Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification

Frese, Marc-Andre; Dierks, Thomas

Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification

Frese M-A, Dierks T (2009)
CHEMBIOCHEM 10(3): 425-427.

Zeitschriftenaufsatz | Veröffentlicht | Englisch

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DOI

https://doi.org/10.1002/cbic.200800801

Autor*in

Frese, Marc-Andre; Dierks, Thomas^UniBi

Einrichtung

Centrum für Biotechnologie > Institut für Biochemie und Biotechnik
Fakultät für Chemie > Biochemie I
Centrum für Biotechnologie > Arbeitsgruppe T. Dierks

Abstract / Bemerkung

Oxidation of a specific cysteine residue to C(alpha)-formylglycine is a novel post-translational modification that is directed by a short recognition motif commonly found in pro- and eukaryotic sulfatases. As recently shown by C. Bertozzi and co-workers, this system can be employed in protein engineering to equip proteins with genetically encoded aldehyde tags for site-specific labeling, conjugation and immobilization.

Stichworte

enzymes; protein; modifications; protein engineering; aldehyde tag; formylglycine

Erscheinungsjahr

2009

Zeitschriftentitel

CHEMBIOCHEM

Band

Ausgabe

Seite(n)

425-427

ISSN

1439-4227

eISSN

1439-7633

Page URI

https://pub.uni-bielefeld.de/record/1635473

Zitieren

Frese M-A, Dierks T. Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification. CHEMBIOCHEM. 2009;10(3):425-427.

Frese, M. - A., & Dierks, T. (2009). Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification. CHEMBIOCHEM, 10(3), 425-427. https://doi.org/10.1002/cbic.200800801

Frese, Marc-Andre, and Dierks, Thomas. 2009. “Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification”. CHEMBIOCHEM 10 (3): 425-427.

Frese, M. - A., and Dierks, T. (2009). Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification. CHEMBIOCHEM 10, 425-427.

Frese, M.-A., & Dierks, T., 2009. Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification. CHEMBIOCHEM, 10(3), p 425-427.

M.-A. Frese and T. Dierks, “Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification”, CHEMBIOCHEM, vol. 10, 2009, pp. 425-427.

Frese, M.-A., Dierks, T.: Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification. CHEMBIOCHEM. 10, 425-427 (2009).

Frese, Marc-Andre, and Dierks, Thomas. “Formylglycine Aldehyde Tag-Protein Engineering through a Novel Post-translational Modification”. CHEMBIOCHEM 10.3 (2009): 425-427.

9 Zitationen in Europe PMC

Daten bereitgestellt von Europe PubMed Central.

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Formylglycine, a post-translationally generated residue with unique catalytic capabilities and biotechnology applications.
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Cho H, Jaworski J., Biosens Bioelectron 54(), 2014
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Rabuka D, Rush JS, deHart GW, Wu P, Bertozzi CR., Nat Protoc 7(6), 2012
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AUTHOR UNKNOWN, 0

Harris, Nat. Rev. Drug Discovery 2(), 2003

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