Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi

Jackel M, Witt C, Antonova O, Curdt I, Labeit S, Jockusch H (1997)
FEBS LETTERS 408(1): 21-24.

Zeitschriftenaufsatz | Veröffentlicht | Englisch
 
Download
Es wurden keine Dateien hochgeladen. Nur Publikationsnachweis!
DOI
Autor*in
Jackel, M; Witt, C; Antonova, O; Curdt, I; Labeit, S; Jockusch, HaraldUniBi
Einrichtung
Fakultät für Biologie
Abstract / Bemerkung
The gene for titin, a 4MDa myofibrillar protein, was analysed in golden hamster DNAs from different sources, using human cDNA probes and PCR. In the DNA from the BHK-21-Bi subline of baby hamster kidney cells, extended sequences coding for Z-line associated domains mere missing, indicating a deletion that renders titin non-functional. These sequences were present in the original BHK-21 line and in hamster DNAs. Our finding shows that, due to the absence of selective pressure on a gene's function, genomic deterioration can occur in a permanent cell line and can lead to a loss of overlapping DNA stretches in both autosomes. (C) 1997 Federation of European Biochemical Societies.
Stichworte
cytoskeleton; sarcomere; genetic deterioration; permanent cell line
Erscheinungsjahr
1997
Zeitschriftentitel
FEBS LETTERS
Band
408
Ausgabe
1
Seite(n)
21-24
ISSN
0014-5793
Page URI
https://pub.uni-bielefeld.de/record/1637137

Zitieren

Jackel M, Witt C, Antonova O, Curdt I, Labeit S, Jockusch H. Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS. 1997;408(1):21-24.
Jackel, M., Witt, C., Antonova, O., Curdt, I., Labeit, S., & Jockusch, H. (1997). Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS, 408(1), 21-24. https://doi.org/10.1016/S0014-5793(97)00381-5
Jackel, M, Witt, C, Antonova, O, Curdt, I, Labeit, S, and Jockusch, Harald. 1997. “Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi”. FEBS LETTERS 408 (1): 21-24.
Jackel, M., Witt, C., Antonova, O., Curdt, I., Labeit, S., and Jockusch, H. (1997). Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS 408, 21-24.
Jackel, M., et al., 1997. Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS, 408(1), p 21-24.
M. Jackel, et al., “Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi”, FEBS LETTERS, vol. 408, 1997, pp. 21-24.
Jackel, M., Witt, C., Antonova, O., Curdt, I., Labeit, S., Jockusch, H.: Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi. FEBS LETTERS. 408, 21-24 (1997).
Jackel, M, Witt, C, Antonova, O, Curdt, I, Labeit, S, and Jockusch, Harald. “Deletion in the Z-line region of the titin gene in a baby hamster kidney cell line, BHK-21-Bi”. FEBS LETTERS 408.1 (1997): 21-24.

1 Zitation in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

Human autoantibodies reveal titin as a chromosomal protein.
Machado C, Sunkel CE, Andrew DJ., J Cell Biol 141(2), 1998
PMID: 9548712

16 References

Daten bereitgestellt von Europe PubMed Central.

Complete cloning of the Duchenne muscular dystrophy (DMD) cDNA and preliminary genomic organization of the DMD gene in normal and affected individuals.
Koenig M, Hoffman EP, Bertelson CJ, Monaco AP, Feener C, Kunkel LM., Cell 50(3), 1987
PMID: 3607877
Decreased osmotic stability of dystrophin-less muscle cells from the mdx mouse.
Menke A, Jockusch H., Nature 349(6304), 1991
PMID: 1985268
Extent of shock-induced membrane leakage in human and mouse myotubes depends on dystrophin.
Menke A, Jockusch H., J. Cell. Sci. 108 ( Pt 2)(), 1995
PMID: 7769014
Connectin, an elastic protein of striated muscle.
Maruyama K., Biophys. Chem. 50(1-2), 1994
PMID: 8011942
The giant protein titin. Emerging roles in physiology and pathophysiology.
Labeit S, Kolmerer B, Linke WA., Circ. Res. 80(2), 1997
PMID: 9012751

Stoker, Virology 14(), 1961
Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle.
Yaffe D, Saxel O., Nature 270(5639), 1977
PMID: 563524
Cytoplasmic activation of human nuclear genes in stable heterocaryons.
Blau HM, Chiu CP, Webster C., Cell 32(4), 1983
PMID: 6839359
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity.
Feinberg AP, Vogelstein B., Anal. Biochem. 132(1), 1983
PMID: 6312838
Titins: giant proteins in charge of muscle ultrastructure and elasticity.
Labeit S, Kolmerer B., Science 270(5234), 1995
PMID: 7569978
The complete primary structure of human nebulin and its correlation to muscle structure.
Labeit S, Kolmerer B., J. Mol. Biol. 248(2), 1995
PMID: 7739042
Inhibition of desmin expression blocks myoblast fusion and interferes with the myogenic regulators MyoD and myogenin.
Li H, Choudhary SK, Milner DJ, Munir MI, Kuisk IR, Capetanaki Y., J. Cell Biol. 124(5), 1994
PMID: 8120103

AUTHOR UNKNOWN, 0
Chromosomal localization of the mouse titin gene and its relation to "muscular dystrophy with myositis" and nebulin genes on chromosome 2.
Muller-Seitz M, Kaupmann K, Labeit S, Jockusch H., Genomics 18(3), 1993
PMID: 8307566
A regular pattern of two types of 100-residue motif in the sequence of titin.
Labeit S, Barlow DP, Gautel M, Gibson T, Holt J, Hsieh CL, Francke U, Leonard K, Wardale J, Whiting A., Nature 345(6272), 1990
PMID: 2129545
Baby hamster kidney (BHK-21/C13) cells can express striated muscle type proteins.
Schaart G, Pieper FR, Kuijpers HJ, Bloemendal H, Ramaekers FC., Differentiation 46(2), 1991
PMID: 2065865
Export

Markieren/ Markierung löschen
Markierte Publikationen

Open Data PUB

Web of Science

Dieser Datensatz im Web of Science®
Quellen

PMID: 9180260
PubMed | Europe PMC

Suchen in

Google Scholar