.
Wollheim FA., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356426

Synovial fluid markers in osteoarthritis.
Myers SL., Rheum Dis Clin North Am 25(2), 1999
PMID: 10356427

In situ zymographic localisation of type II collagen degrading activity in osteoarthritic human articular cartilage.
Freemont AJ, Byers RJ, Taiwo YO, Hoyland JA., Ann Rheum Dis 58(6), 1999
PMID: 10340960

Type II collagen peptide release from rabbit articular cartilage.
Felice BR, Chichester CO, Barrach HJ., Ann N Y Acad Sci 878(), 1999
PMID: 10415782

Inhibition of articular cartilage degradation in culture by a novel nonpeptidic matrix metalloproteinase inhibitor.
Billinghurst RC, O'Brien K, Poole AR, McIlwraith CW., Ann N Y Acad Sci 878(), 1999
PMID: 10415783

Characterization of collagenase 3 (matrix metalloproteinase 13) messenger RNA expression in the synovial membrane and synovial fibroblasts of patients with rheumatoid arthritis.
Westhoff CS, Freudiger D, Petrow P, Seyfert C, Zacher J, Kriegsmann J, Pap T, Gay S, Stiehl P, Gromnica-Ihle E, Wernicke D., Arthritis Rheum 42(7), 1999
PMID: 10403281

Denaturation of type II collagen in articular cartilage in experimental murine arthritis. Evidence for collagen degradation in both reversible and irreversible cartilage damage.
Stoop R, van der Kraan PM, Buma P, Hollander AP, Poole AR, van den Berg WB., J Pathol 188(3), 1999
PMID: 10419604

Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis.
Song Xy, Zeng L, Jin W, Thompson J, Mizel DE, Lei K, Billinghurst RC, Poole AR, Wahl SM., J Exp Med 190(4), 1999
PMID: 10449524

Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody.
Otterness IG, Downs JT, Lane C, Bliven ML, Stukenbrok H, Scampoli DN, Milici AJ, Mézes PS., Matrix Biol 18(4), 1999
PMID: 10517180

Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictably in rheumatoid arthritis patients who have begun activity after a night of bed rest.
Manicourt DH, Poilvache P, Nzeusseu A, van Egeren A, Devogelaer JP, Lenz ME, Thonar EJ., Arthritis Rheum 42(9), 1999
PMID: 10513800

Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: a pivotal role for stromelysin 1 in matrix metalloproteinase activity.
van Meurs J, van Lent P, Stoop R, Holthuysen A, Singer I, Bayne E, Mudgett J, Poole R, Billinghurst C, van der Kraan P, Buma P, van den Berg W., Arthritis Rheum 42(10), 1999
PMID: 10524678

Type II collagen degradation in spontaneous osteoarthritis in C57Bl/6 and BALB/c mice.
Stoop R, van der Kraan PM, Buma P, Hollander AP, Billinghurst RC, Poole AR, van den Berg WB., Arthritis Rheum 42(11), 1999
PMID: 10555034

Degradation of cartilage type II collagen precedes the onset of osteoarthritis following anterior cruciate ligament rupture.
Price JS, Till SH, Bickerstaff DR, Bayliss MT, Hollander AP., Arthritis Rheum 42(11), 1999
PMID: 10555035

Matrix metalloproteinases in repair.
Parks WC., Wound Repair Regen 7(6), 1999
PMID: 10633001

Changes in collagen turnover in early acute respiratory distress syndrome.
Armstrong L, Thickett DR, Mansell JP, Ionescu M, Hoyle E, Billinghurst RC, Poole AR, Millar AB., Am J Respir Crit Care Med 160(6), 1999
PMID: 10588605

Differential detection of type II collagen N-terminal and C-terminal denaturation epitopes in degrading cartilage.
Croucher LJ, Hollander AP., Mol Pathol 52(6), 1999
PMID: 10748865

In vitro sensitivity of the three mammalian collagenases to tetracycline inhibition: relationship to bone and cartilage degradation.
Greenwald RA, Golub LM, Ramamurthy NS, Chowdhury M, Moak SA, Sorsa T., Bone 22(1), 1998
PMID: 9437511

Characterization of helical cleavages in type II collagen generated by matrixins.
Vankemmelbeke M, Dekeyser PM, Hollander AP, Buttle DJ, Demeester J., Biochem J 330 ( Pt 2)(), 1998
PMID: 9480869

Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix.
Kafienah W, Brömme D, Buttle DJ, Croucher LJ, Hollander AP., Biochem J 331 ( Pt 3)(), 1998
PMID: 9560298

Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis.
Huebner JL, Otterness IG, Freund EM, Caterson B, Kraus VB., Arthritis Rheum 41(5), 1998
PMID: 9588741

Collagenase-3 (MMP-13) expression in chondrosarcoma cells and its regulation by basic fibroblast growth factor.
Uría JA, Balbín M, López JM, Alvarez J, Vizoso F, Takigawa M, López-Otín C., Am J Pathol 153(1), 1998
PMID: 9665469

Stromelysin 1, neutrophil collagenase, and collagenase 3 do not play major roles in a model of chondrocyte mediated cartilage breakdown.
Kozaci LD, Brown CJ, Adcocks C, Galloway A, Hollander AP, Buttle DJ., Mol Pathol 51(5), 1998
PMID: 10193524

Evidence for altered synthesis of type II collagen in patients with osteoarthritis.
Nelson F, Dahlberg L, Laverty S, Reiner A, Pidoux I, Ionescu M, Fraser GL, Brooks E, Tanzer M, Rosenberg LC, Dieppe P, Robin Poole A., J Clin Invest 102(12), 1998
PMID: 9854047

52 References

Daten bereitgestellt von Europe PubMed Central.

Localization of proteoglycan monomer and link protein in the matrix of bovine articular cartilage: An immunohistochemical study.
Poole AR, Pidoux I, Reiner A, Tang LH, Choi H, Rosenberg L., J. Histochem. Cytochem. 28(7), 1980
PMID: 6156200

Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies.
Girkontaite I, Frischholz S, Lammi P, Wagner K, Swoboda B, Aigner T, Von der Mark K., Matrix Biol. 15(4), 1996
PMID: 8892223

Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies.
Tetlow LC, Woolley DE., Ann. Rheum. Dis. 54(11), 1995
PMID: 7492239

Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay.
Hollander AP, Heathfield TF, Webber C, Iwata Y, Bourne R, Rorabeck C, Poole AR., J. Clin. Invest. 93(4), 1994
PMID: 7512992

Monoclonal antibodies that specifically recognize neoepitope sequences generated by 'aggrecanase' and matrix metalloproteinase cleavage of aggrecan: application to catabolism in situ and in vitro.
Hughes CE, Caterson B, Fosang AJ, Roughley PJ, Mort JS., Biochem. J. 305 ( Pt 3)(), 1995
PMID: 7531436

VDIPEN, a metalloproteinase-generated neoepitope, is induced and immunolocalized in articular cartilage during inflammatory arthritis.
Singer II, Kawka DW, Bayne EK, Donatelli SA, Weidner JR, Williams HR, Ayala JM, Mumford RA, Lark MW, Glant TT., J. Clin. Invest. 95(5), 1995
PMID: 7537757

Development of a cleavage-site-specific monoclonal antibody for detecting metalloproteinase-derived aggrecan fragments: detection of fragments in human synovial fluids.
Fosang AJ, Last K, Gardiner P, Jackson DC, Brown L., Biochem. J. 310 ( Pt 1)(), 1995
PMID: 7544117

Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization.
Keyszer GM, Heer AH, Kriegsmann J, Geiler T, Trabandt A, Keysser M, Gay RE, Gay S., Arthritis Rheum. 38(7), 1995
PMID: 7612047

Monoclonal antibodies against human fibroblast collagenase and the design of an enzyme-linked immunosorbent assay to measure total collagenase.
Clark IM, Powell LK, Wright JK, Cawston TE, Hazleman BL., Matrix 12(6), 1992
PMID: 1287416

Polyclonal antibodies against human fibroblast collagenase and the design of an enzyme-linked immunosorbent assay to measure TIMP-collagenase complex.
Clark IM, Wright JK, Cawston TE, Hazleman BL., Matrix 12(2), 1992
PMID: 1318493

Detection of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and posttraumatic knee injury.
Walakovits LA, Moore VL, Bhardwaj N, Gallick GS, Lark MW., Arthritis Rheum. 35(1), 1992
PMID: 1370619

Monoclonal antibodies recognizing protease-generated neoepitopes from cartilage proteoglycan degradation. Application to studies of human link protein cleavage by stromelysin.
Hughes CE, Caterson B, White RJ, Roughley PJ, Mort JS., J. Biol. Chem. 267(23), 1992
PMID: 1379586

A novel coumarin-labelled peptide for sensitive continuous assays of the matrix metalloproteinases.
Knight CG, Willenbrock F, Murphy G., FEBS Lett. 296(3), 1992
PMID: 1537400

In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium.
Gravallese EM, Darling JM, Ladd AL, Katz JN, Glimcher LH., Arthritis Rheum. 34(9), 1991
PMID: 1657007

Gene expression (collagenase, tissue inhibitor of metalloproteinases, complement, and HLA-DR) in rheumatoid arthritis and osteoarthritis synovium. Quantitative analysis and effect of intraarticular corticosteroids.
Firestein GS, Paine MM, Littman BH., Arthritis Rheum. 34(9), 1991
PMID: 1657009

Cleavage of Type II and III collagens with mammalian collagenase: site of cleavage and primary structure at the NH2-terminal portion of the smaller fragment released from both collagens.
Miller EJ, Harris ED Jr, Chung E, Finch JE Jr, McCroskery PA, Butler WT., Biochemistry 15(4), 1976
PMID: 174719

Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage.
Wu JJ, Lark MW, Chun LE, Eyre DR., J. Biol. Chem. 266(9), 1991
PMID: 2005102

Human neutrophil collagenase. A distinct gene product with homology to other matrix metalloproteinases.
Hasty KA, Pourmotabbed TF, Goldberg GI, Thompson JP, Spinella DG, Stevens RM, Mainardi CL., J. Biol. Chem. 265(20), 1990
PMID: 2164002

A rapid and reproducible assay for collagenase using [1-14C]acetylated collagen.
Cawston TE, Barrett AJ., Anal. Biochem. 99(2), 1979
PMID: 229741

Hypertrophic chondrocytes produce immunoreactive collagenase in vivo.
Blair HC, Dean DD, Howell DS, Teitelbaum SL, Jeffrey JJ., Connect. Tissue Res. 23(1), 1989
PMID: 2561091

Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1.
Dodge GR, Poole AR., J. Clin. Invest. 83(2), 1989
PMID: 2783591

A sensitive, specific assay for tissue collagenase using telopeptide-free [3H]acetylated collagen.
Dean DD, Woessner JF Jr., Anal. Biochem. 148(1), 1985
PMID: 2994518

Synthesis of type II collagen is decreased in cartilage cultured with interleukin 1 while the rate of intracellular degradation remains unchanged.
Tyler JA, Benton HP., Coll. Relat. Res. 8(5), 1988
PMID: 3265659

Separation of type III collagen from type I collagen and pepsin by differential denaturation and renaturation.
ChandraRajan J., Biochem. Biophys. Res. Commun. 83(1), 1978
PMID: 358975

Collagen cross-linking amino acids.
Eyre D., Meth. Enzymol. 144(), 1987
PMID: 3626870

Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association.
Altman R, Asch E, Bloch D, Bole G, Borenstein D, Brandt K, Christy W, Cooke TD, Greenwald R, Hochberg M., Arthritis Rheum. 29(8), 1986
PMID: 3741515

The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans.
Kempson GE, Muir H, Pollard C, Tuke M., Biochim. Biophys. Acta 297(2), 1973
PMID: 4267503

Tadpole collagenase. Preparation and purification.
Nagai Y, Lapiere CM, Gross J., Biochemistry 5(10), 1966
PMID: 4291361

Isolation and characterization of a collagen from chick cartilage containing three identical alpha chains.
Miller EJ., Biochemistry 10(9), 1971
PMID: 4325605

Cleavage of structural proteins during the assembly of the head of bacteriophage T4.
Laemmli UK., Nature 227(5259), 1970
PMID: 5432063

Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data.
Mankin HJ, Dorfman H, Lippiello L, Zarins A., J Bone Joint Surg Am 53(3), 1971
PMID: 5580011

A simple in vivo model of collagen degradation using collagen-gelled cotton buds: the effects of collagenase inhibitors and other agents.
Karran EH, Dodgson K, Harris SJ, Markwell RE, Harper GP., Inflamm. Res. 44(1), 1995
PMID: 7664028

Human neutrophil collagenase.
Tschesche H., Meth. Enzymol. 248(), 1995
PMID: 7674936

Quantification of a matrix metalloproteinase-generated aggrecan G1 fragment using monospecific anti-peptide serum.
Lark MW, Williams H, Hoernner LA, Weidner J, Ayala JM, Harper CF, Christen A, Olszewski J, Konteatis Z, Webber R., Biochem. J. 307 ( Pt 1)(), 1995
PMID: 7717983

A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling.
Liu X, Wu H, Byrne M, Jeffrey J, Krane S, Jaenisch R., J. Cell Biol. 130(1), 1995
PMID: 7790374

Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas.
Freije JM, Diez-Itza I, Balbin M, Sanchez LM, Blasco R, Tolivia J, Lopez-Otin C., J. Biol. Chem. 269(24), 1994
PMID: 8207000

Differential in vivo expression of collagenase messenger RNA in synovium and cartilage. Quantitative comparison with stromelysin messenger RNA levels in human rheumatoid arthritis and osteoarthritis patients and in two animal models of acute inflammatory arthritis.
Wolfe GC, MacNaul KL, Buechel FF, McDonnell J, Hoerrner LA, Lark MW, Moore VL, Hutchinson NI., Arthritis Rheum. 36(11), 1993
PMID: 8240430

Metalloproteinases, tissue inhibitor, and proteoglycan fragments in knee synovial fluid in human osteoarthritis.
Lohmander LS, Hoerrner LA, Lark MW., Arthritis Rheum. 36(2), 1993
PMID: 8431206

Matrix metalloproteinases: a review.
Birkedal-Hansen H, Moore WG, Bodden MK, Windsor LJ, Birkedal-Hansen B, DeCarlo A, Engler JA., Crit. Rev. Oral Biol. Med. 4(2), 1993
PMID: 8435466

The measurement of collagenase, tissue inhibitor of metalloproteinases (TIMP), and collagenase-TIMP complex in synovial fluids from patients with osteoarthritis and rheumatoid arthritis.
Clark IM, Powell LK, Ramsey S, Hazleman BL, Cawston TE., Arthritis Rheum. 36(3), 1993
PMID: 8452582

Direct evidence for active metalloproteinases mediating matrix degradation in interleukin 1-stimulated human articular cartilage.
Mort JS, Dodge GR, Roughley PJ, Liu J, Finch SJ, DiPasquale G, Poole AR., Matrix 13(2), 1993
PMID: 8492744

Determination of interstitial collagenase (MMP-1) in patients with rheumatoid arthritis.
Maeda S, Sawai T, Uzuki M, Takahashi Y, Omoto H, Seki M, Sakurai M., Ann. Rheum. Dis. 54(12), 1995
PMID: 8546529

Development of an enzyme-linked immunosorbent assay to measure total TIMP-1 (free TIMP-1 and TIMP-1 in combination with matrix-metalloproteinases) and measurement of TIMP 1 and CRP in serum.
Plumpton TA, Clark IM, Plumpton C, Calvin J, Cawston TE., Clin. Chim. Acta 240(2), 1995
PMID: 8548924

Chondrocyte matrix metalloproteinase-8: up-regulation of neutrophil collagenase by interleukin-1 beta in human cartilage from knee and ankle joints.
Chubinskaya S, Huch K, Mikecz K, Cs-Szabo G, Hasty KA, Kuettner KE, Cole AA., Lab. Invest. 74(1), 1996
PMID: 8569187

Biochemical characterization of human collagenase-3.
Knauper V, Lopez-Otin C, Smith B, Knight G, Murphy G., J. Biol. Chem. 271(3), 1996
PMID: 8576151

Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilage.
Mitchell PG, Magna HA, Reeves LM, Lopresti-Morrow LL, Yocum SA, Rosner PJ, Geoghegan KF, Hambor JE., J. Clin. Invest. 97(3), 1996
PMID: 8609233

The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.
Reboul P, Pelletier JP, Tardif G, Cloutier JM, Martel-Pelletier J., J. Clin. Invest. 97(9), 1996
PMID: 8621789

Chondrocyte matrix metalloproteinase-8. Human articular chondrocytes express neutrophil collagenase.
Cole AA, Chubinskaya S, Schumacher B, Huch K, Szabo G, Yao J, Mikecz K, Hasty KA, Kuettner KE., J. Biol. Chem. 271(18), 1996
PMID: 8631924

Damage to type II collagen in aging and osteoarthritis starts at the articular surface, originates around chondrocytes, and extends into the cartilage with progressive degeneration.
Hollander AP, Pidoux I, Reiner A, Rorabeck C, Bourne R, Poole AR., J. Clin. Invest. 96(6), 1995
PMID: 8675657

Cloning of collagenase 3 from the synovial membrane and its expression in rheumatoid arthritis and osteoarthritis.
Wernicke D, Seyfert C, Hinzmann B, Gromnica-Ihle E., J. Rheumatol. 23(4), 1996
PMID: 8730110

Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes.
Borden P, Solymar D, Sucharczuk A, Lindman B, Cannon P, Heller RA., J. Biol. Chem. 271(38), 1996
PMID: 8798568

The gelatinolytic activity of human skin fibroblast collagenase.
Welgus HG, Jeffrey JJ, Stricklin GP, Eisen AZ., J. Biol. Chem. 257(19), 1982
PMID: 6288690

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